+D Messenger RNA Biogenesis KO
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Prokaryotic Defense System - Methylomonas koyamae
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ACRISPR-Cas system
B Universal Cas proteins
C MKLM6_1308 type I-E CRISPR-associated endonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
C MKLM6_1943 type I-F CRISPR-associated endonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
C MKLM6_2401 CRISPR-associated protein Cas4 K15342 cas1; CRISP-associated protein Cas1
C MKLM6_1309 type I-E CRISPR-associated endoribonuclease Cas2 K09951 cas2; CRISPR-associated protein Cas2
C MKLM6_2402 CRISPR-associated protein Cas2 K09951 cas2; CRISPR-associated protein Cas2
B Type I CRISPR-Cas system
C Type I signiture cas proteins
D MKLM6_1294 CRISPR-associated helicase Cas3 K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D MKLM6_1944 type I-F CRISPR-associated helicase Cas3 K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D MKLM6_2396 hypothetical protein K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
C Subtype I-A factors
C Subtype I-B factors
C Subtype I-C factors
C Subtype I-D factors
C Subtype I-E factors
D MKLM6_1299 type I-E CRISPR-associated protein Cse1/CasA K19123 casA; CRISPR system Cascade subunit CasA
D MKLM6_1300 type I-E CRISPR-associated protein Cse2/CasB K19046 casB; CRISPR system Cascade subunit CasB
D MKLM6_1303 type I-E CRISPR-associated protein Cas7/Cse4/CasC K19124 casC; CRISPR system Cascade subunit CasC
D MKLM6_1304 type I-E CRISPR-associated protein Cas5/CasD K19125 casD; CRISPR system Cascade subunit CasD
D MKLM6_1305 type I-E CRISPR-associated protein Cas6/Cse3/CasE K19126 casE; CRISPR system Cascade subunit CasE
C Subtype I-F factors
D MKLM6_1945 type I-F CRISPR-associated protein Csy1 K19127 csy1; CRISPR-associated protein Csy1
D MKLM6_1946 type I-F CRISPR-associated protein Csy2 K19128 csy2; CRISPR-associated protein Csy2
D MKLM6_1947 type I-F CRISPR-associated protein Csy3 K19129 csy3; CRISPR-associated protein Csy3
D MKLM6_1948 CRISPR-associated endonuclease Csy4 K19130 csy4; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]
C Subtype I-U factors
D MKLM6_2394 type I-U CRISPR-associated protein Cas7 K19131 csb1; CRISPR-associated protein Csb1
D MKLM6_2395 type I-U CRISPR-associated protein Cas5/Cas6 K19132 csb2; CRISPR-associated protein Csb2
B Type II CRISPR-Cas system
C Type II signiture cas proteins
C Subtype II-A factors
C Subtype II-B factors
B Type III CRISPR-Cas system
C Type III signiture cas proteins
C Subtype III-A factors
C Subtype III-B factors
C Subtype III-U factors
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ARestriction and modification system (R-M system)
B Type I R-M system
C MKLM6_0479 restriction endonuclease subunit R K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C MKLM6_3221 Type III restriction protein res subunit K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C MKLM6_3673 type I restriction enzyme subunit R K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C MKLM6_3735 type I restriction enzyme subunit R K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C MKLM6_1466 type I restriction enzyme subunit R K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C MKLM6_3674 type I restriction enzyme subunit S K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C MKLM6_3738 type I restriction enzyme subunit M K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C MKLM6_1468 type I restriction enzyme subunit S K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C MKLM6_0061 Type I restriction-modification system methylation subunit K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_0472 DNA methyltransferase K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_3219 restriction endonuclease subunit M K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_3675 type I restriction enzyme subunit M K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_3736 type I restriction enzyme subunit S K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_1045 DNA methyltransferase K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C MKLM6_1473 type I restriction-modification protein subunit M K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
B Type II R-M system
C Restriction endonucleases
C DNA methyltransferases
B Type III R-M system
C MKLM6_0849 type III restriction endonuclease subunit R K01156 res; type III restriction enzyme [EC:3.1.21.5]
C MKLM6_1586 type III restriction endonuclease subunit R K01156 res; type III restriction enzyme [EC:3.1.21.5]
C MKLM6_1582 DNA methylase N-4 K07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
C MKLM6_0850 DNA methylase K07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
B Type IV R-M system
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AToxin-antitoxin system (TA system)
B Type I TA system
C Hok-Sok
C SymE-SymR
C Ldr-Rdl
C TisB-IstR
C Ibs-Sib
C ShoB-OhsC
C RalR-RalA
B Type II TA system
C MazF-MazE
D MKLM6_3165 growth inhibitor PemK K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D MKLM6_4343 mRNA-degrading endonuclease K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D MKLM6_1680 growth inhibitor PemK K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D MKLM6_4396 AbrB family transcriptional regulator K07172 mazE; antitoxin MazE
D MKLM6_4344 PbsX family transcriptional regulator K07172 mazE; antitoxin MazE
D MKLM6_1681 PbsX family transcriptional regulator K07172 mazE; antitoxin MazE
C ChpB-ChpS
C YhaV-PrlF
C RelE/StbE-RelB/StbD
D MKLM6_1298 hypothetical protein K06218 relE; mRNA interferase RelE/StbE
D MKLM6_1470 hypothetical protein K06218 relE; mRNA interferase RelE/StbE
D MKLM6_1327 hypothetical protein K06218 relE; mRNA interferase RelE/StbE
C YafQ-dinJ
C YoeB-YefM
D MKLM6_1325 Toxin yoeB K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D MKLM6_1324 hypothetical protein K19159 yefM; antitoxin YefM
C HipA-HipB
D MKLM6_2271 toxin HipA K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]
D MKLM6_2270 transcriptional regulator K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB
C HicA-HicB
D MKLM6_2306 hypothetical protein K18843 hicB; antitoxin HicB
C YafO-YafN
C Hha-TomB
C PspC-PspB
C CcdB-CcdA
D MKLM6_3386 acetoacetyl-CoA synthase K19164 ccdA; antitoxin CcdA
C ParE-ParD
D MKLM6_1307 addiction module toxin RelE K19092 parE1_3_4; toxin ParE1/3/4
D MKLM6_0822 hypothetical protein K07746 parD1_3_4; antitoxin ParD1/3/4
C Doc-Phd
D MKLM6_3597 hypothetical protein K07341 doc; death on curing protein
C HigB-HigA
D MKLM6_3155 hypothetical protein K19166 higB; mRNA interferase HigB [EC:3.1.-.-]
D MKLM6_0051 peptidase K07334 higB-1; toxin HigB-1
D MKLM6_3777 plasmid stabilization protein K07334 higB-1; toxin HigB-1
D MKLM6_3156 hypothetical protein K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D MKLM6_0052 LacI family transcriptional regulator K21498 higA-1; antitoxin HigA-1
C MqsR-MqsA
C VapC-VapB
D MKLM6_3498 Ribonuclease VapC K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D MKLM6_3502 tRNA(FMet)-specific endonuclease VapC K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D MKLM6_1503 plasmid maintenance protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D MKLM6_1160 twitching motility protein PilT K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D MKLM6_3497 antitoxin K18829 mvpT; antitoxin VapB
D MKLM6_3501 antitoxin K18829 mvpT; antitoxin VapB
D MKLM6_1504 virulence factor K18829 mvpT; antitoxin VapB
C PezT-PezA
C YobL-YobK
C YokI-YokJ
C YqcG-YqcF
C YxiD-YxxD
C FitB-FitA
D MKLM6_3504 twitching motility protein PilT K07062 fitB; toxin FitB [EC:3.1.-.-]
D MKLM6_1096 twitching motility protein PilT K07062 fitB; toxin FitB [EC:3.1.-.-]
D MKLM6_3500 hypothetical protein K07062 fitB; toxin FitB [EC:3.1.-.-]
D MKLM6_0825 DNA-binding protein K21495 fitA; antitoxin FitA
C BC_0920-BC_0921
C Type II TA system related factors
D MKLM6_4035 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D MKLM6_3702 Rod shape-determining protein MreB K03569 mreB; rod shape-determining protein MreB and related proteins
D MKLM6_3588 DNA topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D MKLM6_1261 DNA topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D MKLM6_3081 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
B Type III TA system
C AbiQ system
B Type IV TA system
C YeeV-YeeU
C CptA-CptB
D MKLM6_1987 hypothetical protein K09159 cptB; antitoxin CptB
B Type V TA system
C GhoT-GhoS
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ADNA phosphothiolation system
B Sulfur modification proteins
C MKLM6_3238 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C MKLM6_3507 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C MKLM6_4282 3'-phosphoadenosine 5'-phosphosulfate sulfurtransferase DndC K19170 dndC; DNA sulfur modification protein DndC
C MKLM6_4283 hypothetical protein K19171 dndD; DNA sulfur modification protein DndD
C MKLM6_4284 hypothetical protein K19172 dndE; DNA sulfur modification protein DndE
B DNA phosphorothioation-dependent restriction proteins
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 7, 2023