+E Replication protein KO
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DNA Replication Proteins - Marasmius oreades (fairy-ring mushroom)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D E1B28_010851 uncharacterized protein K02603 ORC1; origin recognition complex subunit 1
D E1B28_009154 uncharacterized protein K02604 ORC2; origin recognition complex subunit 2
D E1B28_006509 uncharacterized protein K02605 ORC3; origin recognition complex subunit 3
D E1B28_004319 uncharacterized protein K02606 ORC4; origin recognition complex subunit 4
D E1B28_007647 uncharacterized protein K02607 ORC5; origin recognition complex subunit 5
D E1B28_010137 uncharacterized protein K02213 CDC6; cell division control protein 6
D E1B28_000594 MCM2; MCM DNA helicase complex subunit K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D E1B28_000823 MCM3; MCM DNA helicase complex subunit K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D E1B28_006510 uncharacterized protein K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D E1B28_001368 MCM5; minichromosome maintenance protein 5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D E1B28_004683 uncharacterized protein K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D E1B28_009093 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D E1B28_004857 uncharacterized protein K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D E1B28_009939 uncharacterized protein K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D E1B28_012421 uncharacterized protein K10732 GINS1; GINS complex subunit 1
D E1B28_004572 uncharacterized protein K10733 GINS2; GINS complex subunit 2
D E1B28_004541 uncharacterized protein K10734 GINS3; GINS complex subunit 3
D E1B28_003227 uncharacterized protein K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D E1B28_012107 uncharacterized protein K03507 DPB11; DNA replication regulator DPB11
D E1B28_002580 uncharacterized protein K06628 CDC45; cell division control protein 45
D E1B28_007517 uncharacterized protein K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D E1B28_007104 uncharacterized protein K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D E1B28_007834 uncharacterized protein K02321 POLA2; DNA polymerase alpha subunit B
D E1B28_009977 uncharacterized protein K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D E1B28_008690 uncharacterized protein K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D E1B28_005988 uncharacterized protein K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D E1B28_006000 uncharacterized protein K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D E1B28_012589 uncharacterized protein K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D E1B28_007428 POL3; DNA-directed DNA polymerase delta K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D E1B28_008602 uncharacterized protein K02328 POLD2; DNA polymerase delta subunit 2
D E1B28_007688 uncharacterized protein K03504 POLD3; DNA polymerase delta subunit 3
D E1B28_007782 uncharacterized protein K03505 POLD4; DNA polymerase delta subunit 4
D E1B28_009423 uncharacterized protein K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D E1B28_012395 uncharacterized protein K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D E1B28_009203 uncharacterized protein K07466 RFA1; replication factor A1
D E1B28_008880 uncharacterized protein K10739 RFA2; replication factor A2
D E1B28_013545 uncharacterized protein K10740 RPA3; replication factor A3
C RFC (replication factor C)
D E1B28_011187 uncharacterized protein K10754 RFC1; replication factor C subunit 1
D E1B28_007503 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D E1B28_008640 uncharacterized protein K10755 RFC2_4; replication factor C subunit 2/4
D E1B28_007296 RFC3; Subunit of heteropentameric Replication factor C (RF-C) K10756 RFC3_5; replication factor C subunit 3/5
D E1B28_011070 uncharacterized protein K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D E1B28_001677 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D E1B28_001679 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D E1B28_010553 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D E1B28_013473 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D E1B28_011263 uncharacterized protein K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
C Other elongation factors
D E1B28_003273 uncharacterized protein K04802 PCNA; proliferating cell nuclear antigen
D E1B28_005628 uncharacterized protein K04802 PCNA; proliferating cell nuclear antigen
D E1B28_005882 uncharacterized protein K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D E1B28_003205 uncharacterized protein K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D E1B28_007083 FEN1; Elongation of fatty acids protein 2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D E1B28_006133 uncharacterized protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D E1B28_001063 uncharacterized protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
D E1B28_001678 uncharacterized protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D E1B28_009094 uncharacterized protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D E1B28_010295 uncharacterized protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
E E1B28_003996 uncharacterized protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E E1B28_012115 uncharacterized protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
C Telomerase complex (animals)
D E1B28_008616 uncharacterized protein K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D E1B28_011140 uncharacterized protein K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E E1B28_004061 uncharacterized protein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E E1B28_004335 uncharacterized protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E E1B28_001199 CBF5; centromere/microtubule-binding protein cbf5 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D E1B28_011140 uncharacterized protein K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E E1B28_003948 uncharacterized protein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E E1B28_003263 SMD1; mRNA splicing protein smd1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E E1B28_001235 SMD2; mRNA splicing protein K11096 SNRPD2; small nuclear ribonucleoprotein D2
E E1B28_000534 uncharacterized protein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E E1B28_009858 uncharacterized protein K11097 SNRPE; small nuclear ribonucleoprotein E
E E1B28_004647 uncharacterized protein K11098 SNRPF; small nuclear ribonucleoprotein F
E E1B28_004054 uncharacterized protein K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D E1B28_007503 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D E1B28_008640 uncharacterized protein K10755 RFC2_4; replication factor C subunit 2/4
D E1B28_007296 RFC3; Subunit of heteropentameric Replication factor C (RF-C) K10756 RFC3_5; replication factor C subunit 3/5
D E1B28_011070 uncharacterized protein K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D E1B28_006394 MRE11; meiotic recombination K10865 MRE11; double-strand break repair protein MRE11
D E1B28_012426 uncharacterized protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D E1B28_007361 uncharacterized protein K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D E1B28_012146 uncharacterized protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D E1B28_009490 uncharacterized protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D E1B28_009520 uncharacterized protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D E1B28_009824 uncharacterized protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D E1B28_010059 uncharacterized protein K11135 PINX1; Pin2-interacting protein X1
D E1B28_008663 uncharacterized protein K11137 TELO2; telomere length regulation protein
D E1B28_001399 uncharacterized protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D E1B28_001400 uncharacterized protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D E1B28_008497 uncharacterized protein K23314 WRAP53; telomerase Cajal body protein 1
D E1B28_011552 uncharacterized protein K25059 SDE2; replication stress response regulator SDE2
D E1B28_010248 uncharacterized protein K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C E1B28_000519 uncharacterized protein K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C E1B28_009848 uncharacterized protein K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C E1B28_000402 uncharacterized protein K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E E1B28_001677 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_001679 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_010553 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_013473 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E E1B28_001677 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_001679 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_010553 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E E1B28_013473 uncharacterized protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E E1B28_005882 uncharacterized protein K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E E1B28_007083 FEN1; Elongation of fatty acids protein 2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E E1B28_001063 uncharacterized protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022