+E Ubiquitin system KO
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Ubiquitin System - Neurospora crassa
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C NCU05995 ubi; ubiquitin K08770 UBC; ubiquitin C
C NCU05275 ubiquitin fusion protein K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C NCU05032 60S ribosomal protein L40 K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C NCU04553 ubi::crp-6; ubiquitin/cytoplasmic ribosomal protein-6 K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C NCU03309 Nedd8-like protein K12158 NEDD8; ubiquitin-like protein Nedd8
C NCU09089 hypothetical protein K02983 RP-S30e; small subunit ribosomal protein S30e
C NCU06048 40S ribosomal protein S30 K02983 RP-S30e; small subunit ribosomal protein S30e
C NCU01545 atg-8; autophagy protein 8 K08341 GABARAP; GABA(A) receptor-associated protein
C NCU10049 autophagy protein Apg12 K08336 ATG12; ubiquitin-like protein ATG12
C NCU04177 hypothetical protein K12161 URM1; ubiquitin related modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C NCU04370 ubiquitin-activating enzyme E1 1 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C NCU09006 NEDD8-activating enzyme E1 regulatory subunit K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C NCU03526 ubiquitin-activating enzyme E1 3 K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C NCU02532 NEDD8-activating enzyme E1 catalytic subunit K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C NCU08040 NEDD8-activating enzyme E1 regulatory subunit K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C NCU00736 molybdenum cofactor biosynthetic protein K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C NCU06672 autophagy ubiquitin-activating enzyme ApgG K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C NCU09731 mus-8; mutagen sensitive-8 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C NCU08345 ubiquitin-conjugating enzyme E K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C NCU02289 ubiquitin-conjugating enzyme E2 K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C NCU07264 ubiquitin-conjugating enzyme E2 15 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C NCU03623 ubiquitin-conjugating enzyme E K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C NCU10046 ubiquitin conjugating enzyme Ubc8 K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C NCU01268 ubiquitin-conjugating enzyme E2 6 K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C NCU05592 ubiquitin-conjugating enzyme K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C NCU01225 ubiquitin conjugating enzyme K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C NCU02113 ubiquitin-conjugating enzyme E2 13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C NCU01188 ubiquitin conjugating enzyme K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C NCU09122 ubiquitin conjugating enzyme K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
C NCU02688 ubiquitin-conjugating enzyme E2Z K10585 UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]
C NCU02636 pex4; peroxin 4 K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C NCU04302 ubiquitin-conjugating enzyme E K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C NCU03610 NEDD8-conjugating enzyme UBC12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C NCU01955 autophagocytosis protein Aut1 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C NCU02779 hypothetical protein K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
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AUbiquitin ligases (E3)
B HECT type E3
C NCU04800 E3 ubiquitin-protein ligase K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C NCU03041 hypothetical protein K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
C NCU09866 thyroid hormone receptor interactor 12 K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C NCU03947 ubiquitin ligase K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C NCU08501 E3 ubiquitin-protein ligase TOM1-like protein K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C NCU06756 ubiquitin-protein ligase K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C NCU03357 ubiquitin conjugation factor E4 K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C NCU10270 hypothetical protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C NCU00181 peptidyl-prolyl cis-trans isomerase-like 2 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C NCU11357 cell cycle control protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D NCU07544 ubiquitin ligase BRE1 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D NCU07516 RING finger membrane protein K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D NCU03273 NF-X1 finger transcription factor K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D NCU03277 pex10; peroxin 10 K13346 PEX10; peroxin-10
D NCU05245 pex12; peroxin 12 K13345 PEX12; peroxin-12
D NCU02070 pex2; peroxin 2 K06664 PEX2; peroxin-2
C RBR proteins
D NCU06882 RING-5 K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D NCU03719 RING finger protein K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D NCU06584 hypothetical protein K11976 RNF216; E3 ubiquitin-protein ligase RNF216 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D NCU03234 ubr1; ubr1-like K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
D NCU04328 metaphase-anaphase transition protein K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D NCU11215 RING-10 protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D NCU04073 hypothetical protein K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D NCU06534 hypothetical protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D NCU05210 uvs-2; ultraviolet sensitive-2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D NCU11263 RING-15 protein K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
D NCU05314 hypothetical protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D NCU06815 hypothetical protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D NCU11222 hypothetical protein K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D NCU03652 SNF2 family helicase/ATPase K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D NCU07975 DNA repair and recombination protein RAD5B K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D NCU04633 RING finger protein K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D NCU02203 C2H2 finger domain-containing protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D NCU03740 hypothetical protein K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
D NCU06269 FHA domain-containing protein K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
B Atypical E3
C NCU06992 DNA repair protein Nse1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C NCU06213 MIZ zinc finger protein K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
C NCU03968 hypothetical protein K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C NCU05716 hypothetical protein K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
D Cullin
E NCU05204 cul-1; cullin-1 K03347 CUL1; cullin 1
D Adaptor protein
E NCU08991 scon-3; sulfur control-3 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E NCU04540 fwd-1; F-box/WD-40 domain containing protein-1 K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E NCU07521 fwd-2; F-box/WD-40 domain containing protein-2 K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E NCU08563 scon-2; sulfur control-2 K10259 MET30; F-box and WD-40 domain protein MET30
E NCU06483 F-box and WD repeat-containing protein K03361 CDC4; F-box and WD-40 domain protein CDC4
E NCU05939 cell division control protein 4 K03361 CDC4; F-box and WD-40 domain protein CDC4
E NCU06250 F-box/LRR repeat containing protein 2 K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E NCU08642 cyclic nucleotide-binding domain-containing protein K10273 FBXL7; F-box and leucine-rich repeat protein 7
E NCU01216 hpth-1; hpth ortholog K03360 GRR1; F-box and leucine-rich repeat protein GRR1
E NCU03146 F-box protein pof7 K10295 FBXO9; F-box protein 9
E NCU02379 mus-10; mutagen sensitive-10 K10301 FBXO21; F-box protein 21
E NCU03658 secretion pathway protein Sls2/Rcy1 K15071 RCY1; recyclin-1
C Cul2 complex
D Ring finger protein
D Cullin
D Adoptor protein
E NCU03406 hypothetical protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
D Cullin
E NCU02498 Cullin-3 K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E NCU03186 ankyrin repeat and BTB/POZ domain-containing protein K10520 ABTB1; ankyrin repeat and BTB/POZ domain-containing protein 1
C Cul4 complex
D Ring finger protein
D Cullin
E NCU00272 cul-4; cullin-4 K10609 CUL4; cullin 4
D Adoptor protein
E NCU06605 dim-8; defective in methylation-8 K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E NCU06039 WD repeat protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E NCU02151 WD repeat containing protein 23 K11801 DCAF11; DDB1- and CUL4-associated factor 11
E NCU01595 SOF1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E NCU04101 WD domain-containing protein K22382 WDR26; WD repeat-containing protein 26
E NCU06489 WD repeat protein K24752 WDR70; WD repeat-containing protein 70
E NCU09302 WD repeat-containing protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E NCU03406 hypothetical protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
D Cullin
D Adaptor protein
E NCU08991 scon-3; sulfur control-3 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
D Cullin
C APC/C
D Ring finger protein
E NCU11300 RING finger domain-containing protein K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E NCU00512 hypothetical protein K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E NCU02616 WD-repeat containing protein slp1 K03363 CDC20; cell division cycle 20, cofactor of APC complex
E NCU01269 cell cycle regulatory protein K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E NCU05901 hypothetical protein K03348 APC1; anaphase-promoting complex subunit 1
E NCU00213 nuclear protein bimA K03350 APC3; anaphase-promoting complex subunit 3
E NCU00494 hypothetical protein K03351 APC4; anaphase-promoting complex subunit 4
E NCU01963 eat-6; encodes anonymous transcript-6 K03352 APC5; anaphase-promoting complex subunit 5
E NCU01377 anaphase-promoting complex subunit Cut9 K03353 APC6; anaphase-promoting complex subunit 6
E NCU01174 anaphase-promoting complex subunit CDC23 K03355 APC8; anaphase-promoting complex subunit 8
E NCU08731 anaphase-promoting complex subunit 10 K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D NCU02741 mei-3; meiotic-3 K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D NCU00898 hypothetical protein K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D NCU01409 ran-binding protein K23334 RANBP9_10; Ran-binding protein 9/10
D NCU01737 hypothetical protein K23336 ARMC8; armadillo repeat-containing protein 8
D NCU09000 fyv-10 K18624 MAEA; macrophage erythroblast attacher
D NCU04406 vesicle-mediated transporter Vid24 K23335 GID4; glucose-induced degradation protein 4
D NCU05222 CTLH domain-containing protein K23338 GID8; glucose-induced degradation protein 8
D NCU04101 WD domain-containing protein K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
D NCU03459 UBA domain-containing protein Ucp14 K25216 UBAC2; ubiquitin-associated domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D NCU08875 Cullin binding protein CanA K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D NCU00771 UBX domain-containing protein 7 K24350 UBXN7; UBX domain-containing protein 7
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D NCU06372 ubiquitin hydrolase L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D NCU03704 ubiquitin carboxyl-terminal hydrolase 2 K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
D NCU02382 hypothetical protein K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D NCU00480 ubiquitin C-terminal hydrolase K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D NCU05777 ubiquitin carboxyl-terminal hydrolase 14 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D NCU03797 ubiquitin C-terminal hydrolase K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D NCU04014 hypothetical protein K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D NCU04333 ubiquitin C-terminal hydrolase K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D NCU01919 ubiquitin C-terminal hydrolase K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D NCU02375 ubiquitin carboxyl-terminal hydrolase 2 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D NCU02281 hypothetical protein K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D NCU00320 hypothetical protein K11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]
D NCU01457 ubiquitin C-terminal hydrolase K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D NCU08378 ubiquitin C-terminal hydrolase CreB K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
D NCU08579 ubiquitin C-terminal hydrolase K11874 UBP16; ubiquitin carboxyl-terminal hydrolase 16 [EC:3.4.19.12]
C OTU
D NCU00595 ubiquitin thiolesterase K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D NCU01397 hypothetical protein K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
C MINDY
D NCU03336 hypothetical protein K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
C JAMM
D NCU00823 rpn-11; regulatory particle, non-ATPase-like-11 K03030 PSMD14; 26S proteasome regulatory subunit N11
D NCU06939 endosome-associated ubiquitin isopeptidase K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
C PPPDE
C ZUFSP
D NCU01442 DUF1671 domain-containing protein K24134 ZUP1; zinc finger-containing ubiquitin peptidase 1 [EC:3.4.19.12]
C BRISC complex
B UBL-specific proteases (ULPs)
C NCU01366 hypothetical protein K08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]
C NCU00734 Ulp1 protease K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C NCU06372 ubiquitin hydrolase L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C NCU03714 thioredoxin K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D NCU00157 csn-1; COP9 signalosome-1 K12175 GPS1; COP9 signalosome complex subunit 1
D NCU00593 csn-2; COP9 signalosome-2 K12176 COPS2; COP9 signalosome complex subunit 2
D NCU01408 csn-3; COP9 signalosome-3 K12177 COPS3; COP9 signalosome complex subunit 3
D NCU07361 csn-4; COP9 signalosome-4 K12178 COPS4; COP9 signalosome complex subunit 4
D NCU00467 csn-5; COP9 signalosome-5 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D NCU07019 csn-6; COP9 signalosome-6 K12179 COPS6; COP9 signalosome complex subunit 6
D NCU08342 csn-7; COP9 signalosome-7 K12180 COPS7; COP9 signalosome complex subunit 7
D NCU08388 COP9 signalosome complex subunit 12 K24364 CSN12; COP9 signalosome complex subunit 12
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 27, 2024