+F Repair protein KO
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DNA Repair and Recombination Proteins - Leishmania mexicana
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LMXM_13_0500 putative RNA helicase K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D LMXM_32_0470 putative DNA repair enzyme K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E LMXM_18_0480 putative uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LMXM_28_2140 putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LMXM_33_2170 putative 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E LMXM_09_0050 putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E LMXM_16_0680 AP-endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F LMXM_32_1690 putative DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F LMXM_25_1410 putative DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F LMXM_34_4360 DNA polymerase epsilon catalytic subunit,putative K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F LMXM_34_1790 putative DNA polymerase epsilon subunit b K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E LMXM_15_1450 proliferative cell nuclear antigen (PCNA),putative K04802 PCNA; proliferating cell nuclear antigen
E LMXM_27_0250 putative flap endonuclease-1 (FEN-1) K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E LMXM_29_3440 putative DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E LMXM_08_0890 mitochondrial DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E LMXM_08_0900 putative mitochondrial DNA polymerase beta-PAK K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other BER factors
E LMXM_32_3050 tyrosyl-DNA phosphodiesterase-like protein K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E LMXM_08_29_0640 hypothetical protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F LMXM_34_3450 putative DNA-repair protein K10838 XPC; xeroderma pigmentosum group C-complementing protein
F LMXM_29_3300 UV excision repair RAD23-like protein K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F LMXM_21_0023 putative ring-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F LMXM_24_1610 putative ring-box protein K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F LMXM_25_0740 putative DNA repair protein K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F LMXM_30_2610 RNA polymerase ii largest subunit K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F LMXM_30_0160 DNA-directed RNA polymerase II subunit 2,putative K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F LMXM_08_29_0140 DNA-directed RNA polymerase I-like protein K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F LMXM_18_0780 putative DNA-directed RNA polymerases II K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F LMXM_33_0890 putative DNA-directed RNA polymerase subunit K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F LMXM_31_1280 putative RNA polymerase-like protein K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F LMXM_28_0810 putative RNA polymerase B subunit RPB8 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F LMXM_28_0120 DNA-direcetd RNA polymerase II, subunit 9,putative K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F LMXM_25_1315 DNA-directed RNA polymerase ii K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F LMXM_13_1120 putative DNA-directed RNA polymerase ii 8.2 Kd polypeptide K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F LMXM_27_1550 DNA-directed RNA polymerase II-like protein K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F LMXM_21_0023 putative ring-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F LMXM_24_1610 putative ring-box protein K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E Other TCR factor
F LMXM_14_0840 putative DNA excision repair protein K10841 ERCC6; DNA excision repair protein ERCC-6
D TFIIH complex
E LMXM_31_3920 putative DNA repair helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E LMXM_24_2280 putative DNA excision repair protein K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E LMXM_24_1680 hypothetical protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E LMXM_36_0800 hypothetical protein K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
D RPA (replication factor A)
E LMXM_28_1820 putative replication factor A, 51kDa subunit K07466 RFA1; replication factor A1
E LMXM_15_0270 putative replication Factor A 28 kDa subunit K10739 RFA2; replication factor A2
D Other NER factors
E LMXM_08_0140 putative DNA repair protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E LMXM_34_3590 putative DNA repair protein RAD2 K10846 ERCC5; DNA excision repair protein ERCC-5
E LMXM_29_3440 putative DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E LMXM_10_0050 hypothetical protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E LMXM_32_0410 MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E LMXM_15_1420 putative mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
D MutL homologs
E LMXM_24_1420 putative mismatch repair protein K08734 MLH1; DNA mismatch repair protein MLH1
E LMXM_34_1660 mismatch repair protein K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E LMXM_32_1690 putative DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E LMXM_25_1410 putative DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E LMXM_28_1820 putative replication factor A, 51kDa subunit K07466 RFA1; replication factor A1
E LMXM_15_0270 putative replication Factor A 28 kDa subunit K10739 RFA2; replication factor A2
D RFC (replication factor C)
E LMXM_24_0990 putative replication factor C, subunit 1 K10754 RFC1; replication factor C subunit 1
E LMXM_29_2630 putative replication factor C, subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E LMXM_27_0550 putative replication factor C, subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E LMXM_36_6710 putative replication factor C, subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E LMXM_34_3250 putative replication factor C, subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E LMXM_15_1450 proliferative cell nuclear antigen (PCNA),putative K04802 PCNA; proliferating cell nuclear antigen
E LMXM_23_1270 hypothetical protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E LMXM_29_3440 putative DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E LMXM_27_1890 putative endo/exonuclease Mre11 K10865 MRE11; double-strand break repair protein MRE11
E LMXM_28_0530 RAD50 DNA repair-like protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
E LMXM_26_2430 metallo-peptidase, Clan MP, Family M67 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E LMXM_08_29_1790 hypothetical protein K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E LMXM_27_1890 putative endo/exonuclease Mre11 K10865 MRE11; double-strand break repair protein MRE11
E LMXM_28_0530 RAD50 DNA repair-like protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E LMXM_28_0550 putative RAD51 protein K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E LMXM_28_0550 putative RAD51 protein K04482 RAD51; DNA repair protein RAD51
D Rad52 family proteins
D Rad54 family proteins
E LMXM_24_0760 DNA repair and recombination protein RAD54,putative K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E LMXM_24_1530 putative ATP-dependent DEAD/H DNA helicase recQ K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E LMXM_24_1530 putative ATP-dependent DEAD/H DNA helicase recQ K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E LMXM_36_3200 putative DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E LMXM_28_1780 putative DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E LMXM_28_1820 putative replication factor A, 51kDa subunit K07466 RFA1; replication factor A1
E LMXM_15_0270 putative replication Factor A 28 kDa subunit K10739 RFA2; replication factor A2
D Protein phosphatase 4
E LMXM_31_3040 protein phosphatase 2A catalytic subunit,putative K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E LMXM_18_0700 hypothetical protein K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
E LMXM_25_1330 hypothetical protein K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E LMXM_31_2540 hypothetical protein K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E LMXM_15_0500 katanin-like protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E LMXM_36_0710 hypothetical protein K23456 CFAP410; cilla- and flagella-associated protein
E LMXM_31_1310 hypothetical protein K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E LMXM_08_29_1050 putative KU70 protein K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E LMXM_29_0340 putative KU80 protein K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E LMXM_27_1890 putative endo/exonuclease Mre11 K10865 MRE11; double-strand break repair protein MRE11
E LMXM_28_0530 RAD50 DNA repair-like protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
D X-family DNA polymerases
E LMXM_08_0890 mitochondrial DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E LMXM_08_0900 putative mitochondrial DNA polymerase beta-PAK K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E LMXM_08_29_0640 hypothetical protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E LMXM_24_1530 putative ATP-dependent DEAD/H DNA helicase recQ K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E LMXM_36_3200 putative DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E LMXM_28_1780 putative DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E LMXM_28_0550 putative RAD51 protein K04482 RAD51; DNA repair protein RAD51
E LMXM_34_0870 hypothetical protein K11137 TELO2; telomere length regulation protein
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E LMXM_31_3640 hypothetical protein K23314 WRAP53; telomerase Cajal body protein 1
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D LmxM_21_0630_1 hypothetical protein K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D LMXM_21_0620 putative DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D LMXM_28_1420 putative DNA polymerase IV K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D LMXM_28_1430 putative DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
C B-family DNA polymerases
D LMXM_23_1330 putative DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D LMXM_22_0610 ubiquitin-conjugating enzyme-like protein K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D LMXM_13_1580 ubiquitin-conjugating enzyme-like protein K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D LMXM_04_0680 putative ubiquitin-conjugating enzyme e2 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D LMXM_15_1450 proliferative cell nuclear antigen (PCNA),putative K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
D LMXM_29_2630 putative replication factor C, subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D LMXM_27_0550 putative replication factor C, subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D LMXM_36_6710 putative replication factor C, subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D LMXM_34_3250 putative replication factor C, subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
D LMXM_34_0870 hypothetical protein K11137 TELO2; telomere length regulation protein
C BAG6-UBL4A-GET4 complex
C Other check point factors
D LMXM_11_0350 putative 14-3-3 protein K06630 YWHAE; 14-3-3 protein epsilon
D LMXM_36_3210 14-3-3 protein-like protein K06630 YWHAE; 14-3-3 protein epsilon
D LMXM_21_1565 putative serine/threonine-protein kinase K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D LMXM_33_3350 ATPase-like protein K12196 VPS4; vacuolar protein-sorting-associated protein 4
D LMXM_08_29_2500 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D LMXM_32_0030 hypothetical protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D LMXM_36_2330 putative endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
C Helicases
C PSO4 complex
D LMXM_27_2480 WD-repeat protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D LMXM_17_0710 hypothetical protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D LMXM_36_4820 hypothetical protein K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D LMXM_06_0560 dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LMXM_28_0890 ribonucleoside-diphosphate reductase large chain,putative K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D LMXM_22_1290 ribonucleoside-diphosphate reductase small chain,putative K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D LMXM_27_2050 ribonucleoside-diphosphate reductase small chain,putative K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LMXM_32_0470 putative DNA repair enzyme K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E LMXM_18_0480 putative uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LMXM_28_2140 putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LMXM_09_0050 putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D LMXM_06_0560 dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024