+C Two-component system KO #

  Two-Component System - Mycobacterium tuberculosis H37Rv

% ! AOmpR family B PhoR-PhoB (phosphate starvation response) B SenX3-RegX3 (phosphate starvation response) C Rv0490 senX3; two component sensor histidine kinase SenX3 K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3] C Rv0491 regX3; two component sensory transduction protein RegX K07776 regX3; two-component system, OmpR family, response regulator RegX3 B PhoQ-PhoP (magnesium transport) B EnvZ-OmpR (osmotic stress response) B RstB-RstA B CpxA-CpxR (envelope stress response) B CssS-CssR (secretion stress response) B CreC-CreB (phosphate regulation) B BaeS-BaeR (envelope stress response) B BasS-BasR (antimicrobial peptide resistance) B CusS-CusR (copper tolerance) B QseC-QseB (quorum sensing) B KdpD-KdpE (potassium transport) C Rv1028c kdpD; sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] C Rv1027c kdpE; transcriptional regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE B TorS-TorR (TMAO respiration) B ArcB-ArcA (anoxic redox control) B TctE-TctD (tricarboxylic acid transport) B ResE-ResD (aerobic and anaerobic respiration) B VicK-VicR (cell wall metabolism) B MprB-MprA (maintenance of persistent infection) C Rv0982 mprB; two component histidine-protein kinase/phosphatase MprB K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3] C Rv0981 mprA; two-component response regulator MrpA K07669 mprA; two-component system, OmpR family, response regulator MprA B MtrB-MtrA (osmotic stress response) C Rv3245c mtrB; two component sensory histidine kinase MtrB K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3] C Rv3246c mtrA; two component DNA-binding response regulator MtrA K07670 mtrA; two-component system, OmpR family, response regulator MtrA B PrrB-PrrA (intracellular multiplication) C Rv0902c prrB; two component sensor histidine kinase PrrB K07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3] C Rv0903c prrA; two component transcriptional regulator PrrA K07671 prrA; two-component system, OmpR family, response regulator PrrA B TrcS-TrcR C Rv1032c trcS; two component sensor histidine kinase TrcS K07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3] C Rv1033c trcR; two component transcriptional regulator TrcR K07672 trcR; two-component system, OmpR family, response regulator TrcR B NrsS-NrsR (nickel tolerance) B ManS-ManR (manganese homeostasis) B NblS-NblR (photosynthesis) B SasA-RpaAB (circadian timing mediating) B SaeS-SaeR (staphylococcal virulence regulation) B BceS-BceR (bacitracin transport) B BraS-BraR (bacitracin transport) B GraS-GraR (cationic antimicrobial peptide transport) B YxdK-YxdJ (antimicrobial peptide response) B ChvG-ChvI (acidity sensing) B CiaH-CiaR B ParS-ParR (polymyxin-adaptive resistance) B AdeS-AdeR B VanS-VanR (VanB type vancomycin resistance) B VanS-VanR (VanE type vancomycin resistance) B VanS-VanR (actinomycete type vancomycin resistance) B ArlS-ArlR (virulence regulation) B Ihk-Irr (virulence regulation) B PfeS-PfeR (enterobactin-dependent iron acquisition) B NisK-NisR (lantibiotic biosynthesis) B Unclassified C Rv0600c two component sensor kinase HK1 K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C Rv0758 phoR; two component system response sensor kinase PhoR K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C Rv3764c tcrY; two component sensor kinase TcrY K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C Rv0757 phoP; two component system response transcriptional positive regulator PhoP K02483 K02483; two-component system, OmpR family, response regulator C Rv3765c tcrX; two component transcriptional regulator TcrX K02483 K02483; two-component system, OmpR family, response regulator # ANarL family B NarX-NarL (nitrate respiration) C Rv0844c narL; nitrate/nitrite response transcriptional regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL B NarQ-NarP (nitrate respiration) B UhpB-UhpA (hexose phosphates uptake) B FusK-FusR (virulence regulation) B RcsC-RcsD-RcsB (capsule synthesis) B BarA-UvrY (central carbon metabolism) B ComP-ComA (competence) B EvgS-EvgA (acid and drug tolerance) B DegS-DegU (multicellular behavior control) B DesK-DesR (membrane lipid fluidity regulation) B VraS-VraR (cell-wall peptidoglycan synthesis) B LiaS-LiaR (cell wall stress response) B DevS-DevR (redox response) C Rv3132c devS; two component sensor histidine kinase DevS K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3] C Rv2027c dosT; two component sensor histidine kinase DosT K27105 dosT; two-component system, NarL family, sensor histidine kinase DosT [EC:2.7.13.3] C Rv3133c devR; two component transcriptional regulator DevR K07695 devR; two-component system, NarL family, response regulator DevR B NreB-NreC (dissimilatory nitrate/nitrite reduction) B YdfH-YdfI B SalK-SalR B PprA–PprB (biofilm formation) B Unclassified C Rv0845 sensor histidine kinase NarS K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] # ASpo family B KinABCDE-Spo0FA (sporulation control) # ACitB family B CitA-CitB (citrate fermentation) B CitS-CitT (magnesium-citrate transport) B DcuS-DcuR (C4-dicarboxylate metabolism) B DctS-DctR (C4-dicarboxylate transport) B MalK-MalR (malate transport) B Unclassified # ALytTR family B LysS-LysR B AlgZ-AlgR (alginate production) B NatK-NatR (sodium extrusion) B AgrC-AgrA (exoprotein synthesis) B AgrC2-AgrA2 (virulence regulation) B ComD-ComE (competence) B BtsS-BtsR (pyruvate reutilization) B PyrS-PyrR (pyruvate reutilization) B Unclassified # ANtrC family B GlnL-GlnG (nitrogen regulation) B NtrY-NtrX (nitrogen regulation) B HydH-HydG (metal tolerance) B AtoS-AtoC (cPHB biosynthesis) B PilS-PilR (type 4 fimbriae synthesis) B GlrK-GlrR (amino sugar metabolism) B PgtB-PgtA (phosphoglycerate transport) B DctB-DctD (C4-dicarboxylate transport) B KinB-AlgB (alginate production) B HupT-HupR (hydrogenase synthesis regulation) B Unclassified # ACheA family B CheA-CheYBV (chemotaxis) B ChpA-ChpB/PilGH (chemosensory) B PixL-PixGH (positive phototaxis) B WspE-WspRF (chemosensory) B Cph1-Rcp1 (light response) # ACell cycle family B PleC-PleD (cell fate control) B CckA-CtrA/CpdR (cell cycle control) B Hk1-Rrp1 (glycerol uptake and utilization) # ALux family B LuxQN/CqsS-LuxU-LuxO (quorum sensing) # ALuxR family B DctS-DctR (C4-dicarboxylate transport) B TtrS-TtrR (tetrathionate respiration) B FixL-FixJ (nitrogen fixation) B SsrA-SsrB # AOther families B FlrB-FlrC (polar flagellar synthesis) B AauS-AauR (acidic amino acids utilization) B SLN1-YPD1-SSK1/SKN7 (osmosensing) B RpfC-RpfG (cell-to-cell signaling) B GlnK-GlnL (glutamine utilization) B HspS-HspR (hexose phosphates uptake) B YesM-YesN B CikA B RegB-RegA (redox response) B FitF-FitH (insecticidal toxin regulation) B PhcS-PhcRQ B SagS-HptB-HsbR (swarming activity and biofilm formation) B PdtaS-PdtaR C Rv3220c two component sensor kinase K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3] C Rv1626 two-component system transcriptional regulator K22010 pdtaR; two-component system, response regulator PdtaR B NasS-NasT B Unclassified ! #
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#Last updated: October 8, 2024