+F Repair protein KO
#
DNA Repair and Recombination Proteins - Microtus fortis (reed vole)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 126498903 methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 126487975 DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 126504682 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 126487424 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 126487974 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126507953 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 126503755 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 126495489 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 126491212 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 126494511 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 126505555 methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 126505572 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 126507687 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 126504795 endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 126498701 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 126496329 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 126492850 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 126492164 DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
E 126506471 DNA-(apurinic or apyrimidinic site) endonuclease 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
E 126506472 DNA-(apurinic or apyrimidinic site) endonuclease 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 126488085 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 126500800 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 126508914 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 126498521 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 126511663 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 126508424 DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 126493907 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 126515369 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 126496620 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 126498705 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 126494648 LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 126504412 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 126491421 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 126492350 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 126507243 LOW QUALITY PROTEIN: tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 126503631 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 126515630 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 126488142 bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 126498623 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126512579 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126513472 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126513703 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 126487501 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126494014 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126508806 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 126514870 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126515661 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126489584 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126503244 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 126502132 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 126504801 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 126492591 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 126492883 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 126499944 protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 126512452 DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 126487734 UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 126515421 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 126508150 centrin-2-like K10840 CETN2; centrin-2
F 126489394 centrin-2 isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 126492120 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126501446 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126498637 cullin-4A K10609 CUL4; cullin 4
F 126494663 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 126491104 cullin-4B-like K10609 CUL4; cullin 4
F 126498120 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 126489766 DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 126514141 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 126506603 DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 126502590 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 126503349 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 126494751 DNA-directed RNA polymerase II subunit RPB4-like isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 126497189 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 126504767 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 126489335 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 126490668 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 126498901 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 126515712 DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 126498895 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 126504256 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 126486761 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 126498769 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 126491907 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 126514276 DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 126492120 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126501446 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126498637 cullin-4A K10609 CUL4; cullin 4
F 126494663 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 126491104 cullin-4B-like K10609 CUL4; cullin 4
F 126498120 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 126512587 DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 126500582 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 126500827 UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 126506114 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 126490547 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 126497095 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 126490969 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 126493717 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 126512563 general transcription factor IIH subunit 2-like protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 126504309 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 126494411 general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 126499353 general transcription factor IIH subunit 5-like K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 126509469 general transcription factor IIH subunit 5-like K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 126497640 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 126512605 cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 126487166 cyclin-H K06634 CCNH; cyclin H
E 126508448 CDK-activating kinase assembly factor MAT1 isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 126492376 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126506727 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 126513756 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 126509934 DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 126490946 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 126490683 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 126511766 DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 126494648 LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 126502908 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 126512996 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 126486912 cullin-5 K10612 CUL5; cullin 5
E 126498927 elongin-C-like K03872 ELOC; elongin-C
E 126501407 elongin-C K03872 ELOC; elongin-C
E 126515004 elongin-C-like K03872 ELOC; elongin-C
E 126513547 elongin-B-like K03873 ELOB; elongin-B
E 126494140 elongin-B-like K03873 ELOB; elongin-B
E 126498192 elongin-B K03873 ELOB; elongin-B
E 126509497 elongin-A isoform X1 K15076 ELOA; elongin-A
E 126496203 LOW QUALITY PROTEIN: ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
E 126509799 ubiquitin-associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
E 126516091 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 126493661 LOW QUALITY PROTEIN: ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 126504129 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 126508490 DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 126504000 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 126511826 PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 126499829 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 126489856 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 126515176 DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 126488085 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 126500800 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 126508914 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 126498521 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 126492376 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126506727 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 126513756 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 126506409 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 126512284 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 126516011 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 126513519 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 126511680 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 126496620 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 126502091 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 126498623 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126512579 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126513472 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126513703 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 126487501 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126494014 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126508806 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 126514870 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126515661 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126489584 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 126494648 LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 126496756 WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 126487655 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 126510938 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 126515117 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126508838 BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126509679 LOW QUALITY PROTEIN: BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 126503032 BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 126492217 BRISC and BRCA1-A complex member 1 isoform X1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 126494595 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 126490208 lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126486968 LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 126499787 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126512785 DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 126487655 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 126510938 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 126515117 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126513498 breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 126502379 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 126495244 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 126495244 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 126511360 DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 126486980 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 126492354 DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 126489449 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 126509045 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 126505532 DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 126510133 RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 126494152 DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 126500052 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 126486494 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 126497318 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 126504391 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 126508710 recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126503537 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 126500381 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 126508710 recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126514660 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126489021 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126502566 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 126514885 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 126492376 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126506727 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 126513756 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 126515975 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 126508048 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 126508328 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 126506060 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 126493037 protein PPP4R3C-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126507209 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126495183 protein PPP4R3C-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126489562 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126507267 serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 126498856 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 126513835 AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 126495507 AP-5 complex subunit sigma-1 isoform X1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 126514330 AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 126511565 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 126501254 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 126501368 protein LRATD1 K22805 FAM84A; protein FAM84A
E 126502304 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 126503579 E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 126498864 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 126505933 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 126515964 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 126503732 EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 126488602 SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 126504345 SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 126510498 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 126498363 probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 126511475 exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 126498857 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 126503905 swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 126515898 structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 126492372 structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 126501255 LOW QUALITY PROTEIN: flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 126494985 spatacsin K19026 SPG11; spatacsin
E 126511359 zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 126488510 RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 126510649 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126503397 LOW QUALITY PROTEIN: mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126507063 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 126501005 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 126490285 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 126503376 protein LRATD2 K22810 FAM84B; protein FAM84B
E 126514315 BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 126502817 cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 126490324 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 126514643 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 126490541 ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 126509022 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 126501146 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 126503339 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 126503318 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 126506520 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 126503806 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 126515807 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 126489467 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 126490314 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 126487655 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 126510938 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 126498322 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 126487183 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 126492954 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 126503244 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 126500955 DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 126505537 DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 126504412 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 126503631 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 126515630 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 126506757 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 126501859 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 126516057 structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 126489269 PWWP domain-containing DNA repair factor 3A isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 126496259 PWWP domain-containing DNA repair factor 3B-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 126489702 PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 126509251 protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 126505252 cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 126487079 jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 126496795 shieldin complex subunit 1 isoform X1 K26128 SHLD1; shieldin complex subunit 1
E 126500628 shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 126512597 shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 126515486 Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 126512732 Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 126502449 Fanconi anemia group C protein isoform X1 K10890 FANCC; fanconi anemia group C protein
E 126500101 Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 126488556 Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 126509893 Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 126488304 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 126493709 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 126486637 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 126500534 Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 126512263 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 126508235 centromere protein S K11511 APITD1; centromere protein S
E 126504956 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 126508710 recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126514660 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126489021 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126502566 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 126514885 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 126505473 Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 126508648 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 126510109 breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 126513498 breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 126486968 LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 126502379 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 126505904 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 126495244 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 126486980 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 126497823 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 126498061 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 126501095 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 126490156 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 126493646 serine/threonine-protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 126493414 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 126498388 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 126499030 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 126511800 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 126492072 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 126499417 E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 126512171 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 126508911 E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 126500299 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 126513921 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 126509245 taperin K24164 TPRN; taperin
E 126494004 zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 126499735 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 126496371 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 126496756 WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 126488931 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 126488329 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 126508481 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 126496881 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 126499080 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 126500729 DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 126488428 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 126510985 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 126505497 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 126490658 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 126487082 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 126487395 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 126496513 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 126490311 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 126488408 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 126497351 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 126503716 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 126496620 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 126503806 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 126504522 DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 126487063 germ cell nuclear acidic protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 126498517 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 126511631 cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 126500900 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 126501556 checkpoint protein HUS1B K10996 HUS1B; checkpoint protein HUS1B
D 126499725 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 126512604 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 126512284 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 126516011 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 126513519 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 126511680 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 126499725 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 126492062 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 126507500 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 126509754 claspin K25773 CLSPN; claspin
C Triple T complex
D 126497823 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 126506866 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 126504468 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 126494866 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 126491899 ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 126490251 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 126514364 Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 126510625 serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 126499799 ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 126486910 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 126513928 cellular tumor antigen p53 isoform X1 K04451 TP53; tumor protein p53
D 126490587 serine/threonine-protein kinase Chk1 isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 126488526 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 126499932 M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 126496720 M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 126497036 M-phase inducer phosphatase 3 isoform X1 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 126506985 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126513294 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126500949 14-3-3 protein theta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126501311 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126492728 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 126500863 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 126492421 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 126488585 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 126514440 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 126515053 LOW QUALITY PROTEIN: wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 126505279 LOW QUALITY PROTEIN: wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 126513971 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 126514246 LOW QUALITY PROTEIN: period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 126508169 period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 126494391 mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 126491296 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 126508696 apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 126494533 serine/threonine-protein kinase PLK3 isoform X1 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 126489271 inactive serine/threonine-protein kinase PLK5 isoform X1 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 126498830 serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 126513439 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 126511160 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 126512639 serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 126499916 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 126515253 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 126494047 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 126490490 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 126511008 KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 126498059 KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 126513362 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 126487100 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 126502638 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 126495234 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 126502224 replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 126505679 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 126513878 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 126504816 DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 126499801 three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 126490245 three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 126503223 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 126510787 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 126487018 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 126500462 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 126513223 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 126492216 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 126509677 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 126502692 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 126498916 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126495467 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126496200 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126486828 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 126510853 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 126495057 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
D 126496077 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
D 126511606 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
D 126511725 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 126514325 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 126496731 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126488854 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 126501367 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 126508957 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 126513701 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 126498903 methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 126487974 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126491212 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 126495489 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 126494511 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 126498701 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 126496329 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 126505280 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 126505280 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 126496731 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024