+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Mycobacterium tuberculosis H37Rv</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
C    Rv2817c CRISPR-associated endonuclease Cas1	K15342 cas1; CRISP-associated protein Cas1 
C    Rv2816c CRISPR-associated endoribonuclease Cas2	K09951 cas2; CRISPR-associated protein Cas2 
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
D      Rv2823c CRISPR-associated protein Cas10/Csm1	K07016 csm1; CRISPR-associated protein Csm1 
C    Subtype III-A factors
D      Rv2822c CRISPR type III-associated protein Csm2	K19138 csm2; CRISPR-associated protein Csm2 
D      Rv2821c CRISPR type III-associated RAMP protein Csm3	K09002 csm3; CRISPR-associated protein Csm3 
D      Rv2820c CRISPR type III-associated RAMP protein Csm4	K19139 csm4; CRISPR-associated protein Csm4 
D      Rv2819c CRISPR type III-associated RAMP protein Csm5	K19140 csm5; CRISPR-associated protein Csm5 
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
C    Rv2756c hsdM; type I restriction/modification system DNA methylase HsdM	K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 
B  Type II R-M system
C    Restriction endonucleases
C    DNA methyltransferases
B  Type III R-M system
B  Type IV R-M system
C    Rv2528c mrr; restriction system protein	K07448 mrr; restriction system protein 
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
D      Rv0456A mazF1; toxin MazF1	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv1102c mazF3; mRNA interferase MazF3	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv1495 mazF4; mRNA interferase MazF4	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv0659c mazF2; toxin MazF2	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv1942c mazF5; toxin MazF5	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv3098A PemK-like protein	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv2063A mazF7; mRNA interferase MazF7	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv1991c mazF6; mRNA interferase MazF6	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv2801c mazF9; mRNA interferase MazF9	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv2274c mazF8; toxin MazF8	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      Rv0456B mazE1; antitoxin MazE1	K26981 mazE1; antitoxin MazE1 
D      Rv0660c mazE2; antitoxin MazE2	K26982 mazE2; antitoxin MazE2 
D      Rv1103c mazE3; antitoxin MazE3	K26983 mazE3; antitoxin MazE3 
D      Rv1494 mazE4; antitoxin MazE4	K26984 mazE4; antitoxin MazE4 
D      Rv1943c mazE5; antitoxin MazE5	K26985 mazE5; antitoxin MazE5 
D      Rv1991A mazE6; antitoxin MazE6	K26986 mazE6; antitoxin MazE6 
D      Rv2063 mazE7; antitoxin MazE7	K26987 mazE7; antitoxin MazE7 
D      Rv2274A mazE8; antitoxin MazE8	K26988 mazE8; antitoxin MazE8 
D      Rv2801A mazE9; antitoxin MazE9	K26989 mazE9; antitoxin MazE9 
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
C    YafQ-dinJ
C    YoeB-YefM
D      Rv3358 relK; toxin RelK	K19158 yoeB; toxin YoeB [EC:3.1.-.-] 
D      Rv3357 relJ; antitoxin RelJ	K19159 yefM; antitoxin YefM 
C    HipA-HipB
C    HicA-HicB
C    YafO-YafN
C    Hha-TomB
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
D      Rv1959c parE1; toxin ParE1	K19092 parE1_3_4; toxin ParE1/3/4 
D      Rv2142c parE2; toxin ParE2	K19093 parE2; toxin ParE2 
D      Rv1960c parD1; antitoxin ParD1	K07746 parD1_3_4; antitoxin ParD1/3/4 
D      Rv2142A parD2; antitoxin ParD2	K19094 parD2; antitoxin ParD2 
C    Doc-Phd
C    HigB-HigA
C    MqsR-MqsA
C    VapC-VapB
D      Rv0624 vapC30; ribonuclease VapC30	K19686 vapC; ribonuclease VapC [EC:3.1.-.-] 
D      Rv0609 vapC28; ribonuclease VapC28	K19686 vapC; ribonuclease VapC [EC:3.1.-.-] 
D      Rv1982c vapC36; ribonuclease VapC36	K19686 vapC; ribonuclease VapC [EC:3.1.-.-] 
D      Rv1741 vapC34; ribonuclease VapC34	K19686 vapC; ribonuclease VapC [EC:3.1.-.-] 
D      Rv2759c vapC42; ribonuclease VapC42	K19686 vapC; ribonuclease VapC [EC:3.1.-.-] 
D      Rv0623 vapB30; antitoxin VapB30	K19687 vapB; antitoxin VapB 
D      Rv1740 vapB34; antitoxin VapB34	K19687 vapB; antitoxin VapB 
D      Rv0608 vapB28; antitoxin VapB28	K19687 vapB; antitoxin VapB 
D      Rv1982A vapB36; antitoxin VapB36	K19687 vapB; antitoxin VapB 
D      Rv2760c vapB42; antitoxin VapB42	K19687 vapB; antitoxin VapB 
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
C    BC_0920-BC_0921
C    Type II TA system related factors
D      Rv2150c ftsZ; cell division protein FtsZ	K03531 ftsZ; cell division protein FtsZ 
D      Rv2992c gltS; glutamate--tRNA ligase	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
B  Type V TA system
C    GhoT-GhoS
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    Rv3025c iscS; cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: November 7, 2023