+E Transcription factors KO
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Transcription Factors - Mixta intestinalis
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AEukaryotic type
B Basic leucine zipper (bZIP)
C AP-1(-like) components, Jun
C AP-1(-like) components, Fos
C AP-1(-like) components, Maf
C AP-1(-like) components, NF-E2
C AP-1(-like) components, Fungal regulators
C AP-1(-like) components, CRE-BP/ATF
C CREB
C C/EBP-like factors
C bZIP/PAR
C Plant bZIP factors
C ZIP only
B Basic helix-loop-helix (bHLH)
C Ubiquitous (class A) factors
C Myogenic transcription factors
C Achaete-Scute
C Tal/Twist/Atonal/Hen, Lymphoid factors
C Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors
C Tal/Twist/Atonal/Hen, HEN
C Tal/Twist/Atonal/Hen, Mesp
C Tal/Twist/Atonal/Hen, Atonal
C Tal/Twist/Atonal/Hen, Pancreatic factors
C Hairy, Hairy/E(SPL)
C Hairy, Fungal regulators
C Factors with PAS domain
C Yabby
C INO
C HLH domain only
B Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
C Ubiquitous bHLH-ZIP factors
C Cell cycle controlling factors, Myc
C Cell cycle controlling factors, Mad/Max
C Other bHLH-ZIP factors
B Other basic domains
C NF-1
C RF-X
C AP-2 (bHSH)
B Zinc finger
C Cys4 thyroid hormone receptor-like
C Cys4 hepatocyte nuclear factor 4-like
C Cys4 estrogen receptor-like
C Cys4 nerve growth factor IB-like
C Cys4 Fushi tarazu-F1-like
C Cys4 germ cell nuclear factor
C Cys4 Knirps/DAX1-like
C Cys4 GATA-factors
C Cys2His2 SP/KLF family and related proteins
C Cys2His2 GLI-like
C Cys2His2 Snail
C Cys2His2 BTB-ZF factors
C Cys2His2 BED
C Cys2His2 PRDM
C Cys2His2 metabolic regulators in fungi
C Cys2His2 others
C Cys2HisCys zinc factors
C Cys3His zinc factors
C Cys2CysHis zinc factors
C CXXC CpG-binding proteins
D C7M51_01796 dcm; DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Cys6 metabolic regulators in fungi
C Other zinc fingers
B Helix-turn-helix
C Homeo domain ANTP: HOXL
C Homeo domain ANTP: NKL
C Homeo domain Paired-related
C Homeo domain LIM
C Homeo domain POU
C Homeo domain SINE
C Homeo domain ZF
C Homeo domain CUT
C Homeo domain PROS
C Homeo domain TALE
C Homeo domain other
C Fork head/winged helix developmental regulators
C Fork head/winged helix tissue-specific regulators
C Fork head/winged helix cell cycle-controlling factors, E2F
C Fork head/winged helix cell cycle-controlling factors, DP
C Fork head/winged helix other regulators
C Heat shock factors
C Tryptophan clusters Myb, Myb-factors
C Tryptophan clusters Myb, Myb-like factors
C Tryptophan clusters Ets-type
C Tryptophan clusters interferon-regulating factors
C TEA domain
C ARID
B beta-Scaffold factors with minor groove contacts
C RHR (Rel homology region) Rel/Ankyrin
C RHR (Rel homology region) Ankyrin only
C RHR (Rel homology region) NF-AT
C STAT
C p53
C MADS-box regulators of differentiation, MEF-2
C MADS-box regulators of differentiation, Homeotic genes
C MADS-box regulators of differentiation, Yeast regulators
C MADS-box responders to external signals
C SAND domain-containing proteins
C TATA-binding proteins
C HMG SOX
C HMG TCF-1
C HMG2-related
C UBF
C Other HMG box factors
C Heteromeric CCAAT factors
C Grainyhead
C Cold-shock domain factors, DbpA-like
C Cold-shock domain factors, YB-1/DbpB-like
C Cold-shock domain factors, FRG Y2-like
C Runt
C MYRF
B Other transcription factors
C HMGI(Y)
C NUPR
E Line #4
C Pocket domain Rb
C Pocket domain CBP
C T-box
C DMRT
C LRRFIP
C TCP
C AP2/ERF
C WRKY
C LOB
C Copper-fist proteins fungal regulators
C Others
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AProkaryotic type
B Helix-turn-helix
C AraC family
D C7M51_01218 araC_2; Arabinose operon regulatory protein K02099 araC; AraC family transcriptional regulator, arabinose operon regulatory protein
D C7M51_01339 rhaR; HTH-type transcriptional activator RhaR K02854 rhaR; AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR
D C7M51_01338 rhaS; HTH-type transcriptional activator RhaS K02855 rhaS; AraC family transcriptional regulator, L-rhamnose operon regulatory protein RhaS
D C7M51_03064 soxS; Regulatory protein SoxS K13631 soxS; AraC family transcriptional regulator, mar-sox-rob regulon activator
D C7M51_01329 marA; Multiple antibiotic resistance protein MarA K13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator
D C7M51_04308 rob_2; Right origin-binding protein K05804 rob; AraC family transcriptional regulator, mar-sox-rob regulon activator
D C7M51_03034 rob_1; Right origin-binding protein K05804 rob; AraC family transcriptional regulator, mar-sox-rob regulon activator
D C7M51_03039 tetD; Transposon Tn10 TetD protein K18325 ramA; AraC family of transcriptional regulator, multidrug resistance transcriptional activator
D C7M51_00588 alkA; putative bifunctional transcriptional activator/DNA repair enzyme AlkA K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
C LysR family
D C7M51_02564 gcvA_2; Glycine cleavage system transcriptional activator K03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator
D C7M51_01247 gcvA_1; Glycine cleavage system transcriptional activator K03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator
D C7M51_03226 oxyR_3; Hydrogen peroxide-inducible genes activator K02521 ilvY; LysR family transcriptional regulator, positive regulator for ilvC
D C7M51_03173 metR; HTH-type transcriptional regulator MetR K03576 metR; LysR family transcriptional regulator, regulator for metE and metH
D C7M51_04325 nhaR; Transcriptional activator protein NhaR K03717 nhaR; LysR family transcriptional regulator, transcriptional activator of nhaA
D C7M51_03248 oxyR_4; Hydrogen peroxide-inducible genes activator K04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator
D C7M51_02630 argP; HTH-type transcriptional regulator ArgP K05596 iciA; LysR family transcriptional regulator, chromosome initiation inhibitor
D C7M51_01422 cysB; HTH-type transcriptional regulator CysB K13634 cysB; LysR family transcriptional regulator, cys regulon transcriptional activator
D C7M51_01825 cbl; HTH-type transcriptional regulator cbl K13635 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator
D C7M51_02709 gltC_3; HTH-type transcriptional regulator GltC K13928 mdcR; LysR family transcriptional regulator, malonate utilization transcriptional regulator
D C7M51_00233 pgrR_2; HTH-type transcriptional regulator PgrR K18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC
D C7M51_01082 dmlR_2; HTH-type transcriptional regulator DmlR K18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC
D C7M51_01826 oxyR_2; Hydrogen peroxide-inducible genes activator K19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein
D C7M51_03983 dmlR_8; HTH-type transcriptional regulator DmlR K21698 aaeR; LysR family transcriptional regulator, transcriptional activator for aaeXAB operon
D C7M51_03234 gltC_4; HTH-type transcriptional regulator GltC K23773 hdfR; LysR family transcriptional regulator, flagellar master operon regulator
C DeoR family
D C7M51_04303 deoR_2; Deoxyribose operon repressor K11534 deoR; DeoR family transcriptional regulator, deoxyribose operon repressor
D C7M51_03828 glpR; Glycerol-3-phosphate regulon repressor K02444 glpR; DeoR family transcriptional regulator, glycerol-3-phosphate regulon repressor
D C7M51_03022 srlR_3; Glucitol operon repressor K02081 agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor
C LacI family
D C7M51_03595 lacI; Lactose operon repressor K27069 lacI; LacI family transcriptional regulator, lactose operon repressor
D C7M51_02597 galR; HTH-type transcriptional regulator GalR K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D C7M51_03453 rbsR; Ribose operon repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D C7M51_01988 galS; HTH-type transcriptional regulator GalS K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D C7M51_03626 xylR; Xylose operon regulatory protein K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D C7M51_02178 ccpA; Catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D C7M51_03530 kdgR_3; HTH-type transcriptional regulator KdgR K02525 kdgR; LacI family transcriptional regulator, kdg operon repressor
D C7M51_03268 cytR_2; HTH-type transcriptional repressor CytR K05499 cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG
D C7M51_03883 cytR_3; HTH-type transcriptional repressor CytR K05499 cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG
D C7M51_00016 cra_1; Catabolite repressor/activator K03435 fruR1; LacI family transcriptional regulator, fructose operon transcriptional repressor
D C7M51_04166 cra_2; Catabolite repressor/activator K03484 scrR; LacI family transcriptional regulator, sucrose operon repressor
D C7M51_04212 ascG; HTH-type transcriptional regulator AscG K03487 ascG; LacI family transcriptional regulator, asc operon repressor
D C7M51_01180 purR; HTH-type transcriptional repressor PurR K03604 purR; LacI family transcriptional regulator, purine nucleotide synthesis repressor
D C7M51_03794 gntR_2; HTH-type transcriptional regulator GntR K06145 gntR; LacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor
D C7M51_02422 gntR_1; HTH-type transcriptional regulator GntR K06145 gntR; LacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor
D C7M51_03032 malI; Maltose regulon regulatory protein MalI K16136 malI; LacI family transcriptional regulator, maltose regulon regulatory protein
C GntR family
D C7M51_01818 phnF; putative transcriptional regulator PhnF K02043 phnF; GntR family transcriptional regulator, phosphonate transport system regulatory protein
D C7M51_00057 yvoA; HTH-type transcriptional repressor YvoA K05836 hutC; GntR family transcriptional regulator, histidine utilization repressor
D C7M51_01496 fadR_1; Fatty acid metabolism regulator protein K03603 fadR; GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA
D C7M51_00049 pdhR_1; Pyruvate dehydrogenase complex repressor K05799 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex
D C7M51_01276 pdhR_2; Pyruvate dehydrogenase complex repressor K05799 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex
D C7M51_02825 lldR_1; Putative L-lactate dehydrogenase operon regulatory protein K19775 exuR; GntR family transcriptional regulator, hexuronate regulon transcriptional repressor
D C7M51_03538 lldR_2; Putative L-lactate dehydrogenase operon regulatory protein K14348 lldR; GntR family transcriptional regulator, L-lactate dehydrogenase operon regulator
D C7M51_03515 lutR_1; HTH-type transcriptional regulator LutR K19776 dgoR; GntR family transcriptional regulator, galactonate operon transcriptional repressor
D C7M51_01281 gabR_1; HTH-type transcriptional regulatory protein GabR K00375 K00375; GntR family transcriptional regulator / MocR family aminotransferase
D C7M51_01398 gabR_2; HTH-type transcriptional regulatory protein GabR K00375 K00375; GntR family transcriptional regulator / MocR family aminotransferase
D C7M51_01911 rspR_1; HTH-type transcriptional repressor RspR K22293 rspR; GntR family transcriptional regulator, rspAB operon transcriptional repressor
C TetR/AcrR family
D C7M51_00429 acrR; HTH-type transcriptional regulator AcrR K03577 acrR; TetR/AcrR family transcriptional regulator, acrAB operon repressor
D C7M51_03406 slmA; Nucleoid occlusion factor SlmA K05501 slmA; TetR/AcrR family transcriptional regulator
D C7M51_00816 rutR; HTH-type transcriptional regulator RutR K09017 rutR; TetR/AcrR family transcriptional regulator
D C7M51_01185 nemR; HTH-type transcriptional repressor NemR K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon
D C7M51_03246 fabR; HTH-type transcriptional repressor FabR K22105 fabR; TetR/AcrR family transcriptional regulator, fatty acid biosynthesis regulator
C Lrp/AsnC family
D C7M51_03467 asnC; Regulatory protein AsnC K03718 asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA
D C7M51_00735 lrp_1; Leucine-responsive regulatory protein K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein
D C7M51_00416 decR; DNA-binding transcriptional activator DecR K05800 decR; Lrp/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator
D C7M51_01018 lrp_2; Leucine-responsive regulatory protein K26601 azlB; Lrp/AsnC family transcriptional regulator, repressor for azl operon
C LuxR family
D C7M51_00819 sdiA; Regulatory protein SdiA K07782 sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA
D C7M51_01593 esaR_1; Transcriptional activator protein EsaR K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D C7M51_02682 esaR_2; Transcriptional activator protein EsaR K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D C7M51_01779 rcsA; Transcriptional regulatory protein RcsA K07781 rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor
D C7M51_03829 malT; HTH-type transcriptional regulator MalT K03556 malT; LuxR family transcriptional regulator, maltose regulon positive regulatory protein
C MarR family
D C7M51_00849 slyA_1; Transcriptional regulator SlyA K06075 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin
D C7M51_01189 slyA_2; Transcriptional regulator SlyA K06075 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin
D C7M51_02466 mprA; Transcriptional repressor MprA K15974 emrR; MarR family transcriptional regulator, negative regulator of the multidrug operon emrRAB
D C7M51_03655 ohrR; Organic hydroperoxide resistance transcriptional regulator K23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator
C MerR family
D C7M51_00448 cueR; HTH-type transcriptional regulator CueR K19591 cueR; MerR family transcriptional regulator, copper efflux regulator
D C7M51_03063 soxR; Redox-sensitive transcriptional activator SoxR K13639 soxR; MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR
D C7M51_00659 bluR; HTH-type transcriptional repressor BluR K21972 bluR; MerR family transcriptional regulator, repressor of blue light- and temperature-responsive genes
C Fur family
D C7M51_00546 fur; Ferric uptake regulation protein K03711 fur; Fur family transcriptional regulator, ferric uptake regulator
D C7M51_03083 zur; Zinc uptake regulation protein K09823 zur; Fur family transcriptional regulator, zinc uptake regulator
C IclR family
D C7M51_01524 kdgR_1; Pectin degradation repressor protein KdgR K19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor
D C7M51_02025 kdgR_2; Transcriptional regulator KdgR K19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor
C CRP/FNR family
D C7M51_03877 crp; cAMP-activated global transcriptional regulator CRP K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
D C7M51_01349 fnr; Fumarate and nitrate reduction regulatory protein K01420 fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein
C Rrf2 family
D C7M51_02364 iscR; HTH-type transcriptional regulator IscR K13643 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor
D C7M51_02884 nsrR_2; HTH-type transcriptional repressor NsrR K13771 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor
D C7M51_01332 nsrR_1; HTH-type transcriptional repressor NsrR K19587 oqxR; Rrf2 family transcriptional regulator, repressor of oqxAB
C ArsR family
C XRE family
D C7M51_01321 sutR_1; HTH-type transcriptional regulator SutR K23779 sutR; XRE family transcriptional regulator, regulator of sulfur utilization
C PadR family
C Other families
D C7M51_00671 mntR; Transcriptional regulator MntR K11924 mntR; DtxR family transcriptional regulator, manganese transport regulator
D C7M51_01627 hexR_1; HTH-type transcriptional regulator HexR K19337 hexR; RpiR family transcriptional regulator, carbohydrate utilization regulator
D C7M51_04079 hexR_3; HTH-type transcriptional regulator HexR K19337 hexR; RpiR family transcriptional regulator, carbohydrate utilization regulator
D C7M51_03147 birA; Bifunctional ligase/repressor BirA K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D C7M51_03963 fis; DNA-binding protein Fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
D C7M51_04305 trpR; Trp operon repressor K03720 trpR; TrpR family transcriptional regulator, trp operon repressor
D C7M51_03008 Limonene hydroxylase K02688 prpR; transcriptional regulator, propionate catabolism operon regulatory protein
D C7M51_04034 hypothetical protein K07724 ner; Ner family transcriptional regulator
D C7M51_01930 hypothetical protein K07724 ner; Ner family transcriptional regulator
D C7M51_00008 sgrR; HTH-type transcriptional regulator SgrR K11925 sgrR; SgrR family transcriptional regulator
D C7M51_04298 nadR; Trifunctional NAD biosynthesis/regulator protein NadR K06211 nadR; HTH-type transcriptional regulator, transcriptional repressor of NAD biosynthesis genes [EC:2.7.7.1 2.7.1.22]
D C7M51_01858 puuR; HTH-type transcriptional regulator PuuR K14056 puuR; HTH-type transcriptional regulator, repressor for puuD
D C7M51_01603 hypothetical protein K22300 dicA; HTH-type transcriptional regulator, cell division transcriptional repressor
D C7M51_01592 hypothetical protein K22300 dicA; HTH-type transcriptional regulator, cell division transcriptional repressor
D C7M51_00962 hypothetical protein K22300 dicA; HTH-type transcriptional regulator, cell division transcriptional repressor
D C7M51_04219 dgaR; Transcriptional regulatory protein DagR K19505 gfrR; sigma-54 dependent transcriptional regulator, gfr operon transcriptional activator
D C7M51_00310 norR; Anaerobic nitric oxide reductase transcription regulator NorR K12266 norR; anaerobic nitric oxide reductase transcription regulator
D C7M51_00258 fhlA; Formate hydrogenlyase transcriptional activator K15836 fhlA; formate hydrogenlyase transcriptional activator
D C7M51_00124 cdaR; Carbohydrate diacid regulator K02647 cdaR; carbohydrate diacid regulator
D C7M51_02416 rocR_1; Arginine utilization regulatory protein RocR K06714 rocR; arginine utilization regulatory protein
D C7M51_04184 rocR_2; Arginine utilization regulatory protein RocR K06714 rocR; arginine utilization regulatory protein
D C7M51_00602 modE; Transcriptional regulator ModE K02019 modE; molybdate transport system regulatory protein
D C7M51_02305 mopA; Molybdenum-pterin-binding protein MopA K02019 modE; molybdate transport system regulatory protein
D C7M51_03653 hypothetical protein K07726 K07726; putative transcriptional regulator
B Ribbon-helix-helix
C CopG family
C Other families
D C7M51_03265 metJ; Met repressor K03764 metJ; MetJ family transcriptional regulator, methionine regulon repressor
D C7M51_01725 putA; Bifunctional protein PutA K13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
B Other transcription factors
C BglG family
D C7M51_02225 bglG; Cryptic beta-glucoside bgl operon antiterminator K03488 licT; beta-glucoside operon transcriptional antiterminator
C Others
D C7M51_00403 bolA; DNA-binding transcriptional regulator BolA K05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator
D C7M51_04410 hypothetical protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D C7M51_04421 virB; Virulence regulon transcriptional activator VirB K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D C7M51_03161 rfaH; Transcription antitermination protein RfaH K05785 rfaH; transcriptional antiterminator RfaH
D C7M51_03991 argR; Arginine repressor K03402 argR; transcriptional regulator of arginine metabolism
D C7M51_00538 nagC_1; N-acetylglucosamine repressor K02565 nagC; N-acetylglucosamine repressor
D C7M51_01226 nagC_2; N-acetylglucosamine repressor K15545 mlc; transcriptional regulator of PTS gene
D C7M51_03648 mtlR; Mannitol operon repressor K02562 mtlR; mannitol operon repressor
D C7M51_01379 tyrR; Transcriptional regulatory protein TyrR K03721 tyrR; transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport
D C7M51_02311 gcvR; Glycine cleavage system transcriptional repressor K03567 gcvR; glycine cleavage system transcriptional repressor
D C7M51_01386 pspF; Psp operon transcriptional activator K03974 pspF; psp operon transcriptional activator
D C7M51_01383 pspC; Phage shock protein C K03973 pspC; phage shock protein C
D C7M51_04109 hypothetical protein K07733 alpA; prophage regulatory protein
D C7M51_04137 hypothetical protein K07733 alpA; prophage regulatory protein
D C7M51_02662 hypothetical protein K07735 algH; putative transcriptional regulator
D C7M51_00106 dksA; RNA polymerase-binding transcription factor DksA K06204 dksA; RNA polymerase-binding transcription factor
D C7M51_00379 nrdR; Transcriptional repressor NrdR K07738 nrdR; transcriptional repressor NrdR
D C7M51_00220 crl; Sigma factor-binding protein Crl K11926 crl; sigma factor-binding protein Crl
D C7M51_01602 hypothetical protein K22302 dicC; transcriptional repressor of cell division inhibition gene dicB
D C7M51_00017 mraZ; Transcriptional regulator MraZ K03925 mraZ; transcriptional regulator MraZ
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 7, 2024
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Classification taken and modified from TRANSFAC 7.0