+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Methanohalophilus portucalensis</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
D      BKM01_10555 replication factor A	K07466 RFA1; replication factor A1 
C    RFC (replication factor C)
C    RNase H
C    Other elongation factors
D      BKM01_06885 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
D      BKM01_00525 flap endonuclease-1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      BKM01_07840 DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
D      BKM01_01230 DNA (cytosine-5-)-methyltransferase	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      BKM01_10565 hypothetical protein	K02316 dnaG; DNA primase [EC:2.7.7.101] 
C    Initiation factors (archaeal)
D      BKM01_06550 cdc6; cell division control protein 6	K10725 cdc6A; archaeal cell division control protein 6 
D      BKM01_10440 cell division control protein Cdc6	K10725 cdc6A; archaeal cell division control protein 6 
D      BKM01_08185 AAA family ATPase	K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] 
D      BKM01_01280 DNA primase	K02683 priS; DNA primase small subunit [EC:2.7.7.102] 
D      BKM01_06880 DNA primase	K18882 priL; DNA primase large subunit 
D      BKM01_01275 hypothetical protein	K09723 ginS; DNA replication factor GINS 
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        BKM01_03290 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
C    Elongation factors (archaeal)
D      B-family DNA polymerases
E        BKM01_10210 DNA polymerase elongation subunit	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
D      D-family DNA polymerases
E        BKM01_08115 DNA polymerase II large subunit	K02322 polC; DNA polymerase II large subunit [EC:2.7.7.7] 
E        BKM01_10450 DNA polymerase II	K02323 polB; DNA polymerase II small subunit [EC:2.7.7.7] 
D      RNase H
E        BKM01_03290 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
E        BKM01_06950 replication protein C	K04800 rfcL; replication factor C large subunit 
E        BKM01_01350 Replication factor C small subunit	K04801 rfcS; replication factor C small subunit 
E        BKM01_05985 replication protein C	K04801 rfcS; replication factor C small subunit 
D      Other elongation factors
E        BKM01_00525 flap endonuclease-1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        BKM01_07840 DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    BKM01_09160 DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    BKM01_09165 DNA gyrase subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    BKM01_07515 DNA topoisomerase VI	K03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2] 
C    BKM01_07510 DNA topoisomerase VI subunit B	K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2] 
C    BKM01_03830 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
C    BKM01_09265 DNA topoisomerase	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: August 27, 2025