+D Protein KO
#
Membrane Trafficking - Metarhizium robertsii
%
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AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
D MAA_01145 cell division control protein 3 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D MAA_02689 serine/threonine protein kinase, AGC family K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D MAA_06168 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_07090 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_00804 BcPLC2, phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_01185 Phospholipase C, phosphatidylinositol-specific, X domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_05583 phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D MAA_01129 Phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D MAA_04911 phosphatidylinositol-4-phosphate 5-Kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D MAA_02118 PakB K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D MAA_07473 serine/threonine-protein kinase 24 K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D MAA_07873 Serine/threonine-protein kinase domain protein K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D MAA_06230 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D MAA_02037 protein kinase K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D MAA_10864 Anaphase-promoting complex, subunit CDC26 K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D MAA_06335 secretion-related GTPase K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D MAA_03671 adaptor protein complex gamma-adaptin subunit K02183 CALM; calmodulin
D MAA_10365 guanyl-nucleotide exchange factor K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D MAA_07010 Sec1 family superfamily K15292 STXBP1; syntaxin-binding protein 1
D MAA_04620 WD40 repeat 2 K08518 STXBP5; syntaxin-binding protein 5
D MAA_10636 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D MAA_09862 GTPase activating protein (Gyp3) K19953 GRTP1; TBC1 domain family member 6
D MAA_07426 GTPase activating protein (Gyp5) K19951 TBC1D8_9; TBC1 domain family member 8/9
D MAA_03902 peroxisomal targeting signal receptor K13342 PEX5; peroxin-5
D MAA_09082 Rab protein geranylgeranyltransferase, component A, fungi K23460 CHM; Rab proteins geranylgeranyltransferase component A
D MAA_05663 geranylgeranyltransferase beta subunit K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D MAA_02694 WD repeat protein K24155 DMXL; rabconnectin-3a
C Rho GTPases
D MAA_03565 Small GTPase superfamily, Rho type K04393 CDC42; cell division control protein 42
D MAA_03762 Small GTPase superfamily, Rho type K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D MAA_01993 Exocyst complex, component Exoc1 K19983 EXOC1; exocyst complex component 1
D MAA_01214 exocyst complex subunit K17637 EXOC2; exocyst complex component 2
D MAA_08829 exocyst component K06110 EXOC3; exocyst complex component 3
D MAA_01540 exocyst complex component K06111 EXOC4; exocyst complex component 4
D MAA_07251 exocyst complex component Sec10 K19984 EXOC5; exocyst complex component 5
D MAA_03640 Exocyst complex subunit Sec15-like protein K19985 EXOC6; exocyst complex component 6
D MAA_05288 exocyst complex subunit K07195 EXOC7; exocyst complex component 7
D MAA_05063 exocyst complex component EXO84 K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D MAA_08658 dss1/sem1 K10881 SHFM1; 26 proteasome complex subunit DSS1
D MAA_06824 hypothetical protein K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D MAA_03840 brct K19877 CHS5; chitin biosynthesis protein CHS5
D MAA_09477 Chs5p-Arf1p binding protein K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D MAA_02804 zinc finger domain-containing protein K12481 RBSN; rabenosyn-5
D MAA_09294 Cellular retinaldehyde-binding/triple function K19996 SFH5; phosphatidylinositol transfer protein SFH5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D MAA_00610 Target SNARE coiled-coil domain protein K08486 STX1B_2_3; syntaxin 1B/2/3
D MAA_05574 ssoi K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
C Stx-TGN / EE
D MAA_03672 hypothetical protein K08489 STX16; syntaxin 16
C Stx-cisGolgi
D MAA_08721 Target SNARE coiled-coil domain protein K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
B SNAP-25[N] (Qb)
C Vti1
D MAA_02622 vesicle transport v-SNARE protein K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D MAA_04071 Golgi SNAP receptor complex, subunit 1 K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D MAA_05518 v-SNARE protein K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D MAA_04214 Sec20 domain protein K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
D MAA_09196 Target SNARE coiled-coil domain protein K08499 TLG1; member of the syntaxin family of t-SNAREs
C STX8
D MAA_02687 SNARE complex subunit (Syn8) K08501 STX8; syntaxin 8
D MAA_09681 Phox like protein K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D MAA_01817 hypothetical protein K08504 BET1; blocked early in transport 1
C Sft1
C Syp7
C Use1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D MAA_10882 Serine/threonine dehydratase, pyridoxal-phosphate-binding site K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D MAA_09069 Synaptobrevin K08513 VAMP4; vesicle-associated membrane protein 4
C Ykt6
D MAA_05079 v-snare-like protein K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D MAA_06253 Longin K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D MAA_04620 WD40 repeat 2 K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D MAA_07010 Sec1 family superfamily K15292 STXBP1; syntaxin-binding protein 1
D MAA_03120 sec1 protein K19998 SCFD1; sec1 family domain-containing protein 1
D MAA_06164 myosin-like coiled-coil protein K26808 TXLN; taxilin
C Palmitoyltransferases
D MAA_11361 hypothetical protein K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D MAA_02076 Zinc finger, DHHC-type, palmitoyltransferase K20003 ZDHHC4; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D MAA_09695 palmitoyltransferase AKR1 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D MAA_02584 NsfA K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D MAA_07665 Tetratricopeptide-like helical K15296 NAPA; alpha-soluble NSF attachment protein
D MAA_05264 sorting nexin K17919 SNX4; sorting nexin-4
D MAA_05815 sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D MAA_04529 Golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D MAA_03481 AAA ATPase K13525 VCP; transitional endoplasmic reticulum ATPase
D MAA_01445 SEP domain protein K14012 NSFL1C; UBX domain-containing protein 1
D MAA_03636 protein VTS1 K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D MAA_03365 clathrin heavy chain-like protein K04646 CLTC; clathrin heavy chain
C Dynamin
D MAA_00205 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D MAA_01691 adaptor protein complex alpha-adaptin subunit K11824 AP2A; AP-2 complex subunit alpha
D MAA_06463 AP-2 adaptor complex, beta-adaptin subunit K11825 AP2B1; AP-2 complex subunit beta-1
D MAA_04992 adaptor protein complex AP-2, medium chain K11826 AP2M1; AP-2 complex subunit mu-1
D MAA_06488 Adaptor protein complex, sigma subunit K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D MAA_08189 Fes/CIP4 domain-containing protein K20042 FCHO; F-BAR domain only protein
D MAA_02279 Epsin-lik K12471 EPN; epsin
D MAA_05235 epsin-3 K12471 EPN; epsin
D MAA_08830 UBA/TS-N domain-containing protein K12472 EPS15; epidermal growth factor receptor substrate 15
D MAA_08084 ANTH domain-containing protein K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D MAA_05634 Src like protein K12562 AMPH; amphiphysin
D MAA_00254 SH3 domain-containing protein K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D MAA_05811 polyA nuclease K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D MAA_06451 calcium binding protein K20048 END3; actin cytoskeleton-regulatory complex protein END3
D MAA_00656 hsp70 family protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D MAA_07707 heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D MAA_04911 phosphatidylinositol-4-phosphate 5-Kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D MAA_10426 arrestin (or S-antigen) domain protein K20059 LDB19; arrestin-related trafficking adapter 1
D MAA_02453 arrestin domain-containing protein K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D MAA_01593 Arrestin-lik K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D MAA_02246 beta-arrestin protein K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D MAA_04080 pH response protein PalF K20063 RIM8; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D MAA_10636 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D MAA_07272 phosphatidylinositol 4,5-bisphosphate 5-phosphatase K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D MAA_03415 serine/threonine protein kinase K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D MAA_02099 protein kinase domain-containing protein ppk32 K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D MAA_00029 HECT-domain-containing protein K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D MAA_01724 Zinc finger, TRAF-type K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
C Others
D MAA_03717 cytoskeleton assembly control protein Sla2 K20040 HIP1R; huntingtin-interacting protein 1-related protein
D MAA_04217 calreticulin K08054 CANX; calnexin
D MAA_04858 adaptin ear-binding coat-associated protein 2 K20069 NECAP1_2; adaptin ear-binding coat-associated protein 1/2
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D MAA_00205 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D MAA_07035 protein kinase C K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
D MAA_09377 SPFH domain/Band 7 family protein K07192 FLOT; flotillin
C GRAF1-dependent endocytosis
D MAA_03565 Small GTPase superfamily, Rho type K04393 CDC42; cell division control protein 42
D MAA_04064 RAS-like GTPase, Rho2 subfamily K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D MAA_08044 Small GTPase superfamily, ARF type K07941 ARF6; ADP-ribosylation factor 6
D MAA_03762 Small GTPase superfamily, Rho type K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C RhoA-dependent endocytosis
D MAA_05388 Small GTPase superfamily, Rho type K04513 RHOA; Ras homolog gene family, member A
D MAA_00205 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D MAA_00560 myosin K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D MAA_11113 hypothetical protein K07827 KRAS; GTPase KRas
D MAA_06380 Small GTPase superfamily, Ras type K07827 KRAS; GTPase KRas
D MAA_03762 Small GTPase superfamily, Rho type K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D MAA_03565 Small GTPase superfamily, Rho type K04393 CDC42; cell division control protein 42
C Kinases
D MAA_07417 phosphatidylinositol 3-kinase K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D MAA_05182 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D MAA_02118 PakB K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D MAA_06168 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_07090 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_00804 BcPLC2, phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D MAA_01185 Phospholipase C, phosphatidylinositol-specific, X domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D MAA_04723 vacuolar sorting protein K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D MAA_05634 Src like protein K12562 AMPH; amphiphysin
D MAA_05004 The Bin/Amphiphysin/Rvs (BAR) domain protein K20120 BIN3; bridging integrator 3
C F-BAR proteins
D MAA_03204 BZZ1 protein K20121 FNBP1; formin-binding protein 1
D MAA_08189 Fes/CIP4 domain-containing protein K20042 FCHO; F-BAR domain only protein
D MAA_03824 RhoGAP protein K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D MAA_00760 secretion-related small GTPase K07889 RAB5C; Ras-related protein Rab-5C
D MAA_03451 rab5-like GTPase K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D MAA_04138 guanine nucleotide exchange factor Vps9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D MAA_02804 zinc finger domain-containing protein K12481 RBSN; rabenosyn-5
D MAA_10636 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D MAA_07417 phosphatidylinositol 3-kinase K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D MAA_01153 vacuolar sorting protein K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D MAA_11402 sec1 protein K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
D MAA_04064 RAS-like GTPase, Rho2 subfamily K07937 ARF1_2; ADP-ribosylation factor 1/2
D MAA_08044 Small GTPase superfamily, ARF type K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D MAA_02108 Arf GTPase activating protein K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D MAA_04017 phosphatidylinositol-4-kinase K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D MAA_03788 protein EFR3 K21842 EFR3; protein EFR3
D MAA_07057 Tetratricopeptide-like helical K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D MAA_00760 secretion-related small GTPase K07889 RAB5C; Ras-related protein Rab-5C
D MAA_03451 rab5-like GTPase K07889 RAB5C; Ras-related protein Rab-5C
D MAA_01489 small GTPase of the Rab/Ypt family K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D MAA_00293 vacuolar sorting protein K18468 VPS35; vacuolar protein sorting-associated protein 35
D MAA_01739 MJ0936 family phosphodiesterase K18467 VPS29; vacuolar protein sorting-associated protein 29
D MAA_04012 vacuolar protein sorting-associated protein 26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
D MAA_02678 hypothetical protein K16536 HOOK3; protein HOOK3
C Rab associated proteins
D MAA_01123 zinc finger domain-containing protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D MAA_07417 phosphatidylinositol 3-kinase K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D MAA_05851 RasGAP protein K18469 TBC1D5; TBC1 domain family member 5
D MAA_06236 RasGAP protein K20168 TBC1D15; TBC1 domain family member 15
D MAA_09082 Rab protein geranylgeranyltransferase, component A, fungi K23460 CHM; Rab proteins geranylgeranyltransferase component A
D MAA_05663 geranylgeranyltransferase beta subunit K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D MAA_08594 Rab-GAP/TBC domain protein K20176 SGSM3; small G protein signaling modulator 3
D MAA_04529 Golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
D MAA_03356 Small GTPase superfamily, ARF type K07955 ARL8; ADP-ribosylation factor-like protein 8
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D MAA_04509 N-terminal acetyltransferase C complex catalytic subunit MAK3 K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D MAA_07614 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D MAA_00675 LSM domain-containing protein K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D MAA_02152 VHS domain-containing protein K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D MAA_02275 SH3 domain protein K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D MAA_00342 Ubiquitin E2 variant K12183 TSG101; ESCRT-I complex subunit TSG101
D MAA_05184 Vacuolar protein sorting-associated, VPS28 K12184 VPS28; ESCRT-I complex subunit VPS28
C ESCRT-II complex
D MAA_02498 ESCRT-2 complex, Snf8 K12188 SNF8; ESCRT-II complex subunit VPS22
D MAA_02213 ESCRT-II complex, vps25 subunit K12189 VPS25; ESCRT-II complex subunit VPS25
D MAA_06295 EAP30/Vps36 family protein K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D MAA_08785 vacuolar protein-sorting-associated protein 46 K12197 CHMP1; charged multivesicular body protein 1
D MAA_02608 vacuolar protein-sorting-associated protein K12193 VPS24; charged multivesicular body protein 3
D MAA_03023 Snf7 family protein K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D MAA_05487 Snf7 protein K12198 CHMP5; charged multivesicular body protein 5
D MAA_02654 Snf7 family protein K12195 CHMP6; charged multivesicular body protein 6
D MAA_02722 Snf7 family protein K15053 CHMP7; charged multivesicular body protein 7
D MAA_04951 vacuolar protein sorting-associated protein VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D MAA_06109 vacuolar protein sorting-associated protein VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D MAA_09006 hypothetical protein K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D MAA_08318 pH-response regulator protein palA/RIM20 K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D MAA_03684 vacuolar sorting protein 39 domain 1 K20177 VPS3; vacuolar protein sorting-associated protein 3
D MAA_00700 golgi complex component K20178 VPS8; vacuolar protein sorting-associated protein 8
D MAA_08568 vacuolar protein sorting protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D MAA_08907 vacuolar sorting protein K20180 VPS16; vacuolar protein sorting-associated protein 16
D MAA_03546 vacuolar sorting protein K20181 VPS18; vacuolar protein sorting-associated protein 18
D MAA_05740 Sec1 family protein K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D MAA_08568 vacuolar protein sorting protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D MAA_08907 vacuolar sorting protein K20180 VPS16; vacuolar protein sorting-associated protein 16
D MAA_03546 vacuolar sorting protein K20181 VPS18; vacuolar protein sorting-associated protein 18
D MAA_05740 Sec1 family protein K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D MAA_05340 vacuolar sorting protein 39 domain 1 K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D MAA_04651 vacuolar sorting protein K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D MAA_02694 WD repeat protein K24155 DMXL; rabconnectin-3a
C RAVE complex
D MAA_02694 WD repeat protein K24155 DMXL; rabconnectin-3a
D MAA_05788 SKP1 component K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D MAA_06817 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D MAA_07045 AP-3 adaptor protein complex beta-adaptin subunit K12397 AP3B; AP-3 complex subunit beta
D MAA_02948 adaptor complexes medium subunit family protein K12398 AP3M; AP-3 complex subunit mu
D MAA_11079 hypothetical protein K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
D MAA_02580 putative domain KxDL K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Others
D MAA_04380 vacuolar fusion protein mon1 K20195 MON1; vacuolar fusion protein MON1
D MAA_02151 ubiquitin carboxyl-terminal hydrolase 2 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D MAA_04953 Mov34/MPN/PAD-1 K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
D MAA_11103 hypothetical protein K23879 GRN; progranulin
D MAA_09999 vacuolar sorting protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D MAA_10259 beige/BEACH domain protein K24781 BPH1; beige protein homolog 1
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D MAA_05329 secretion-related small GTPase K07904 RAB11A; Ras-related protein Rab-11A
C Rab4 associated proteins
D MAA_02804 zinc finger domain-containing protein K12481 RBSN; rabenosyn-5
D MAA_05264 sorting nexin K17919 SNX4; sorting nexin-4
D MAA_10308 dynein light intermediate chain K10416 DYNC1LI; dynein cytoplasmic 1 light intermediate chain
C Rab11 associated proteins
D MAA_10682 mucin K20241 WDR44; WD repeat-containing protein 44
D MAA_02024 nuclear pore complex, component sec13 K14004 SEC13; protein transport protein SEC13
D MAA_03640 Exocyst complex subunit Sec15-like protein K19985 EXOC6; exocyst complex component 6
D MAA_04529 Golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D MAA_10636 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D MAA_04138 guanine nucleotide exchange factor Vps9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D MAA_04013 Nucleoporin Nup120/160 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D MAA_04578 Vps51/Vps67-like protein K20296 ANG2; vacuolar protein sorting-associated protein 51
D MAA_01104 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D MAA_00710 Golgi-associated retrograde protein complex component K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D MAA_02198 2-oxoisovalerate dehydrogenase beta subunit K10364 CAPZA; F-actin-capping protein subunit alpha
D MAA_07232 hypothetical protein K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D MAA_01739 MJ0936 family phosphodiesterase K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
D MAA_10382 ankyrin repeat-containing protein K21440 ANKRD50; ankyrin repeat domain-containing protein 50
D MAA_10122 Ankyrin repeat-containing domain protein K21440 ANKRD50; ankyrin repeat domain-containing protein 50
D MAA_09510 Ankyrin repeat-containing domain protein K21440 ANKRD50; ankyrin repeat domain-containing protein 50
D MAA_06114 natch and ankyrin domain protein K21440 ANKRD50; ankyrin repeat domain-containing protein 50
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D MAA_02737 RAS small monomeric GTPase Rab6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D MAA_04529 Golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D MAA_07426 GTPase activating protein (Gyp5) K19951 TBC1D8_9; TBC1 domain family member 8/9
D MAA_00222 M protein repeat protein K20286 TMF1; TATA element modulatory factor
D MAA_07388 Dynein light chain-related protein K10419 DYNLRB; dynein light chain roadblock-type
D MAA_08863 p150/dynactin-like protein K04648 DCTN1; dynactin 1
D MAA_10636 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D MAA_05500 vacuolar protein sorting-associated protein vps13 K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D MAA_04064 RAS-like GTPase, Rho2 subfamily K07937 ARF1_2; ADP-ribosylation factor 1/2
D MAA_05786 Small GTPase superfamily, ARF type K07942 ARL1; ADP-ribosylation factor-like protein 1
D MAA_03463 ADP-ribosylation factor-like protein K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D MAA_01239 zinc finger protein gcs1 K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D MAA_06442 GTPase-activating protein K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D MAA_02108 Arf GTPase activating protein K12486 SMAP; stromal membrane-associated protein
D MAA_05679 ARF GTPase activator K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D MAA_02749 guanine nucleotide exchange factor for ADP ribosylation factor K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D MAA_02705 cytohesin-2 K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D MAA_03506 oligomeric Golgi complex component K20288 COG1; conserved oligomeric Golgi complex subunit 1
D MAA_06186 hypothetical protein K20289 COG2; conserved oligomeric Golgi complex subunit 2
D MAA_04589 oligomeric Golgi complex component 3 K20290 COG3; conserved oligomeric Golgi complex subunit 3
D MAA_04203 intra-Golgi transport complex, subunit 4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
D MAA_04483 oligomeric complex COG6 K20293 COG6; conserved oligomeric Golgi complex subunit 6
D MAA_00256 oligomeric Golgi complex component K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D MAA_04578 Vps51/Vps67-like protein K20296 ANG2; vacuolar protein sorting-associated protein 51
D MAA_01104 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D MAA_00710 Golgi-associated retrograde protein complex component K20299 VPS53; vacuolar protein sorting-associated protein 53
D MAA_07583 Vps54-like protein K17600 VPS54; vacuolar protein sorting-associated protein 54
D MAA_09170 vacuolar protein sorting-associated protein K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D MAA_05807 sybindin-like family protein K20300 TRAPPC1; trafficking protein particle complex subunit 1
D MAA_03441 Sedlin K20301 TRAPPC2; trafficking protein particle complex subunit 2
D MAA_02946 Longin-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D MAA_00350 NO signaling/Golgi transport ligand-binding domain protein K20302 TRAPPC3; trafficking protein particle complex subunit 3
D MAA_11242 hypothetical protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D MAA_06176 TRAPP I complex, Trs31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D MAA_02721 cis-Golgi transport protein particle complex subunit K20305 TRAPPC8; trafficking protein particle complex subunit 8
D MAA_06240 cis-Golgi transport protein particle complex subunit K20306 TRAPPC9; trafficking protein particle complex subunit 9
D MAA_01188 cis-Golgi transport protein particle complex subunit K20307 TRAPPC10; trafficking protein particle complex subunit 10
D MAA_02188 hypothetical protein K20308 TRAPPC11; trafficking protein particle complex subunit 11
D MAA_09874 Tetratricopeptide-like helical K20309 TRAPPC12; trafficking protein particle complex subunit 12
D MAA_07648 hypothetical protein K20310 TRAPPC13; trafficking protein particle complex subunit 13
B Others
C AP-1 complex
D MAA_10965 hypothetical protein K12391 AP1G1; AP-1 complex subunit gamma-1
D MAA_04575 adaptor protein (AP-1) complex beta-adaptin large subunit K12392 AP1B1; AP-1 complex subunit beta-1
D MAA_09727 adaptor complexes medium subunit family protein K12393 AP1M; AP-1 complex subunit mu
D MAA_05639 Adaptor protein complex, sigma subunit K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D MAA_06817 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D MAA_07045 AP-3 adaptor protein complex beta-adaptin subunit K12397 AP3B; AP-3 complex subunit beta
D MAA_02948 adaptor complexes medium subunit family protein K12398 AP3M; AP-3 complex subunit mu
D MAA_11079 hypothetical protein K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D MAA_04533 Golgi-localized gamma-adaptin K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D MAA_05772 HEAT repeat protein K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D MAA_05583 phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D MAA_01129 Phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D MAA_04017 phosphatidylinositol-4-kinase K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D MAA_04911 phosphatidylinositol-4-phosphate 5-Kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D MAA_05182 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D MAA_01187 hypothetical protein K20316 SCOC; short coiled-coil protein
D MAA_04919 SYS1-related integral membrane protein K20318 SYS1; protein SYS1
D MAA_03737 putative protein family UPF0016 K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D MAA_03331 ATPase, vacuolar ER assembly factor, Vma12 K23542 TMEM199; TMEM199 family protein
D MAA_03563 hypothetical protein K23543 CCDC115; coiled-coil domain-containing protein 115
D MAA_01083 serine incorporator K23544 SERINC1; serine incorporator 1
D MAA_10362 Phox like protein K17918 SNX3_12; sorting nexin-3/12
D MAA_02430 sorting nexin Mvp1 K17922 SNX8; sorting nexin-8
D MAA_02052 endosomal peripheral membrane protein K26678 MON2; protein MON2
D MAA_04381 dopey K26680 DOP1; protein dopey
D MAA_06476 Golgi apparatus membrane protein TVP15 K26750 TVP15; golgi apparatus membrane protein TVP15
D MAA_02104 golgi apparatus membrane protein TVP18 K26751 TVP18; golgi apparatus membrane protein TVP18
D MAA_04263 hypothetical protein K26752 TVP23; golgi apparatus membrane protein TVP23
D MAA_05704 TLG2-vesicle protein of 38 kDa K26753 TVP38; golgi apparatus membrane protein TVP38
D MAA_09999 vacuolar sorting protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D MAA_06059 lipase K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D MAA_02024 nuclear pore complex, component sec13 K14004 SEC13; protein transport protein SEC13
D MAA_07654 COPII component protein K14005 SEC31; protein transport protein SEC31
D MAA_03652 sec23 protein K14006 SEC23; protein transport protein SEC23
D MAA_04926 Sec23/Sec24 family protein K14007 SEC24; protein transport protein SEC24
D MAA_04504 COPII component protein K14007 SEC24; protein transport protein SEC24
D MAA_01478 SEC16 protein K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D MAA_05807 sybindin-like family protein K20300 TRAPPC1; trafficking protein particle complex subunit 1
D MAA_03441 Sedlin K20301 TRAPPC2; trafficking protein particle complex subunit 2
D MAA_02946 Longin-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D MAA_00350 NO signaling/Golgi transport ligand-binding domain protein K20302 TRAPPC3; trafficking protein particle complex subunit 3
D MAA_11242 hypothetical protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D MAA_06176 TRAPP I complex, Trs31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
C p24 family proteins
D MAA_02922 emp24/gp25L/p24 family protein K20346 TMED4_9_11; p24 family protein alpha
D MAA_04063 emp24/gp25L/p24 family protein K20347 TMED2; p24 family protein beta-1
D MAA_02975 emp24/gp25L/p24 family protein K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D MAA_07263 protein disulfide isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D MAA_02593 ER-resident thioredoxin K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D MAA_09454 Thioredoxin-like fold protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D MAA_09007 hypothetical protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D MAA_02645 Small GTPase superfamily, Rab type K07874 RAB1A; Ras-related protein Rab-1A
D MAA_01838 secretion-related small GTPase SrgD K07877 RAB2A; Ras-related protein Rab-2A
C Rab associated proteins
D MAA_05736 prenylated Rab acceptor 1 K20359 RABAC1; PRA1 family protein 1
D MAA_10816 hypothetical protein K20359 RABAC1; PRA1 family protein 1
D MAA_01103 Rab-GAP/TBC domain protein K20372 TBC1D20; TBC1 domain family member 20
D MAA_00032 GTPase-activating protein K20360 TBC1D22; TBC1 domain family member 2
D MAA_00794 ER to Golgi transport protein Yif1 K20362 YIF1; protein transport protein YIF1
D MAA_02696 ER to Golgi protein transport K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D MAA_08948 Legume-like lectin K10080 LMAN1; lectin, mannose-binding 1
D MAA_05977 Legume-like lectin K10082 LMAN2; lectin, mannose-binding 2
D MAA_05570 glycoside hydrolase family 47 protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_05506 Glycoside hydrolase, family 47 K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_08798 glycoside hydrolase family 47 K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_03432 glycoside hydrolase family 47 protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_02006 Glycoside hydrolase, family 47 K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_04584 glycoside hydrolase family 47 protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D MAA_04109 glycoside hydrolase family 47 protein K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D MAA_03227 hypothetical protein K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D MAA_04327 ER-derived vesicle Erv46-like protein K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D MAA_00568 Cornichon K20368 CNIH; protein cornichon
D MAA_04174 Surfeit locus 4 K20369 ERV29; ER-derived vesicles protein
D MAA_02142 heat shock 70 kDa protein K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D MAA_04443 vesicle coatomer complex, alpha subunit K05236 COPA; coatomer subunit alpha
D MAA_00270 adaptor protein K17301 COPB1; coatomer subunit beta
D MAA_08219 vesicle coatamer complex, beta subunit K17302 COPB2; coatomer subunit beta'
D MAA_03785 Adaptor protein complex K17267 COPG; coatomer subunit gamma
D MAA_03574 coatomer subunit delta K20471 COPD; coatomer subunit delta
D MAA_02859 Tetratricopeptide repeat-containing K17268 COPE; coatomer subunit epsilon
D MAA_04205 coatomer complex, zeta subunit K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D MAA_04586 RINT-1 family protein K20474 RINT1; RAD50-interacting protein 1
D MAA_06167 centromere kinetochore protein K11578 ZW10; protein transport protein DSL1/ZW10
D MAA_03657 Secretory pathway Sec39 K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D MAA_05384 CHD5 domain-containing protein K22384 GET1; tail-anchored protein insertion receptor
D MAA_07666 GET complex, subunit GET2 K22386 GET2; GET complex subunit GET2
D MAA_05653 Arsenical pump ATPase, ArsA K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D MAA_07592 protein family UPF0363 K23387 GET4; golgi to ER traffic protein 4
D MAA_07687 Ubiquitin supergroup K23388 UBL4; ubiquitin-like protein 4
C Rab GTPases
D MAA_02737 RAS small monomeric GTPase Rab6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D MAA_00169 DUF1339 domain protein K20476 RIC1; RAB6A-GEF complex partner protein 1
D MAA_01756 Rgp1 K20477 RGP1; RAB6A-GEF complex partner protein 2
D MAA_08325 ER lumen protein retaining receptor K10949 KDELR; ER lumen protein retaining receptor
D MAA_02804 zinc finger domain-containing protein K12481 RBSN; rabenosyn-5
D MAA_00032 GTPase-activating protein K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D MAA_09090 oxysterol-binding protein K20456 OSBP; oxysterol-binding protein 1
D MAA_03041 oxysterol binding protein K20463 OSBPL3_6_7; oxysterol-binding protein-related protein 3/6/7
D MAA_05733 oxysterol-binding protein K22285 OSBPL8; oxysterol-binding protein-related protein 8
D MAA_04619 hypothetical protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
D MAA_00278 hypothetical protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D MAA_01107 Yip1 domain family protein K22940 YIPF1_2; protein YIPF1/2
D MAA_02323 hypothetical protein K20363 YIPF5_7; protein YIPF5/7
D MAA_01096 DEAD/DEAH box helicase K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D MAA_09789 DUF1620-domain-containing protein K23562 EMC1; ER membrane protein complex subunit 1
D MAA_06814 tetratricopeptide repeat domain-containing protein K23563 EMC2; ER membrane protein complex subunit 2
D MAA_03389 hypothetical protein K23564 EMC3; ER membrane protein complex subunit 3
D MAA_06464 hypothetical protein K23565 EMC4; ER membrane protein complex subunit 4
D MAA_00249 MutS domain V K23566 MMGT1; membrane magnesium transporter 1
D MAA_01834 hypothetical protein K23568 EMC7; ER membrane protein complex subunit 7
C SEC61 complex
D MAA_09744 protein transport protein sec61 alpha subunit K10956 SEC61A; protein transport protein SEC61 subunit alpha
D MAA_00538 Preprotein translocase Sec, Sec61-beta subunit K09481 SEC61B; protein transport protein SEC61 subunit beta
D MAA_08509 Protein translocase complex, SecE/Sec61-gamma subunit K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D MAA_05896 DUF1682 domain protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D MAA_05278 GPI inositol-deacylase K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D MAA_03925 Mn2+ homeostasis protein Per1 K23553 PGAP3; post-GPI attachment to proteins factor 3
D MAA_05175 Metallophosphoesterase domain protein K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
D MAA_09003 Metallophosphoesterase domain protein K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D MAA_03120 sec1 protein K19998 SCFD1; sec1 family domain-containing protein 1
D MAA_02514 ER membrane protein K20724 TMEM33; transmembrane protein 33
D MAA_01089 Arv1-like family protein K21848 ARV1; lipid intermediate transporter
D MAA_02012 Arv1-like family protein K21848 ARV1; lipid intermediate transporter
D MAA_04529 Golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D MAA_10979 calmodulin A K26681 INSIG; insulin-induced protein
D MAA_07714 protein SEY1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D MAA_02276 Autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
D MAA_05809 DUF1649 domain protein K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D MAA_03501 Protein kinase-like protein K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D MAA_02276 Autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
C PI3K complex
D MAA_07417 phosphatidylinositol 3-kinase K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D MAA_01153 vacuolar sorting protein K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D MAA_11399 hypothetical protein K08334 BECN; beclin
C ATG9 transmembrane protein
D MAA_04484 Autophagy-related protein 9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D MAA_05300 protein-vacuolar targeting protein Atg18 K17908 WIPI1_2; autophagy-related protein 18
D MAA_03175 ATG C terminal domain-containing protein K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D MAA_03074 E1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D MAA_04110 autophagy-related protein Atg10 K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
D MAA_02911 autophagy protein 5 K08339 ATG5; autophagy-related protein 5
C Atg8 conjugation proteins
D MAA_02674 Ubiquitin domain of GABA-receptor-associated protein K08341 GABARAP; GABA(A) receptor-associated protein
D MAA_04475 peptidase family C54 protein K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D MAA_03074 E1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D MAA_03709 autophagy-like protein 3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D MAA_08385 peptidase M18-like protein K01268 LAP4; aminopeptidase I [EC:3.4.11.22]
D MAA_05698 glycoside hydrolase family 38 protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D MAA_07055 peptidase M18-like protein K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
D MAA_04312 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D MAA_05815 sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D MAA_05264 sorting nexin K17919 SNX4; sorting nexin-4
D MAA_00506 autophagy related lipase K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D MAA_01720 Autophagy-related protein 27 K21141 ATG27; autophagy-related protein 27
D MAA_01337 vacuolar protein 8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
C Scaffold proteins
D MAA_04312 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D MAA_05849 Dynamin, GTPase domain protein K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
D MAA_05592 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Other mitophagy associated proteins
D MAA_00809 glucokinase K00844 HK; hexokinase [EC:2.7.1.1]
D MAA_02211 hexokinase-1 K00844 HK; hexokinase [EC:2.7.1.1]
D MAA_04209 hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D MAA_05713 ATPase inhibitor, IATP, mitochondria K22255 ATPIF1; ATPase inhibitor, mitochondrial
D MAA_04168 hypothetical protein K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D MAA_05808 peroxin-3 protein K13336 PEX3; peroxin-3
D MAA_02016 Peroxisome membrane anchor protein Pex14p K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
D MAA_05592 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
D MAA_05657 ATPase, AAA-type, core K13338 PEX1; peroxin-1
D MAA_03396 peroxisomal biogenesis factor 6 K13339 PEX6; peroxin-6
B Aggrephagy
C Cargo receptors
D MAA_05592 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Scaffold proteins
C Other aggrephagy associated proteins
D MAA_03481 AAA ATPase K13525 VCP; transitional endoplasmic reticulum ATPase
D MAA_05326 histone deacetylase K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
D MAA_07021 Tetratricopeptide repeat-containing K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
B Xenophagy
C Cargo receptors
D MAA_05592 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Other xenophagy associated proteins
B Chaperone mediated autophagy (CMA)
C Selective cargos
D MAA_06467 aspartate aminotransferase K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D MAA_07675 Glyceraldehyde/Erythrose phosphate dehydrogenase family K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D MAA_06851 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D MAA_07465 Ubiquitin-associated/translation elongation factor EF1B, eukaryote K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D MAA_00656 hsp70 family protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D MAA_07707 heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D MAA_04726 hypothetical protein K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D MAA_03797 translation elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
D MAA_05766 serine carboxypeptidase K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D MAA_02797 Peptidase S10, serine carboxypeptidase, active site protein K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D MAA_07696 Peptidase S10, serine carboxypeptidase K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D MAA_01337 vacuolar protein 8 K08332 VAC8; vacuolar protein 8
C Midbophagy
D MAA_05592 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D MAA_05849 Dynamin, GTPase domain protein K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D MAA_02388 PIK-related kinase, FAT K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D MAA_05612 WD domain-containing protein K08266 MLST8; target of rapamycin complex subunit LST8
D MAA_07359 TORC1 growth control complex subunit Kog1 K07204 RAPTOR; regulatory associated protein of mTOR
C mTORC2 complex
D MAA_02388 PIK-related kinase, FAT K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D MAA_05612 WD domain-containing protein K08266 MLST8; target of rapamycin complex subunit LST8
D MAA_03555 stress activated MAP kinase interacting protein Sin1 K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D MAA_02491 HR1 repeat, rho-binding protein K08267 RICTOR; rapamycin-insensitive companion of mTOR
C SEACIT/GATOR1 complex
D MAA_06387 Dishevelled, Egl-10, and Pleckstrin domain protein K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D MAA_07464 Nitrogen permease regulator 2 K20405 NPRL2; nitrogen permease regulator 2
D MAA_00188 protein family UPF0171 K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D MAA_08108 WD repeat protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D MAA_00822 WD repeat protein K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D MAA_05841 WD40 repeat-like-containing domain protein K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D MAA_06364 nuclear pore complex subunit K14299 SEH1; nucleoporin SEH1
D MAA_02024 nuclear pore complex, component sec13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D MAA_02645 Small GTPase superfamily, Rab type K07874 RAB1A; Ras-related protein Rab-1A
D MAA_06335 secretion-related GTPase K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D MAA_05062 serine/threonine-protein phosphatase PP2A catalytic subunit K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D MAA_05048 TAP42-like protein K17606 IGBP1; immunoglobulin-binding protein 1
D MAA_08109 UV radiation resistance-associated protein K21249 UVRAG; UV radiation resistance-associated gene protein
D MAA_07230 autophagy protein Atg22 K06902 UMF1; MFS transporter, UMF1 family
D MAA_00582 amino acid transporter K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D MAA_01481 transmembrane amino acid transporter protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D MAA_10306 WD40 repeat-like-containing domain protein K22991 WDR45; WD repeat-containing protein 45
D MAA_00141 vacuolar ATPase assembly integral membrane protein K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
D MAA_00772 UPF0183 domain-containing protein K27411 PHAF1; phagosome assembly factor 1
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
D MAA_00619 NADPH oxidase K08008 NOX1; NADPH oxidase 1
D MAA_04914 NADPH oxidase K21421 NOX2; NADPH oxidase 2 [EC:1.-.-.-]
C Nox associated proteins
D MAA_03762 Small GTPase superfamily, Rho type K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
B Actin-binding proteins
C Myosins
D MAA_00560 myosin K10356 MYO1; myosin I
D MAA_06844 Myosin head, motor domain protein K10357 MYO5; myosin V
C Arp2/3 complex
D MAA_04112 actin related protein 2/3 complex subunit K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D MAA_04339 Arp2/3 complex K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D MAA_10288 ARP2/3 complex, p21-Arc subunit K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D MAA_09296 ARP23 complex 20kDa subunit K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D MAA_01689 ARP2/3 complex 16kDa subunit (p16-Arc) K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D MAA_08046 actin-related protein 2 K17260 ACTR2; actin-related protein 2
D MAA_02630 Actin-like protein 3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D MAA_03848 evh1 K23612 WASL; neural Wiskott-Aldrich syndrome protein
D MAA_00200 Src like protein K20520 DBNL; drebrin-like protein
D MAA_05811 polyA nuclease K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D MAA_05634 Src like protein K12562 AMPH; amphiphysin
D MAA_00254 SH3 domain-containing protein K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D MAA_04852 Src like protein K20521 BBC1; myosin tail region-interacting protein MTI1
D MAA_03765 Src like protein K20522 LSB1_2; LAS seventeen-binding protein 1/2
D MAA_02110 Src like protein K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D MAA_04729 duf500 domain containing protein K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D MAA_10707 nitrilase K20524 LSB5; LAS seventeen-binding protein 5
D MAA_06343 phosphatidylinositol 3 K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D MAA_05077 Profilin, plant K05759 PFN; profilin
D MAA_07686 cofilin/tropomyosin-type actin-binding protein K05765 CFL; cofilin
D MAA_05284 Adenylate cyclase-associated CAP K17261 CAP1_2; adenylyl cyclase-associated protein
D MAA_06482 kinesin K10396 KIF5; kinesin family member 5
D MAA_05856 calponin-like actin-binding domain-containing protein K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D MAA_03824 RhoGAP protein K20643 RGD1; Rho GTPase-activating protein RGD1
D MAA_03986 RhoGAP domain-containing protein K08773 RALBP1; RalA-binding protein 1
C Rho guanine nucleotide exchange factors (GEFs)
D MAA_03909 Rho guanyl nucleotide exchange factor K20705 DNMBP; dynamin-binding protein
D MAA_02540 SH3 domain-containing protein K05727 DOCK3; dedicator of cytokinesis protein 3
D MAA_02352 Armadillo K27817 RAP1GDS1; Rap1 GTPase-GDP dissociation stimulator 1
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: September 2, 2024