+F Repair protein KO
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DNA Repair and Recombination Proteins - Mycolicibacter sinensis
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D JDM601_1319 ogt; methylated-DNA-protein-cysteine methyltransferase Ogt K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E JDM601_2680 ung; uracil-DNA glycosylase Ung K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E JDM601_1846 mpg; 3-methyladenine DNA glycosylase Mpg K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E JDM601_3882 mutY; adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E JDM601_3952 nth; endonuclease III Nth K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E JDM601_0789 ercc3; DNA helicase Ercc3 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D JDM601_1148 mutT2; mutator protein MutT2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D JDM601_0384 mutT3; mutator protein MutT3 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D JDM601_2439 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase DutT K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D JDM601_1319 ogt; methylated-DNA-protein-cysteine methyltransferase Ogt K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E JDM601_2680 ung; uracil-DNA glycosylase Ung K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E JDM601_1365 glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E JDM601_1228 conserved hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E JDM601_3073 conserved hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E JDM601_1320 alkA; Ada regulatory protein AlkA K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E JDM601_1846 mpg; 3-methyladenine DNA glycosylase Mpg K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E JDM601_3882 mutY; adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E JDM601_1185 tagA; DNA-3-methyladenine glycosylase I TagA K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E JDM601_0890 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E JDM601_2656 fpg; formamidopyrimidine-DNA glycosylase Fpg K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E JDM601_1444 formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E JDM601_3116 nei; endonuclease VIII Nei K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E JDM601_3952 nth; endonuclease III Nth K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E JDM601_0401 xthA; exodeoxyribonuclease III protein XthA K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E JDM601_0685 end; endonuclease IV (apurinase) K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E JDM601_2737 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E JDM601_1802 polA; DNA polymerase I PolA K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E JDM601_1814 uvrA; excinuclease ABC (subunit A-DNA-binding ATPase) UvrA K03701 uvrA; excinuclease ABC subunit A
E JDM601_1809 uvrB; excinuclease ABC (subunit B-helicase) UvrB K03702 uvrB; excinuclease ABC subunit B
E JDM601_2282 uvrC; excinuclease ABC (subunit c-nuclease) UvrC K03703 uvrC; excinuclease ABC subunit C
E JDM601_0894 uvrD1; ATP-dependent DNA helicase II UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_2912 uvrD2; ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_2916 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_1802 polA; DNA polymerase I PolA K02335 polA; DNA polymerase I [EC:2.7.7.7]
E JDM601_2737 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F JDM601_0682 rpoB; DNA-directed RNA polymerase beta subunit RpoB K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F JDM601_0683 rpoC; DNA-directed RNA polymerase beta chain RpoC K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F JDM601_3280 rpoA; DNA-directed RNA polymerase (alpha chain) RpoA K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F JDM601_2306 rpoZ; DNA-directed RNA polymerase (omega chain) RpoZ K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F JDM601_0983 mfd; transcription-repair coupling factor Mfd (TrcF) K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E JDM601_1058 xseA; exodeoxyribonuclease VII (large subunit) XseA K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E JDM601_1057 exodeoxyribonuclease K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E JDM601_2180 dnaE; DNA polymerase III alpha subunit DnaE1 K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E JDM601_0002 dnaN; DNA polymerase III (beta chain) DnaN K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E JDM601_1502 holA; DNA polymerase III delta subunit HolA K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E JDM601_3929 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E JDM601_1711 conserved hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E JDM601_3994 dnaQ; DNA polymerase III (epsilon subunit) DnaQ K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E JDM601_4010 dnaZX; DNA polymerase III (subunit gamma/tau) DnaZX K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E JDM601_2737 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E JDM601_0894 uvrD1; ATP-dependent DNA helicase II UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_2912 uvrD2; ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_2916 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E JDM601_1430 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E JDM601_4307 ssb; single-strand binding protein Ssb K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E JDM601_0643 recB; exodeoxyribonuclease V (beta chain) RecB K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E JDM601_0644 recC; exodeoxyribonuclease V (gamma chain) RecC K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E JDM601_0642 recD; exodeoxyribonuclease V (alpha chain) RecD K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E JDM601_2483 RecA protein K03553 recA; recombination protein RecA
E JDM601_2379 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E JDM601_2378 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E JDM601_2380 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E JDM601_2297 priA; primosomal protein N' PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E JDM601_2483 RecA protein K03553 recA; recombination protein RecA
E JDM601_3878 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E JDM601_0003 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E JDM601_2677 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E JDM601_1563 recO; recombination protein O RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E JDM601_4003 recR; recombination protein RecR K06187 recR; recombination protein RecR
E JDM601_1852 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E JDM601_2379 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E JDM601_2378 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E JDM601_2380 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E JDM601_1395 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E JDM601_0881 ATP dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E JDM601_3038 putative DNA ligase-like protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F JDM601_0006 gyrA; DNA gyrase (subunit A) GyrA K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F JDM601_0026 gyrA; DNA gyrase (subunit A) GyrA K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F JDM601_0005 gyrB; DNA gyrase (subunit B) GyrB K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F JDM601_0027 gyrB; DNA gyrase (subunit B) GyrB K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F JDM601_3931 topA; DNA topoisomerase I TopA K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F JDM601_1881 conserved hypothetical protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F JDM601_2689 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F JDM601_1563 recO; recombination protein O RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F JDM601_4003 recR; recombination protein RecR K06187 recR; recombination protein RecR
F JDM601_2737 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F JDM601_3678 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F JDM601_1814 uvrA; excinuclease ABC (subunit A-DNA-binding ATPase) UvrA K03701 uvrA; excinuclease ABC subunit A
F JDM601_1809 uvrB; excinuclease ABC (subunit B-helicase) UvrB K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D JDM601_2188 dinP_1; DNA polymerase IV DinP_1 K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D JDM601_2483 RecA protein K03553 recA; recombination protein RecA
D JDM601_2459 lexA; repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D JDM601_1852 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D JDM601_3216 conserved hypothetical protein K14161 imuB; protein ImuB
D JDM601_3205 dnaE2; DNA polymerase III alpha chain DnaE2 K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D JDM601_1430 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D JDM601_4307 ssb; single-strand binding protein Ssb K03111 ssb; single-strand DNA-binding protein
D JDM601_2482 recX; regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D JDM601_1332 dinG; ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D JDM601_3115 lhr; ATP-dependent helicase Lhr K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D JDM601_1148 mutT2; mutator protein MutT2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D JDM601_0384 mutT3; mutator protein MutT3 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D JDM601_2688 mutT1; hydrolase MutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D JDM601_1856 NUDIX hydrolase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D JDM601_2439 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase DutT K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D JDM601_2787 nrdE; ribonucleoside-diphosphate reductase (alpha chain) NrdE K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D JDM601_2780 nrdF; ribonucleoside-diphosphate reductase (beta chain) NrdF2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D JDM601_0215 ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D JDM601_2561 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024