+F Repair protein KO
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DNA Repair and Recombination Proteins - Megalopta genalis
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117224275 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 117223337 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117224639 uncharacterized protein LOC117224639 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 117225009 uncharacterized protein LOC117225009 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 117226214 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117226732 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117221363 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 117217692 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 117220304 exodeoxyribonuclease isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 117227904 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 117224554 DNA polymerase delta small subunit-like isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 117226655 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
F 117228573 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 117220098 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 117218351 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 117228554 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 117217902 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 117222646 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 117223500 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117224365 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117217912 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 117227502 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 117227891 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 117229957 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 117226850 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 117223654 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117219255 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117229966 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 117218371 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 117221431 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 117222630 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 117223892 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 117217818 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117225145 cullin-4A K10609 CUL4; cullin 4
F 117221372 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 117220456 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 117225271 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 117220551 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 117220032 DNA-directed RNA polymerase II subunit RPB3 isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 117222901 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 117222900 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 117220395 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 117226729 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 117227480 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 117228228 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117221450 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117221453 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117221454 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117221455 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117218780 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 117227056 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 117217818 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117225145 cullin-4A K10609 CUL4; cullin 4
F 117221372 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 117217886 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 117219792 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 117229986 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 117224970 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 117229462 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 117228666 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 117228667 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 117224411 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 117222774 general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 117227292 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 117218422 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 117224695 cyclin-H K06634 CCNH; cyclin H
E 117228752 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 117219224 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117223550 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117229872 uncharacterized protein LOC117229872 isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 117229253 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 117218172 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 117221897 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 117219310 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 117217912 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 117228868 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 117229911 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 117229545 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 117220852 elongin-C isoform X1 K03872 ELOC; elongin-C
E 117223789 elongin-B K03873 ELOB; elongin-B
E 117224470 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 117219850 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 117219262 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 117229764 DNA mismatch repair protein MutL-like K10864 PMS1; DNA mismatch repair protein PMS1
E 117219690 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 117222833 mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 117227904 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 117224554 DNA polymerase delta small subunit-like isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 117226655 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
E 117228573 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 117219224 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117223550 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117229872 uncharacterized protein LOC117229872 isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 117218335 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 117220307 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 117229817 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 117229807 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 117226395 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 117222646 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 117223500 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117228524 exonuclease 1-like isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 117224065 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 117218371 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 117217912 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 117224828 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117218176 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 117218204 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117220355 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117220357 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117228316 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117226133 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117223095 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117218193 BRISC complex subunit FAM175B-like isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 117219320 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 117220901 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 117217954 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117221979 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 117220623 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117220878 myosin-2 heavy chain-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 117224828 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117218176 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 117218204 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117220355 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117220357 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117228316 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117226133 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117218301 breast cancer type 2 susceptibility protein-like isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 117219205 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 117219205 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 117220519 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 117218043 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 117220135 DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 117225900 DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 117223207 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 117219783 uncharacterized protein LOC117219783 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 117223318 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 117224627 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 117220741 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117228374 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 117220741 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117220428 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117228464 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117219223 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 117219224 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117223550 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117229872 uncharacterized protein LOC117229872 isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 117219195 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 117223580 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 117229702 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 117221275 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 117220248 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 117222552 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 117220935 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 117222165 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 117220497 melanoma-associated antigen F1-like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 117226104 non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 117221121 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 117219621 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 117225281 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117218348 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 117219563 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 117224789 structure-specific endonuclease subunit slx1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 117227723 uncharacterized protein LOC117227723 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 117224527 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 117220343 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 117226440 uncharacterized protein LOC117226440 K23112 BRAT1; BRCA1-associated ATM activator 1
E 117222949 uncharacterized protein LOC117222949 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 117217758 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 117228094 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 117219278 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 117226374 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 117219045 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 117224957 biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 117222281 Werner Syndrome-like exonuclease isoform X1 K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 117218119 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 117219669 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 117220698 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 117224828 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117218176 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 117218204 double-strand break repair protein MRE11-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 117220355 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117220357 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117228316 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 117227285 uncharacterized protein LOC117227285 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 117227502 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 117223654 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117219255 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117225093 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 117227488 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 117217725 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 117220741 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117220428 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117228464 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117219223 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 117218227 Fanconi anemia group I protein homolog isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 117217654 uncharacterized protein LOC117217654 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117218301 breast cancer type 2 susceptibility protein-like isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 117221979 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 117226398 fanconi-associated nuclease 1-like isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 117219205 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 117229946 uncharacterized protein LOC117229946 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 117227453 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 117217891 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 117221437 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 117226376 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 117226569 E3 ubiquitin-protein ligase rnf8-B-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 117220260 uncharacterized protein LOC117220260 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 117227682 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 117222912 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 117225323 uncharacterized protein LOC117225323 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 117220255 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 117223736 DNA polymerase iota-like K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 117223163 DNA repair protein rev1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 117227409 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 117219268 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 117227274 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 117217423 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 117224242 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 117222646 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 117223500 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 117223673 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 117225058 serine-rich adhesin for platelets K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 117224829 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 117228792 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 117217756 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 117226826 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 117220307 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 117229817 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 117229807 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 117226395 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 117217756 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 117220556 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 117221687 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 117224596 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 117219897 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 117222031 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 117223061 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 117220967 NEDD8 K23388 UBL4; ubiquitin-like protein 4
D 117219396 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 117226373 serine/threonine-protein kinase atr-like isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 117228900 LOW QUALITY PROTEIN: serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 117228452 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 117225470 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 117218214 uncharacterized protein LOC117218214 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 117223364 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117224412 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 117224641 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 117223991 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 117219811 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 117223169 dentin sialophosphoprotein-like isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 117218701 mediator of DNA damage checkpoint protein 1-like isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 117228703 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 117221816 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117226432 abscission/NoCut checkpoint regulator-like isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 117226435 abscission/NoCut checkpoint regulator-like isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 117221408 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 117222434 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 117223245 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 117219551 DNA-directed primase/polymerase protein-like isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 117220338 uncharacterized protein LOC117220338 isoform X1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 117218957 uncharacterized protein LOC117218957 isoform X1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 117226760 uncharacterized protein LOC117226760 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 117219006 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 117220657 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 117218106 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 117220564 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 117217761 cell division cycle 5-like protein isoform X1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 117228208 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 117224239 pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 117227047 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 117219638 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 117223688 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 117223052 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 117217615 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117223337 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117226732 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117226214 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117217692 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 117227121 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 117227121 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 117223688 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024