+F Repair protein KO
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DNA Repair and Recombination Proteins - Mycolicibacterium smegmatis MC2 155
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MSMEI_4801 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MSMEI_4216 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MSMEI_2515 Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MSMEI_2339 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MSMEI_3670 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E MSMEI_5923 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MSMEI_6027 nth; DNA-(Apurinic or apyrimidinic site) lyase / endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E MSMEI_5555 ercc3; Type III restriction enzyme, res subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D MSMEI_5016 mutT2; putative mutator protein MutT2/NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_0773 mutT3; putative mutator protein MutT3 (MutT/nudix family) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_4377 MutT/NUDIX family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_2696 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MSMEI_4801 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MSMEI_4216 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MSMEI_2515 Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MSMEI_2339 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MSMEI_0259 Phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MSMEI_4903 Uracil DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MSMEI_4798 DNA-3-methyladenine glycosylase II / DNA-O6-methylguanine--protein-cysteine S-methyltransferase / Transcriptional regulator Ada K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E MSMEI_3670 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E MSMEI_5923 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MSMEI_4956 tagA; DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E MSMEI_2358 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E MSMEI_5392 DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E MSMEI_1714 nei; DNA glycosylase/endonuclease K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E MSMEI_4565 Putative DNA glycosylase Mb2491c K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E MSMEI_6027 nth; DNA-(Apurinic or apyrimidinic site) lyase / endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E MSMEI_1617 Exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E MSMEI_0810 xthA; Exodeoxyribonuclease III protein XthA K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E MSMEI_1344 nfo; Endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E MSMEI_2302 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E MSMEI_3749 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E MSMEI_3720 uvrA; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E MSMEI_6624 Excinuclease ABC K03701 uvrA; excinuclease ABC subunit A
E MSMEI_3727 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E MSMEI_3000 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E MSMEI_1900 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_1909 uvrD; ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_5382 pcrA; ATP-dependent DNA helicase pcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_3749 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E MSMEI_2302 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F MSMEI_1328 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F MSMEI_1329 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F MSMEI_1488 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F MSMEI_2977 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F MSMEI_5274 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E MSMEI_5089 xseA; Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E MSMEI_5090 xseB; Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E MSMEI_3096 dnaE1; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E MSMEI_0003 dnaN; DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E MSMEI_4460 DNA polymerase III, delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E MSMEI_5996 holB; DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E MSMEI_4158 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MSMEI_6111 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MSMEI_6120 dnaX; DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E MSMEI_2302 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E MSMEI_1900 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_1909 uvrD; ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_5382 pcrA; ATP-dependent DNA helicase pcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MSMEI_4584 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E MSMEI_6712 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E MSMEI_1289 recB; Exodeoxyribonuclease V beta chain K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E MSMEI_1290 recC; Exonuclease V (Gamma chain) recC K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E MSMEI_1288 recD; Exonuclease V (Alpha chain) recD K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E MSMEI_2656 recA; Protein recA K03553 recA; recombination protein RecA
E MSMEI_2870 ruvA; Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E MSMEI_2871 ruvB; Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MSMEI_2869 ruvC; Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E MSMEI_2985 priA; Primosomal protein N priA (Replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E MSMEI_2656 recA; Protein recA K03553 recA; recombination protein RecA
E MSMEI_5919 radA; DNA repair protein radA K04485 radA; DNA repair protein RadA/Sms
E MSMEI_0005 recF; DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF
E MSMEI_2342 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E MSMEI_4380 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
E MSMEI_6115 recR; Recombination protein recR K06187 recR; recombination protein RecR
E MSMEI_3660 recN; DNA repair protein recN K03631 recN; DNA repair protein RecN (Recombination protein N)
E MSMEI_2870 ruvA; Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E MSMEI_2871 ruvB; Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MSMEI_2869 ruvC; Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E MSMEI_4606 ATP/GTP-binding site motif A K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E MSMEI_5431 Ku70/Ku80 protein K10979 ku; DNA end-binding protein Ku
E MSMEI_5419 DNA ligase (ATP) K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F MSMEI_0008 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F MSMEI_0443 DNA gyrase/topoisomerase IV, subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F MSMEI_0007 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MSMEI_0444 DNA topoisomerase (ATP-hydrolyzing) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MSMEI_1195 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MSMEI_5999 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F MSMEI_1740 Topoisomerase IB K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F MSMEI_2329 hup; DNA-binding protein hupB K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F MSMEI_4380 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
F MSMEI_6115 recR; Recombination protein recR K06187 recR; recombination protein RecR
F MSMEI_2302 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F MSMEI_5249 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MSMEI_5776 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MSMEI_3720 uvrA; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F MSMEI_6624 Excinuclease ABC K03701 uvrA; excinuclease ABC subunit A
F MSMEI_3727 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D MSMEI_2236 dinB2; DNA-directed DNA polymerase K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D MSMEI_0985 dinB2; DNA-directed DNA polymerase K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D MSMEI_3089 dinB1; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D MSMEI_6274 DNA-directed DNA polymerase K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D MSMEI_2656 recA; Protein recA K03553 recA; recombination protein RecA
D MSMEI_2673 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MSMEI_3660 recN; DNA repair protein recN K03631 recN; DNA repair protein RecN (Recombination protein N)
D MSMEI_1583 putative DNA-directed DNA polymerase K14161 imuB; protein ImuB
D MSMEI_1593 dnaE2; DNA polymerase III subunit alpha K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D MSMEI_4584 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D MSMEI_6712 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D MSMEI_2657 recX; Regulatory protein recX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D MSMEI_4785 Putative ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D MSMEI_1715 lhr; ATP-dependent DNA helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D MSMEI_5016 mutT2; putative mutator protein MutT2/NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_0773 mutT3; putative mutator protein MutT3 (MutT/nudix family) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_4377 MutT/NUDIX family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MSMEI_2330 mutT1; Hydrolase MutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D MSMEI_3655 NTP pyrophosphohydrolase including oxidative damage repair enzymes K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D MSMEI_2696 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D MSMEI_2241 nrdE; Ribonucleoside-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MSMEI_0990 nrdE; Ribonucleoside-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MSMEI_2253 nrdF2; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MSMEI_1002 nrdF2; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MSMEI_0351 nrdB; Ribonucleoside-diphosphate reductase subunit beta NrdB K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D MSMEI_2567 Phosphoesterase, RecJ-like protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024