+F Repair protein KO
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DNA Repair and Recombination Proteins - Methylosinus sp. C49
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MSC49_04340 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MSC49_31060 ung2; uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MSC49_00020 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MSC49_00380 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D MSC49_34450 NTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSC49_30940 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MSC49_00360 transcriptional regulator K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D MSC49_04340 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D MSC49_18750 alkylated DNA repair dioxygenase K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E MSC49_31060 ung2; uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MSC49_12440 uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MSC49_02200 uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MSC49_00020 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MSC49_10300 tag; DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E MSC49_31170 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E MSC49_00380 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E MSC49_14200 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E MSC49_22440 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E MSC49_24180 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E MSC49_30480 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E MSC49_11770 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E MSC49_28830 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
E MSC49_29540 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E MSC49_18120 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E MSC49_31380 uvrD1_1; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_39450 uvrD1_2; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_40160 DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_02110 pcrA; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_11770 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E MSC49_30480 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F MSC49_03730 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F MSC49_03720 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F MSC49_06870 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F MSC49_02180 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F MSC49_04940 mfd; transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E MSC49_07280 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E MSC49_32840 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E MSC49_27740 xseA; exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E MSC49_24480 dnaE; DNA-directed DNA polymerase K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E MSC49_15250 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E MSC49_14190 DNA polymerase III subunit chi K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E MSC49_10980 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E MSC49_24220 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E MSC49_05290 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MSC49_02460 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E MSC49_30480 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E MSC49_31380 uvrD1_1; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_39450 uvrD1_2; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_40160 DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_02110 pcrA; DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSC49_28050 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E MSC49_39780 hypothetical protein K03111 ssb; single-strand DNA-binding protein
E MSC49_17010 very short patch repair endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
E MSC49_04400 hypothetical protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E MSC49_40200 recD2; ATP-dependent RecD-like DNA helicase K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E MSC49_10190 recA; protein RecA K03553 recA; recombination protein RecA
E MSC49_16080 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E MSC49_18540 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MSC49_16070 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E MSC49_30130 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E MSC49_10190 recA; protein RecA K03553 recA; recombination protein RecA
E MSC49_17980 racA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E MSC49_30990 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E MSC49_25350 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E MSC49_24180 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E MSC49_05670 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E MSC49_02440 recR; recombination protein RecR K06187 recR; recombination protein RecR
E MSC49_29010 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E MSC49_16080 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E MSC49_18540 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MSC49_16070 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E MSC49_10710 double-strand break repair helicase AddA K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E MSC49_10780 double-strand break repair protein AddB K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E MSC49_14010 hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E MSC49_22000 ku; non-homologous end joining protein Ku K10979 ku; DNA end-binding protein Ku
E MSC49_22010 hypothetical protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F MSC49_23610 gyrA_2; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F MSC49_29930 gyrB_1; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MSC49_22150 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F MSC49_34080 transcriptional regulator K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F MSC49_24180 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F MSC49_05670 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F MSC49_02440 recR; recombination protein RecR K06187 recR; recombination protein RecR
F MSC49_30480 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F MSC49_18010 hypothetical protein K04764 ihfA; integration host factor subunit alpha
F MSC49_32890 ihfA; integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F MSC49_39410 integration host factor subunit beta K04764 ihfA; integration host factor subunit alpha
F MSC49_12210 ihfB; integration host factor subunit beta K05788 ihfB; integration host factor subunit beta
E Supressor
F MSC49_08680 hypothetical protein K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MSC49_18800 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MSC49_28830 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
F MSC49_29540 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D MSC49_08010 dinB2; DNA polymerase IV 2 K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D MSC49_10190 recA; protein RecA K03553 recA; recombination protein RecA
D MSC49_14110 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MSC49_29010 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D MSC49_39590 hypothetical protein K14160 imuA; protein ImuA
D MSC49_02620 hypothetical protein K14160 imuA; protein ImuA
D MSC49_39600 nucleotidyltransferase K14161 imuB; protein ImuB
D MSC49_02610 hypothetical protein K14161 imuB; protein ImuB
D MSC49_24830 dnaE2-1_1; error-prone DNA polymerase 1 K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D MSC49_39610 dnaE2-1_2; error-prone DNA polymerase 1 K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D MSC49_28050 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D MSC49_39780 hypothetical protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D MSC49_09460 ATP-dependent DNA helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D MSC49_34450 NTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSC49_30940 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D MSC49_26440 nrdJ; vitamin B12-dependent ribonucleotide reductase K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MSC49_40150 hypothetical protein K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024