+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Mycobacterium tuberculosis H37Rv</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
C    RVBD_2817c CRISPR-associated endonuclease cas1	K15342 cas1; CRISP-associated protein Cas1 
C    RVBD_2816c CRISPR-associated endoribonuclease cas2	K09951 cas2; CRISPR-associated protein Cas2 
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
D      RVBD_2823c CRISPR-associated protein cas10/csm1, subtype III-a/mtube	K07016 csm1; CRISPR-associated protein Csm1 
C    Subtype III-A factors
D      RVBD_2822c CRISPR type III-a/mtube-associated protein csm2	K19138 csm2; CRISPR-associated protein Csm2 
D      RVBD_2821c CRISPR type III-a/mtube-associated ramp protein csm3	K09002 csm3; CRISPR-associated protein Csm3 
D      RVBD_2820c CRISPR type III-a/mtube-associated ramp protein csm4	K19139 csm4; CRISPR-associated protein Csm4 
D      RVBD_2819c CRISPR type III-a/mtube-associated ramp protein csm5	K19140 csm5; CRISPR-associated protein Csm5 
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
C    RVBD_2756c type I restriction/modification system DNA methylase HsdM	K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 
B  Type II R-M system
C    Restriction endonucleases
C    DNA methyltransferases
B  Type III R-M system
B  Type IV R-M system
C    RVBD_2528c restriction system protein Mrr	K07448 mrr; restriction system protein 
#
A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
D      RVBD_0456A toxin MazF1	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_0659c toxin MazF2	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_1102c toxin MazF3	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_1495 toxin MazF4	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_1942c toxin MazF5	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_1991c toxin MazF6	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_2063A toxin MazF7	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_2274c toxin MazF8	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_2801c toxin MazF9	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_3098A antitoxin	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      RVBD_0456B antitoxin MazE1	K26981 mazE1; antitoxin MazE1 
D      RVBD_0660c antitoxin MazE2	K26982 mazE2; antitoxin MazE2 
D      RVBD_1103c antitoxin MazE3	K26983 mazE3; antitoxin MazE3 
D      RVBD_1494 antitoxin MazE4	K26984 mazE4; antitoxin MazE4 
D      RVBD_1943c antitoxin MazE5	K26985 mazE5; antitoxin MazE5 
D      RVBD_1991A antitoxin MazE6	K26986 mazE6; antitoxin MazE6 
D      RVBD_2063 antitoxin MazE7	K26987 mazE7; antitoxin MazE7 
D      RVBD_2274A antitoxin MazE8	K26988 mazE8; antitoxin MazE8 
D      RVBD_2801A antitoxin MazE9	K26989 mazE9; antitoxin MazE9 
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
D      RVBD_1246c toxin RelE	K06218 relE; mRNA interferase RelE/StbE 
D      RVBD_2866 toxin RelG	K06218 relE; mRNA interferase RelE/StbE 
D      RVBD_1247c antitoxin RelB	K28297 relB_F; antitoxin RelB/F 
D      RVBD_2865 antitoxin RelF	K28297 relB_F; antitoxin RelB/F 
C    YafQ-dinJ
C    YoeB-YefM
D      RVBD_3358 toxin RelK	K19158 yoeB; toxin YoeB [EC:3.1.-.-] 
D      RVBD_3357 antitoxin RelJ	K19159 yefM; antitoxin YefM 
C    HipA-HipB
C    HicA-HicB
C    YafO-YafN
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
D      RVBD_1959c toxin	K19092 parE1_3_4; toxin ParE1/3/4 
D      RVBD_2142c toxin ParE2	K19093 parE2; toxin ParE2 
D      RVBD_1960c antitoxin ParD1	K07746 parD1_3_4; antitoxin ParD1/3/4 
D      RVBD_2142A antitoxin ParD2	K19094 parD2; antitoxin ParD2 
C    Doc-Phd
C    HigB-HigA
D      RVBD_1955 toxin	K28253 higB1; endoribonuclease HigB1 
D      RVBD_1956 antitoxin HigA	K28254 higA1; antitoxin HigA1 
C    MqsR-MqsA
C    VapC-VapB
D      RVBD_0065 toxin VapC1	K28141 vapC1S; ribonuclease VapC1/3/9/12 [EC:3.1.-.-] 
D      RVBD_0549c toxin VapC3	K28141 vapC1S; ribonuclease VapC1/3/9/12 [EC:3.1.-.-] 
D      RVBD_0960 toxin VapC9	K28141 vapC1S; ribonuclease VapC1/3/9/12 [EC:3.1.-.-] 
D      RVBD_1720c toxin VapC12	K28141 vapC1S; ribonuclease VapC1/3/9/12 [EC:3.1.-.-] 
D      RVBD_0064A antitoxin VapB1	K28142 vapB1; antitoxin VapB1 
D      RVBD_0550c antitoxin VapB3	K28255 vapB3; antitoxin VapB3 
D      RVBD_0959A antitoxin VapB9	K28256 vapB9; antitoxin VapB9 
D      RVBD_1721c antitoxin VapB12	K28257 vapB12; antitoxin VapB12 
D      RVBD_0229c toxin	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_0301 toxin VapC2	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_0656c toxin VapC6	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_1561 toxin VapC11	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_2010 toxin VapC15	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_2527 toxin VapC17	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_2546 toxin VapC18	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_2757c toxin VapC21	K28147 vapC2S; ribonuclease VapC2/6/11/15/17/18/21/51 [EC:3.1.-.-] 
D      RVBD_0300 antitoxin VapB2	K28148 vapB2; antitoxin VapB2 
D      RVBD_0657c antitoxin VapB6	K28152 vapB6S; antitoxin VapB6/11/15/18/21 
D      RVBD_1560 antitoxin VapB11	K28152 vapB6S; antitoxin VapB6/11/15/18/21 
D      RVBD_2009 antitoxin VapB15	K28152 vapB6S; antitoxin VapB6/11/15/18/21 
D      RVBD_2545 antitoxin VapB18	K28152 vapB6S; antitoxin VapB6/11/15/18/21 
D      RVBD_2758c antitoxin VapB21	K28152 vapB6S; antitoxin VapB6/11/15/18/21 
D      RVBD_2526 antitoxin VapB17	K28259 vapB17; antitoxin VapB17 
D      RVBD_0595c toxin VapC4	K28149 vapC4_5_8; ribonuclease VapC4/5/8 [EC:3.1.-.-] 
D      RVBD_0627 toxin VapC5	K28149 vapC4_5_8; ribonuclease VapC4/5/8 [EC:3.1.-.-] 
D      RVBD_0665 toxin VapC8	K28149 vapC4_5_8; ribonuclease VapC4/5/8 [EC:3.1.-.-] 
D      RVBD_0596c antitoxin VapB4	K28150 vapB4_5; antitoxin VapB4/5 
D      RVBD_0626 antitoxin VapB5	K28150 vapB4_5; antitoxin VapB4/5 
D      RVBD_2873A prevent-host-death family protein	K28150 vapB4_5; antitoxin VapB4/5 
D      RVBD_0664 antitoxin VapB8	K28258 vapB8; antitoxin VapB8 
D      RVBD_0661c toxin VapC7	K28262 vapC7_13_23; ribonuclease VapC7/13/23 [EC:3.1.-.-] 
D      RVBD_1838c toxin VapC13	K28262 vapC7_13_23; ribonuclease VapC7/13/23 [EC:3.1.-.-] 
D      RVBD_2863 toxin VapC23	K28262 vapC7_13_23; ribonuclease VapC7/13/23 [EC:3.1.-.-] 
D      RVBD_0662c antitoxin VapB7	K28263 vapB7; antitoxin VapB7 
D      RVBD_1839c antitoxin VapB13	K28264 vapB13; antitoxin VapB13 
D      RVBD_2862A antitoxin VapB23	K28265 vapB23; antitoxin VapB23 
D      RVBD_1114 toxin VapC32	K28260 vapC10_19_32; ribonuclease VapC10/19/32 [EC:3.1.-.-] 
D      RVBD_1397c toxin VapC10	K28260 vapC10_19_32; ribonuclease VapC10/19/32 [EC:3.1.-.-] 
D      RVBD_2548 toxin VapC19	K28260 vapC10_19_32; ribonuclease VapC10/19/32 [EC:3.1.-.-] 
D      RVBD_1398c antitoxin VapB10	K28266 vapB10_19; antitoxin VapB10/19 
D      RVBD_2547 antitoxin VapB19	K28266 vapB10_19; antitoxin VapB10/19 
D      RVBD_1113 antitoxin VapB32	K28267 vapB32; antitoxin VapB32 
D      RVBD_1953 toxin VapC14	K28268 vapC14; ribonuclease VapC14 [EC:3.1.-.-] 
D      RVBD_1952 antitoxin VapB14	K28269 vapB14; antitoxin VapB14 
D      RVBD_2231Ac toxin VapC16	K28151 vapC16; ribonuclease VapC16 [EC:3.1.-.-] 
D      RVBD_2231B antitoxin VapB16	K28270 vapB16; antitoxin VapB16 
D      RVBD_2549c toxin VapC20	K28277 vapC20; ribonuclease VapC20 [EC:3.1.-.-] 
D      RVBD_2550c antitoxin VapB20	K28278 vapB20; antitoxin VapB20 
D      RVBD_2829c toxin VapC22	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      RVBD_2830c antitoxin VapB22	K28280 vapB22; antitoxin VapB22 
D      RVBD_0240 toxin VapC24	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_0277c toxin VapC25	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_0617 toxin VapC29	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_0749 toxin VapC31	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_1242 toxin VapC33	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_2103c toxin VapC37	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_2494 toxin VapC38	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_2530c toxin VapC39	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_2602 toxin VapC41	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_2872 toxin VapC43	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_3320c toxin VapC44	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_3697c toxin VapC48	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      RVBD_0239 antitoxin VapB24	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_0277Ac antitoxin	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_0616A antitoxin VapB29	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_0748 antitoxin VapB31	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_1241 antitoxin VapB33	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2104c antitoxin VapB37	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2132 hypothetical protein	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2493 antitoxin VapB38	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2530A antitoxin VapB39	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2601A antitoxin VapB41	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_2871 antitoxin VapB43	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_3321c antitoxin VapB44	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_3697A antitoxin VapB48	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      RVBD_0582 toxin VapC26	K28282 vapC26; ribonuclease VapC26 [EC:3.1.-.-] 
D      RVBD_0581 antitoxin VapB26	K28283 vapB26; antitoxin VapB26 
D      RVBD_0598c toxin VapC27	K28272 vapC27_40; ribonuclease VapC27/40 [EC:3.1.-.-] 
D      RVBD_2596 toxin VapC40	K28272 vapC27_40; ribonuclease VapC27/40 [EC:3.1.-.-] 
D      RVBD_0599c antitoxin VapB27	K28273 vapB27_40; ribonuclease VapB27/40 
D      RVBD_2595 antitoxin VapB40	K28273 vapB27_40; ribonuclease VapB27/40 
D      RVBD_0609 toxin VapC28	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      RVBD_0624 toxin VapC30	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      RVBD_1741 toxin VapC34	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      RVBD_1982c toxin VapC36	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      RVBD_2759c toxin VapC42	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      RVBD_0608 antitoxin VapB28	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
D      RVBD_0623 antitoxin VapB30	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
D      RVBD_1740 antitoxin VapB34	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
D      RVBD_1982A antitoxin VapB36	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
D      RVBD_2760c antitoxin VapB42	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
D      RVBD_1962c toxin VapC35	K28275 vapC35S; ribonuclease VapC35/45/46/47 [EC:3.1.-.-] 
D      RVBD_3180c alanine rich protein	K28275 vapC35S; ribonuclease VapC35/45/46/47 [EC:3.1.-.-] 
D      RVBD_3384c toxin VapC46	K28275 vapC35S; ribonuclease VapC35/45/46/47 [EC:3.1.-.-] 
D      RVBD_3408 toxin VapC47	K28275 vapC35S; ribonuclease VapC35/45/46/47 [EC:3.1.-.-] 
D      RVBD_1962A antitoxin VapB35	K28276 vapB35S; antitoxin VapB35/45/46/47 
D      RVBD_3181c prevent-host-death family protein	K28276 vapB35S; antitoxin VapB35/45/46/47 
D      RVBD_3385c antitoxin VapB46	K28276 vapB35S; antitoxin VapB35/45/46/47 
D      RVBD_3407 antitoxin VapB47	K28276 vapB35S; antitoxin VapB35/45/46/47 
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
C    BC_0920-BC_0921
C    SpoIISA-SpoIISB
C    Tse6-Tsi6
C    Type II TA system related factors
D      RVBD_2150c cell division protein FtsZ	K03531 ftsZ; cell division protein FtsZ 
D      RVBD_2992c glutamyl-tRNA synthetase GltS	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
C    AbiEii-AbiEi
D      RVBD_2826c hypothetical protein	K09144 abiEii; nucleotidyl transferase AbiEii/AbiGii toxin family protein 
D      RVBD_2827c hypothetical protein	K28193 abiEi; AbiEi antitoxin C-terminal domain-containing protein 
B  Type V TA system
C    GhoT-GhoS
C    Other GhoT/OrtT toxin family protein
B  Type VI TA system
C    SocB-SocA
B  Type VII TA system
C    Hha-TomB
C    TglT-TakA
D      RVBD_1045 hypothetical protein	K28188 tglT; guanylyltransferase TglT toxin 
D      RVBD_1044 hypothetical protein	K28189 takA; serine protein kinase TakA antitoxin 
C    HepT-MntA
B  Type VIII TA system
C    SdsR-RyeA
#
A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    RVBD_3025c cysteine desulfurase LscS	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: May 19, 2025