+D Chaperone KO
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Chaperones and Folding Catalysts - Necator americanus (New World hookworm)
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AHeat shock proteins
B HSP110
C NECAME_00084 hypothetical protein K09486 HYOU1; hypoxia up-regulated 1
C NECAME_05116 DnaK family protein K09486 HYOU1; hypoxia up-regulated 1
B HSP100
C NECAME_05423 ATP-dependent Clp protease, ATP-binding subunit ClpX K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
B HSP90
C NECAME_07351 putative heat shock protein 90 K04079 HSP90A; molecular chaperone HtpG
C NECAME_11242 Hsp90 protein K09487 HSP90B; heat shock protein 90kDa beta
C NECAME_12727 Hsp90 protein K09488 TRAP1; TNF receptor-associated protein 1
B HSP70 / DNAK
C NECAME_14190 putative chaperone protein DnaK K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C NECAME_02547 DnaK family protein K09489 HSPA4; heat shock 70kDa protein 4
C NECAME_05615 putative chaperone protein DnaK K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C NECAME_08499 heat shock cognate protein 1 K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C NECAME_07393 DnaK family protein K09491 HSPA13; heat shock 70kDa protein 13
C NECAME_12361 chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
B HSP60 / Chaperonin
C NECAME_11672 T-complex protein 1, beta subunit K09494 CCT2; T-complex protein 1 subunit beta
C NECAME_13187 T-complex protein 1, gamma subunit K09495 CCT3; T-complex protein 1 subunit gamma
C NECAME_12706 T-complex protein 1, delta subunit K09496 CCT4; T-complex protein 1 subunit delta
C NECAME_10660 putative T-complex protein 1, epsilon subunit K09497 CCT5; T-complex protein 1 subunit epsilon
C NECAME_15134 T-complex protein 1, zeta subunit K09498 CCT6; T-complex protein 1 subunit zeta
C NECAME_04607 T-complex protein 1, theta subunit K09500 CCT8; T-complex protein 1 subunit theta
C NECAME_04064 chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B HSP47
B HSP40 / DNAJ
C NECAME_10342 DnaJ domain protein K09502 DNAJA1; DnaJ homolog subfamily A member 1
C NECAME_06912 DnaJ domain protein K09503 DNAJA2; DnaJ homolog subfamily A member 2
C NECAME_04519 DnaJ region K09504 DNAJA3; DnaJ homolog subfamily A member 3
C NECAME_11729 DnaJ domain protein K09506 DNAJA5; DnaJ homolog subfamily A member 5
C NECAME_08172 DnaJ domain protein K09507 DNAJB1; DnaJ homolog subfamily B member 1
C NECAME_16518 DnaJ domain protein K09517 DNAJB11; DnaJ homolog subfamily B member 11
C NECAME_04074 Myb-like DNA-binding domain protein K09521 DNAJC1; DnaJ homolog subfamily C member 1
C NECAME_12675 DnaJ domain protein K09522 DNAJC2; DnaJ homolog subfamily C member 2
C NECAME_08410 tetratricopeptide repeat protein K09523 DNAJC3; DnaJ homolog subfamily C member 3
C NECAME_18779 DnaJ domain protein K09524 DNAJC4; DnaJ homolog subfamily C member 4
C NECAME_03610 DnaJ domain protein K09525 DNAJC5; DnaJ homolog subfamily C member 5
C NECAME_03853 DnaJ domain protein K09528 DNAJC8; DnaJ homolog subfamily C member 8
C NECAME_15402 DnaJ domain protein K09529 DNAJC9; DnaJ homolog subfamily C member 9
C NECAME_12042 protein disulfide-isomerase domain protein K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
C NECAME_16185 DnaJ domain protein K09531 DNAJC11; DnaJ homolog subfamily C member 11
C NECAME_17303 DnaJ domain protein K09534 DNAJC14; DnaJ homolog subfamily C member 14
C NECAME_04712 DnaJ domain protein K09536 DNAJC16; DnaJ homolog subfamily C member 16
C NECAME_15271 hypothetical protein K09539 DNAJC19; DnaJ homolog subfamily C member 19
C NECAME_14646 DnaJ domain protein K09540 SEC63; translocation protein SEC63
C NECAME_04134 hypothetical protein K19371 DNAJC25; DnaJ homolog subfamily C member 25
B HSP33
B HSP24
C NECAME_07145 co-chaperone GrpE K03687 GRPE; molecular chaperone GrpE
B HSP20
C NECAME_17791 Hsp20/alpha crystallin family protein K09541 CRYAA; crystallin, alpha A
C NECAME_18935 hypothetical protein K09541 CRYAA; crystallin, alpha A
C NECAME_02526 Hsp20/alpha crystallin family protein K09542 CRYAB; crystallin, alpha B
C NECAME_03608 Hsp20/alpha crystallin family protein K09542 CRYAB; crystallin, alpha B
C NECAME_07300 Hsp20/alpha crystallin family protein K09542 CRYAB; crystallin, alpha B
B HSP15
B HSP10
C NECAME_04063 chaperonin GroS K04078 groES; chaperonin GroES
B GimC
C NECAME_11247 prefoldin subunit K09548 PFDN1; prefoldin subunit 1
C NECAME_05411 prefoldin subunit K09550 PFDN4; prefoldin subunit 4
C NECAME_12934 prefoldin, alpha subunit K04797 pfdA; prefoldin alpha subunit
C NECAME_13454 prefoldin subunit K04798 pfdB; prefoldin beta subunit
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AOther chaperones and cochaperones
B Calnexin / calreticulin
C NECAME_09703 calreticulin family protein K08054 CANX; calnexin
C NECAME_09948 calreticulin family protein K08057 CALR; calreticulin
B DegP / HtrA
B AAA proteases
C NECAME_07936 ATP-dependent metallopeptidase HflB K09552 SPG7; spastic paraplegia 7 [EC:3.4.24.-]
C NECAME_01587 ATP-dependent metallopeptidase HflB K08956 AFG3; AFG3 family protein [EC:3.4.24.-]
B PapD
B SecB
B Sti1 / p60
C NECAME_02045 tetratricopeptide repeat protein K09553 STIP1; stress-induced-phosphoprotein 1
B Cdc37 / p50
C NECAME_16815 Cdc37 Hsp90 binding domain protein K09554 CDC37; cell division cycle protein 37
B BAG
C NECAME_09735 hypothetical protein K09556 BAG2; BCL2-associated athanogene 2
B Others
C NECAME_07249 u-box domain protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C NECAME_12260 hypothetical protein K09562 HSPBP1; hsp70-interacting protein
C NECAME_09226 hypothetical protein K23327 HIKESHI; protein Hikeshi
C NECAME_01386 CS domain protein K16729 CHORDC1; cysteine and histidine-rich domain-containing protein
C NECAME_04340 hypothetical protein K19606 CRTAP; cartilage-associated protein
C NECAME_04416 hypothetical protein K21804 METTL21A; protein N-lysine methyltransferase METTL21A [EC:2.1.1.-]
C NECAME_15126 hypothetical protein K23151 METTL23; methyltransferase-like protein 23 [EC:2.1.1.-]
C NECAME_07153 tetratricopeptide repeat protein K21991 UNC45; protein unc-45
C NECAME_04890 Torsin K22990 TOR1; torsin-1
C NECAME_04314 Kazal-type serine protease inhibitor domain protein K24262 SPARC; secreted protein acidic and rich in cysteine
C NECAME_08318 tetratricopeptide repeat protein K16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha
C NECAME_04188 hypothetical protein K24927 TTC4; tetratricopeptide repeat protein 4
C NECAME_02581 hypothetical protein K24962 CCDC47; PAT complex subunit CCDC47
C NECAME_08683 hypothetical protein K25366 MESD; LRP chaperone MESD
C NECAME_05035 hypothetical protein K26164 RIC3; protein RIC-3
C NECAME_11069 activator of Hsp90 ATPase K26216 AHSA1; activator of Hsp90 ATPase protein 1
C NECAME_15092 hypothetical protein K28128 HYPK; huntingtin-interacting protein K
C NECAME_04633 Phosducin K28206 PDCL; phosducin-like protein
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AIntramolecular chaperones
B Subtilisin family
C NECAME_01389 convertase P-domain protein K01349 FURIN; furin [EC:3.4.21.75]
C NECAME_01697 hypothetical protein K01360 PCSK2; proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
C NECAME_12953 peptidase, S8/S53 family K01360 PCSK2; proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
C NECAME_01499 peptidase, S8/S53 family K01280 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10]
B Papain family
C NECAME_01684 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_02725 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_02726 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_02743 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_02744 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_03383 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_04857 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_06064 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_12453 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_12455 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_14048 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_14336 papain family cysteine protease K01363 CTSB; cathepsin B [EC:3.4.22.1]
C NECAME_02194 papain family cysteine protease K01365 CTSL; cathepsin L [EC:3.4.22.15]
B Other peptidases
B Others
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AProtein folding catalysts
B Peptidyl prolyl isomerase
C Cyclophilin
D NECAME_14285 peptidyl-prolyl cis-trans isomerase, cyclophilin-type K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D NECAME_15322 putative peptidyl-prolyl cis-trans isomerase A K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D NECAME_12736 peptidyl-prolyl cis-trans isomerase, cyclophilin-type K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
D NECAME_14187 peptidyl-prolyl cis-trans isomerase, cyclophilin-type K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
D NECAME_09278 putative iojap-like protein K12734 PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 [EC:5.2.1.8]
D NECAME_12705 peptidyl-prolyl cis-trans isomerase, cyclophilin-type K12736 PPWD1; peptidylprolyl isomerase domain and WD repeat-containing protein 1 [EC:5.2.1.8]
C FKBP
D NECAME_13898 peptidyl-prolyl cis-trans isomerase, FKBP-type K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]
D NECAME_11933 putative peptidylprolyl isomerase K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
D NECAME_01686 tetratricopeptide repeat protein K09574 FKBP8; FK506-binding protein 8 [EC:5.2.1.8]
D NECAME_00652 peptidyl-prolyl cis-trans isomerase, FKBP-type K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
D NECAME_11942 peptidyl-prolyl cis-trans isomerase, FKBP-type K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
C Parvulin
D NECAME_14602 PPIC-type PPIASE domain protein K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
D NECAME_02055 PPIC-type PPIASE domain protein K09579 PIN4; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 [EC:5.2.1.8]
B Protein disulfide isomerase
C NECAME_01277 putative thioredoxin K03671 TXN; thioredoxin
C NECAME_00076 Glutaredoxin K03676 grxC; glutaredoxin 3
C NECAME_19065 glutaredoxin K03676 grxC; glutaredoxin 3
C NECAME_09161 monothiol glutaredoxin, Grx4 family K07390 grxD; monothiol glutaredoxin
C NECAME_15504 hypothetical protein K17479 GRXCR1; glutaredoxin domain-containing cysteine-rich protein 1
C NECAME_01085 protein disulfide-isomerase domain protein K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
C NECAME_11559 protein disulfide-isomerase domain protein K08056 PDIA3; protein disulfide-isomerase A3 [EC:5.3.4.1]
C NECAME_17673 protein disulfide-isomerase domain protein K09582 PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]
C NECAME_02688 protein disulfide-isomerase domain protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C NECAME_05131 protein disulfide-isomerase domain protein K09585 TMX3; protein disulfide-isomerase [EC:5.3.4.1]
C NECAME_13159 calcium binding EGF domain protein K24335 CRELD; protein disulfide-isomerase [EC:5.3.4.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: September 25, 2025