+F Repair protein KO
#
DNA Repair and Recombination Proteins - Nilaparvata lugens (brown planthopper)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 120352174 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111047540 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111058955 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111053209 uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111048183 uncharacterized protein LOC111048183 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111047014 putative 3-methyladenine DNA glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111045331 single-strand selective monofunctional uracil DNA glycosylase isoform X2 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111052275 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 120352673 endonuclease III homolog 2, chloroplastic isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 111046320 LOW QUALITY PROTEIN: exodeoxyribonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 111054845 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 120356487 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 111049779 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 111054767 DNA polymerase delta subunit 3 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 111044438 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 120351010 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 111045035 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 111063407 LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 111062759 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 111055857 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111046965 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111062381 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 111051738 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 111043444 DNA polymerase lambda K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 111049477 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 111050056 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 111049516 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 111049854 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 120348853 aprataxin-like isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111047718 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 111058862 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 111064395 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 120356650 LOW QUALITY PROTEIN: DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111047882 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111052744 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 111058538 centrin-2 isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111064123 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 111052867 LOW QUALITY PROTEIN: DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 111048005 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111045127 DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111060465 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 111049639 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111050973 DNA-directed RNA polymerase II subunit Rpb4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 120352799 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111044444 DNA-directed RNA polymerase II subunit Rpb4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111054467 DNA-directed RNA polymerase II subunit Rpb4-like isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 120353712 DNA-directed RNA polymerase II subunit Rpb4-like isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 120354020 DNA-directed RNA polymerase II subunit Rpb4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111054797 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit Rpb4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111060375 DNA-directed RNA polymerase II subunit Rpb4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111049263 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111064124 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111047145 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 111053043 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 111058243 DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 111048712 DNA-directed RNA polymerases I, II, and III subunit RPABC5 isoform X2 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111055067 DNA-directed RNA polymerase II subunit RPB11 isoform X1 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 111060170 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111064123 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 111052867 LOW QUALITY PROTEIN: DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 111053139 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 111051228 LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 111049279 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 111057430 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 111063697 LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 111050016 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 111044187 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 111050270 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 111063115 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 111047787 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111048232 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 111053823 cyclin-H K06634 CCNH; cyclin H
E 111044635 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 111058664 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111061654 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 111053999 replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 111043707 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 111050812 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 111050756 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 111048643 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 111062381 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 111047874 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111058577 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 111051499 cullin-5 K10612 CUL5; cullin 5
E 111057199 LOW QUALITY PROTEIN: elongin-C K03872 ELOC; elongin-C
E 111057230 elongin-B K03873 ELOB; elongin-B
E 111061496 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 111052242 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 111064441 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 120349370 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2-like K08735 MSH2; DNA mismatch repair protein MSH2
E 111055647 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 111064525 PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 111053205 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 111044592 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 111054845 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 120356487 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 111049779 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 111054767 DNA polymerase delta subunit 3 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 111058664 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111061654 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 111053999 replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 111053953 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 111043471 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 111056414 LOW QUALITY PROTEIN: replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 111049710 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 120350068 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
E 111046789 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 111055857 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111063000 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 111058862 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 111062381 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 111048115 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111047842 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111045714 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 111063260 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 111056727 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 120351067 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 120355521 uncharacterized protein LOC120355521 K12173 BRE; BRCA1-A complex subunit BRE
E 111049053 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 111062169 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 111055149 DNA topoisomerase 2-binding protein 1-B K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 111048115 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111047842 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111045714 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 111058017 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 111058017 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111061475 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111043232 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 111048561 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 111056454 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 111052761 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 111049654 LOW QUALITY PROTEIN: uncharacterized protein LOC111049654 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 111045498 DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 111046244 ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111045012 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111048479 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111062323 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 111058830 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 111048479 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111051567 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111054193 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111064428 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 111043940 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 111058664 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111061654 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 111053999 replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 111045544 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111062614 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111061044 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 111050877 serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 111046239 uncharacterized protein LOC111046239 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 111064225 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 111062074 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111043520 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111049776 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111056395 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 111058592 uncharacterized protein LOC111058592 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 120355372 non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 111058082 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 111045261 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 111060504 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111058434 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111051322 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 111044839 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 111060214 flap endonuclease GEN isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 111055400 spatacsin K19026 SPG11; spatacsin
E 111062947 uncharacterized protein LOC111062947 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 111052724 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111052554 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 111046908 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111056904 uncharacterized protein LOC111056904 K23112 BRAT1; BRCA1-associated ATM activator 1
E 111044351 uncharacterized protein F09G8.5 isoform X3 K23456 CFAP410; cilla- and flagella-associated protein
E 111051203 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 111046585 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 111059537 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 111043303 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 111047417 Werner syndrome ATP-dependent helicase K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 111051942 X-ray repair cross-complementing protein 5 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 111062285 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 111058704 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 111048115 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111047842 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 111048235 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 111062449 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 111058342 non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 111051738 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 111043444 DNA polymerase lambda K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 111049854 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 120348853 aprataxin-like isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111044854 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 111061540 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 111046324 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 111059310 centromere protein S-like K11511 APITD1; centromere protein S
E 111047223 centromere protein X K15360 STRA13; centromere protein X
E 111046779 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
E 111058551 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 111048479 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111051567 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111054193 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111064428 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 111043940 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 111059944 Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 111043316 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 111062094 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 111058017 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111061475 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111046836 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 111050214 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 111059946 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111062892 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 111064253 E3 ubiquitin-protein ligase RNF8-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 111060231 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 111051412 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 111054081 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 111048895 uncharacterized protein LOC111048895 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 111053275 gastrulation defective protein 1 homolog isoform X1 K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 111055449 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111059610 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 111053254 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 120355162 DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 111048559 LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 111044702 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111063218 eisosome protein SEG2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 111046024 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 120353322 5' exonuclease Apollo-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111046495 ubiquitin-conjugating enzyme E2 variant 2 isoform X2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111057859 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
C Other TLS factors
D 111055857 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111053381 DNA-dependent metalloprotease SPRTN isoform X2 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 111060193 uncharacterized protein LOC111060193 isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 111062728 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 111052791 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 111051257 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 111044302 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 111043471 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 111056414 LOW QUALITY PROTEIN: replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111049710 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 120350068 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 111046789 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 111051257 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 111049358 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 111056553 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 111051054 claspin K25773 CLSPN; claspin
C Triple T complex
D 111057381 uncharacterized protein LOC111057381 K20403 TTI1; TELO2-interacting protein 1
D 111048560 TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 111046949 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 120355113 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 111056979 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 111059602 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 111044847 LOW QUALITY PROTEIN: Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 111047709 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 111051994 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111063362 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 111043225 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 111048925 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111053751 14-3-3 protein zeta isoform X2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111051339 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111044403 LOW QUALITY PROTEIN: 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 111048750 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 111045932 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 111047376 uncharacterized protein LOC111047376 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 111060297 plastin-2 K17336 PLS3; plastin-3
D 111048676 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111050245 uncharacterized protein LOC111050245 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111051708 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111049634 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 111058624 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 111054956 uncharacterized protein LOC111054956 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 111053395 uncharacterized protein LOC111053395 isoform X2 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 120351495 DNA cross-link repair protein SNM1-like isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
C Helicases
D 111048016 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 111048476 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 120350060 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111047798 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111062271 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 111062098 pleiotropic regulator 1-like isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 111055735 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 111051479 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 111054389 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 120355441 ribonucleoside-diphosphate reductase large chain-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111045786 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111047300 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111058955 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111053209 uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111045331 single-strand selective monofunctional uracil DNA glycosylase isoform X2 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 120353210 DNA-3-methyladenine glycosylase 2-like K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E 111047014 putative 3-methyladenine DNA glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 120352673 endonuclease III homolog 2, chloroplastic isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 111046186 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 111046186 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 111054389 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024