+F Repair protein KO
#
DNA Repair and Recombination Proteins - Lucilia sericata (common green bottle fly)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 119614232 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 119614706 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 119614816 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 119610998 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 119607434 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 119610769 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 119599796 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 119612125 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
F 119614225 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 119612724 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 119613669 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 119610559 uncharacterized protein DDB_G0286299 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 119608281 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 119605249 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 119609031 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 119600101 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 119606733 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 119601795 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 119616530 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 119603652 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 119612922 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 119608299 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 119600733 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 119602775 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 119615909 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 119602244 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 119602247 UV excision repair protein RAD23 homolog A-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 119604129 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 119604908 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 119609091 cullin-4A K10609 CUL4; cullin 4
F 119603108 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 119610908 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 119605462 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 119600157 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 119606970 DNA-directed RNA polymerase II subunit Rpb4 isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 119601729 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 119605374 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 119607791 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 119605142 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 119614120 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 119605205 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 119600280 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 119602783 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 119611532 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 119604129 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 119604908 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 119609091 cullin-4A K10609 CUL4; cullin 4
F 119603108 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 119602103 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 119613433 LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPB-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 119600093 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 119611567 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 119611833 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 119606900 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 119600251 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 119599976 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 119611284 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 119609509 cyclin-H K06634 CCNH; cyclin H
E 119607758 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 119603065 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 119601111 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 119616079 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Other NER factors
E 119606821 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 119604706 LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 119601453 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 119609189 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 119610161 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 119606818 LOW QUALITY PROTEIN: cullin-5 K10612 CUL5; cullin 5
E 119600684 elongin-C K03872 ELOC; elongin-C
E 119602679 elongin-B K03873 ELOB; elongin-B
E 119599907 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 119612984 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 119613478 DNA mismatch repair protein spellchecker 1 K08735 MSH2; DNA mismatch repair protein MSH2
E 119611301 LOW QUALITY PROTEIN: probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
E 119602940 probable DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 119615108 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 119611668 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 119614225 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 119612724 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 119613669 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 119610559 uncharacterized protein DDB_G0286299 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 119603065 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 119601111 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 119616079 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 119605571 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 119613647 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 119607875 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 119599929 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 119601017 replication factor C subunit 5-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 119606733 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 119611220 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 119600733 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 119610814 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 119606948 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 119609408 nibrin K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
E 119599858 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 119610814 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 119606948 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 119609408 nibrin K10867 NBN; nibrin
D BRCA complex
E 119609526 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 119609526 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 119604454 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 119608637 LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 119600633 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 119616499 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 119604217 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 119608054 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 119602146 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 119604217 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 119606705 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 119601410 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 119603065 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 119601111 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 119616079 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 119615043 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 catalytic subunit-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 119614272 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 119605517 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 119600688 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 119599670 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 119603096 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 119614800 uncharacterized protein LOC119614800 isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 119612433 uncharacterized protein LOC119612433 isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 119604829 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 119603044 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 119606831 exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 119600381 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 119603241 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 119601529 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 119603700 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 119609212 LOW QUALITY PROTEIN: uncharacterized protein LOC119609212 K19026 SPG11; spatacsin
E 119606969 LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 119605401 nuA4 complex subunit EAF3 homolog K11339 MORF4L1; mortality factor 4-like protein 1
E 119615801 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 119611670 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 119608559 uncharacterized protein LOC119608559 K23112 BRAT1; BRCA1-associated ATM activator 1
E 119600782 putative uncharacterized protein DDB_G0291608 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 119601277 chitinase-like protein PB1E7.04c K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 119601402 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 119607267 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 119607161 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 119605473 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 119607691 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 119610814 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 119606948 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 119612455 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
E 119599820 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 119614879 uncharacterized protein LOC119614879 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 119602077 ubiquitin-conjugating enzyme E2 D1-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 119604217 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 119606705 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 119601410 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 119610720 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 119610138 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 119609526 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 119613202 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 119611371 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 119616120 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 119608238 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 119603834 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 119612035 probable E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 119610657 telomerase Cajal body protein 1 homolog isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 119609906 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 119603326 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 119603645 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 119611840 LOW QUALITY PROTEIN: DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 119613204 LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 119602470 LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 119605574 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 119602102 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 119603193 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 119606733 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 119604680 uncharacterized protein LOC119604680 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 119602814 uncharacterized protein DDB_G0284459 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 119609313 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 119605891 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 119604215 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 119599937 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 119613647 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 119607875 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 119599929 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 119601017 replication factor C subunit 5-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 119604215 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 119608376 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 119611230 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 119608298 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 119609126 LOW QUALITY PROTEIN: large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 119600335 ubiquitin-like protein 4A-B K23388 UBL4; ubiquitin-like protein 4
D 119605953 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 119610310 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 119608445 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 119608965 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 119600412 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 119600749 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 119610672 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 119605292 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 119600958 LOW QUALITY PROTEIN: protein sickie-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 119606731 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 119599751 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 119610042 LOW QUALITY PROTEIN: formin-J K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 119604497 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 119605373 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 119606139 LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 119604828 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 119604423 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 119610727 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 119602913 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 119601398 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 119602318 uncharacterized protein LOC119602318 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 119602319 uncharacterized protein LOC119602319 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 119606128 DNA cross-link repair 1 protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 119613678 uncharacterized protein LOC119613678 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 119605861 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 119600031 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 119607292 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 119606681 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 119611776 pre-mRNA-splicing factor SPF27-like K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 119614824 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
D 119611335 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 119601540 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 119602949 deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 119613187 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 119610679 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 119610998 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 119607434 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 119610769 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 119612125 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 119601911 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 119601911 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 119602949 deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024