+F Repair protein KO
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DNA Repair and Recombination Proteins - Mycobacterium sp. MOTT36Y
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D W7S_06700 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D W7S_18640 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E W7S_18245 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E W7S_14545 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E W7S_02310 adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E W7S_01960 hypothetical protein K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E W7S_04235 DNA or RNA helicase of superfamily protein II K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D W7S_05920 NUDIX family hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_23410 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_03375 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_17105 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D W7S_06700 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D W7S_18640 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E W7S_18245 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E W7S_06360 uracil-DNA glycosylase superfamily protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E W7S_19670 hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E W7S_06705 AraC family transcriptional regulator K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E W7S_14545 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E W7S_02310 adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E W7S_06155 DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E W7S_18110 formamidopyrimidine/5-formyluracil/5-hydroxymethyluracil DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E W7S_04630 DNA-formamidopyrimidine glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E W7S_14840 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E W7S_20630 hypothetical protein K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E W7S_07515 hypothetical protein K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E W7S_01960 hypothetical protein K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E W7S_23265 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E W7S_10090 endonuclease/exonuclease/phosphatase K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E W7S_22140 endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E W7S_18455 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E W7S_14875 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E W7S_09650 ABC transporter K03701 uvrA; excinuclease ABC subunit A
E W7S_14775 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E W7S_14800 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E W7S_16065 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E W7S_04650 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_19950 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_19970 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_10070 DNA/RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_14875 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E W7S_18455 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F W7S_22150 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F W7S_22145 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F W7S_21410 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F W7S_16180 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F W7S_05210 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E W7S_05555 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E W7S_05550 exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E W7S_15220 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E W7S_00010 DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E W7S_07780 hypothetical protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E W7S_02110 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E W7S_01690 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E W7S_10695 hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E W7S_01640 DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E W7S_18455 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E W7S_04650 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_19950 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_19970 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_10070 DNA/RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E W7S_00350 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E W7S_07440 hypothetical protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E W7S_22340 exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E W7S_22335 exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E W7S_22345 hypothetical protein K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E W7S_17280 recA; recombinase A K03553 recA; recombination protein RecA
E W7S_16585 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E W7S_16580 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E W7S_16590 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E W7S_16145 primosome assembly protein PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E W7S_17280 recA; recombinase A K03553 recA; recombination protein RecA
E W7S_02330 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E W7S_00015 recF; recombination protein F K03629 recF; DNA replication and repair protein RecF
E W7S_18185 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E W7S_09450 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E W7S_01670 recR; recombination protein RecR K06187 recR; recombination protein RecR
E W7S_14505 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E W7S_16585 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E W7S_16580 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E W7S_16590 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E W7S_07330 ATP-binding protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
E W7S_08760 DEAD/DEAH box helicase K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E W7S_04560 ku protein K10979 ku; DNA end-binding protein Ku
E W7S_04585 ATP-dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E W7S_14835 putative DNA ligase-like protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F W7S_00030 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F W7S_00025 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F W7S_02100 DNA topoisomerase I subunit omega K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F W7S_19660 DNA topoisomerase K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F W7S_18290 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F W7S_09450 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F W7S_01670 recR; recombination protein RecR K06187 recR; recombination protein RecR
F W7S_18455 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F W7S_09650 ABC transporter K03701 uvrA; excinuclease ABC subunit A
F W7S_14775 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F W7S_14800 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D W7S_00870 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D W7S_15265 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D W7S_18785 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D W7S_17280 recA; recombinase A K03553 recA; recombination protein RecA
D W7S_17220 LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D W7S_14505 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D W7S_21075 hypothetical protein K14161 imuB; protein ImuB
D W7S_21015 dnaE2; error-prone DNA polymerase K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D W7S_00350 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D W7S_07440 hypothetical protein K03111 ssb; single-strand DNA-binding protein
D W7S_17275 recX; recombination regulator RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D W7S_06755 deaD/DeaH family protein helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D W7S_20625 DEAD/DEAH box helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D W7S_05920 NUDIX family hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_23410 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_03375 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D W7S_18285 mutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D W7S_14485 hypothetical protein K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D W7S_06525 nudix hydrolase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D W7S_17105 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D W7S_18760 ribonucleotide-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D W7S_18720 nrdF; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D W7S_24295 ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D W7S_23070 nrdF1; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D W7S_17605 hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024