+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Nocardia iowensis
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
D KV110_15745 acyltransferase domain-containing protein K21254 calO5; orsellinic acid synthase [EC:2.3.1.-]
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E KV110_14185 SRPBCC family protein K14670 whiEVI; aromatase
E KV110_14160 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E KV110_14170 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14175 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14180 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Nonaketide PKS
E KV110_14170 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14175 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14180 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E KV110_14170 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14175 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E KV110_14180 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D KV110_15715 type III polyketide synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D KV110_03355 MbtH family protein K05375 mbtH; MbtH protein
D KV110_37285 MbtH family protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D KV110_22505 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_22835 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_32010 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35825 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35895 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_33850 amino acid adenylation domain-containing protein K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72]
C Bacillibactin synthetase
D KV110_22505 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_22835 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_32010 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35825 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35895 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
D KV110_22880 amino acid adenylation domain-containing protein K12239 pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69]
D KV110_22875 amino acid adenylation domain-containing protein K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]
D KV110_35845 amino acid adenylation domain-containing protein K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]
C Mycobactin synthetase
D KV110_03815 AMP-binding protein K04787 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-]
D KV110_03820 amino acid adenylation domain-containing protein K04788 mbtB; mycobactin phenyloxazoline synthetase
D KV110_04565 polyketide synthase K04790 mbtC; mycobactin polyketide synthetase MbtC
D KV110_04570 nbtC; nocobactin polyketide synthase NbtC K04791 mbtD; mycobactin polyketide synthetase MbtD
D KV110_04550 amino acid adenylation domain-containing protein K04789 mbtE; mycobactin peptide synthetase MbtE
D KV110_04555 amino acid adenylation domain-containing protein K04792 mbtF; mycobactin peptide synthetase MbtF
C Vibriobactin synthetase
D KV110_22505 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_22835 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_32010 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35825 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35895 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D KV110_22505 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_22835 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_32010 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35825 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35895 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D KV110_22505 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_22835 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_32010 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35825 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D KV110_35895 AMP-binding protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C KV110_01240 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C KV110_15580 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C KV110_16390 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C KV110_18315 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C KV110_27215 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C KV110_10810 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_17105 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_18980 hypothetical protein K21159 sgcF; epoxide hydrolase
C KV110_19005 epoxide hydrolase 1 K21159 sgcF; epoxide hydrolase
C KV110_19295 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_23470 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_25800 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_34460 epoxide hydrolase 1 K21159 sgcF; epoxide hydrolase
C KV110_37035 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C KV110_38955 epoxide hydrolase 1 K21159 sgcF; epoxide hydrolase
C KV110_24360 epoxide hydrolase 1 K21159 sgcF; epoxide hydrolase
C KV110_15725 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
C KV110_14165 cupin domain-containing protein K14673 whiEII; putative monooxygenase
B Methylase
C KV110_22915 methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C KV110_31495 DUF1702 family protein K21160 sgcE2; enediyne biosynthesis protein E2
C KV110_31480 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C KV110_31485 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C KV110_31490 flavin reductase family protein K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
C KV110_22870 Gfo/Idh/MocA family oxidoreductase K12241 pchG; pyochelin biosynthesis protein PchG
B Thioesterase
B Oxygenase
C KV110_04540 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein K04793 mbtG; mycobactin lysine-N-oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
C KV110_08485 hypothetical protein K16105 vioL; carbamoyltransferase
C KV110_15720 enoyl-CoA hydratase/isomerase family protein K16425 dpgB; isomerase DpgB
C KV110_15725 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
C KV110_15730 enoyl-CoA hydratase/isomerase family protein K16426 dpgD; dehydration protein DpgD
C KV110_15865 amino acid racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024