+D Messenger RNA Biogenesis KO
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Prokaryotic Defense System - Methylomonas methanica
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ACRISPR-Cas system
B Universal Cas proteins
C Metme_1395 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
C Metme_3038 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
C Metme_3039 CRISPR-associated protein Cas2 K09951 cas2; CRISPR-associated protein Cas2
B Type I CRISPR-Cas system
C Type I signiture cas proteins
D Metme_1396 CRISPR-associated helicase Cas3 family K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D Metme_3031 CRISPR-associated HD domain protein K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
C Subtype I-A factors
D Metme_3037 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
C Subtype I-B factors
D Metme_3037 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
C Subtype I-C factors
D Metme_3034 CRISPR-associated protein, Csd1 family K19117 csd1; CRISPR-associated protein Csd1
D Metme_3035 CRISPR-associated protein, Csd2 family K19118 csd2; CRISPR-associated protein Csd2
D Metme_3037 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D Metme_3033 CRISPR-associated protein Cas5 family K19119 cas5d; CRISPR-associated protein Cas5d
C Subtype I-D factors
D Metme_3037 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
C Subtype I-E factors
C Subtype I-F factors
D Metme_1397 CRISPR-associated protein Csy1 K19127 csy1; CRISPR-associated protein Csy1
D Metme_1398 CRISPR-associated protein, Csy2 family K19128 csy2; CRISPR-associated protein Csy2
D Metme_1399 CRISPR-associated protein, Csy3 family K19129 csy3; CRISPR-associated protein Csy3
D Metme_1400 CRISPR-associated protein, Csy4 family K19130 csy4; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]
C Subtype I-U factors
B Type II CRISPR-Cas system
C Type II signiture cas proteins
C Subtype II-A factors
C Subtype II-B factors
D Metme_3037 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
B Type III CRISPR-Cas system
C Type III signiture cas proteins
C Subtype III-A factors
C Subtype III-B factors
C Subtype III-U factors
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ARestriction and modification system (R-M system)
B Type I R-M system
C Metme_1711 Type I site-specific deoxyribonuclease K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C Metme_1967 type I site-specific deoxyribonuclease, HsdR family K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C Metme_4222 Restriction endonuclease, type I, EcoRI, R subunit/Type III K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C Metme_4477 Type I site-specific deoxyribonuclease K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C Metme_1708 restriction modification system DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C Metme_1965 restriction modification system DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C Metme_4218 restriction modification system DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C Metme_4475 restriction modification system DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C Metme_1709 Site-specific DNA-methyltransferase (adenine-specific) K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C Metme_1963 Site-specific DNA-methyltransferase (adenine-specific) K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C Metme_4216 N-6 DNA methylase K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
C Metme_4476 N-6 DNA methylase K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
B Type II R-M system
C Restriction endonucleases
C DNA methyltransferases
D Metme_4481 phage DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D Metme_1361 D12 class N6 adenine-specific DNA methyltransferase K07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
B Type III R-M system
B Type IV R-M system
C Metme_4214 restriction endonuclease K07448 mrr; restriction system protein
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AToxin-antitoxin system (TA system)
B Type I TA system
C Hok-Sok
C SymE-SymR
C Ldr-Rdl
C TisB-IstR
C Ibs-Sib
C ShoB-OhsC
C RalR-RalA
B Type II TA system
C MazF-MazE
D Metme_0429 transcriptional modulator of MazE/toxin, MazF K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D Metme_0026 transcriptional regulator/antitoxin, MazE K07172 mazE; antitoxin MazE
D Metme_0430 SpoVT/AbrB domain-containing protein K07172 mazE; antitoxin MazE
D Metme_1757 transcriptional regulator/antitoxin, MazE K07172 mazE; antitoxin MazE
C ChpB-ChpS
C YhaV-PrlF
C RelE/StbE-RelB/StbD
D Metme_0213 plasmid stabilization system K06218 relE; mRNA interferase RelE/StbE
D Metme_1360 addiction module toxin, RelE/StbE family K06218 relE; mRNA interferase RelE/StbE
D Metme_3454 addiction module toxin, RelE/StbE family K06218 relE; mRNA interferase RelE/StbE
D Metme_3463 addiction module toxin, RelE/StbE family K06218 relE; mRNA interferase RelE/StbE
D Metme_3465 addiction module toxin, RelE/StbE family K06218 relE; mRNA interferase RelE/StbE
D Metme_3464 hypothetical protein K18918 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB
C YafQ-dinJ
C YoeB-YefM
C HipA-HipB
C HicA-HicB
C YafO-YafN
C PspC-PspB
C CcdB-CcdA
D Metme_1771 CcdB-like toxin protein K19163 ccdB; toxin CcdB
D Metme_1772 Post-segregation antitoxin CcdA K19164 ccdA; antitoxin CcdA
C ParE-ParD
D Metme_2316 plasmid stabilization system K19092 parE1_3_4; toxin ParE1/3/4
D Metme_3371 plasmid stabilization system K19092 parE1_3_4; toxin ParE1/3/4
D Metme_2315 addiction module antidote protein, CC2985 family K07746 parD1_3_4; antitoxin ParD1/3/4
D Metme_3196 CopG-like domain-containing protein DNA-binding protein K07746 parD1_3_4; antitoxin ParD1/3/4
D Metme_3370 addiction module antidote protein, CC2985 family K07746 parD1_3_4; antitoxin ParD1/3/4
C Doc-Phd
C HigB-HigA
D Metme_4147 plasmid maintenance system killer K07334 higB-1; toxin HigB-1
D Metme_4148 putative plasmid maintenance system antidote protein, XRE family K21498 higA-1; antitoxin HigA-1
C MqsR-MqsA
C VapC-VapB
D Metme_3851 hypothetical protein K18829 mvpT; antitoxin VapB
D Metme_0680 PilT protein domain protein K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]
D Metme_3883 prevent-host-death family protein K28280 vapB22; antitoxin VapB22
C PezT-PezA
C YobL-YobK
C YokI-YokJ
C YqcG-YqcF
C YxiD-YxxD
C FitB-FitA
C BC_0920-BC_0921
C SpoIISA-SpoIISB
C Tse6-Tsi6
C Type II TA system related factors
D Metme_0253 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D Metme_1062 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins
D Metme_1074 DNA topoisomerase IV, A subunit K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D Metme_3452 DNA topoisomerase IV, B subunit K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D Metme_3892 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
B Type III TA system
C AbiQ system
B Type IV TA system
C YeeV-YeeU
C CptA-CptB
D Metme_1920 hypothetical protein K19168 cptA; toxin CptA
D Metme_2143 protein of unknown function DUF339 K09159 cptB; antitoxin CptB
C AbiEii-AbiEi
B Type V TA system
C GhoT-GhoS
C Other GhoT/OrtT toxin family protein
B Type VI TA system
C SocB-SocA
B Type VII TA system
C Hha-TomB
C TglT-TakA
C HepT-MntA
D Metme_4220 protein of unknown function DUF86 K28186 hepT; HepT family RNase toxin
D Metme_4219 DNA polymerase beta domain protein region K28187 mntA; MntA family adenylyltransferase antitoxin
B Type VIII TA system
C SdsR-RyeA
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ADNA phosphothiolation system
B Sulfur modification proteins
C Metme_3136 cysteine desulfurase NifS K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C Metme_3916 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C Metme_0211 phosphoadenosine phosphosulfate reductase K19170 dndC; DNA sulfur modification protein DndC
C Metme_0209 DNA sulfur modification protein DndD K19171 dndD; DNA sulfur modification protein DndD
B DNA phosphorothioation-dependent restriction proteins
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 19, 2025