+E Messenger RNA Biogenesis KO #

  Messenger RNA Biogenesis - Leishmania mexicana

% ! AEukaryotic type B mRNA processing factors C 5' end processing D Capping factors E LMXM_36_0120 putative mRNA capping methyltransferase K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56] E LMXM_21_1080 cdc2-related kinase K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22] E LMXM_36_6660 ensangp00000010174-like protein K14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57] E LMXM_24_0110 hypothetical protein K18776 MTR2; cap2 methyltransferase [EC:2.1.1.296] E LMXM_34_3380 hypothetical protein K18777 MTR3; cap3/cap4 methyltransferase [EC:2.1.1.-] D Cap binding complex E LMXM_29_0540 putative nuclear cap binding protein K12883 NCBP2; nuclear cap-binding protein subunit 2 C 3' end processing D Pre-mRNA cleavage factor Im (CFIm) E LMXM_26_0290 hypothetical protein K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5 D Pre-mRNA cleavage factor IIm (CFIIm) E LMXM_29_2410 pre-mRNA cleavage complex II Clp1-like protein K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] E LMXM_30_0210 hypothetical protein K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] E LMXM_30_0211 hypothetical protein K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] D Cleavage and polyadenylation specificity factor (CPSF) complex E LMXM_31_1340 cleavage and polyadenylation specificity factor-like protein K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1 E LMXM_25_0170 cleavage and polyadenylation specificity factor,putative K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 E LMXM_33_3430 cleavage and polyadenylation specificity factor,putative K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] E LMXM_09_0720 putative cleavage and polyadenylation specificity factor 30 kDa subunit K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4 E LMXM_28_0690 putative serine/threonine protein phosphatase catalytic subunit K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] E LMXM_30_2630 serine/threonine protein phosphatase pp1(5.9),putative K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] D Cleavage stimulation factor (CSTF) complex E LMXM_32_0280 hypothetical protein K14406 CSTF1; cleavage stimulation factor subunit 1 D U7-dependent histone pre-mRNA processing factors E LMXM_27_1970 small nuclear ribonucleoprotein protein,putative K11086 SNRPB; small nuclear ribonucleoprotein B and B' E LMXM_33_3860 putative small nuclear ribonucleoprotein K11088 SNRPD3; small nuclear ribonucleoprotein D3 E LMXM_29_1205 small nuclear ribonucleoprotein polypeptide e,putative K11097 SNRPE; small nuclear ribonucleoprotein E E LMXM_34_4460 putative sm-f snRNP core complex protein K11098 SNRPF; small nuclear ribonucleoprotein F E LMXM_31_1070 putative small nuclear ribonucleoprotein K11099 SNRPG; small nuclear ribonucleoprotein G E LMXM_25_0170 cleavage and polyadenylation specificity factor,putative K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 E LMXM_33_3430 cleavage and polyadenylation specificity factor,putative K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] D DRB sensitivity inducing factor (DSIF) complex E LMXM_34_2390 hypothetical protein K15171 SUPT4H1; transcription elongation factor SPT4 E LMXM_27_2300 transcription elongation regulator-like protein K15172 SUPT5H; transcription elongation factor SPT5 D N6-methyltransferase complex D Poly(A) addition factors E LMXM_08_29_2600 putative poly(A) polymerase K14376 PAP; poly(A) polymerase [EC:2.7.7.19] E LMXM_14_1180 putative poly(A) polymerase K14376 PAP; poly(A) polymerase [EC:2.7.7.19] D Negative regulators of mRNA 3' end processing C Other processing factors B mRNA surveillance and transport factors C Transport factors D EJC complex E LMXM_26_0780 hypothetical protein K12876 RBM8A; RNA-binding protein 8A E LMXM_29_3560 putative mago nashi-like protein K12877 MAGOH; protein mago nashi E LMXM_21_1552 putative RNA helicase K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7] E LMXM_28_1530 putative DEAD box RNA helicase K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] D TREX complex D TREX-2 complex E LMXM_33_2390 putative centrin K16466 CETN3; centrin-3 D Nuclear pore complex E LMXM_01_0320 putative poly(A) export protein K14298 RAE1; mRNA export factor E LMXM_31_0050 putative protein transport protein Sec13 K14004 SEC13; protein transport protein SEC13 E LMXM_31_2350 hypothetical protein K14306 NUP62; nuclear pore complex protein Nup62 E LMXM_27_0380 putative nucleoporin K14297 NUP98; nuclear pore complex protein Nup98-Nup96 E LMXM_36_6890 putative nuclear pore complex protein (NUP155) K14312 NUP155; nuclear pore complex protein Nup155 E LMXM_33_2390 putative centrin K16466 CETN3; centrin-3 E LMXM_27_1690 hypothetical protein K14284 NXF; nuclear RNA export factor E LMXM_06_1170 nuclear transport factor 2 protein(NFT2),putative K14285 NXT1_2; NTF2-related export protein 1/2 D Ran-mediated transport factors E LMXM_25_1420 putative GTP-binding protein K07936 RAN; GTP-binding nuclear protein Ran E LMXM_23_1470 hypothetical protein K18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D E LMXM_34_1970 hypothetical protein K18726 FAF2; FAS-associated factor 2 E LMXM_36_1370 Transitional endoplasmic reticulum ATPase,putative K13525 VCP; transitional endoplasmic reticulum ATPase E LMXM_34_2330 hypothetical protein K18727 TNPO2; transportin-2 E LMXM_31_1100 putative exportin 1 K14290 XPO1; exportin-1 E LMXM_10_1200 hypothetical protein K18460 XPO7; exportin-7 D eIF4F and regulatory proteins E LMXM_19_1480 eukaryotic translation initiation factor-like protein K03259 EIF4E; translation initiation factor 4E E LMXM_27_1620 eukaryotic translation initiation factor eIF-4E,putative K03259 EIF4E; translation initiation factor 4E E LMXM_01_0770 hypothetical protein K03257 EIF4A; translation initiation factor 4A E LMXM_31_0400 putative ATP-dependent RNA helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] E LMXM_34_5040 putative polyadenylate-binding protein 1 K13126 PABPC; polyadenylate-binding protein E LMXM_11_0180 hypothetical protein K07575 MCTS; malignant T-cell-amplified sequence E LMXM_25_0410 hypothetical protein K24272 DENR; density-regulated protein D APOBEC1-ACF complex D Other transport factors E LMXM_26_0200 cell cycle regulation-like protein K06965 PELO; protein pelota E LMXM_29_2610 putative RNA-binding protein K14396 PABPN1; polyadenylate-binding protein 2 E LMXM_23_1550 hypothetical protein K12867 SYF1; pre-mRNA-splicing factor SYF1 E LMXM_34_5320 hypothetical protein K23802 LENG8; SAC3 family protein LENG8/THP3 C Surveillance factors D Surveillance complex E LMXM_27_1710 putative eukaryotic translation release factor K03265 ETF1; peptide chain release factor subunit 1 E LMXM_11_1170 putative eukaryotic release factor 3 K03267 ERF3; peptide chain release factor subunit 3 D Protein phosphatase 2A E LMXM_25_1320 putative serine/threonine protein phosphatase K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] E LMXM_20_0660 putative serine/threonine protein phosphatase 2A regulatory subunit K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A E LMXM_32_0670 protein phosphatase 2A regulatory subunit,putative K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B E LMXM_08_29_1930 hypothetical protein K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' E LMXM_17_0750 hypothetical protein K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' D Other surveillance factors E LMXM_32_2790 GTP-binding elongation factor tu family protein,putative K24887 GTPBP1; GTP-binding protein 1 C Factors involved in mRNA localization D Cargo complex E LMXM_25_2360 hypothetical protein K14844 PUF6; pumilio homology domain family member 6 E LMXM_31_1880 hypothetical protein, unknown function K18740 EXD1; exonuclease 3'-5' domain-containing protein 1 D Factors that have mRNA localization signals D Trans-acting binding proteins E LMXM_17_0080 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha E LMXM_17_0081 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha E LMXM_17_0082 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha E LMXM_17_0085 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha E LMXM_09_0970 elongation factor-1 gamma K03233 EEF1G; elongation factor 1-gamma E LMXM_32_1540 putative elongation factor 1-gamma K03233 EEF1G; elongation factor 1-gamma D Other mRNA localization factors C mRNA cycle factors D Common to processing body (P body) and stress granule E LMXM_06_0260 putative 5'-3' exonuclease K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] E LMXM_19_1480 eukaryotic translation initiation factor-like protein K03259 EIF4E; translation initiation factor 4E E LMXM_27_1620 eukaryotic translation initiation factor eIF-4E,putative K03259 EIF4E; translation initiation factor 4E E LMXM_31_0400 putative ATP-dependent RNA helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] E LMXM_34_0370 putative ATP-dependent DEAD-box RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] E LMXM_25_0540 hypothetical protein K18749 LSM14; protein LSM14 E LMXM_34_3960 protein kinase A catalytic subunit isoform 2 K04345 PKA; protein kinase A [EC:2.7.11.11] E LMXM_34_4010 protein kinase A catalytic subunit isoform 1 K04345 PKA; protein kinase A [EC:2.7.11.11] D P-body specific factors E LMXM_31_0715 U6 snRNA-associated Sm-like protein LSm4p K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 E LMXM_01_0160 hypothetical protein K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 E LMXM_26_0005 putative Lsm7p protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 E LMXM_25_1705 hypothetical protein K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 E LMXM_13_0280 alpha tubulin K07374 TUBA; tubulin alpha E LMXM_13_0390 alpha tubulin K07374 TUBA; tubulin alpha E LmxM_13_0300_1 hypothetical protein K07374 TUBA; tubulin alpha E LMXM_21_0800 hypothetical protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1 E LMXM_25_1840 hypothetical protein K12580 CNOT3; CCR4-NOT transcription complex subunit 3 E LMXM_22_1630 putative CCR4 associated factor K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 E LMXM_28_0450 putative ribonuclease II-like protein K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-] E LMXM_29_0250 cysteine peptidase, Clan CA, family C19,putative K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] E LMXM_31_0720 hypothetical protein K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 E LMXM_31_1280 putative RNA polymerase-like protein K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 E LMXM_34_4370 hypothetical protein K18762 ZAR1; zygote arrest protein 1 D Stress granule specific factors E LMXM_34_5040 putative polyadenylate-binding protein 1 K13126 PABPC; polyadenylate-binding protein E LMXM_16_0690 hypothetical protein K15026 EIF2A; translation initiation factor 2A E LMXM_01_0770 hypothetical protein K03257 EIF4A; translation initiation factor 4A E LMXM_28_1530 putative DEAD box RNA helicase K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] E LMXM_28_2740 activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit-like protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein E LmxM_28_2740a_1 hypothetical protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein E LMXM_27_1690 hypothetical protein K14284 NXF; nuclear RNA export factor E LMXM_23_0090 hypothetical protein K18404 TDRD3; tudor domain-containing protein 3 B mRNA degradation factors C 5'-3' decay D Decapping complex E LMXM_34_0370 putative ATP-dependent DEAD-box RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] D Lsm complex E LMXM_31_0715 U6 snRNA-associated Sm-like protein LSm4p K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 E LMXM_01_0160 hypothetical protein K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 E LMXM_26_0005 putative Lsm7p protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 E LMXM_25_1705 hypothetical protein K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 D 5' exonucleases E LMXM_06_0260 putative 5'-3' exonuclease K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] E LMXM_23_0543 putative 5'-3' exonuclease XRNC K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-] E LMXM_36_1790 putative exoribonuclease 2 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-] D Other 5'-3' decay factors C 3'-5' decay D Core exosome factors E LMXM_23_1770 putative Csl4p homologue K07573 CSL4; exosome complex component CSL4 E LMXM_14_0010 putative exosome complex exonuclease K03679 RRP4; exosome complex component RRP4 E LMXM_04_0120 putative exosome complex exonuclease RRP40 K03681 RRP40; exosome complex component RRP40 E LMXM_36_3020 putative exosome complex exonuclease rrp41 K11600 RRP41; exosome complex component RRP41 E LMXM_36_4895 putative exosome-associated protein 4 K12587 MTR3; exosome complex component MTR3 E LMXM_22_1580 exosome complex exonuclease RRP45 homolog,putative K03678 RRP45; exosome complex component RRP45 D Exosome cofactors E LMXM_28_0330 putative rrp44p homologue K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-] E LMXM_33_3080 putative exosome subunit rrp6p homologue K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-] E LMXM_03_0690 hypothetical protein K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7] D TRAMP complex E LMXM_36_3991 hypothetical protein K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19] E LMXM_36_3000 putative ATP-dependent RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6] D Ski complex D Ccr4-NOT complex E LMXM_21_0800 hypothetical protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1 E LMXM_25_1840 hypothetical protein K12580 CNOT3; CCR4-NOT transcription complex subunit 3 E LMXM_22_1630 putative CCR4 associated factor K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 E LMXM_33_4550 cell differentiation protein-like protein K12606 RCD1; CCR4-NOT transcription complex subunit 9 E LMXM_29_1330 putative ABC transporter K12608 CAF16; CCR4-NOT complex subunit CAF16 D Pan complex E LMXM_29_0250 cysteine peptidase, Clan CA, family C19,putative K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] E LMXM_31_0720 hypothetical protein K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 D Other 3'-5' decay factors E LMXM_36_6350 hypothetical protein K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4] E LMXM_08_29_0550 hypothetical protein K18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-] C Other degradation factors D RNases # AProkaryotic type B Bacterial mRNA degradation factors C RNA degradosome components D Ribonucreases D Helicases D Other RNA degradosome components E LMXM_14_1160 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] E LMXM_31_3760 hypothetical protein K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] E LMXM_08_29_2510 putative 6-phospho-1-fructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] C Other RNA degradation factors D Chaperones E LMXM_29_2460 putative heat shock 70-related protein 1, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK E LMXM_29_2470 putative heat shock 70-related protein 1, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK E LMXM_29_2490 putative heat shock 70-related protein 1, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK E LMXM_29_2550 putative heat shock 70-related protein 1, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK E LMXM_31_1850 chaperonin HSP60, mitochondrial precursor,putative K04077 groEL; chaperonin GroEL [EC:5.6.1.7] E LMXM_36_2020 chaperonin HSP60, mitochondrial precursor K04077 groEL; chaperonin GroEL [EC:5.6.1.7] E LMXM_36_2030 chaperonin HSP60, mitochondrial precursor K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Others D Bacterial Small RNA Regulators B Archeal mRNA degradation factors C Exosome components D Core exosome E LMXM_14_0010 putative exosome complex exonuclease K03679 RRP4; exosome complex component RRP4 E LMXM_23_1770 putative Csl4p homologue K07573 CSL4; exosome complex component CSL4 D Cofactors E LMXM_36_3020 putative exosome complex exonuclease rrp41 K11600 RRP41; exosome complex component RRP41 D Others ! #
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025