+E Replication protein KO
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DNA Replication Proteins - Leguminivora glycinivorella (soybean pod borer)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 125224851 LOW QUALITY PROTEIN: origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 125226189 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 125238692 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 125238126 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 125231751 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 125226160 DNA replication licensing factor Mcm2 isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 125242367 DNA replication licensing factor Mcm3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 125234434 DNA replication licensing factor MCM4 isoform X1 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 125232796 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 125238304 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 125241603 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 125228532 cyclin-A2-like K06627 CCNA; cyclin-A
D 125225825 G1/S-specific cyclin-E K06626 CCNE; G1/S-specific cyclin-E1
D 125236679 LOW QUALITY PROTEIN: cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 125241157 cell division cycle 7-related protein kinase-like isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 125229911 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 125228383 LOW QUALITY PROTEIN: probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 125234987 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 125241250 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 125232089 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 125236379 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 125225630 LOW QUALITY PROTEIN: DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 125237103 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 125230925 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 125231788 mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 125230661 uncharacterized protein LOC125230661 K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 125241601 LOW QUALITY PROTEIN: DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 125232551 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 125227823 DNA primase small subunit isoform X1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 125227230 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
D 125241752 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 125232730 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 125242401 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 125237212 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 125226268 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 125228273 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 125232258 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 125240174 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 125235924 LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D 125230210 LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 125230160 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
C RFC (replication factor C)
D 125241389 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 125235852 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 125241575 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 125229495 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 125230682 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 125236446 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 125240335 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 125241219 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 125229722 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 125241155 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 125239461 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 125226325 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 125236817 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 125237925 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 125231833 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 125237781 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 125232081 ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 125230454 LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase PliMCI-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 125230089 geminin K10749 GMNN; geminin
D 125241416 uncharacterized protein LOC125241416 K10749 GMNN; geminin
D 125225372 G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 125227240 G2/mitotic-specific cyclin-B3 isoform X1 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 125236291 cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 125227930 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 125234027 nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 125238375 uncharacterized protein LOC125238375 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 125227270 LOW QUALITY PROTEIN: probable H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 125238415 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 125232800 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 125239973 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 125238375 uncharacterized protein LOC125238375 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 125227506 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 125239967 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 125238392 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 125232127 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 125231915 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
C ELG1-RFC complex
D 125235852 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 125241575 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 125229495 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 125230682 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 125228624 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 125230252 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 125230279 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D 125226790 serine-protein kinase ATM-like K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 125234120 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 125226465 LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 125226062 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 125239769 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 125228073 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 125227721 telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 125231038 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 125235379 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
D 125237883 LOW QUALITY PROTEIN: replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 125225480 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 125226891 DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 125232220 DNA topoisomerase 2 isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 125233619 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 125236087 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 125229009 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 125236446 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 125240335 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 125241219 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 125236446 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 125240335 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 125241219 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 125236817 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 125237925 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 125237781 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025