+F Repair protein KO
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DNA Repair and Recombination Proteins - Lawsonia intracellularis PHE/MN1-00
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LI0023 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E LI0165 mutY; A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LI0778 nth; endonuclease III, putative K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D LI0579 mutT; NTP pyrophosphohydrolases including oxidative damage repair enzymes K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LI0940 yqiE; ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LI0088 dut; dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LI0023 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E LI0165 mutY; A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LI0637 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E LI0778 nth; endonuclease III, putative K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E LI0839 xthA; Exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E LI0313 recJ; Single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E LI0242 lig; NAD-dependent DNA ligase (contains BRCT domain type II) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E LI1177 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E LI0241 uvrB; Helicase subunit of the DNA excision repair complex K03702 uvrB; excinuclease ABC subunit B
E LI0701 uvrC; Nuclease subunit of the excinuclease complex K03703 uvrC; excinuclease ABC subunit C
E LI0672 pcrA; Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LI0242 lig; NAD-dependent DNA ligase (contains BRCT domain type II) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F LI0905 rpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F LI0904 rpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F LI0982 rpoA; DNA-directed RNA polymerase, alpha subunit/40 kD subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F LI0305 transcription-repair coupling factor (superfamily II helicase) K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E LI0236 mutS; Mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E LI0628 mutL; DNA mismatch repair enzyme (predicted ATPase) K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E LI0405 xseA; Exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E LI0257 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E LI0786 dnaN; DNA polymerase sliding clamp subunit (PCNA homolog) K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E LI0150 hypothetical protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E LI0011 polB; DNA polymerase I-3'-5' exonuclease and polymerase domains K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E LI0916 dnaX; DNA polymerase III, gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E LI0242 lig; NAD-dependent DNA ligase (contains BRCT domain type II) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E LI0672 pcrA; Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LI0492 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E LI0652 DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E LI0287 recD; ATP-dependent exoDNAse (exonuclease V), alpha subunit-helicase superfamily I member K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E LI1182 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
E LI1186 ruvA; Holliday junction resolvasome, DNA-binding subunit K03550 ruvA; holliday junction DNA helicase RuvA
E LI1187 ruvB; Holliday junction resolvasome, helicase subunit K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LI0268 ruvC; Holliday junction resolvasome, endonuclease subunit K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E LI0194 priA; Primosomal protein N' (replication factor Y)-superfamily II helicase K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E LI0585 DNA repair exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E LI1182 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
E LI0616 radA; predicted ATP-dependent serine protease K04485 radA; DNA repair protein RadA/Sms
E LI0313 recJ; Single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E LI0301 recO; hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O)
E LI0918 recR; Recombinational DNA repair protein (RecF pathway) ref|ZP_00131299.1| 353: Recombinational DNA repair protein (RecF pathway) K06187 recR; recombination protein RecR
E LI0249 recN; ATPase involved in DNA repair K03631 recN; DNA repair protein RecN (Recombination protein N)
E LI0253 hypothetical protein K03554 rdgC; recombination associated protein RdgC
E LI1186 ruvA; Holliday junction resolvasome, DNA-binding subunit K03550 ruvA; holliday junction DNA helicase RuvA
E LI1187 ruvB; Holliday junction resolvasome, helicase subunit K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LI0268 ruvC; Holliday junction resolvasome, endonuclease subunit K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E LI0585 DNA repair exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F LI0784 gyrA; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F LI0785 gyrB; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F LI0654 topA; Zn-finger domain associated with topoisomerase type I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F LI0313 recJ; Single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F LI0301 recO; hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O)
F LI0918 recR; Recombinational DNA repair protein (RecF pathway) ref|ZP_00131299.1| 353: Recombinational DNA repair protein (RecF pathway) K06187 recR; recombination protein RecR
F LI0242 lig; NAD-dependent DNA ligase (contains BRCT domain type II) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F LI0431 himA; Bacterial nucleoid DNA-binding protein K04764 ihfA; integration host factor subunit alpha
F LI0894 himD; Bacterial nucleoid DNA-binding protein K05788 ihfB; integration host factor subunit beta
E Supressor
F LI1177 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F LI0241 uvrB; Helicase subunit of the DNA excision repair complex K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D LI1182 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
D LI0249 recN; ATPase involved in DNA repair K03631 recN; DNA repair protein RecN (Recombination protein N)
D LI0492 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D LI0579 mutT; NTP pyrophosphohydrolases including oxidative damage repair enzymes K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LI0940 yqiE; ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LI0088 dut; dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LI0476 nrdA; Ribonucleotide reductase large subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LI0477 nrdB; Ribonucleotide reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D LI0536 mgpa; Exopolyphosphatase-related proteins K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024