+E	Polyketide biosynthesis proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Polyketide Biosynthesis Proteins - Micromonospora carbonacea</h2>
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A<b>Polyketide synthase (PKS)</b>
B  Modular type I PKS
C    cis-AT PKS
D      Erythronolide PKS
D      Oleandomycin synthase
D      Pikromycin PKS
D      Avermectin PKS
D      Tylactone synthase
D      Protomycinolide IV synthase
D      Niddamycin PKS
D      Rapamycin PKS
D      Immunomycin PKS
D      Ansamitocin PKS
D      Rifamycin PKS
D      Polyene macrolide PKS
D      Pimaricinolide synthase
D      Candicidin PKS
D      Soraphen PKS
D      Stigmatellin PKS
D      Mycolactone PKS
D      Coelimycin PKS
D      Aureothin PKS
D      Spectinabilin PKS
D      Phthiocerol / Phenolphthiocerol PKS
C    trans-AT PKS
D      Bacillanene hybrid PKS-NRPS
D      Macrolactin PKS
D      Difficidin PKS
D      Rhizoxin hybrid PKS-NRPS
D      Albicidin synthase, hybrid PKS-NRPS
B  Iterative type I PKS
C    Fungal nonreducing PKS (NR-PKS)
C    Fungal partially reducing PKS (PR-PKS)
D      HXZ27_20980 acyltransferase domain-containing protein	K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165] 
C    Fungal highly reducing PKS (HR-PKS)
C    Fungal hybrid type
D      Zearalenone synthase
C    Bacterial type
D      HXZ27_19185 SDR family NAD(P)-dependent oxidoreductase	K15314 sgcE; enediyne polyketide synthase 
B  Type II PKS
C    C9-C14 cyclized polyketide type
D      Spore pigment PKS
E        HXZ27_15990 beta-ketoacyl-[acyl-carrier-protein] synthase family protein	K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] 
E        HXZ27_15995 ketosynthase chain-length factor	K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] 
E        HXZ27_18160 ketosynthase chain-length factor	K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] 
E        HXZ27_16000 acyl carrier protein	K14669 whiEV; minimal PKS acyl carrier protein 
E        HXZ27_16005 SRPBCC family protein	K14670 whiEVI; aromatase 
E        HXZ27_18145 SRPBCC family protein	K14670 whiEVI; aromatase 
E        HXZ27_18130 TcmI family type II polyketide cyclase	K14671 whiEVII; cyclase 
E        HXZ27_18140 TcmI family type II polyketide cyclase	K14671 whiEVII; cyclase 
C    C7-C14 cyclized polyketide type
D      Octaketide PKS
D      Nonaketide PKS
D      Decaketide PKS
B  Type III PKS
C    Plant type
C    Fungal type
C    Bacterial type
B  PKS-NRPS hybrid
C    Bacterial type (modular)
D      Myxalamid hybrid PKS-NRPS
D      Coronatine hybrid PKS-NRPS
D      Microcystin synthetase
D      Epothilone synthetase
D      Bleomycin synthetase
D      Colibactin synthetase
D      Myxothiazol hybrid PKS-NRPS
C    Fungal type (trans-ER, iterative)
D      Aspyridone synthetase
C    Fungal type (iterative)
D      HXZ27_24215 amino acid adenylation domain-containing protein	K15395 ftdB; hybrid polyketide synthase / nonribosomal peptide synthetase FtdB 
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A<b>Nonribosomal peptide synthetase (NRPS)</b>
B  Linear NRPS
C    Emericellamide synthetase
C    Cyanopeptolin synthetase
C    ACV synthetase
C    Bacitracin synthetase
C    Viomycin synthetase
C    Pristinamycin I synthetase
C    Tyrocidine synthetase
C    Surfactin family lipopeptide synthetase
C    Iturin family lipopeptide synthetase
C    Fengycin family lipopeptide synthetase
C    Arthrofactin type cyclic lipopeptide synthetase
C    Vancomycin synthetase
C    Nocardicin synthetase
D      HXZ27_06735 MbtH family protein	K05375 mbtH; MbtH protein 
D      HXZ27_17030 MbtH family protein	K05375 mbtH; MbtH protein 
C    Bialaphos synthetase
C    L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
C    Anabaenopeptin synthetase
C    Linear gramicidin synthetase
B  Iterative NRPS
C    Enterobactin synthetase
D      HXZ27_10525 4'-phosphopantetheinyl transferase superfamily protein	K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] 
C    Bacillibactin synthetase
C    Gramicidin synthetase
B  Nonlinear NRPS
C    Yersiniabactin synthetase
C    Pyochelin synthetase
C    Mycobactin synthetase
C    Vibriobactin synthetase
C    Myxochelin synthetase
C    Petrobacin synthetase
C    Syringomycin synthetase
C    Vanchrobactin synthetase
C    Isonitrile lipopeptide synthase
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A<b>Polyketide tailoring proteins</b>
B  Hydrolase
C    HXZ27_19180 acyl-CoA thioesterase	K15315 sgcE10; enediyne core biosynthesis thioesterase 
B  Ketoreductase
B  Oxygenase
C    HXZ27_10340 bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase	K16022 rif19; flavoprotein hydroxylase 
C    HXZ27_15985 cupin domain-containing protein	K14673 whiEII; putative monooxygenase 
C    HXZ27_18150 cupin domain-containing protein	K14673 whiEII; putative monooxygenase 
B  Methylase
B  Glycosyltransferase
B  Halogenase
B  beta-Branched incorporating proteins
B  Others
C    HXZ27_31165 3-hydroxyacyl-CoA dehydrogenase family protein	K16024 asm13; methoxymalonate biosynthesis protein 
C    HXZ27_31160 acyl carrier protein	K16025 asm14; methoxymalonate biosynthesis acyl carrier protein 
C    HXZ27_31155 acyl-CoA dehydrogenase family protein	K16026 asm15; methoxymalonate biosynthesis protein 
C    HXZ27_31145 HAD-IIIC family phosphatase	K16027 asm16; methoxymalonate biosynthesis protein 
C    HXZ27_19165 DUF1702 family protein	K21161 sgcE3; enediyne biosynthesis protein E3 
C    HXZ27_19195 CRTAC1 family protein	K21162 sgcE4; enediyne biosynthesis protein E4 
C    HXZ27_19190 enediyne biosynthesis protein	K21163 sgcE5; enediyne biosynthesis protein E5 
C    HXZ27_19170 cytochrome P450	K21164 sgcE7; enediyne biosynthesis protein E7 
C    HXZ27_18985 STM4012 family radical SAM protein	K21168 calE1; enediyne biosynthesis protein CalE1 
C    HXZ27_19175 flavin reductase family protein	K21185 sgcE6; flavin reductase 
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A<b>Nonribosomal peptide tailoring proteins</b>
B  Reductase
B  Thioesterase
B  Oxygenase
B  Glycosyltransferase
C    HXZ27_03580 glycosyltransferase family 1 protein	K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] 
C    HXZ27_05415 glycosyltransferase family 1 protein	K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] 
B  Aminotransferase
C    HXZ27_18280 PLP-dependent aminotransferase family protein	K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] 
B  Others
C    HXZ27_08180 aminotransferase class V-fold PLP-dependent enzyme	K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17] 
C    HXZ27_18210 hppD; 4-hydroxyphenylpyruvate dioxygenase	K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] 
C    HXZ27_13965 alpha-hydroxy-acid oxidizing protein	K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] 
C    HXZ27_18275 alpha-hydroxy-acid oxidizing protein	K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] 
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#Last updated: December 18, 2025