+F Repair protein KO
#
DNA Repair and Recombination Proteins - Lynx rufus (bobcat)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 124507232 methylated-DNA--protein-cysteine methyltransferase-like isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 124518250 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 124505824 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 124528114 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 124518426 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 124503035 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 124506685 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 124501717 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 124525484 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 124501769 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 124515158 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 124524238 methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 124523181 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 124508394 endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 124520799 endonuclease 8-like 2 isoform X1 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 124521248 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 124525556 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 124508752 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 124522281 DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 124510875 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 124524784 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 124505034 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 124505020 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 124527821 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 124512221 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 124503292 DNA polymerase epsilon subunit 3 isoform X1 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 124504191 DNA polymerase epsilon subunit 4 isoform X1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 124503991 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 124505097 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 124510957 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 124520494 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 124511062 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 124513076 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 124512582 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 124501277 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 124504109 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 124510894 bifunctional polynucleotide phosphatase/kinase-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 124511302 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 124501547 LOW QUALITY PROTEIN: high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 124507075 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 124510292 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 124503097 protein mono-ADP-ribosyltransferase PARP4-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 124524566 protein mono-ADP-ribosyltransferase PARP3-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 124508748 poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 124523921 DNA repair protein complementing XP-C cells-like K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 124502699 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 124524077 UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 124525365 centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 124501699 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 124525807 cullin-4B-like K10609 CUL4; cullin 4
F 124525809 cullin-4B-like K10609 CUL4; cullin 4
F 124527574 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 124513894 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 124513898 cullin-4A K10609 CUL4; cullin 4
F 124505109 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 124504922 DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 124519461 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 124520178 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 124511340 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 124515734 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 124527694 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 124502282 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 124505858 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 124526370 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 124511195 DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 124527537 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 124519284 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 124519014 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 124501699 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 124525807 cullin-4B-like K10609 CUL4; cullin 4
F 124525809 cullin-4B-like K10609 CUL4; cullin 4
F 124527574 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 124513894 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 124513898 cullin-4A K10609 CUL4; cullin 4
F 124505109 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 124517514 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 124506957 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 124522630 UV-stimulated scaffold protein A-like isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 124524459 transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 124515726 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 124511023 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 124504790 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 124517924 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 124518318 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 124528396 general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 124528984 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 124517869 cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 124518806 cyclin-H isoform X1 K06634 CCNH; cyclin H
E 124512140 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 124512958 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 124514113 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 124524788 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 124502145 DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 124511022 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 124517791 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 124513577 DNA excision repair protein ERCC-5-like isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 124510957 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 124507031 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 124516583 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 124505039 cullin-5 K10612 CUL5; cullin 5
E 124507724 elongin-C K03872 ELOC; elongin-C
E 124528988 elongin-C-like K03872 ELOC; elongin-C
E 124517897 elongin-B isoform X1 K03873 ELOB; elongin-B
E 124506000 elongin-B-like K03873 ELOB; elongin-B
E 124516626 elongin-B-like K03873 ELOB; elongin-B
E 124514858 elongin-A-like K15076 ELOA; elongin-A
E 124501375 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 124521688 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 124504069 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 124518549 DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 124503151 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 124515419 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 124526785 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 124519138 mismatch repair endonuclease PMS2-like isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 124512638 DNA mismatch repair protein Mlh3-like isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 124510875 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 124524784 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 124505034 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 124505020 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 124512958 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 124514113 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 124524788 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 124519911 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 124519209 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 124526309 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 124518204 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 124511491 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 124503991 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 124510266 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 124511302 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 124501547 LOW QUALITY PROTEIN: high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 124510957 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 124508641 WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 124505174 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 124515499 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 124519010 nibrin-like isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124516100 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124520002 BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 124520085 BRCA1-A complex subunit RAP80-like isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 124524376 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 124504381 BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 124527621 lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124513160 LOW QUALITY PROTEIN: Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 124526602 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124517640 DNA endonuclease RBBP8-like isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 124505174 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 124515499 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 124519010 nibrin-like isoform X1 K10867 NBN; nibrin
D BRCA complex
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124511444 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 124517995 partner and localizer of BRCA2-like K10897 PALB2; partner and localizer of BRCA2
E 124508704 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 124508704 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 124512091 DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 124513184 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 124513078 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 124524321 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 124512485 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 124501391 DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 124515170 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 124524125 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 124519065 DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 124501613 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 124520459 Werner syndrome ATP-dependent helicase-like isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 124517280 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 124507585 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 124513415 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 124517280 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 124519585 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 124519843 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 124529015 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 124518035 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 124512958 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 124514113 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 124524788 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 124517738 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 124504186 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 124519872 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 124522999 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 124503641 serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 124512572 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 124509662 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 124512349 serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 124505853 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 124512161 AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 124503390 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 124519185 AP-5 complex subunit zeta-1-like isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 124528366 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 124503357 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 124503023 protein LRATD1 K22805 FAM84A; protein FAM84A
E 124518013 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 124507798 E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 124517359 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 124507193 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 124502654 EP300-interacting inhibitor of differentiation 3-like K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 124519082 SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 124507067 SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 124513233 crossover junction endonuclease EME1-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 124525537 probable crossover junction endonuclease EME2 isoform X1 K10883 EME2; crossover junction endonuclease EME2
E 124512080 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 124505542 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 124529145 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 124504697 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 124506729 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 124517838 structure-specific endonuclease subunit SLX1-like isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 124517819 structure-specific endonuclease subunit SLX4-like K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 124503609 flap endonuclease GEN homolog 1-like K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 124508634 spatacsin isoform X1 K19026 SPG11; spatacsin
E 124512090 zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 124501705 RAD51-associated protein 1-like K20778 RAD51AP1; RAD51-associated protein 1
E 124517286 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 124503098 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 124525071 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 124507631 DNA repair-scaffolding protein-like isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 124507803 protein LRATD2 K22810 FAM84B; protein FAM84B
E 124519208 BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 124526241 cilia- and flagella-associated protein 410-like isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 124524368 hepatoma-derived growth factor-related protein 2-like isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 124519631 zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 124523815 ATPase SWSAP1-like K25771 SWSAP1; ATPase SWSAP1
E 124505035 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 124527055 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 124528797 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 124507896 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 124520610 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 124501558 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 124501964 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 124515206 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 124507635 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 124505174 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 124515499 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 124513624 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 124518642 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 124515336 non-homologous end-joining factor 1-like K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 124507075 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 124524478 DNA-directed DNA/RNA polymerase mu-like isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 124506703 DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 124520494 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 124501277 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 124504109 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 124501278 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 124528321 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 124517648 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 124525841 PWWP domain-containing DNA repair factor 3B-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 124527677 PWWP domain-containing DNA repair factor 3A-like isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 124513786 PWWP domain-containing DNA repair factor 3B-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 124522382 protein PAXX-like K25772 PAXX; protein PAXX
E 124523553 cell cycle regulator of non-homologous end joining-like isoform X1 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 124525501 jmjC domain-containing protein 8-like isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 124503313 shieldin complex subunit 1-like K26128 SHLD1; shieldin complex subunit 1
E 124506949 shieldin complex subunit 2-like isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 124517747 shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 124511597 Fanconi anemia group A protein-like isoform X1 K10888 FANCA; fanconi anemia group A protein
E 124509362 Fanconi anemia group B protein-like K10889 FANCB; fanconi anemia group B protein
E 124529230 Fanconi anemia group C protein-like K10890 FANCC; fanconi anemia group C protein
E 124529020 Fanconi anemia group E protein-like K10892 FANCE; fanconi anemia group E protein
E 124505186 Fanconi anemia group F protein-like K10893 FANCF; fanconi anemia group F protein
E 124501577 Fanconi anemia group G protein-like K10894 FANCG; fanconi anemia group G protein
E 124503220 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 124508935 Fanconi anemia group M protein-like K10896 FANCM; fanconi anemia group M protein
E 124511266 Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 124522555 Fanconi anemia core complex-associated protein 100-like K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 124526288 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 124514812 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 124522583 centromere protein X-like isoform X1 K15360 STRA13; centromere protein X
E 124510402 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 124517280 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 124519585 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 124519843 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 124529015 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 124518035 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 124523679 Fanconi anemia group D2 protein-like K10891 FANCD2; fanconi anemia group D2 protein
E 124517248 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 124522205 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 124511444 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 124513160 LOW QUALITY PROTEIN: Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 124517995 partner and localizer of BRCA2-like K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 124517349 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 124508704 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 124513184 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 124525463 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 124515230 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 124526955 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 124504097 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 124527792 serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 124502151 serine/threonine-protein phosphatase 6 regulatory subunit 2-like isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 124504859 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 124526172 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 124515147 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 124501274 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 124528549 E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 124526621 E3 ubiquitin-protein ligase RNF168-like isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 124509454 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 124505468 E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 124517247 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 124519603 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
E 124522442 taperin-like K24164 TPRN; taperin
E 124519390 zinc finger CW-type PWWP domain protein 1-like isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 124522111 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 124508641 WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 124527935 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 124517060 DNA polymerase iota-like isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 124518196 DNA polymerase kappa-like isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 124504388 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 124528047 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 124513875 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 124515709 ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 124524018 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 124526471 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 124524279 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124511248 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124520424 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124507637 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124507927 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124502886 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124516628 ubiquitin-conjugating enzyme E2 variant 1-like isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 124521774 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 124502137 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 124509930 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 124503991 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 124501558 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
D 124518600 DNA-dependent metalloprotease SPRTN-like K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 124521614 germ cell nuclear acidic protein-like isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 124504708 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 124518325 LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9B-like K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 124524386 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 124522279 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 124517905 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 124519209 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 124526309 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 124518204 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 124511491 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 124522279 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 124502497 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 124508473 TIMELESS-interacting protein-like K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 124515933 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 124525463 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 124503503 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 124520578 TELO2-interacting protein 2-like isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 124528400 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 124525849 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 124514940 ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 124519266 Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 124526514 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 124525168 ATR-interacting protein-like isoform X1 K10905 ATRIP; ATR interacting protein
D 124504822 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 124519563 cellular tumor antigen p53 isoform X1 K04451 TP53; tumor protein p53
D 124505184 serine/threonine-protein kinase Chk1 isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 124518366 serine/threonine-protein kinase Chk2-like isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 124523955 M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 124503343 M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 124516125 M-phase inducer phosphatase 3-like K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 124503145 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 124503513 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 124518954 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 124512264 LOW QUALITY PROTEIN: 14-3-3 protein theta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 124517052 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 124518269 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 124519118 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 124512972 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 124501900 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 124505224 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 124505599 wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 124522873 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 124519597 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 124516348 period circadian protein homolog 2-like K02633 PER2; period circadian protein 2
D 124514419 LOW QUALITY PROTEIN: period circadian protein homolog 3-like K21945 PER3; period circadian protein 3
D 124528529 mediator of DNA damage checkpoint protein 1-like isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 124513951 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 124517381 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 124516451 serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 124527644 inactive serine/threonine-protein kinase PLK5-like K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 124511815 serine/threonine-protein kinase Nek5-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 124520095 serine/threonine-protein kinase Nek1-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 124524228 serine/threonine-protein kinase Nek4-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 124527051 serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 124526530 serine/threonine-protein kinase Nek11-like K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 124526412 protein downstream neighbor of Son-like K22422 DONSON; protein downstream neighbor of Son
D 124524602 KN motif and ankyrin repeat domain-containing protein 3-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 124528165 KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 124514500 KN motif and ankyrin repeat domain-containing protein 4-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 124523910 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 124507440 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 124511437 vacuolar protein sorting-associated protein 4A isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 124516989 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 124508698 abscission/NoCut checkpoint regulator-like K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 124510298 replication stress response regulator SDE2-like isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 124527093 DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 124519484 myb-binding protein 1A-like K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 124520431 DNA-directed primase/polymerase protein-like isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 124525170 three-prime repair exonuclease 1-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 124525862 three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 124507152 DNA cross-link repair 1A protein-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 124515018 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 124516334 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 124522532 endonuclease V-like isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 124515754 DNA annealing helicase and endonuclease ZRANB3-like K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 124524116 ankyrin repeat and LEM domain-containing protein 1-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 124520000 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 124529252 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 124505643 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 124528344 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 124516128 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 124520518 pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 124512290 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 124519123 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 124520257 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 124521617 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 124508611 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 124505231 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 124504016 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 124519049 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 124507232 methylated-DNA--protein-cysteine methyltransferase-like isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 124518426 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 124503035 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 124501769 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 124525484 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 124515158 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 124525556 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 124524497 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 124524497 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 124512290 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 124521617 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 124508611 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024