+D Protein KO
#
Membrane Trafficking - Necator americanus (New World hookworm)
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
D NECAME_04123 C2 domain protein K15290 SYT1; synaptotagmin-1
D NECAME_11771 C2 domain protein K19907 SYT7; synaptotagmin-7
D NECAME_15279 C2 domain protein K28063 ESYT; extended synaptotagmin
C Septins
D NECAME_15987 cell division protein K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D NECAME_04827 hypothetical protein K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D NECAME_12177 C2 domain protein K15297 RIMS2; regulating synaptic membrane exocytosis protein 2
C Phospholipases
D NECAME_11387 hypothetical protein K14621 PLB1; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]
D NECAME_13344 Phosphatidylinositol-specific phospholipase C, X domain protein K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
D NECAME_00937 Phosphatidylinositol-specific phospholipase C, X domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D NECAME_11673 Phosphatidylinositol-specific phospholipase C, Y domain protein K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
D NECAME_13698 phospholipase D domain protein K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D NECAME_03265 phospholipase D domain protein K16860 PLD3_4; phospholipase D3/4 [EC:3.1.4.4]
D NECAME_04873 phospholipase D domain protein K16860 PLD3_4; phospholipase D3/4 [EC:3.1.4.4]
D NECAME_17115 phospholipase D domain protein K16860 PLD3_4; phospholipase D3/4 [EC:3.1.4.4]
C Kinases and associated proteins
D NECAME_11256 hypothetical protein K02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
D NECAME_07968 Cyclin-dependent kinase 5 activator protein K11716 CDK5R1; cyclin-dependent kinase 5 activator 1
D NECAME_06269 hypothetical protein K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D NECAME_07204 putative tyrosine-protein kinase transforming protein Src K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D NECAME_08350 variant SH3 domain protein K06103 CASK; calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1]
D NECAME_04996 hypothetical protein K08796 BRSK; BR serine/threonine kinase [EC:2.7.11.1]
D NECAME_03244 kinase domain protein K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D NECAME_04361 nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
C Others
D NECAME_03429 phosphotyrosine interaction domain protein K04531 APBA1; amyloid beta A4 precursor protein-binding family A member 1
D NECAME_00990 EF hand K19932 NCS1; neuronal calcium sensor
D NECAME_01529 EF hand K19932 NCS1; neuronal calcium sensor
D NECAME_13044 hypothetical protein K19933 CADPS; calcium-dependent secretion activator
D NECAME_04710 hypothetical protein K19934 SDF4; calcium-binding protein
D NECAME_09808 b-box zinc finger K10649 TRIM9_67; tripartite motif-containing protein 9/67
D NECAME_09809 SPRY domain protein K10649 TRIM9_67; tripartite motif-containing protein 9/67
B Small GTPases and associated proteins
C Rab GTPases
D NECAME_06192 Ras family protein K07883 RAB3C; Ras-related protein Rab-3C
D NECAME_08466 Ras family protein K07901 RAB8A; Ras-related protein Rab-8A
D NECAME_05180 Ras family protein K07903 RAB10; Ras-related protein Rab-10
D NECAME_03317 Ras family protein K07914 RAB37; Ras-related protein Rab-37
C Rab associated proteins
D NECAME_14415 GDP/GTP exchange factor Sec2p K16779 RAB3IP; Rab-3A-interacting protein
D NECAME_17387 hypothetical protein K18270 RAB3GAP1; Rab3 GTPase-activating protein catalytic subunit
D NECAME_03836 hypothetical protein K19937 RAB3GAP2; Rab3 GTPase-activating protein non-catalytic subunit
D NECAME_17549 Rabphilin-3A effector domain protein K19939 RPH3AL; Rab effector Noc2
D NECAME_05472 hypothetical protein K05699 ACTN1_4; actinin alpha 1/4
D NECAME_00013 EF hand K02183 CALM; calmodulin
D NECAME_04141 EF hand K02183 CALM; calmodulin
D NECAME_07239 EF hand K02183 CALM; calmodulin
D NECAME_09810 EF hand K02183 CALM; calmodulin
D NECAME_11941 EF hand K02183 CALM; calmodulin
D NECAME_12924 EF hand K02183 CALM; calmodulin
D NECAME_14138 hypothetical protein K02183 CALM; calmodulin
D NECAME_16658 EF hand K02183 CALM; calmodulin
D NECAME_07828 hypothetical protein K19941 SYN; synapsin
D NECAME_02657 Sec1 family protein K15292 STXBP1; syntaxin-binding protein 1
D NECAME_01642 WD domain, G-beta repeat protein K08518 STXBP5; syntaxin-binding protein 5
D NECAME_12177 C2 domain protein K15297 RIMS2; regulating synaptic membrane exocytosis protein 2
D NECAME_00155 hypothetical protein K26226 PPFIA; liprin-alpha
D NECAME_09849 hypothetical protein K27096 PPFIBP; liprin-beta
D NECAME_16303 hypothetical protein K19952 RABIF; guanine nucleotide exchange factor
D NECAME_09933 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D NECAME_04130 TBC domain protein K19953 GRTP1; TBC1 domain family member 6
D NECAME_03499 TBC domain protein K19944 TBC1D10; TBC1 domain family member 10
D NECAME_14230 hypothetical protein K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225]
D NECAME_17151 hypothetical protein K25572 EHBP1; EH domain-binding protein 1
D NECAME_01774 LLGL2 K06094 LLGL; lethal(2) giant larvae protein
D NECAME_07749 GDP dissociation inhibitor K23460 CHM; Rab proteins geranylgeranyltransferase component A
D NECAME_03559 hypothetical protein K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D NECAME_00503 prenyltransferase and squalene oxidase repeat-containing domain protein K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D NECAME_10074 hypothetical protein K24155 DMXL; rabconnectin-3a
D NECAME_04661 DENN domain protein K26162 MADD; MAP kinase-activating death domain protein
C Rho GTPases
D NECAME_08964 Ras family protein K04393 CDC42; cell division control protein 42
D NECAME_10295 Ras family protein K04393 CDC42; cell division control protein 42
D NECAME_00612 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_17162 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_07752 Ras family protein K07865 RHOU; Ras homolog gene family, member U
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D NECAME_07065 hypothetical protein K19983 EXOC1; exocyst complex component 1
D NECAME_15780 IPT/TIG domain protein K17637 EXOC2; exocyst complex component 2
D NECAME_05934 Sec8 exocyst complex component specific domain protein K06111 EXOC4; exocyst complex component 4
D NECAME_03579 tetratricopeptide repeat protein K19984 EXOC5; exocyst complex component 5
D NECAME_13332 putative exocyst complex subunit Sec15 K19985 EXOC6; exocyst complex component 6
D NECAME_01677 Vps51/Vps67 K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D NECAME_04658 immunoglobulin domain protein K06491 NCAM; neural cell adhesion molecule
D NECAME_10030 Ras family protein K07834 RALA; Ras-related protein Ral-A
D NECAME_12314 hypothetical protein K25768 RALGAPA; Ral GTPase-activating protein subunit alpha
D NECAME_11004 hypothetical protein K25769 RALGAPB; Ral GTPase-activating protein subunit beta
D NECAME_09564 DSS1/SEM1 family protein K10881 SHFM1; 26 proteasome complex subunit DSS1
B Others
C Exomer complex
C Others
D NECAME_11441 hypothetical protein K12481 RBSN; rabenosyn-5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D NECAME_15578 Syntaxin K04560 STX1A; syntaxin 1A
D NECAME_01173 SNARE domain protein K08486 STX1B_2_3; syntaxin 1B/2/3
D NECAME_04078 SNARE domain protein K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
D NECAME_00293 SNARE domain protein K13813 STX12; syntaxin 12/13
C Stx-TGN / EE
D NECAME_10610 SNARE domain protein K08489 STX16; syntaxin 16
C Stx-cisGolgi
D NECAME_03032 SNARE domain protein K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
D NECAME_06442 hypothetical protein K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D NECAME_11919 vesicle transport v-SNARE protein K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
C Bos1 / Membrin
D NECAME_02760 vesicle transport v-SNARE protein K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
B SNAP-25[C] (Qc)
C STX6
C STX8
C STX10
C Bet1
C Sft1
C Syp7
C Use1
D NECAME_03409 hypothetical protein K08507 USE1; unconventional SNARE in the endoplasmic reticulum protein 1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D NECAME_04828 SNARE domain protein K18211 SNAP25; synaptosomal-associated protein 25
D NECAME_06435 SNARE domain protein K18211 SNAP25; synaptosomal-associated protein 25
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D NECAME_06443 Synaptobrevin K13504 VAMP2; vesicle-associated membrane protein 2
D NECAME_08439 Synaptobrevin K13505 VAMP3; vesicle-associated membrane protein 3
D NECAME_19153 Synaptobrevin K08512 VAMP8; vesicle-associated membrane protein 8
C Ykt6
D NECAME_07228 hypothetical protein K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D NECAME_03420 hypothetical protein K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D NECAME_01642 WD domain, G-beta repeat protein K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D NECAME_02657 Sec1 family protein K15292 STXBP1; syntaxin-binding protein 1
D NECAME_11523 hypothetical protein K15293 UNC13A_B_C; protein unc-13 A/B/C
D NECAME_11881 Sec1 family protein K19998 SCFD1; sec1 family domain-containing protein 1
D NECAME_07079 hypothetical protein K15294 CPLX1_2; complexin-1/2
D NECAME_04379 hypothetical protein K26808 TXLN; taxilin
C Palmitoyltransferases
D NECAME_05900 hypothetical protein K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D NECAME_08238 palmitoyltransferase ZDHHC3 K20029 ZDHHC3_7_25; palmitoyltransferase ZDHHC3/7/25 [EC:2.3.1.225]
D NECAME_14911 hypothetical protein K20029 ZDHHC3_7_25; palmitoyltransferase ZDHHC3/7/25 [EC:2.3.1.225]
D NECAME_01117 DHHC zinc finger domain protein K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D NECAME_10979 hypothetical protein K20002 SNAPIN; SNARE-associated protein Snapin
D NECAME_12151 hypothetical protein K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D NECAME_11813 Aromatic-di-Alanine repeat protein K15296 NAPA; alpha-soluble NSF attachment protein
D NECAME_13881 tetratricopeptide repeat protein K21198 NAPG; gamma-soluble NSF attachment protein
D NECAME_02182 golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D NECAME_06043 RUN domain protein K23282 PLEKHM1; pleckstrin homology domain-containing family M member 1
D NECAME_04890 Torsin K22990 TOR1; torsin-1
D NECAME_04155 transitional endoplasmic reticulum ATPase K13525 VCP; transitional endoplasmic reticulum ATPase
D NECAME_16108 SEP domain protein K14012 NSFL1C; UBX domain-containing protein 1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D NECAME_09145 hypothetical protein K04646 CLTC; clathrin heavy chain
C Dynamin
D NECAME_11259 dynamin family protein K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D NECAME_05530 dynamin family protein K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D NECAME_05300 adaptin region K11824 AP2A; AP-2 complex subunit alpha
D NECAME_05021 adaptor complexe medium subunit family protein K11826 AP2M1; AP-2 complex subunit mu-1
D NECAME_13129 adaptor complexe medium subunit family protein K11826 AP2M1; AP-2 complex subunit mu-1
D NECAME_04641 clathrin adaptor complex small chain K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D NECAME_11251 hypothetical protein K20042 FCHO; F-BAR domain only protein
D NECAME_16011 ENTH domain protein K12471 EPN; epsin
D NECAME_03792 EF hand K12472 EPS15; epidermal growth factor receptor substrate 15
D NECAME_01714 ANTH domain protein K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D NECAME_04654 SH3 domain protein K20045 ITSN; intersectin
D NECAME_13837 BAR domain protein K12562 AMPH; amphiphysin
D NECAME_06737 PX domain protein K17923 SNX9_18_33; sorting nexin-9/18/33
D NECAME_01473 hypothetical protein K08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]
D NECAME_14190 putative chaperone protein DnaK K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
D NECAME_00764 hypothetical protein K06233 LRP2; low density lipoprotein-related protein 2
D NECAME_07426 Low-density lipoprotein receptor domain class A K20053 VLDLR; very low-density lipoprotein receptor
C LDLR adaptor proteins
D NECAME_10675 phosphotyrosine interaction domain protein K06057 NUMBL; numb
D NECAME_03429 phosphotyrosine interaction domain protein K04531 APBA1; amyloid beta A4 precursor protein-binding family A member 1
D NECAME_03900 phosphotyrosine interaction domain protein K04434 MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1
D NECAME_06269 hypothetical protein K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D NECAME_09419 hypothetical protein K20056 GIPC; PDZ domain-containing protein GIPC
D NECAME_12082 hypothetical protein K20056 GIPC; PDZ domain-containing protein GIPC
D NECAME_09521 hypothetical protein K20058 ITGB1BP1; integrin beta-1-binding protein 1
C GPCR adaptor proteins
D NECAME_01530 arrestin domain protein K04439 ARRB; beta-arrestin
C Receptor tyrosine kinase (RTK) adaptor proteins
D NECAME_09671 SH3 domain protein K04364 GRB2; growth factor receptor-bound protein 2
C Inositol 5-phosphatases
D NECAME_09933 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
C Kinases
D NECAME_07303 kinase domain protein K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D NECAME_07204 putative tyrosine-protein kinase transforming protein Src K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D NECAME_16777 hypothetical protein K08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
C Ubiquitin E3 ligases
D NECAME_04660 CBL proto-oncogene, SH2-like domain protein K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
D NECAME_04283 hypothetical protein K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D NECAME_14860 NEDD4-like E3 ubiquitin-protein ligase WWP1 family protein K05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]
C Others
D NECAME_04058 I/LWEQ domain protein K04559 HIP1; huntingtin interacting protein 1
D NECAME_04059 ANTH domain protein K20040 HIP1R; huntingtin-interacting protein 1-related protein
D NECAME_07650 repeat in HS1/Cortactin K06106 CTTN; cortactin
D NECAME_09703 calreticulin family protein K08054 CANX; calnexin
D NECAME_02221 BAR domain protein K11247 SH3GL; endophilin-A
D NECAME_06128 BAR domain protein K21269 SH3GLB2; endophilin-B2
D NECAME_09624 putative GTP-ase activating protein K15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1
D NECAME_10966 adaptor complexe medium subunit family protein K20067 STON; stonin
D NECAME_03262 hypothetical protein K20068 REPS; RalBP1-associated Eps domain-containing protein
D NECAME_13333 ubiquitin--protein ligase K20069 NECAP1_2; adaptin ear-binding coat-associated protein 1/2
D NECAME_12529 DHHC zinc finger domain protein K20031 ZDHHC6; palmitoyltransferase ZDHHC6 [EC:2.3.1.225]
D NECAME_09127 hypothetical protein K21437 ANKRD13; ankyrin repeat domain-containing protein 13
D NECAME_14382 hypothetical protein K21437 ANKRD13; ankyrin repeat domain-containing protein 13
D NECAME_17601 FYVE zinc finger K23532 WDFY2; WD repeat and FYVE domain-containing protein 2
D NECAME_17151 hypothetical protein K25572 EHBP1; EH domain-binding protein 1
D NECAME_01084 hypothetical protein K26401 TOM1; target of Myb membrane trafficking protein 1 and related proteins
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D NECAME_07538 Caveolin K06278 CAV1; caveolin 1
D NECAME_07765 Caveolin K12958 CAV2; caveolin 2
D NECAME_11259 dynamin family protein K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D NECAME_05530 dynamin family protein K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D NECAME_07204 putative tyrosine-protein kinase transforming protein Src K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D NECAME_04654 SH3 domain protein K20045 ITSN; intersectin
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D NECAME_03876 hypothetical protein K20071 ARHGAP26; Rho GTPase-activating protein 26
D NECAME_08964 Ras family protein K04393 CDC42; cell division control protein 42
D NECAME_10295 Ras family protein K04393 CDC42; cell division control protein 42
D NECAME_08101 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_09251 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_12206 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_18537 hypothetical protein K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D NECAME_15058 ADP-ribosylation factor family protein K07941 ARF6; ADP-ribosylation factor 6
D NECAME_00612 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_17162 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C RhoA-dependent endocytosis
D NECAME_10243 Ras family protein K04513 RHOA; Ras homolog gene family, member A
D NECAME_11259 dynamin family protein K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D NECAME_05530 dynamin family protein K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
D NECAME_15363 integrin beta cytoplasmic domain protein K05719 ITGB1; integrin beta 1
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D NECAME_00283 myosin head K10356 MYO1; myosin I
D NECAME_00828 phosphotyrosine interaction domain protein K23285 GULP1; PTB domain-containing engulfment adapter protein 1
B Macropinocytosis
C Ras GTPases
D NECAME_05045 Ras family protein K07827 KRAS; GTPase KRas
D NECAME_05978 Miro-like protein K07827 KRAS; GTPase KRas
D NECAME_00612 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_17162 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_08964 Ras family protein K04393 CDC42; cell division control protein 42
D NECAME_10295 Ras family protein K04393 CDC42; cell division control protein 42
C Kinases
D NECAME_07204 putative tyrosine-protein kinase transforming protein Src K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D NECAME_15093 phosphoinositide 3-kinase family, accessory domain protein K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
C Phospholipase C
D NECAME_13344 Phosphatidylinositol-specific phospholipase C, X domain protein K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
D NECAME_11673 Phosphatidylinositol-specific phospholipase C, Y domain protein K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
D NECAME_00937 Phosphatidylinositol-specific phospholipase C, X domain protein K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D NECAME_01442 PX domain protein K17917 SNX1_2; sorting nexin-1/2
D NECAME_10185 hypothetical protein K17920 SNX5_6_32; sorting nexin-5/6/32
D NECAME_06737 PX domain protein K17923 SNX9_18_33; sorting nexin-9/18/33
C Others
D NECAME_01801 putative phosphoglycerate dehydrogenase K04496 CTBP; C-terminal binding protein [EC:1.1.1.428]
D NECAME_16662 hypothetical protein K20072 SWAP70; switch-associated protein 70
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D NECAME_13837 BAR domain protein K12562 AMPH; amphiphysin
D NECAME_02221 BAR domain protein K11247 SH3GL; endophilin-A
C F-BAR proteins
D NECAME_10924 SH3 domain protein K20121 FNBP1; formin-binding protein 1
D NECAME_11251 hypothetical protein K20042 FCHO; F-BAR domain only protein
D NECAME_05150 protein tyrosine kinase K08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]
D NECAME_10975 SH2 domain protein K08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D NECAME_06290 ankyrin repeat protein K20129 ANKFY1; rabankyrin-5
D NECAME_06472 FYVE zinc finger K12480 RABEP1; Rab GTPase-binding effector protein 1
D NECAME_12731 vacuolar sorting protein 9 domain protein K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D NECAME_11441 hypothetical protein K12481 RBSN; rabenosyn-5
D NECAME_09933 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D NECAME_15093 phosphoinositide 3-kinase family, accessory domain protein K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D NECAME_11685 TBC domain protein K20133 USP6NL; USP6 N-terminal-like protein
D NECAME_10713 GTPase-activator protein K27566 GAPVD1; GTPase-activating protein and VPS9 domain-containing protein 1
B Arf GTPases and associated proteins
C Arf GTPases
D NECAME_08101 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_09251 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_12206 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_18537 hypothetical protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_15058 ADP-ribosylation factor family protein K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D NECAME_13177 PH domain protein K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
D NECAME_07543 putative GTP-ase activating protein K12486 SMAP; stromal membrane-associated protein
D NECAME_04841 hypothetical protein K05737 GIT1; G protein-coupled receptor kinase interactor 1
D NECAME_12282 Sec7 domain protein K12494 PSD; PH and SEC7 domain-containing protein
D NECAME_13569 Sec7 domain protein K12495 IQSEC; IQ motif and SEC7 domain-containing protein
D NECAME_00653 hypothetical protein K21841 TBC1D24; TBC1 domain family member 24
D NECAME_11870 ELMO/CED-12 family protein K23538 ELMOD; ELMO domain-containing protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D NECAME_14035 phosphoinositide 3-kinase family, accessory domain protein K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D NECAME_11212 EFR3-like family protein K21842 EFR3; protein EFR3
D NECAME_00921 tetratricopeptide repeat protein K21843 TTC7; tetratricopeptide repeat protein 7
D NECAME_12200 hypothetical protein K21844 FAM126; protein FAM126
C Insulin-like growth factor-binding proteins
C Others
D NECAME_01209 hypothetical protein K25442 NCOA7; nuclear receptor coactivator 7
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D NECAME_12443 Ras family protein K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D NECAME_15873 vacuolar protein sorting-associated protein 35 K18468 VPS35; vacuolar protein sorting-associated protein 35
D NECAME_06691 vacuolar protein sorting-associated protein 26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
D NECAME_16280 ubiquitin--protein ligase K26419 AKTIP; AKT-interacting protein
D NECAME_04724 hypothetical protein K16536 HOOK3; protein HOOK3
D NECAME_12479 hypothetical protein K26420 FHIP1; FHF complex subunit HOOK interacting protein 1
C FERRY complex
D NECAME_01176 TBC domain protein K17544 TBCK; TBC domain-containing protein kinase-like protein
D NECAME_04230 hypothetical protein K28020 FERRY3; Ferry endosomal RAB5 effector complex subunit 3
C Rab associated proteins
D NECAME_15093 phosphoinositide 3-kinase family, accessory domain protein K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D NECAME_03342 multicatalytic endopeptidase K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D NECAME_15786 hypothetical protein K18469 TBC1D5; TBC1 domain family member 5
D NECAME_06274 TBC domain protein K20168 TBC1D15; TBC1 domain family member 15
D NECAME_07749 GDP dissociation inhibitor K23460 CHM; Rab proteins geranylgeranyltransferase component A
D NECAME_03559 hypothetical protein K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D NECAME_00503 prenyltransferase and squalene oxidase repeat-containing domain protein K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D NECAME_00164 TBC domain protein K20176 SGSM3; small G protein signaling modulator 3
D NECAME_02182 golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
D NECAME_10246 ADP-ribosylation factor family protein K07955 ARL8; ADP-ribosylation factor-like protein 8
C BLOC-one-related complex (BORC)
D NECAME_11195 GCN5-like protein 1 K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
D NECAME_00452 hypothetical protein K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
D NECAME_10979 hypothetical protein K20002 SNAPIN; SNARE-associated protein Snapin
D NECAME_13475 hypothetical protein K20819 BORCS5; BLOC-1 related complex subunit 5
D NECAME_08749 hypothetical protein K20822 MEF2BNB; BLOC-1 related complex subunit 8
C N-acetyl transferase complex C (NatC)
D NECAME_03748 acetyltransferase, GNAT family K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D NECAME_10127 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D NECAME_14659 LSM domain protein K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D NECAME_13204 hypothetical protein K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D NECAME_17255 VHS domain protein K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D NECAME_06077 VPS28 protein K12184 VPS28; ESCRT-I complex subunit VPS28
D NECAME_17378 modifier of rudimentary (Mod(r)) protein K12185 VPS37; ESCRT-I complex subunit VPS37
D NECAME_00147 hypothetical protein K12186 FAM125; ESCRT-I complex subunit MVB12
C ESCRT-II complex
D NECAME_10866 EAP30/Vps36 family protein K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D NECAME_19344 hypothetical protein K12197 CHMP1; charged multivesicular body protein 1
D NECAME_09084 SNF7 family protein K12191 CHMP2A; charged multivesicular body protein 2A
D NECAME_00796 SNF7 family protein K12192 CHMP2B; charged multivesicular body protein 2B
D NECAME_03776 SNF7 family protein K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D NECAME_04709 SNF7 family protein K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D NECAME_16639 SNF7 family protein K12198 CHMP5; charged multivesicular body protein 5
D NECAME_03385 SNF7 family protein K12195 CHMP6; charged multivesicular body protein 6
D NECAME_13753 SNF7 family protein K15053 CHMP7; charged multivesicular body protein 7
D NECAME_08185 ATPase, AAA family K12196 VPS4; vacuolar protein-sorting-associated protein 4
D NECAME_11491 ATPase, AAA family K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D NECAME_13374 hypothetical protein K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D NECAME_13853 BRO1-like domain protein K12200 PDCD6IP; programmed cell death 6-interacting protein
D NECAME_15212 BRO1-like domain protein K12200 PDCD6IP; programmed cell death 6-interacting protein
D NECAME_04108 arrestin domain protein K26229 ARRDC2_3; arrestin domain-containing protein 2/3
D NECAME_17133 arrestin domain protein K26229 ARRDC2_3; arrestin domain-containing protein 2/3
D NECAME_01084 hypothetical protein K26401 TOM1; target of Myb membrane trafficking protein 1 and related proteins
B Tethering complex
C CORVET complex
D NECAME_02389 hypothetical protein K20177 VPS3; vacuolar protein sorting-associated protein 3
D NECAME_05310 hypothetical protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D NECAME_12422 Vps16, region K20180 VPS16; vacuolar protein sorting-associated protein 16
D NECAME_15124 hypothetical protein K20181 VPS18; vacuolar protein sorting-associated protein 18
C Hops complex
D NECAME_05310 hypothetical protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D NECAME_12422 Vps16, region K20180 VPS16; vacuolar protein sorting-associated protein 16
D NECAME_15124 hypothetical protein K20181 VPS18; vacuolar protein sorting-associated protein 18
D NECAME_01276 hypothetical protein K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D NECAME_16201 hypothetical protein K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D NECAME_10074 hypothetical protein K24155 DMXL; rabconnectin-3a
D NECAME_17027 WD domain, G-beta repeat protein K24738 WDR7; rabconnectin-3b
C RAVE complex
D NECAME_10074 hypothetical protein K24155 DMXL; rabconnectin-3a
D NECAME_07064 Skp1 family, dimerization domain protein K03094 SKP1; S-phase kinase-associated protein 1
D NECAME_14768 Skp1 family, dimerization domain protein K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D NECAME_04208 adaptin region K12396 AP3D; AP-3 complex subunit delta
D NECAME_01456 adaptin region K12397 AP3B; AP-3 complex subunit beta
D NECAME_01525 adaptor complexe medium subunit family protein K12398 AP3M; AP-3 complex subunit mu
D NECAME_01415 clathrin adaptor complex small chain K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
D NECAME_11195 GCN5-like protein 1 K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
D NECAME_00452 hypothetical protein K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
D NECAME_10979 hypothetical protein K20002 SNAPIN; SNARE-associated protein Snapin
C BLOC-1 complex (yeast)
C BLOC-2 complex
D NECAME_16478 hypothetical protein K20191 HPS5; Hermansky-Pudlak syndrome 5 protein
C BLOC-3 complex
C Ferlins
C Lysosomal membrane proteins
D NECAME_11497 antigen peptide transporter 2 K05656 ABCB9; ATP-binding cassette, subfamily B (MDR/TAP), member 9
D NECAME_17011 antigen peptide transporter 2 family protein K05656 ABCB9; ATP-binding cassette, subfamily B (MDR/TAP), member 9
D NECAME_09622 Lysosome-associated membrane glycoprotein K06528 LAMP1_2; lysosomal-associated membrane protein 1/2
D NECAME_00688 chloride transporter, ClC family K05016 CLCN7; chloride channel 7
D NECAME_09308 ABC transporter, ATP-binding protein K05678 ABCD4; ATP-binding cassette, subfamily D (ALD), member 4 [EC:7.6.2.8]
D NECAME_09801 ABC transporter, ATP-binding protein K05678 ABCD4; ATP-binding cassette, subfamily D (ALD), member 4 [EC:7.6.2.8]
C Others
D NECAME_09053 hypothetical protein K27045 CCZ1; vacuolar fusion protein CCZ1, animal type
D NECAME_12621 hypothetical protein K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
D NECAME_13814 hypothetical protein K25048 TMEM106B; transmembrane protein 106B
D NECAME_11914 transmembrane protein 189 family protein K20656 TMEM189; plasmanylethanolamine desaturase [EC:1.14.19.77]
D NECAME_03320 hypothetical protein K21956 DRAM2; DNA damage-regulated autophagy modulator protein 2
D NECAME_10816 hypothetical protein K21956 DRAM2; DNA damage-regulated autophagy modulator protein 2
D NECAME_10817 hypothetical protein K21956 DRAM2; DNA damage-regulated autophagy modulator protein 2
D NECAME_09583 Sec1 family protein K23281 VPS33B; vacuolar protein sorting-associated protein 33B
D NECAME_11426 hypothetical protein K23287 VIPAS39; VPS33B-interacting protein in polarity and apical restriction
D NECAME_04877 hypothetical protein K23343 CCDC22; coiled-coil domain-containing protein 22
D NECAME_04878 hypothetical protein K23343 CCDC22; coiled-coil domain-containing protein 22
D NECAME_05020 FYVE zinc finger K24780 ZFYVE28; lateral signaling target protein 2
D NECAME_11431 vacuolar protein sorting 55 K28212 LEPROT; OB-RGRP/VPS55 family protein
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D NECAME_05180 Ras family protein K07903 RAB10; Ras-related protein Rab-10
D NECAME_10052 Ras family protein K07905 RAB11B; Ras-related protein Rab-11B
D NECAME_01544 Ras family protein K07881 RAB14; Ras-related protein Rab-14
C Rab4 associated proteins
D NECAME_06472 FYVE zinc finger K12480 RABEP1; Rab GTPase-binding effector protein 1
D NECAME_11441 hypothetical protein K12481 RBSN; rabenosyn-5
D NECAME_15113 regulator of G protein signaling domain protein K16526 AKAP10; A-kinase anchor protein 10
D NECAME_13893 hypothetical protein K10416 DYNC1LI; dynein cytoplasmic 1 light intermediate chain
C Rab11 associated proteins
D NECAME_15241 FIP domain protein K12485 RAB11FIP3_4; Rab11 family-interacting protein 3/4
D NECAME_05704 WD domain, G-beta repeat protein K20241 WDR44; WD repeat-containing protein 44
D NECAME_14125 WD domain, G-beta repeat protein K14004 SEC13; protein transport protein SEC13
D NECAME_13332 putative exocyst complex subunit Sec15 K19985 EXOC6; exocyst complex component 6
D NECAME_12902 hypothetical protein K20242 EVI5; ecotropic viral integration site 5 protein
D NECAME_02182 golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D NECAME_08815 GMP-PDE, delta subunit K23539 UNC119; protein unc-119
D NECAME_08987 SH3 domain-binding protein 5 K23739 SH3BP5; SH3-domain binding protein 5
C Other Rab GTPase associated proteins
D NECAME_09933 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D NECAME_09985 GMP-PDE, delta subunit K13758 PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
D NECAME_14230 hypothetical protein K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225]
D NECAME_17151 hypothetical protein K25572 EHBP1; EH domain-binding protein 1
D NECAME_14395 TBC domain protein K20166 TBC1D2B; TBC1 domain family member 2B
D NECAME_11530 hypothetical protein K20396 TBC1D7; TBC1 domain family member 7
D NECAME_12731 vacuolar sorting protein 9 domain protein K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D NECAME_08781 hypothetical protein K04482 RAD51; DNA repair protein RAD51
D NECAME_13177 PH domain protein K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
D NECAME_10254 dDENN domain protein K20163 DENND4; DENN domain-containing protein 4
D NECAME_15718 hypothetical protein K28416 DENND6; DENN domain-containing protein 6
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
D NECAME_04222 DHHC zinc finger domain protein K20030 ZDHHC5_8; palmitoyltransferase ZDHHC5/8 [EC:2.3.1.225]
C EARP complex
D NECAME_01014 Vps51/Vps67 K20296 ANG2; vacuolar protein sorting-associated protein 51
D NECAME_09540 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D NECAME_09572 Vps53-like protein K20299 VPS53; vacuolar protein sorting-associated protein 53
D NECAME_08818 hypothetical protein K23288 VPS50; syndetin
C WASH complex
D NECAME_04118 hypothetical protein K18465 MRT43; WASH complex subunit 7
D NECAME_07600 f-actin capping protein alpha subunit K10364 CAPZA; F-actin-capping protein subunit alpha
D NECAME_11788 f-actin capping protein, beta subunit K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
C Others
D NECAME_06078 WD domain, G-beta repeat protein K23289 EIPR1; EARP and GARP complex-interacting protein 1
D NECAME_04357 PX domain protein K17936 SNX27; sorting nexin-27
D NECAME_00944 hypothetical protein K23791 PHETA; sesquipedalian
D NECAME_00985 hypothetical protein K28442 TMEM170A; transmembrane protein 170A
D NECAME_00857 thioredoxin K25112 TMX2; thioredoxin-related transmembrane protein 2
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D NECAME_06047 hypothetical protein K18739 BICD; protein bicaudal D
D NECAME_08862 DENN domain protein K20164 DENND5; DENN domain-containing protein 5
D NECAME_08520 GRIP domain protein K20283 GOLGA4; golgin subfamily A member 4
D NECAME_02182 golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D NECAME_00132 hypothetical protein K22555 TBC1D23; TBC1 domain family member 23
D NECAME_11214 hypothetical protein K20286 TMF1; TATA element modulatory factor
D NECAME_14725 Roadblock/LC7 domain protein K10419 DYNLRB; dynein light chain roadblock-type
D NECAME_10325 hypothetical protein K04648 DCTN1; dynactin 1
D NECAME_09933 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D NECAME_13956 hypothetical protein K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
D NECAME_13959 hypothetical protein K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
D NECAME_14247 hypothetical protein K19527 VPS13D; vacuolar protein sorting-associated protein 13D
D NECAME_15230 hypothetical protein K28454 BLTP3B; bridge-like lipid transfer protein family member 3B
B Arf GTPases and associated proteins
C Arf GTPases
D NECAME_08101 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_09251 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_12206 ADP-ribosylation factor family protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_18537 hypothetical protein K07937 ARF1_2; ADP-ribosylation factor 1/2
D NECAME_09013 ADP-ribosylation factor family protein K07939 ARF4; ADP-ribosylation factor 4
D NECAME_15403 ADP-ribosylation factor family protein K07942 ARL1; ADP-ribosylation factor-like protein 1
D NECAME_06088 ADP-ribosylation factor family protein K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D NECAME_10441 putative GTP-ase activating protein K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D NECAME_12695 putative GTP-ase activating protein K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D NECAME_07543 putative GTP-ase activating protein K12486 SMAP; stromal membrane-associated protein
D NECAME_04841 hypothetical protein K05737 GIT1; G protein-coupled receptor kinase interactor 1
D NECAME_06080 Sec7 domain protein K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D NECAME_15949 hypothetical protein K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D NECAME_00227 Vps51/Vps67 K20288 COG1; conserved oligomeric Golgi complex subunit 1
D NECAME_00303 hypothetical protein K20290 COG3; conserved oligomeric Golgi complex subunit 3
D NECAME_04920 hypothetical protein K20291 COG4; conserved oligomeric Golgi complex subunit 4
D NECAME_13320 hypothetical protein K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D NECAME_01014 Vps51/Vps67 K20296 ANG2; vacuolar protein sorting-associated protein 51
D NECAME_09540 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D NECAME_09572 Vps53-like protein K20299 VPS53; vacuolar protein sorting-associated protein 53
C TRAPP complex II
D NECAME_07409 Sedlin, conserved region K20301 TRAPPC2; trafficking protein particle complex subunit 2
D NECAME_11880 hypothetical protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D NECAME_12717 transport protein particle component, Bet3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D NECAME_10025 Sybindin-like family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D NECAME_15792 transport protein particle component, Bet3 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D NECAME_17222 transport protein particle component, Bet3 K20304 TRAPPC6; trafficking protein particle complex subunit 6
D NECAME_03095 hypothetical protein K20306 TRAPPC9; trafficking protein particle complex subunit 9
D NECAME_04707 hypothetical protein K20310 TRAPPC13; trafficking protein particle complex subunit 13
B Others
C AP-1 complex
D NECAME_05169 adaptin region K12391 AP1G1; AP-1 complex subunit gamma-1
D NECAME_06451 adaptin region K12392 AP1B1; AP-1 complex subunit beta-1
D NECAME_01057 adaptor complexe medium subunit family protein K12393 AP1M; AP-1 complex subunit mu
D NECAME_04789 adaptor complexe medium subunit family protein K12393 AP1M; AP-1 complex subunit mu
C AP-3 complex
D NECAME_04208 adaptin region K12396 AP3D; AP-3 complex subunit delta
D NECAME_01456 adaptin region K12397 AP3B; AP-3 complex subunit beta
D NECAME_01525 adaptor complexe medium subunit family protein K12398 AP3M; AP-3 complex subunit mu
D NECAME_01415 clathrin adaptor complex small chain K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D NECAME_01097 VHS domain protein K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D NECAME_02251 hypothetical protein K25218 AFTPH; aftiphilin
D NECAME_06712 HEAT repeat protein K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D NECAME_13698 phospholipase D domain protein K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D NECAME_14035 phosphoinositide 3-kinase family, accessory domain protein K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D NECAME_06269 hypothetical protein K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D NECAME_03864 Arfaptin-like domain protein K20314 ARFIP; arfaptin
D NECAME_01389 convertase P-domain protein K01349 FURIN; furin [EC:3.4.21.75]
D NECAME_18335 hypothetical protein K20316 SCOC; short coiled-coil protein
D NECAME_13219 hypothetical protein K20317 SPAG9; c-Jun-amino-terminal kinase-interacting protein 4
D NECAME_15510 hypothetical protein K20318 SYS1; protein SYS1
D NECAME_06687 M protein repeat protein K10362 MYO18; myosin XVIII
D NECAME_04555 lung seven transmembrane receptor K28026 TMEM87; transmembrane protein 87
D NECAME_15361 hypothetical protein K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D NECAME_04888 hypothetical protein K23542 TMEM199; TMEM199 family protein
D NECAME_13137 TMS membrane protein/tumor differentially expressed protein K23544 SERINC1; serine incorporator 1
D NECAME_01314 PX domain protein K17918 SNX3_12; sorting nexin-3/12
D NECAME_13101 HEAT repeat protein K26678 MON2; protein MON2
D NECAME_01466 Dopey protein K26680 DOP1; protein dopey
D NECAME_02135 hypothetical protein K27258 WLS; protein wntless
D NECAME_02136 hypothetical protein K27258 WLS; protein wntless
D NECAME_08130 hypothetical protein K27894 HID1; protein HID1
D NECAME_15055 hypothetical protein K26752 TVP23; golgi apparatus membrane protein TVP23
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D NECAME_03161 ADP-ribosylation factor family protein K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D NECAME_14125 WD domain, G-beta repeat protein K14004 SEC13; protein transport protein SEC13
D NECAME_08092 Sec23/Sec24 trunk domain protein K14006 SEC23; protein transport protein SEC23
D NECAME_07447 Sec23/Sec24 trunk domain protein K14007 SEC24; protein transport protein SEC24
D NECAME_13635 Sec23/Sec24 trunk domain protein K14007 SEC24; protein transport protein SEC24
D NECAME_09503 WD domain, G-beta repeat protein K14003 PREB; prolactin regulatory element-binding protein
D NECAME_14456 hypothetical protein K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D NECAME_07409 Sedlin, conserved region K20301 TRAPPC2; trafficking protein particle complex subunit 2
D NECAME_11880 hypothetical protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D NECAME_12717 transport protein particle component, Bet3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D NECAME_10025 Sybindin-like family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D NECAME_15792 transport protein particle component, Bet3 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D NECAME_17222 transport protein particle component, Bet3 K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D NECAME_09118 Emp24/gp25L/p24 family protein K20347 TMED2; p24 family protein beta-1
D NECAME_04334 Emp24/gp25L/p24 family protein K14825 TMED5; p24 family protein gamma-2
D NECAME_06044 Emp24/gp25L/p24 family protein K20349 TMED7; p24 family protein gamma-3
D NECAME_09758 transmembrane Emp24 domain-containing protein 10 family protein K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D NECAME_01085 protein disulfide-isomerase domain protein K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D NECAME_11559 protein disulfide-isomerase domain protein K08056 PDIA3; protein disulfide-isomerase A3 [EC:5.3.4.1]
D NECAME_17673 protein disulfide-isomerase domain protein K09582 PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]
D NECAME_02688 protein disulfide-isomerase domain protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D NECAME_01041 thioredoxin K17264 ERP44; endoplasmic reticulum resident protein 44
D NECAME_06202 thioredoxin K17264 ERP44; endoplasmic reticulum resident protein 44
D NECAME_06203 hypothetical protein K17264 ERP44; endoplasmic reticulum resident protein 44
D NECAME_13028 hypothetical protein K05360 TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
D NECAME_16850 hypothetical protein K05360 TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
D NECAME_07014 thioredoxin K26746 TMX1_4; thioredoxin-related transmembrane protein 1/4
D NECAME_05131 protein disulfide-isomerase domain protein K09585 TMX3; protein disulfide-isomerase [EC:5.3.4.1]
D NECAME_12042 protein disulfide-isomerase domain protein K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
C Rab GTPases
D NECAME_07005 Ras family protein K07874 RAB1A; Ras-related protein Rab-1A
D NECAME_08480 Ras family protein K07877 RAB2A; Ras-related protein Rab-2A
C Rab associated proteins
D NECAME_09247 RasGEF domain protein K04351 RAPGEF4; Rap guanine nucleotide exchange factor 4
D NECAME_06443 Synaptobrevin K13504 VAMP2; vesicle-associated membrane protein 2
D NECAME_04980 hypothetical protein K20372 TBC1D20; TBC1 domain family member 20
D NECAME_13317 TBC domain protein K20360 TBC1D22; TBC1 domain family member 2
D NECAME_08032 Hrf1 family protein K20362 YIF1; protein transport protein YIF1
D NECAME_16474 Yos1-like protein K22939 IER3IP1; immediate early response 3-interacting protein 1
D NECAME_10697 hypothetical protein K27568 BLZF1; golgin-45
C ER-Golgi intermediate compartment (ERGIC) proteins
D NECAME_00804 Legume-like lectin family protein K10080 LMAN1; lectin, mannose-binding 1
D NECAME_03028 EF hand K20364 MCFD2; multiple coagulation factor deficiency protein 2
D NECAME_03029 EF hand K20364 MCFD2; multiple coagulation factor deficiency protein 2
D NECAME_03031 hypothetical protein K20364 MCFD2; multiple coagulation factor deficiency protein 2
D NECAME_05011 Legume-like lectin family protein K10082 LMAN2; lectin, mannose-binding 2
D NECAME_06518 Legume-like lectin family protein K10082 LMAN2; lectin, mannose-binding 2
D NECAME_05424 glycosyl hydrolase family 47 K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D NECAME_15419 glycosyl hydrolase family 47 K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D NECAME_02411 hypothetical protein K20365 ERGIC1; endoplasmic reticulum-Golgi intermediate compartment protein 1
D NECAME_00025 hypothetical protein K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D NECAME_15031 hypothetical protein K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D NECAME_00378 cornichon protein K20368 CNIH; protein cornichon
D NECAME_01952 SURF4 family protein K20369 ERV29; ER-derived vesicles protein
D NECAME_05615 putative chaperone protein DnaK K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D NECAME_08499 heat shock cognate protein 1 K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D NECAME_03202 hypothetical protein K20371 NUCB; nucleobindin
B Retrieval pathways
C Coat protein complex I (COP-I)
D NECAME_14383 WD domain, G-beta repeat protein K05236 COPA; coatomer subunit alpha
D NECAME_02146 adaptin region K17301 COPB1; coatomer subunit beta
D NECAME_04298 hypothetical protein K17302 COPB2; coatomer subunit beta'
D NECAME_04625 coatomer gamma subunit appendage domain protein K17267 COPG; coatomer subunit gamma
D NECAME_13531 coatomer subunit delta family protein K20471 COPD; coatomer subunit delta
D NECAME_18750 coatomer epsilon subunit K17268 COPE; coatomer subunit epsilon
D NECAME_02127 clathrin adaptor complex small chain K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D NECAME_15443 hypothetical protein K20473 NBAS; neuroblastoma-amplified sequence
D NECAME_14475 hypothetical protein K20474 RINT1; RAD50-interacting protein 1
C Golgi to ER traffic proteins (GET)
D NECAME_09862 arsenite-activated ATPase K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D NECAME_04191 hypothetical protein K23387 GET4; golgi to ER traffic protein 4
D NECAME_10566 ubiquitin family protein K23388 UBL4; ubiquitin-like protein 4
C Rab GTPases
D NECAME_10154 Ras family protein K07920 RAB33B; Ras-related protein Rab-33B
C Rab associated proteins
D NECAME_15750 hypothetical protein K20476 RIC1; RAB6A-GEF complex partner protein 1
D NECAME_07184 Rgp1 K20477 RGP1; RAB6A-GEF complex partner protein 2
D NECAME_01184 ER lumen protein retaining receptor K10949 KDELR; ER lumen protein retaining receptor
D NECAME_07068 ER lumen protein retaining receptor K10949 KDELR; ER lumen protein retaining receptor
D NECAME_11441 hypothetical protein K12481 RBSN; rabenosyn-5
D NECAME_13317 TBC domain protein K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D NECAME_11162 Oxysterol-binding protein K20456 OSBP; oxysterol-binding protein 1
D NECAME_04287 Oxysterol-binding protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D NECAME_02147 Yip1 domain protein K22940 YIPF1_2; protein YIPF1/2
D NECAME_14723 Yip1 domain protein K22941 YIPF3; protein YIPF3
D NECAME_09759 Yip1 domain protein K22942 YIPF4; protein YIPF4
D NECAME_01052 Yip1 domain protein K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D NECAME_05506 g-patch domain protein K23562 EMC1; ER membrane protein complex subunit 1
D NECAME_06033 hypothetical protein K23563 EMC2; ER membrane protein complex subunit 2
D NECAME_04637 Ras family protein K23564 EMC3; ER membrane protein complex subunit 3
D NECAME_13285 hypothetical protein K23567 EMC6; ER membrane protein complex subunit 6
D NECAME_06331 hypothetical protein K23568 EMC7; ER membrane protein complex subunit 7
D NECAME_00689 hypothetical protein K23570 EMC10; ER membrane protein complex subunit 10
C SEC61 complex
D NECAME_03989 preprotein translocase, SecY subunit K10956 SEC61A; protein transport protein SEC61 subunit alpha
D NECAME_07430 Sec61beta family protein K09481 SEC61B; protein transport protein SEC61 subunit beta
D NECAME_15375 protein translocase SEC61 complex gamma subunit, and eukaryotic K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
D NECAME_00300 Translocon-associated protein, alpha subunit K13249 SSR1; translocon-associated protein subunit alpha
D NECAME_05012 Translocon-associated protein beta K13250 SSR2; translocon-associated protein subunit beta
D NECAME_07431 Translocon-associated protein, gamma subunit K13251 SSR3; translocon-associated protein subunit gamma
D NECAME_12743 Translocon-associated protein, delta subunit K04571 SSR4; translocon-associated protein subunit delta
C Multi-pass translocon (MPT) complex
D NECAME_02581 hypothetical protein K24962 CCDC47; PAT complex subunit CCDC47
D NECAME_06336 hypothetical protein K26498 TMEM147; BOS complex subunit TMEM147
D NECAME_00808 hypothetical protein K26499 NCLN; BOS complex subunit NCLN
D NECAME_04502 hypothetical protein K26500 NOMO1_2_3; BOS complex subunit NOMO
C Post-GPI attachment to proteins factors (PGAP)
D NECAME_04019 hypothetical protein K23552 PGAP2; post-GPI attachment to proteins factor 2
D NECAME_11193 hypothetical protein K23552 PGAP2; post-GPI attachment to proteins factor 2
C Others
D NECAME_11881 Sec1 family protein K19998 SCFD1; sec1 family domain-containing protein 1
D NECAME_04710 hypothetical protein K19934 SDF4; calcium-binding protein
D NECAME_05782 hypothetical protein K21958 FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]
D NECAME_07862 hypothetical protein K20393 ARL6IP5; PRA1 family protein 3
D NECAME_11619 hypothetical protein K20724 TMEM33; transmembrane protein 33
D NECAME_11288 Reticulon K20721 RTN1; reticulon-1
D NECAME_09215 hypothetical protein K23554 GRAMD4; GRAM domain-containing protein 4
D NECAME_08235 MSP domain protein K06096 VAPA; vesicle-associated membrane protein-associated protein A
D NECAME_09609 hypothetical protein K21413 ANKS1; ankyrin repeat and SAM domain-containing protein 1
D NECAME_02182 golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D NECAME_05240 hypothetical protein K22128 PIEZO1_2; piezo-type mechanosensitive ion channel component 1/2
D NECAME_09545 mesencephalic astrocyte-derived neurotrophic factor-like family protein K22556 MANF; mesencephalic astrocyte-derived neurotrophic factor
D NECAME_01574 hypothetical protein K22697 SAMD8; ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62]
D NECAME_02082 Atlastin-1 family protein K17339 ATL; atlastin [EC:3.6.5.-]
D NECAME_00353 hypothetical protein K13254 SPAST; spastin [EC:5.6.1.1]
D NECAME_09856 hypothetical protein K23292 LNPK; endoplasmic reticulum junction formation protein lunapark
D NECAME_03916 hypothetical protein K23951 DYM; dymeclin
D NECAME_15401 hypothetical protein K24996 STEEP1; STING ER exit protein
D NECAME_15982 hypothetical protein K25789 JAGN; protein jagunal
D NECAME_14255 Helix-loop-helix DNA-binding domain protein K07197 SREBP1; sterol regulatory element-binding transcription factor 1
D NECAME_01932 hypothetical protein K28402 FAM8A1; protein FAM8A1
D NECAME_02728 hypothetical protein K28439 TMEM39; transmembrane protein 39
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D NECAME_11072 hypothetical protein K08331 ATG13; autophagy-related protein 13
D NECAME_05014 hypothetical protein K17589 RB1CC1; RB1-inducible coiled-coil protein 1
D NECAME_13868 hypothetical protein K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D NECAME_05912 kinase domain protein K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D NECAME_11072 hypothetical protein K08331 ATG13; autophagy-related protein 13
C PI3K complex
D NECAME_15093 phosphoinositide 3-kinase family, accessory domain protein K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D NECAME_03375 hypothetical protein K17889 ATG14L; beclin 1-associated autophagy-related key regulator
D NECAME_03648 autophagy protein Apg6 K08334 BECN; beclin
C ATG9 transmembrane protein
D NECAME_10905 autophagy protein Apg9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D NECAME_11138 WD domain, G-beta repeat protein K17908 WIPI1_2; autophagy-related protein 18
C Atg12 conjugation proteins
D NECAME_12622 autophagy protein Apg12 K08336 ATG12; ubiquitin-like protein ATG12
D NECAME_10568 e1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D NECAME_12570 autophagocytosis associated protein K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
D NECAME_00223 hypothetical protein K08339 ATG5; autophagy-related protein 5
D NECAME_03712 WD domain, G-beta repeat protein K17890 ATG16L1; autophagy-related protein 16-1
C Atg8 conjugation proteins
D NECAME_13711 gamma-aminobutyric acid receptor-associated protein K08341 GABARAP; GABA(A) receptor-associated protein
D NECAME_08329 peptidase family C54 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D NECAME_15945 peptidase family C54 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D NECAME_10568 e1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D NECAME_12737 autophagocytosis associated protein K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D NECAME_04395 aspartyl aminopeptidase K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
C Other Cvt associated proteins
B Mitophagy
C Cargo receptors
D NECAME_06701 NIP3-like family protein K15464 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
C Scaffold proteins
C PINK1-Parkin associated proteins
D NECAME_12182 hypothetical protein K05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]
D NECAME_11618 IBR domain protein K04556 PARK2; parkin [EC:2.3.2.31]
D NECAME_14398 fzo-like conserved region K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
D NECAME_17400 hypothetical protein K19513 CLEC16A; protein CLEC16A
C Other mitophagy associated proteins
D NECAME_02758 Hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D NECAME_09411 Hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D NECAME_15843 Hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D NECAME_16861 Hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D NECAME_00897 hypothetical protein K22255 ATPIF1; ATPase inhibitor, mitochondrial
D NECAME_14255 Helix-loop-helix DNA-binding domain protein K07197 SREBP1; sterol regulatory element-binding transcription factor 1
D NECAME_06895 F-box domain protein K10260 FBXW7; F-box and WD-40 domain protein 7
D NECAME_14493 F-box domain protein K10260 FBXW7; F-box and WD-40 domain protein 7
D NECAME_07441 ubiquitinyl hydrolase 1 K21343 USP15; ubiquitin carboxyl-terminal hydrolase 15 [EC:3.4.19.12]
D NECAME_16975 putative gamma-aminobutyric acid receptor-associated protein K10435 MAP1LC; microtubule-associated protein 1 light chain
B Pexophagy
C Selective cargos
D NECAME_12679 peroxisomal membrane anchor protein conserved region K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
B Aggrephagy
C Cargo receptors
C Scaffold proteins
D NECAME_10189 hypothetical protein K22262 WDFY3; WD repeat and FYVE domain-containing protein 3
C Other aggrephagy associated proteins
D NECAME_04155 transitional endoplasmic reticulum ATPase K13525 VCP; transitional endoplasmic reticulum ATPase
D NECAME_11618 IBR domain protein K04556 PARK2; parkin [EC:2.3.2.31]
D NECAME_07249 u-box domain protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
D NECAME_11618 IBR domain protein K04556 PARK2; parkin [EC:2.3.2.31]
B ER-phagy
C ER-phagy recepters
D NECAME_15376 hypothetical protein K28116 CDK5RAP3; CDK5 regulatory subunit-associated protein 3
D NECAME_16764 translocation protein, Sec62 family K12275 SEC62; translocation protein SEC62
D NECAME_02082 Atlastin-1 family protein K17339 ATL; atlastin [EC:3.6.5.-]
C Other ER-phagy associated proteins
D NECAME_09703 calreticulin family protein K08054 CANX; calnexin
D NECAME_09250 hypothetical protein K23344 DDRGK1; DDRGK domain-containing protein 1
D NECAME_08235 MSP domain protein K06096 VAPA; vesicle-associated membrane protein-associated protein A
C ER stress-related proteins
D NECAME_05615 putative chaperone protein DnaK K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D NECAME_08499 heat shock cognate protein 1 K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D NECAME_11242 Hsp90 protein K09487 HSP90B; heat shock protein 90kDa beta
D NECAME_10616 basic region leucine zipper K09027 XBP1; X box-binding protein 1
D NECAME_08223 S1 RNA binding domain protein K03237 EIF2S1; translation initiation factor 2 subunit 1
B Chaperone mediated autophagy (CMA)
C Selective cargos
D NECAME_10023 fructose-bisphosphate aldolase class-I K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D NECAME_15515 fructose-bisphosphate aldolase class-I K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D NECAME_13215 hypothetical protein K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D NECAME_10724 bZIP transcription factor K04379 FOS; proto-oncogene protein c-fos
D NECAME_03995 variant SH3 domain protein K17277 EPS8; epidermal growth factor receptor kinase substrate 8
D NECAME_08765 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D NECAME_04629 paired box' domain protein K15608 PAX2; paired box protein 2
D NECAME_03379 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D NECAME_06379 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D NECAME_06627 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D NECAME_11557 hypothetical protein K04523 UBQLN; ubiquilin
C Cargo receptors
D NECAME_09622 Lysosome-associated membrane glycoprotein K06528 LAMP1_2; lysosomal-associated membrane protein 1/2
C Chaperones
D NECAME_14190 putative chaperone protein DnaK K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D NECAME_07351 putative heat shock protein 90 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
D NECAME_10342 DnaJ domain protein K09502 DNAJA1; DnaJ homolog subfamily A member 1
C Other CMA associated proteins
D NECAME_04258 translation elongation factor EF-1, subunit alpha K03231 EEF1A; elongation factor 1-alpha
D NECAME_12519 translation elongation factor EF-1, subunit alpha K03231 EEF1A; elongation factor 1-alpha
B Other autophagy associated proteins
C RNautophagy/DNautophagy
D NECAME_09622 Lysosome-associated membrane glycoprotein K06528 LAMP1_2; lysosomal-associated membrane protein 1/2
C Micronucleophagy
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D NECAME_03738 hypothetical protein K23294 PACS2; phosphofurin acidic cluster sorting protein 2
D NECAME_14398 fzo-like conserved region K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D NECAME_12313 WD domain, G-beta repeat protein K08266 MLST8; target of rapamycin complex subunit LST8
C mTORC2 complex
D NECAME_12313 WD domain, G-beta repeat protein K08266 MLST8; target of rapamycin complex subunit LST8
D NECAME_14956 hypothetical protein K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D NECAME_06644 hypothetical protein K08267 RICTOR; rapamycin-insensitive companion of mTOR
C SEACIT/GATOR1 complex
D NECAME_10399 hypothetical protein K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D NECAME_01509 hypothetical protein K20405 NPRL2; nitrogen permease regulator 2
D NECAME_04634 hypothetical protein K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D NECAME_15693 WD domain, G-beta repeat protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D NECAME_15577 WD domain, G-beta repeat protein K14299 SEH1; nucleoporin SEH1
D NECAME_14125 WD domain, G-beta repeat protein K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
D NECAME_13922 hypothetical protein K23296 ITFG2; KICSTOR complex protein ITFG2
D NECAME_05598 hypothetical protein K23297 C12ORF66; KICSTOR complex protein C12orf66
D NECAME_06111 hypothetical protein K23298 SZT2; KICSTOR complex protein SZT2
C Rab GTPases
D NECAME_07005 Ras family protein K07874 RAB1A; Ras-related protein Rab-1A
D NECAME_08466 Ras family protein K07901 RAB8A; Ras-related protein Rab-8A
D NECAME_17602 Ras family protein K07925 RAB39B; Ras-related protein Rab-39B
C Rab associated proteins
C Others
D NECAME_10734 kinase domain protein K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
D NECAME_07445 Ser/Thr phosphatase family protein K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D NECAME_04032 TAP42-like family protein K17606 IGBP1; immunoglobulin-binding protein 1
D NECAME_11837 Propeller K17988 TECPR1; tectonin beta-propeller repeat-containing protein 1
D NECAME_02345 hypothetical protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D NECAME_04174 transmembrane amino acid transporter protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D NECAME_05149 transmembrane amino acid transporter protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D NECAME_15575 transmembrane amino acid transporter protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D NECAME_16443 transmembrane amino acid transporter protein K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D NECAME_02187 tetratricopeptide repeat protein K24928 TTC5; tetratricopeptide repeat protein 5
D NECAME_00400 FEZ-like protein K25668 FEZ2; fasciculation and elongation protein zeta-2
D NECAME_06262 hypothetical protein K27411 PHAF1; phagosome assembly factor 1
D NECAME_01698 galactose binding lectin domain protein K27569 EVA1; protein eva-1
#
AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
D NECAME_02527 FAD-binding domain protein K13411 DUOX; dual oxidase [EC:1.6.3.1 1.11.1.-]
C Nox associated proteins
D NECAME_00612 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_17162 Ras family protein K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D NECAME_04038 DUOXA-like protein C06E1.3 family protein K17233 DUOXA1; dual oxidase maturation factor 1
B Actin-binding proteins
C Myosins
D NECAME_00283 myosin head K10356 MYO1; myosin I
D NECAME_12604 hypothetical protein K10359 MYO7A; myosin VIIa
D NECAME_06687 M protein repeat protein K10362 MYO18; myosin XVIII
C Arp2/3 complex
D NECAME_06457 WD domain, G-beta repeat protein K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D NECAME_17454 Arp2/3 complex, subunit p34-Arc K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D NECAME_00943 hypothetical protein K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D NECAME_10845 hypothetical protein K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D NECAME_16197 Actin K17260 ACTR2; actin-related protein 2
D NECAME_04812 Actin K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D NECAME_07253 hypothetical protein K23612 WASL; neural Wiskott-Aldrich syndrome protein
D NECAME_13202 WH1 domain protein K23612 WASL; neural Wiskott-Aldrich syndrome protein
D NECAME_13896 leucine Rich repeat-containing domain protein K20493 LRRC16; leucine-rich repeat-containing protein 16
D NECAME_07650 repeat in HS1/Cortactin K06106 CTTN; cortactin
D NECAME_17423 SH3 domain protein K20520 DBNL; drebrin-like protein
D NECAME_13837 BAR domain protein K12562 AMPH; amphiphysin
D NECAME_06886 hypothetical protein K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D NECAME_03702 Profilin K05759 PFN; profilin
D NECAME_06788 Profilin K05759 PFN; profilin
D NECAME_18179 Profilin K05759 PFN; profilin
D NECAME_15711 Cofilin/tropomyosin-type actin-binding protein K05765 CFL; cofilin
D NECAME_15712 Cofilin/tropomyosin-type actin-binding protein K05765 CFL; cofilin
D NECAME_07107 DE Adenylate cyclase associated K17261 CAP1_2; adenylyl cyclase-associated protein
D NECAME_02556 kinesin motor domain protein K10396 KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
D NECAME_01255 hypothetical protein K12567 TTN; titin [EC:2.7.11.1]
D NECAME_00179 hypothetical protein K20526 TAGLN; transgelin
D NECAME_03428 hypothetical protein K20526 TAGLN; transgelin
D NECAME_05769 hypothetical protein K20526 TAGLN; transgelin
D NECAME_09349 hypothetical protein K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B MARVEL domain-containing proteins
C NECAME_00717 hypothetical protein K28042 CMTM4; CKLF-like MARVEL transmembrane domain-containing protein 4
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
D NECAME_10154 Ras family protein K07920 RAB33B; Ras-related protein Rab-33B
D NECAME_03712 WD domain, G-beta repeat protein K17890 ATG16L1; autophagy-related protein 16-1
C Lipid droplets
D NECAME_13523 Ras family protein K07910 RAB18; Ras-related protein Rab-18
D NECAME_04289 hypothetical protein K28100 FITM2; fat storage-inducing transmembrane protein 2 [EC:3.6.1.-]
D NECAME_04180 hypothetical protein K28352 C18ORF32; UPF0729 protein C18orf32
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D NECAME_10422 RhoGAP domain protein K18470 ARHGAP1; Rho GTPase-activating protein 1
D NECAME_04501 RhoGAP domain protein K20630 CHN1_2; chimaerin
D NECAME_16508 RhoGAP domain protein K20631 ARHGAP6; Rho GTPase-activating protein 6
D NECAME_06342 RhoGAP domain protein K20632 DLC; deleted in liver cancer protein
D NECAME_14601 RhoGAP domain protein K20641 ARHGAP20; Rho GTPase-activating protein 20
D NECAME_16813 RhoGAP domain protein K20641 ARHGAP20; Rho GTPase-activating protein 20
D NECAME_03876 hypothetical protein K20071 ARHGAP26; Rho GTPase-activating protein 26
D NECAME_08170 RhoGAP domain protein K20655 SYDE; Rho GTPase-activating protein SYDE
D NECAME_03597 RhoGAP domain protein K16733 RACGAP1; Rac GTPase-activating protein 1
C Rho guanine nucleotide exchange factors (GEFs)
D NECAME_01175 SH3 domain protein K13710 ARHGEF7; Rho guanine nucleotide exchange factor 7
D NECAME_07061 regulator of G protein signaling-like domain protein K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
D NECAME_02804 PH domain protein K20685 MCF2; guanine nucleotide exchange factor MCF2
D NECAME_00290 RhoGEF domain protein K21066 ARHGEF18; A-kinase anchor protein 18
D NECAME_11955 hypothetical protein K20704 ECT2; protein ECT2
D NECAME_16711 BRCA1 protein K20704 ECT2; protein ECT2
D NECAME_00528 SH3 domain protein K20705 DNMBP; dynamin-binding protein
D NECAME_04654 SH3 domain protein K20045 ITSN; intersectin
D NECAME_11864 hypothetical protein K05727 DOCK3; dedicator of cytokinesis protein 3
D NECAME_13473 dedicator of cytokinesis K21852 DOCK6_7_8; dedicator of cytokinesis protein 6/7/8
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 6, 2025