+D	Transcription factors	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Transcription Factors - Methanococcus vannielii</h2>
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A<b>Eukaryotic type</b>
B  Basic leucine zipper (bZIP)
C    AP-1(-like) components, Jun
C    AP-1(-like) components, Fos
C    AP-1(-like) components, Maf
C    AP-1(-like) components, NF-E2
C    AP-1(-like) components, Fungal regulators
C    AP-1(-like) components, CRE-BP/ATF
C    CREB
C    C/EBP-like factors
C    bZIP/PAR
C    Plant bZIP factors
C    ZIP only
B  Basic helix-loop-helix (bHLH)
C    Ubiquitous (class A) factors
C    Myogenic transcription factors
C    Achaete-Scute
C    Tal/Twist/Atonal/Hen, Lymphoid factors
C    Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors
C    Tal/Twist/Atonal/Hen, HEN
C    Tal/Twist/Atonal/Hen, Mesp
C    Tal/Twist/Atonal/Hen, Atonal
C    Tal/Twist/Atonal/Hen, Pancreatic factors
C    Hairy, Hairy/E(SPL)
C    Hairy, Fungal regulators
C    Factors with PAS domain
C    Yabby
C    INO
C    HLH domain only
B  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
C    Ubiquitous bHLH-ZIP factors
C    Cell cycle controlling factors, Myc
C    Cell cycle controlling factors, Mad/Max
C    Other bHLH-ZIP factors
B  Other basic domains
C    NF-1
C    RF-X
C    AP-2 (bHSH)
B  Zinc finger
C    Cys4 thyroid hormone receptor-like
C    Cys4 hepatocyte nuclear factor 4-like
C    Cys4 estrogen receptor-like
C    Cys4 nerve growth factor IB-like
C    Cys4 Fushi tarazu-F1-like
C    Cys4 germ cell nuclear factor
C    Cys4 Knirps/DAX1-like
C    Cys4 GATA-factors
C    Cys2His2 SP/KLF family and related proteins
C    Cys2His2 GLI-like
C    Cys2His2 Snail
C    Cys2His2 BTB-ZF factors
C    Cys2His2 BED
C    Cys2His2 PRDM
C    Cys2His2 metabolic regulators in fungi
C    Cys2His2 others
D      Mevan_0355 nucleic acid binding OB-fold tRNA/helicase-type	K07466 RFA1; replication factor A1 
C    Cys2HisCys zinc factors
C    Cys3His zinc factors
C    Cys2CysHis zinc factors
C    CXXC CpG-binding proteins
D      Mevan_1633 DNA-cytosine methyltransferase	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
C    Cys6 metabolic regulators in fungi
C    Other zinc fingers
B  Helix-turn-helix
C    Homeo domain ANTP: HOXL
C    Homeo domain ANTP: NKL
C    Homeo domain Paired-related
C    Homeo domain LIM
C    Homeo domain POU
C    Homeo domain SINE
C    Homeo domain ZF
C    Homeo domain CUT
C    Homeo domain PROS
C    Homeo domain TALE
C    Homeo domain other
C    Fork head/winged helix developmental regulators
C    Fork head/winged helix tissue-specific regulators
C    Fork head/winged helix cell cycle-controlling factors, E2F
C    Fork head/winged helix cell cycle-controlling factors, DP
C    Fork head/winged helix other regulators
C    Stork head/winged helix factors
C    Heat shock factors
C    Tryptophan clusters Myb, Myb-factors
C    Tryptophan clusters Myb, Myb-like factors
C    Tryptophan clusters Ets-type
C    Tryptophan clusters interferon-regulating factors
C    TEA domain
C    ARID
B  beta-Scaffold factors with minor groove contacts
C    RHR (Rel homology region) Rel/Ankyrin
C    RHR (Rel homology region) Ankyrin only
C    RHR (Rel homology region) NF-AT
C    STAT
C    p53
C    MADS-box regulators of differentiation, MEF-2
C    MADS-box regulators of differentiation, Homeotic genes
C    MADS-box regulators of differentiation, Yeast regulators
C    MADS-box responders to external signals
C    SAND domain-containing proteins
C    TATA-binding proteins
D      Mevan_1270 TATA-box binding	K03120 TBP; transcription initiation factor TFIID TATA-box-binding protein 
C    HMG SOX
C    HMG TCF-1
C    HMG TOX
C    HMG2-related
C    UBF
C    Other HMG box factors
C    Heteromeric CCAAT factors
C    Grainyhead
C    Cold-shock domain factors, DbpA-like
C    Cold-shock domain factors, YB-1/DbpB-like
C    Cold-shock domain factors, FRG Y2-like
C    Runt
C    MYRF
B  Other transcription factors
C    HMGI(Y)
C    NUPR
C    Pocket domain Rb
C    Pocket domain CBP
C    T-box
C    DMRT
C    LRRFIP
C    TCP
C    AP2/ERF
C    WRKY
C    LOB
C    GRAS
C    Copper-fist proteins fungal regulators
C    Others
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A<b>Prokaryotic type</b>
B  Helix-turn-helix
C    AraC family
C    LysR family
D      Mevan_1014 transcriptional regulator, LysR family	K21900 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon 
C    DeoR family
C    LacI family
C    GntR family
C    TetR/AcrR family
D      Mevan_1620 transcriptional regulator, TetR family	K16138 uidR; TetR/AcrR family transcriptional regulator, repressor for uid operon 
C    Lrp/AsnC family
D      Mevan_0459 putative transcriptional regulator, AsnC family	K03718 asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA 
C    LuxR family
C    MarR family
C    MerR family
C    Fur family
C    IclR family
C    CRP/FNR family
C    Rrf2 family
C    ArsR family
D      Mevan_1232 regulatory protein ArsR	K21903 cadC; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor 
C    XRE family
D      Mevan_1109 putative transcriptional regulator, XRE family	K23779 sutR; XRE family transcriptional regulator, regulator of sulfur utilization 
C    PadR family
C    Other families
D      Mevan_1567 iron dependent repressor	K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 
D      Mevan_1124 biotin--acetyl-CoA-carboxylase ligase	K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] 
D      Mevan_1479 Protein of unknown function DUF128	K09720 nrpRI; HTH-type transcriptional regulator, global nitrogen regulator NrpRI 
D      Mevan_1098 DNA binding protein, Tfx family	K09714 tfx; HTH-type transcriptional regulator, fmd operon transcriptional regulator 
D      Mevan_1091 phosphoribosyltransferase	K26599 gfcR; HTH-type transcriptional regulator, activator of D-glucose/D-fructose catabolism 
D      Mevan_0084 CRISPR locus-related DNA-binding protein	K07725 csa3; CRISPR-associated protein Csa3 
D      Mevan_1514 helix-turn-helix domain protein	K07728 K07728; putative transcriptional regulator 
D      Mevan_0320 transcriptional regulator, XRE family	K07729 K07729; putative transcriptional regulator 
D      Mevan_1517 transcriptional regulator, XRE family	K07729 K07729; putative transcriptional regulator 
D      Mevan_0375 regulatory protein Crp	K07730 K07730; putative transcriptional regulator 
D      Mevan_0525 helix-turn-helix domain protein	K07731 K07731; putative transcriptional regulator 
B  Ribbon-helix-helix
C    CopG family
D      Mevan_1201 putative transcriptional regulator, CopG family	K07722 nikR; CopG family transcriptional regulator, nickel-responsive regulator 
D      Mevan_1594 putative transcriptional regulator, CopG family	K07722 nikR; CopG family transcriptional regulator, nickel-responsive regulator 
C    Other families
B  Other transcription factors
C    BglG family
C    Others
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#Last updated: August 21, 2025
#<br>Classification taken and modified from <a href="http://www.gene-regulation.com/pub/databases.html#transfac">TRANSFAC 7.0</a>