+E	Polyketide biosynthesis proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Polyketide Biosynthesis Proteins - Mycolicibacterium monacense</h2>
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A<b>Polyketide synthase (PKS)</b>
B  Modular type I PKS
C    cis-AT PKS
D      Erythronolide PKS
D      Oleandomycin synthase
D      Pikromycin PKS
D      Avermectin PKS
D      Tylactone synthase
D      Protomycinolide IV synthase
D      Niddamycin PKS
D      Rapamycin PKS
D      Immunomycin PKS
D      Ansamitocin PKS
D      Rifamycin PKS
D      Polyene macrolide PKS
D      Pimaricinolide synthase
D      Candicidin PKS
D      Soraphen PKS
D      Stigmatellin PKS
D      Mycolactone PKS
D      Coelimycin PKS
D      Aureothin PKS
D      Spectinabilin PKS
D      Phthiocerol / Phenolphthiocerol PKS
E        EWR22_15020 type I polyketide synthase	K12441 ppsB; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292] 
E        EWR22_15030 type I polyketide synthase	K12441 ppsB; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292] 
E        EWR22_15025 acyltransferase domain-containing protein	K12442 ppsC; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292] 
E        EWR22_15015 acyltransferase domain-containing protein	K12444 ppsE; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292] 
C    trans-AT PKS
D      Bacillanene hybrid PKS-NRPS
D      Macrolactin PKS
D      Difficidin PKS
D      Rhizoxin hybrid PKS-NRPS
D      Albicidin synthase, hybrid PKS-NRPS
B  Iterative type I PKS
C    Fungal nonreducing PKS (NR-PKS)
C    Fungal partially reducing PKS (PR-PKS)
D      EWR22_17970 type I polyketide synthase	K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165] 
C    Fungal highly reducing PKS (HR-PKS)
C    Fungal hybrid type
D      Zearalenone synthase
C    Bacterial type
B  Type II PKS
C    C9-C14 cyclized polyketide type
D      Spore pigment PKS
C    C7-C14 cyclized polyketide type
D      Octaketide PKS
D      Nonaketide PKS
D      Decaketide PKS
B  Type III PKS
C    Plant type
C    Fungal type
C    Bacterial type
D      EWR22_05670 type III polyketide synthase	K16167 bpsA; alkylresorcinol/alkylpyrone synthase 
D      EWR22_11860 type III polyketide synthase	K16167 bpsA; alkylresorcinol/alkylpyrone synthase 
B  PKS-NRPS hybrid
C    Bacterial type (modular)
D      Myxalamid hybrid PKS-NRPS
D      Coronatine hybrid PKS-NRPS
D      Microcystin synthetase
D      Epothilone synthetase
D      Bleomycin synthetase
D      Colibactin synthetase
D      Myxothiazol hybrid PKS-NRPS
C    Fungal type (trans-ER, iterative)
D      Aspyridone synthetase
C    Fungal type (iterative)
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A<b>Nonribosomal peptide synthetase (NRPS)</b>
B  Linear NRPS
C    Emericellamide synthetase
C    Cyanopeptolin synthetase
C    ACV synthetase
C    Bacitracin synthetase
C    Viomycin synthetase
C    Pristinamycin I synthetase
C    Tyrocidine synthetase
C    Surfactin family lipopeptide synthetase
C    Iturin family lipopeptide synthetase
C    Fengycin family lipopeptide synthetase
C    Arthrofactin type cyclic lipopeptide synthetase
C    Vancomycin synthetase
C    Nocardicin synthetase
D      EWR22_17915 MbtH family protein	K05375 mbtH; MbtH protein 
C    Bialaphos synthetase
C    L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
C    Anabaenopeptin synthetase
C    Linear gramicidin synthetase
B  Iterative NRPS
C    Enterobactin synthetase
D      EWR22_10630 4'-phosphopantetheinyl transferase superfamily protein	K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] 
C    Bacillibactin synthetase
C    Gramicidin synthetase
B  Nonlinear NRPS
C    Yersiniabactin synthetase
C    Pyochelin synthetase
C    Mycobactin synthetase
D      EWR22_17955 2,3-dihydroxybenzoate-AMP ligase	K04787 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-] 
D      EWR22_17950 non-ribosomal peptide synthetase	K04788 mbtB; mycobactin phenyloxazoline synthetase 
D      EWR22_17940 polyketide synthase	K04790 mbtC; mycobactin polyketide synthetase MbtC 
D      EWR22_17935 SDR family NAD(P)-dependent oxidoreductase	K04791 mbtD; mycobactin polyketide synthetase MbtD 
D      EWR22_17930 non-ribosomal peptide synthetase	K04789 mbtE; mycobactin peptide synthetase MbtE 
D      EWR22_17925 non-ribosomal peptide synthetase	K04792 mbtF; mycobactin peptide synthetase MbtF 
C    Vibriobactin synthetase
C    Myxochelin synthetase
C    Petrobacin synthetase
C    Syringomycin synthetase
C    Vanchrobactin synthetase
C    Isonitrile lipopeptide synthase
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A<b>Polyketide tailoring proteins</b>
B  Hydrolase
B  Ketoreductase
B  Oxygenase
C    EWR22_08460 epoxide hydrolase	K21159 sgcF; epoxide hydrolase 
C    EWR22_24060 epoxide hydrolase	K21159 sgcF; epoxide hydrolase 
B  Methylase
C    EWR22_05675 hypothetical protein	K16168 bpsB; methyltransferase 
C    EWR22_11865 hypothetical protein	K16168 bpsB; methyltransferase 
B  Glycosyltransferase
B  Halogenase
B  beta-Branched incorporating proteins
B  Others
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A<b>Nonribosomal peptide tailoring proteins</b>
B  Reductase
B  Thioesterase
B  Oxygenase
C    EWR22_17920 lysine 6-monooxygenase	K04793 mbtG; mycobactin lysine-N-oxygenase 
B  Glycosyltransferase
B  Aminotransferase
B  Others
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#Last updated: December 18, 2025