+E Ubiquitin system KO
#
Ubiquitin System - Nilaparvata lugens (brown planthopper)
%
!
AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C 111054232 polyubiquitin K04551 UBB; ubiquitin B
C 111052874 polyubiquitin-C isoform X1 K08770 UBC; ubiquitin C
C 111054644 ubiquitin-60S ribosomal protein L40 K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C 111056997 ubiquitin-40S ribosomal protein S27a K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C 111052465 NEDD8 K12158 NEDD8; ubiquitin-like protein Nedd8
C 111053235 uncharacterized protein LOC111053235 K02983 RP-S30e; small subunit ribosomal protein S30e
C 111051267 small ubiquitin-related modifier 3 K12160 SUMO; small ubiquitin-related modifier
C 111054679 LOW QUALITY PROTEIN: small ubiquitin-related modifier K12160 SUMO; small ubiquitin-related modifier
C 120354236 small ubiquitin-related modifier-like isoform X1 K12160 SUMO; small ubiquitin-related modifier
C 120354837 LOW QUALITY PROTEIN: small ubiquitin-related modifier 3-like K12160 SUMO; small ubiquitin-related modifier
C 111047507 gamma-aminobutyric acid receptor-associated protein K08341 GABARAP; GABA(A) receptor-associated protein
C 111045977 LOW QUALITY PROTEIN: autophagy protein 12-like K08336 ATG12; ubiquitin-like protein ATG12
C 111052591 ubiquitin-related modifier 1 K12161 URM1; ubiquitin related modifier 1
C 111056052 ubiquitin-like protein 3 K28515 UBL3; membrane-anchored ubiquitin-fold protein
C 111051037 AN1-type zinc finger protein 4 K12163 ZFAND4; AN1-type zinc finger protein 4
#
AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C 111048996 ubiquitin-like modifier-activating enzyme 1 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C 111058847 SUMO-activating enzyme subunit 1 K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C 111054957 SUMO-activating enzyme subunit 2 K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C 111046840 NEDD8-activating enzyme E1 catalytic subunit K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C 111054720 NEDD8-activating enzyme E1 regulatory subunit K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C 111048242 adenylyltransferase and sulfurtransferase MOCS3 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C 111044906 ubiquitin-like modifier-activating enzyme 5 K12164 UBA5; ubiquitin-like modifier-activating enzyme 5
C 111056744 ubiquitin-like modifier-activating enzyme ATG7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
#
AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C 111044702 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C 111049304 ubiquitin-conjugating enzyme E2 C K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C 111054111 probable ubiquitin-conjugating enzyme E2 C K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C 111046676 ubiquitin-conjugating enzyme E2-17 kDa K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C 111047090 ubiquitin-conjugating enzyme E2-24 kDa isoform X2 K20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]
C 111043930 probable ubiquitin-conjugating enzyme E2 7 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C 111046590 ubiquitin-conjugating enzyme E2 G1 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C 111059361 ubiquitin-conjugating enzyme E2 G2 K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C 111049594 ubiquitin-conjugating enzyme E2 H-like K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C 111058057 ubiquitin-conjugating enzyme E2 H K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C 111060401 ubiquitin-conjugating enzyme E2 H-like K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C 111048078 ubiquitin-conjugating enzyme E2 J2 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C 111053458 ubiquitin-conjugating enzyme E2-22 kDa K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C 111045247 ubiquitin-conjugating enzyme E2 L3-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 111053340 ubiquitin-conjugating enzyme E2 L3-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 111064292 ubiquitin-conjugating enzyme E2 L3 K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 120352097 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 L5-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 120353372 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 L5-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 120355559 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 L3-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 120356292 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 L3-like K04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
C 111045672 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X1 K10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]
C 111058901 ubiquitin-conjugating enzyme E2Q-like protein 1 K10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]
C 111059595 ubiquitin-conjugating enzyme E2 Q2 K10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]
C 111043317 ubiquitin-conjugating enzyme E2 R2 K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C 111043383 ubiquitin-conjugating enzyme E2 S K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C 111046779 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
C 111058551 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
C 111059848 ubiquitin-conjugating enzyme E2 W isoform X1 K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
C 111054194 ubiquitin-conjugating enzyme E2 Z K10585 UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]
C 120348880 ubiquitin-conjugating enzyme E2 Z-like K10585 UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]
C 111054334 baculoviral IAP repeat-containing protein 6 isoform X1 K10586 BIRC6; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]
B UBL-conjugating enzymes
C 111044837 SUMO-conjugating enzyme UBC9-B isoform X1 K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C 111047739 NEDD8-conjugating enzyme UBE2F-like K10687 UBE2F; ubiquitin-conjugating enzyme E2 F [EC:2.3.2.34]
C 111052398 NEDD8-conjugating enzyme UBE2F K10687 UBE2F; ubiquitin-conjugating enzyme E2 F [EC:2.3.2.34]
C 111050488 NEDD8-conjugating enzyme Ubc12-like K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C 111046045 ubiquitin-like-conjugating enzyme ATG3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C 111050602 ubiquitin-like-conjugating enzyme ATG10 K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
C 111047859 ubiquitin-fold modifier-conjugating enzyme 1 K12165 UFC1; ufm1-conjugating enzyme 1
C 111055320 ubiquitin-fold modifier-conjugating enzyme 1 K12165 UFC1; ufm1-conjugating enzyme 1
#
AUbiquitin ligases (E3)
B HECT type E3
C 111046542 ubiquitin-protein ligase E3A isoform X1 K10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
C 111043221 ubiquitin-protein ligase E3B K10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]
C 111045418 ubiquitin-protein ligase E3C isoform X1 K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C 111064465 E3 ubiquitin-protein ligase SMURF2 K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
C 111049833 E3 ubiquitin-protein ligase Su(dx) isoform X1 K05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]
C 111044972 E3 ubiquitin-protein ligase TRIP12 isoform X1 K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C 111053336 E3 ubiquitin-protein ligase NEDD4 isoform X1 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C 111051988 E3 ubiquitin-protein ligase HUWE1 K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C 120354370 E3 ubiquitin-protein ligase HUWE1-like K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C 111055348 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 K22370 AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1 [EC:2.3.2.26]
C 111064034 E3 ubiquitin-protein ligase hyd K10593 EDD1; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]
C 111046111 G2/M phase-specific E3 ubiquitin-protein ligase K22371 G2H3; G2/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26]
C 111051412 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
C 111053924 probable E3 ubiquitin-protein ligase HERC4 isoform X1 K10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]
C 111050637 LOW QUALITY PROTEIN: mucin-12 K12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
C 111059631 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECTD1-like K12231 HECTD1; E3 ubiquitin-protein ligase HECTD1 [EC:2.3.2.26]
C 111054960 probable E3 ubiquitin-protein ligase HECTD2 K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
C HECT type E3 associated proteins
D 111059020 NEDD4 family-interacting protein 1 K25839 NDFIP; NEDD4 family-interacting protein
D 111057767 UPF0472 protein C16orf72 homolog K27699 HAPSTR1; HUWE1-associated protein modifying stress responses 1
B U-box type E3
C 111046474 ubiquitin conjugation factor E4 A isoform X1 K10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]
C 111048423 ubiquitin conjugation factor E4 B isoform X1 K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C 111064316 E3 ubiquitin-protein ligase CHIP K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C 111063170 RING-type E3 ubiquitin-protein ligase PPIL2 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C 111048476 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
C 111057278 RING finger protein 37 K10600 UBOX5; U-box domain-containing protein 5 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D 111064187 E3 ubiquitin-protein ligase Bre1 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
D 111054292 E3 ubiquitin-protein ligase CBL-B-B K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
C SINA (Seven in absentia) proteins
D 111052499 E3 ubiquitin-protein ligase sina K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
C Ligand of Numb proteins
C March proteins
D 111051702 uncharacterized protein LOC111051702 K10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1/8 [EC:2.3.2.27]
D 111043803 uncharacterized protein LOC111043803 K10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2/3 [EC:2.3.2.27]
D 111052151 E3 ubiquitin-protein ligase MARCHF2 isoform X1 K10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2/3 [EC:2.3.2.27]
D 111063268 E3 ubiquitin-protein ligase MARCHF5 isoform X1 K10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]
D 120351514 E3 ubiquitin-protein ligase MARCHF6 K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
D 111051827 E3 ubiquitin-protein ligase Mdm2 isoform X1 K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
C NFX1 proteins
D 111043615 protein shuttle craft K12236 NFX1; transcriptional repressor NF-X1
D 111057595 NF-X1-type zinc finger protein NFXL1 K15683 NFXL1; NF-X1-type zinc finger protein NFXL1
C Pellino proteins
D 111047706 protein pellino isoform X1 K11964 PELI; pellino [EC:2.3.2.27]
C Peripheral membrane proteins
D 111052304 peroxisome biogenesis factor 10 K13346 PEX10; peroxin-10
D 120348795 peroxisome biogenesis factor 10-like K13346 PEX10; peroxin-10
D 120351453 peroxisome biogenesis factor 10-like K13346 PEX10; peroxin-10
D 111058943 peroxisome biogenesis factor 2 isoform X1 K06664 PEX2; peroxin-2
C RBR proteins
D 111056715 E3 ubiquitin-protein ligase parkin K04556 PARK2; parkin [EC:2.3.2.31]
D 111051560 uncharacterized protein LOC111051560 isoform X1 K11967 ANKIB1; ankyrin repeat and IBR domain-containing protein 1 [EC:2.3.2.31]
D 111059331 E3 ubiquitin-protein ligase ariadne-1 K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D 111043814 potential E3 ubiquitin-protein ligase ariadne-2 K11969 ARIH2; ariadne-2 [EC:2.3.2.31]
D 120349808 potential E3 ubiquitin-protein ligase ariadne-2-like K11969 ARIH2; ariadne-2 [EC:2.3.2.31]
D 111050481 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 K10630 RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
D 111047465 E3 ubiquitin-protein ligase RNF14 K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D 120354390 E3 ubiquitin-protein ligase RNF14-like K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D 111045130 E3 ubiquitin-protein ligase RNF19A K11972 RNF19A; E3 ubiquitin-protein ligase RNF19A [EC:2.3.2.31]
D 111044060 E3 ubiquitin-protein ligase lubel K11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]
D 111059359 uncharacterized protein LOC111059359 isoform X1 K11975 RNF144; E3 ubiquitin-protein ligase RNF144 [EC:2.3.2.31]
D 111060231 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
C TRAF proteins
D 111046887 TNF receptor-associated factor 6 K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
C TRIM/RBCC proteins
D 111055620 tripartite motif-containing protein 3 K11997 TRIM2_3; tripartite motif-containing protein 2/3
D 111059468 brain tumor protein isoform X2 K11997 TRIM2_3; tripartite motif-containing protein 2/3
D 111043657 E3 ubiquitin-protein ligase TRIM9 K10649 TRIM9_67; tripartite motif-containing protein 9/67
D 111046119 E3 ubiquitin-protein ligase TRIM9-like K10649 TRIM9_67; tripartite motif-containing protein 9/67
D 111048292 E3 ubiquitin-protein ligase TRIM23 K07963 TRIM23; tripartite motif-containing protein 23 [EC:2.3.2.27]
D 111051592 E3 ubiquitin-protein ligase TRIM33 isoform X1 K08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]
D 111044924 E3 ubiquitin-protein ligase TRIM37 K10608 TRIM37; tripartite motif-containing protein 37 [EC:2.3.2.27]
D 111060531 tripartite motif-containing protein 45 K12021 TRIM45; tripartite motif-containing protein 45
D 111050875 E3 ubiquitin-protein ligase TRIM71 K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
C UBR box proteins
D 111058886 E3 ubiquitin-protein ligase UBR2 K10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]
D 111064279 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Ubr3 K11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]
D 111048180 protein purity of essence K10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
D 111048398 putative E3 ubiquitin-protein ligase UBR7 K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D 111046173 E3 ubiquitin-protein ligase AMFR K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
D 111061132 death-associated inhibitor of apoptosis 2 K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
D 111050317 death-associated inhibitor of apoptosis 1-like K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
D 111052920 death-associated inhibitor of apoptosis 1 isoform X1 K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
D 111054983 E3 ubiquitin-protein ligase Hakai isoform X1 K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
D 111062330 E3 ubiquitin-protein ligase CCNB1IP1 isoform X2 K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
D 111045709 CCR4-NOT transcription complex subunit 4 isoform X2 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D 111063160 protein deltex K06058 DTX; deltex [EC:2.3.2.27]
D 111046324 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D 111061540 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D 111047865 E3 ubiquitin-protein ligase KCMF1 isoform X1 K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
D 111050483 E3 ubiquitin-protein ligase LRSAM1 isoform X1 K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
D 111055365 E3 ubiquitin-protein ligase listerin K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D 111060753 RNA-binding protein MEX3B-like K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
D 111048168 E3 ubiquitin-protein ligase MIB1 isoform X1 K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
D 111048198 E3 ubiquitin-protein ligase MIB1 K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
D 111060182 E3 ubiquitin-protein ligase MIB2 K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
D 111049021 mitochondrial E3 ubiquitin protein ligase 1 K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
D 111048490 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MYCBP2 K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
D 111057624 E3 ubiquitin-protein ligase MYLIP K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
D 111048224 protein neuralized isoform X3 K01931 NEUR; protein neuralized [EC:2.3.2.27]
D 111046024 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 111063218 eisosome protein SEG2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 111051119 RING finger and CHY zinc finger domain-containing protein 1 K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
D 111050457 roquin-1 isoform X1 K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
D 111044558 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase COP1 K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
D 111056892 E3 ubiquitin-protein ligase RING1 K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
D 111056393 E3 ubiquitin-protein ligase RNF185 isoform X2 K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
D 111064253 E3 ubiquitin-protein ligase RNF8-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
D 111049103 RING finger protein 10 K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
D 111051755 RING finger protein 11 isoform X4 K11980 RNF11; E3 ubiquitin-protein ligase RNF11
D 111054589 E3 ubiquitin-protein ligase RNF167 K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
D 111045685 E3 ubiquitin-protein ligase RNF25 K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
D 111053563 RING finger protein 44 K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
D 111055583 E3 ubiquitin-protein ligase NRDP1 isoform X1 K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
D 111056995 E3 ubiquitin-protein ligase RNF103 K15695 RNF103; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27]
D 111049715 trithorax group protein osa isoform X1 K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
D 111060210 E3 ubiquitin-protein ligase RNF115 isoform X1 K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D 111060263 RING finger protein 121 K15698 RNF121_175; RING finger protein 121/175
D 111053921 E3 ubiquitin-protein ligase RNF123 isoform X2 K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
D 111048731 protein TRC8 homolog K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
D 111045624 E3 ubiquitin-protein ligase RNF168 K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
D 111059546 E3 ubiquitin-protein ligase rnf146 K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
D 111045828 E3 ubiquitin-protein ligase MGRN1 isoform X1 K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
D 111057520 E3 ubiquitin-protein ligase RNF170 K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
D 111049172 E3 ubiquitin-protein ligase RNF180-like K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
D 111043241 E3 ubiquitin-protein ligase Rnf220 K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
D 111060457 U4/U6.U5 tri-snRNP-associated protein 1-like isoform X1 K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D 111057348 E3 ubiquitin-protein ligase SHPRH K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D 111045494 E3 ubiquitin-protein ligase SH3RF3 isoform X1 K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
D 111050500 E3 ubiquitin-protein ligase synoviolin K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D 111060799 transmembrane protein 129 K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
D 111053780 E3 ubiquitin-protein ligase Topors isoform X1 K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
D 111044492 E3 ubiquitin-protein ligase TRAIP K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]
D 111054510 E3 ubiquitin-protein ligase TRAIP K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]
D 111044426 E3 ubiquitin-protein ligase UHRF1 K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
D 111048638 putative E3 ubiquitin-protein ligase UNKL K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
D 111044884 E3 ubiquitin-protein ligase ZNF598 K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D 111050266 E3 ubiquitin-protein ligase znrf2 K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
D 111057944 uncharacterized protein LOC111057944 K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
B Atypical E3
C 111049776 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
C 111050229 interferon regulatory factor 2-binding protein 1 K22383 IRF2BP; interferon regulatory factor 2-binding protein
B UBL E3 ligases
C 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C 111053780 E3 ubiquitin-protein ligase Topors isoform X1 K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
C 111047726 E3 SUMO-protein ligase RanBP2 isoform X1 K12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
C 111056395 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C 111050701 RING finger protein 212B isoform X1 K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C 111049121 E3 SUMO-protein ligase ZBED1 K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 111057233 E3 SUMO-protein ligase ZBED1 isoform X1 K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 111059093 uncharacterized protein LOC111059093 K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 111060359 E3 SUMO-protein ligase ZBED1-like K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 111061420 zinc finger BED domain-containing protein 4-like isoform X1 K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 120348773 zinc finger BED domain-containing protein 4-like K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 120350927 zinc finger BED domain-containing protein RICESLEEPER 3-like K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 120352165 E3 SUMO-protein ligase ZBED1-like K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 120354763 E3 SUMO-protein ligase ZBED1-like K24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]
C 111051035 E3 UFM1-protein ligase 1 homolog K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
C 111050934 DCN1-like protein 1 K17822 DCUN1D1_2; DCN1-like protein 1/2
C 111043499 LOW QUALITY PROTEIN: DCN1-like protein 3 K17823 DCUN1D3; DCN1-like protein 3
C 111046321 DCN1-like protein 5 isoform X1 K17824 DCUN1D4_5; DCN1-like protein 4/5
C 120348710 DCN1-like protein 5 K17824 DCUN1D4_5; DCN1-like protein 4/5
B Multi subunit type E3
C SCF complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E 111056797 S-phase kinase-associated protein 1 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E 111049173 beta-TrCP isoform X3 K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E 111044546 F-box/WD repeat-containing protein 4 K10262 FBXW4; F-box and WD-40 domain protein 4
E 111054626 F-box/WD repeat-containing protein 5 isoform X1 K10263 FBXW5; F-box and WD-40 domain protein 5
E 111053617 F-box/WD repeat-containing protein 7 K10260 FBXW7; F-box and WD-40 domain protein 7
E 111057232 F-box/WD repeat-containing protein 9 isoform X1 K10265 FBXW9; F-box and WD-40 domain protein 9
E 111057013 S-phase kinase-associated protein 2 isoform X3 K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
E 111044634 dynein regulatory complex subunit 6 isoform X3 K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E 111052767 F-box/LRR-repeat protein 20 K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E 111054873 F-box/LRR-repeat protein 4 K10270 FBXL4; F-box and leucine-rich repeat protein 4
E 111049895 F-box/LRR-repeat protein 6 K10272 FBXL6; F-box and leucine-rich repeat protein 6
E 111050737 F-box/LRR-repeat protein 7 isoform X1 K10273 FBXL7; F-box and leucine-rich repeat protein 7
E 111046140 jmjC domain-containing histone demethylation protein 1 isoform X2 K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E 111047214 jmjC domain-containing histone demethylation protein 1-like K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E 111050824 F-box/LRR-repeat protein 14 K10280 FBXL14; F-box and leucine-rich repeat protein 14
E 111043956 F-box/LRR-repeat protein 15 K10281 FBXL15; F-box and leucine-rich repeat protein 15
E 111044267 F-box/LRR-repeat protein 16 K10282 FBXL16; F-box and leucine-rich repeat protein 16
E 111055860 uncharacterized protein LOC111055860 K10099 FBXO2; F-box protein 2
E 111058595 uncharacterized protein LOC111058595 K10293 FBXO7; F-box protein 7
E 111064125 uncharacterized protein LOC111064125 isoform X3 K10293 FBXO7; F-box protein 7
E 111051466 F-box only protein 9 K10295 FBXO9; F-box protein 9
E 111046206 F-box only protein 11 K10297 FBXO11; F-box protein 11
E 111054515 uncharacterized protein LOC111054515 isoform X1 K06084 LMO7; F-box protein 20
E 111046683 F-box only protein 25-like K10305 FBXO25_32; F-box protein 25/32
E 111044316 uncharacterized protein LOC111044316 K10306 FBXO28; F-box protein 28
E 111052337 uncharacterized protein LOC111052337 isoform X1 K10306 FBXO28; F-box protein 28
E 111048333 F-box only protein 33 K10310 FBXO33; F-box protein 33
E 111048069 F-box only protein 39 K10314 FBXO39; F-box protein 39
E 111064417 uncharacterized protein LOC111064417 isoform X1 K10314 FBXO39; F-box protein 39
E 111049011 F-box only protein 42 isoform X1 K10317 FBXO42; F-box protein 42
E 111055254 F-box/SPRY domain-containing protein 1 K10319 FBXO45; F-box protein 45
C Cul2 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E 111048223 cullin-2 isoform X1 K03870 CUL2; cullin 2
E 120356520 cullin-2-like K03870 CUL2; cullin 2
D Adoptor protein
E 111057199 LOW QUALITY PROTEIN: elongin-C K03872 ELOC; elongin-C
E 111057230 elongin-B K03873 ELOB; elongin-B
D Target recognizing subunit
E 111058866 uncharacterized protein LOC111058866 isoform X1 K03871 VHL; von Hippel-Lindau disease tumor supressor
E 111051291 leucine-rich repeat protein 1 isoform X1 K10348 LRR1; LRR-repeat protein 1
E 111056782 protein fem-1 homolog CG6966 K25805 FEM1A_C; protein fem-1 homolog A/C
E 111050006 protein fem-1 homolog B K10349 FEM1B; protein fem-1 homolog B
E 111056974 amyloid protein-binding protein 2 K25806 APPBP2; amyloid protein-binding protein 2
E 111050232 kelch domain-containing protein 1 isoform X1 K25807 KLHDC2; kelch domain-containing protein 2
E 111052111 kelch domain-containing protein 3 K25808 KLHDC3; kelch domain-containing protein 3
E 111057569 kelch domain-containing protein 10 K25809 KLHDC10; kelch domain-containing protein 10
E 111050480 protein zyg-11 homolog B isoform X1 K10350 ZYG11; Zyg-11 protein
E 111052067 protein zer-1 homolog K10350 ZYG11; Zyg-11 protein
E 111043945 zinc finger SWIM domain-containing protein 8 isoform X1 K25207 ZSWIM8; zinc finger SWIM domain-containing protein 8
E 120349675 zinc finger SWIM domain-containing protein 8-like K25207 ZSWIM8; zinc finger SWIM domain-containing protein 8
C Cul3 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E 111058577 cullin-3 isoform X1 K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E 111044720 LOW QUALITY PROTEIN: kelch-like protein 5 K10442 KLHL1_4_5; kelch-like protein 1/4/5
E 111058209 LOW QUALITY PROTEIN: ring canal kelch homolog K10443 KLHL2_3; kelch-like protein 2/3
E 111045545 kelch-like protein 10 K10448 KLHL10; kelch-like protein 10
E 111064636 kelch-like protein 10 K10448 KLHL10; kelch-like protein 10
E 111048053 kelch-like protein 17 K10454 KLHL17; kelch-like protein 17 (actinfilin)
E 111048131 kelch-like protein 28 K10454 KLHL17; kelch-like protein 17 (actinfilin)
E 111048771 LOW QUALITY PROTEIN: kelch-like protein 12 K10454 KLHL17; kelch-like protein 17 (actinfilin)
E 120351652 kelch-like protein 3 K10454 KLHL17; kelch-like protein 17 (actinfilin)
E 111064197 kelch-like protein 18 isoform X1 K10455 KLHL18; kelch-like protein 18
E 111049245 kelch-like protein diablo K10457 KLHL20; kelch-like protein 20
E 111048553 kelch-like protein 26 K10463 KLHL26; kelch-like protein 26
E 111055475 actin-binding protein IPP K13956 IPP; actin-binding protein IPP
E 111048127 LOW QUALITY PROTEIN: BTB/POZ domain-containing protein 3 K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2
E 111053489 BTB/POZ domain-containing protein 1 K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2
E 111062514 BTB/POZ domain-containing protein 1 K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2
E 120351267 BTB/POZ domain-containing protein 2-like K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2
E 111050379 BTB/POZ domain-containing protein 1 isoform X1 K10478 BTBD3_6; BTB/POZ domain-containing protein 3/6
E 111061964 BTB/POZ domain-containing protein 6-B isoform X1 K10478 BTBD3_6; BTB/POZ domain-containing protein 3/6
E 111054373 BTB/POZ domain-containing protein 7 K10479 BTBD7; BTB/POZ domain-containing protein 7
E 111052894 BTB/POZ domain-containing protein 9 K10481 BTBD9; BTB/POZ domain-containing protein 9
E 111058444 protein germ cell-less K10485 BTBD13; BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
E 111043785 ankyrin repeat and BTB/POZ domain-containing protein 2 K10521 ABTB2; ankyrin repeat and BTB/POZ domain-containing protein 2
E 111045398 rho-related BTB domain-containing protein 1 isoform X1 K07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
E 111049396 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform X2 K15074 BACURD; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein
E 111048106 BTB/POZ domain-containing protein KCTD1 isoform X2 K21754 KCTD1_15; BTB/POZ domain-containing protein KCTD1/15
E 111050974 BTB/POZ domain-containing protein KCTD5 K21914 KCTD2_5_17; BTB/POZ domain-containing protein KCTD2/5/17
E 111043450 LOW QUALITY PROTEIN: BTB/POZ domain-containing protein KCTD3 K21915 KCTD3; BTB/POZ domain-containing protein KCTD3
E 111051819 BTB/POZ domain-containing protein KCTD12 K21918 KCTD8_12_16; BTB/POZ domain-containing protein KCTD8/12/16
E 111064158 BTB/POZ domain-containing protein KCTD9 K21919 KCTD9; BTB/POZ domain-containing protein KCTD9
E 111044877 speckle-type POZ protein isoform X1 K10523 SPOP; speckle-type POZ protein
E 111061313 leucine-zipper-like transcriptional regulator 1 isoform X1 K23330 LZTR1; leucine-zipper-like transcriptional regulator 1
C Cul4 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E 111064123 cullin-4A isoform X1 K10609 CUL4; cullin 4
D Adoptor protein
E 111052867 LOW QUALITY PROTEIN: DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E 111053139 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E 111049404 DET1 homolog K10571 DET1; de-etiolated-1
E 111044558 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase COP1 K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
E 111057763 DET1- and DDB1-associated protein 1 K11792 DDA1; DET1- and DDB1-associated protein 1
E 111051378 protein cereblon K11793 CRBN; cereblon
E 111049932 DDB1- and CUL4-associated factor 1 K11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]
E 111059074 protein lethal(2)denticleless K11790 DTL; denticleless
E 111043918 DDB1- and CUL4-associated factor 5 K11800 DCAF5; DDB1- and CUL4-associated factor 5
E 111052678 DDB1- and CUL4-associated factor 6 K11795 DCAF6; DDB1- and CUL4-associated factor 6
E 120356497 DDB1- and CUL4-associated factor 6-like K11795 DCAF6; DDB1- and CUL4-associated factor 6
E 111050171 DDB1- and CUL4-associated factor 7 K11805 DCAF7; DDB1- and CUL4-associated factor 7
E 111055327 DDB1- and CUL4-associated factor 8 K11804 DCAF8; DDB1- and CUL4-associated factor 8
E 120356183 DDB1- and CUL4-associated factor 6-like K11804 DCAF8; DDB1- and CUL4-associated factor 8
E 111051877 WD and tetratricopeptide repeats protein 1-like isoform X1 K11807 WDTC1; WD and tetratricopeptide repeats protein 1
E 111061946 WD and tetratricopeptide repeats protein 1 K11807 WDTC1; WD and tetratricopeptide repeats protein 1
E 111056036 DDB1- and CUL4-associated factor 10 homolog K11802 DCAF10; DDB1- and CUL4-associated factor 10
E 111049795 DDB1- and CUL4-associated factor 11 K11801 DCAF11; DDB1- and CUL4-associated factor 11
E 111056209 DDB1- and CUL4-associated factor 12 K11803 DCAF12; DDB1- and CUL4-associated factor 12
E 111043586 LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 13-like K11806 DCAF13; DDB1- and CUL4-associated factor 13
E 111051052 bromodomain and WD repeat-containing protein 3 isoform X1 K11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1/3
E 111057152 WD repeat-containing protein 26 isoform X1 K22382 WDR26; WD repeat-containing protein 26
E 111053275 gastrulation defective protein 1 homolog isoform X1 K24752 WDR70; WD repeat-containing protein 70
C Cul5 complex
D Ring finger protein
E 111043368 RING-box protein 2 isoform X1 K10611 RBX2; RING-box protein 2
D Cullin
E 111051499 cullin-5 K10612 CUL5; cullin 5
D Adoptor protein
E 111057199 LOW QUALITY PROTEIN: elongin-C K03872 ELOC; elongin-C
E 111057230 elongin-B K03873 ELOB; elongin-B
D Target recognizing subunit
E 111044268 suppressor of cytokine signaling 4 K04699 SOCS6_7; suppressor of cytokine signaling 6/7
E 111054243 uncharacterized protein LOC111054243 K04699 SOCS6_7; suppressor of cytokine signaling 6/7
E 111054851 ankyrin repeat and SOCS box protein 3-like K10325 ASB3; ankyrin repeat and SOCS box protein 3
E 111056762 uncharacterized protein LOC111056762 K10339 ASB17; ankyrin repeat and SOCS box protein 17
E 111046027 protein gustavus isoform X1 K10343 SPSB1_4; SPRY domain-containing SOCS box protein 1/4
E 111049208 SPRY domain-containing SOCS box protein 3 isoform X1 K10345 SPSB3; SPRY domain-containing SOCS box protein 3
E 111056275 SPRY domain-containing SOCS box protein 3 K10345 SPSB3; SPRY domain-containing SOCS box protein 3
E 111054004 ras-related protein Rab-40C K07928 RAB40; Ras-related protein Rab-40
E 111046948 RING finger and SPRY domain-containing protein 1 K23332 RSPRY1; RING finger and SPRY domain-containing protein 1
C Cul7 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E 111056797 S-phase kinase-associated protein 1 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E 111058671 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E 120355673 anaphase-promoting complex subunit 11-like K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E 111057205 LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2 K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E 111046109 LOW QUALITY PROTEIN: cell division cycle protein 20 homolog K03363 CDC20; cell division cycle 20, cofactor of APC complex
E 111048790 protein cortex K03363 CDC20; cell division cycle 20, cofactor of APC complex
E 111048336 LOW QUALITY PROTEIN: fizzy-related protein homolog K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
E 111060595 fizzy-related protein homolog K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E 111048298 anaphase-promoting complex subunit 1 K03348 APC1; anaphase-promoting complex subunit 1
E 111046599 cell division cycle protein 27 homolog K03350 APC3; anaphase-promoting complex subunit 3
E 111058151 anaphase-promoting complex subunit 4 K03351 APC4; anaphase-promoting complex subunit 4
E 111059345 anaphase-promoting complex subunit 5 isoform X1 K03352 APC5; anaphase-promoting complex subunit 5
E 111044164 cell division cycle protein 16 homolog K03353 APC6; anaphase-promoting complex subunit 6
E 111045410 anaphase-promoting complex subunit 7 isoform X1 K03354 APC7; anaphase-promoting complex subunit 7
E 111043564 anaphase-promoting complex subunit 10 K03357 APC10; anaphase-promoting complex subunit 10
E 111045530 anaphase-promoting complex subunit 15B K25228 APC15; anaphase-promoting complex subunit 15
E 120351504 anaphase-promoting complex subunit 15B-like K25228 APC15; anaphase-promoting complex subunit 15
C BRCC complex
D 111062169 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D 111063260 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D 111049053 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
D 120351067 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
D 120355521 uncharacterized protein LOC120355521 K12173 BRE; BRCA1-A complex subunit BRE
D 111058017 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
C KPC complex
D 111053921 E3 ubiquitin-protein ligase RNF123 isoform X2 K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
D 111058952 ubiquitin-associated domain-containing protein 1 K12174 KPC2; Kip1 ubiquitination-promoting complex protein 2
C LUBAC complex
D 111050481 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 K10630 RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
D 111044060 E3 ubiquitin-protein ligase lubel K11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]
C CTLH complex
D 111043868 E3 ubiquitin-protein ligase RMND5A isoform X1 K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D 120355718 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RMND5A-like K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D 111061376 ran-binding protein 9 K23334 RANBP9_10; Ran-binding protein 9/10
D 111057822 armadillo repeat-containing protein 8 K23336 ARMC8; armadillo repeat-containing protein 8
D 111052203 muskelin K23337 MKLN1; muskelin
D 111060568 E3 ubiquitin-protein transferase MAEA K18624 MAEA; macrophage erythroblast attacher
D 111050975 glucose-induced degradation protein 4 homolog K23335 GID4; glucose-induced degradation protein 4
D 111054999 glucose-induced degradation protein 8-B homolog K23338 GID8; glucose-induced degradation protein 8
D 111049983 protein yippee-like 5 K23339 YPEL5; protein yippee-like 5
D 111057152 WD repeat-containing protein 26 isoform X1 K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
D 111046173 E3 ubiquitin-protein ligase AMFR K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
D 111054685 transmembrane and ubiquitin-like domain-containing protein 1 K23340 TMUB; transmembrane and ubiquitin-like domain-containing protein
D 111057616 erlin-1-like K23341 ERLIN; erlin
C LMBR1L-GP78-UBAC2 complex
D 111044536 protein Lilipod K25215 LMBR1L; protein LMBR1L
D 111046173 E3 ubiquitin-protein ligase AMFR K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
C STUB1-CHIC2 complex
D 111064316 E3 ubiquitin-protein ligase CHIP K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
D 111052281 cysteine-rich hydrophobic domain-containing protein 2 K28185 CHIC2; cysteine-rich hydrophobic domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D 111047593 COMM domain-containing protein 2-like K22558 COMMD2; COMM domain containing 2
D 111052640 COMM domain-containing protein 3 K22559 COMMD3; COMM domain containing 3
D 120348707 COMM domain-containing protein 3-like isoform X1 K22559 COMMD3; COMM domain containing 3
D 111049984 COMM domain-containing protein 4 K22560 COMMD4; COMM domain containing 4
D 111054280 COMM domain-containing protein 5-like K22561 COMMD5; COMM domain containing 5
D 111049784 COMM domain-containing protein 7-like K22563 COMMD7; COMM domain containing 7
D 120350619 COMM domain-containing protein 7-like K22563 COMMD7; COMM domain containing 7
D 111061832 COMM domain-containing protein 10 K22566 COMMD10; COMM domain containing 10
D 111054645 coiled-coil domain-containing protein 22 homolog K23343 CCDC22; coiled-coil domain-containing protein 22
D 111045315 DDRGK domain-containing protein 1 K23344 DDRGK1; DDRGK domain-containing protein 1
D 111052193 influenza virus NS1A-binding protein-like K15046 IVNS1ABP; influenza virus NS1A-binding protein
D 111062923 parkin coregulated gene protein homolog isoform X2 K26163 PACRG; parkin coregulated gene protein
D 111052242 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
D 111047076 SH3 domain-containing protein Dlish K26546 Dlish; SH3 domain-containing protein Dlish
#
ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D 111058754 ubiquitin carboxyl-terminal hydrolase calypso K08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]
D 120353971 ubiquitin carboxyl-terminal hydrolase calypso-like K08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]
D 111046687 ubiquitin carboxyl-terminal hydrolase isozyme L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D 111056967 ubiquitin carboxyl-terminal hydrolase isozyme L5 K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D 111054634 ubiquitin carboxyl-terminal hydrolase CYLD-like K08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
D 111060347 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 K08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
D 111046836 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D 111045884 ubiquitin carboxyl-terminal hydrolase 2 K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D 111046942 ubiquitin carboxyl-terminal hydrolase 2 isoform X1 K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D 111049255 ubiquitin carboxyl-terminal hydrolase 2 K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D 111056251 ubiquitin carboxyl-terminal hydrolase 3 K11986 USP3; ubiquitin carboxyl-terminal hydrolase 3 [EC:3.4.19.12]
D 111048158 ubiquitin carboxyl-terminal hydrolase 4 isoform X1 K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D 111061459 ubiquitin carboxyl-terminal hydrolase 5 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D 111064485 ubiquitin carboxyl-terminal hydrolase 32 isoform X1 K11837 USP6_32; ubiquitin carboxyl-terminal hydrolase 6/32 [EC:3.4.19.12]
D 111048289 ubiquitin carboxyl-terminal hydrolase 7 isoform X1 K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D 111044038 LOW QUALITY PROTEIN: probable ubiquitin carboxyl-terminal hydrolase FAF-X K11840 USP9_24; ubiquitin carboxyl-terminal hydrolase 9/24 [EC:3.4.19.12]
D 111045593 ubiquitin carboxyl-terminal hydrolase 10-B isoform X1 K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D 111050118 ubiquitin carboxyl-terminal hydrolase 12 K11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12/46 [EC:3.4.19.12]
D 111060440 ubiquitin carboxyl-terminal hydrolase 14 K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D 111060735 ubiquitin carboxyl-terminal hydrolase 16 K11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16/45 [EC:3.4.19.12]
D 111045249 ubiquitin carboxyl-terminal hydrolase 33 K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D 111051594 ubiquitin carboxyl-terminal hydrolase 20 K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D 111053505 ubiquitin carboxyl-terminal hydrolase 33 K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D 111056987 ubiquitin carboxyl-terminal hydrolase 33-like K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D 111044895 ubiquitin carboxyl-terminal hydrolase 33-like isoform X1 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D 111055160 ubiquitin carboxyl-terminal hydrolase 22 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D 111064360 ubiquitin carboxyl-terminal hydrolase 30 homolog isoform X1 K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
D 111063855 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 31 K11852 USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]
D 111046519 ubiquitin carboxyl-terminal hydrolase 34 isoform X1 K11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]
D 111055670 ubiquitin carboxyl-terminal hydrolase 36 isoform X1 K11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12]
D 111057870 ubiquitin carboxyl-terminal hydrolase 47 isoform X1 K11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]
D 111058345 ubiquitin carboxyl-terminal hydrolase 48 K11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]
D 111050585 uncharacterized protein LOC111050585 K27920 USP54; ubiquitin carboxyl-terminal hydrolase 54 [EC:3.4.19.12]
C OTU
D 111045538 ubiquitin thioesterase otubain-like isoform X1 K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D 120349279 LOW QUALITY PROTEIN: ubiquitin thioesterase otubain-like K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D 111049015 OTU domain-containing protein 5 K12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]
D 120350034 OTU domain-containing protein 5-like isoform X1 K12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]
D 111044717 deubiquitinase OTUD6B K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
D 111049938 OTU domain-containing protein 7B K11860 OTUD7A_B; OTU domain-containing protein 7 [EC:3.4.19.12]
D 111057325 deubiquitinating protein VCPIP1-like K11861 VCPIP1; deubiquitinating protein VCIP135 [EC:3.4.19.12]
D 111045124 ubiquitin thioesterase trabid K11862 ZRANB1; ubiquitin thioesterase ZRANB1 [EC:3.4.19.12]
C MJD
D 111054953 ataxin-3 K11863 ATXN3; Ataxin-3 [EC:3.4.22.-]
D 111056994 ataxin-3 isoform X1 K11863 ATXN3; Ataxin-3 [EC:3.4.22.-]
D 111058360 josephin-1 K15235 JOSD; josephin [EC:3.4.19.12]
C MINDY
D 111044721 ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog K22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12]
D 111049213 probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2 K22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12]
D 111054807 inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B isoform X1 K22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12]
C JAMM
D 111062169 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D 111046227 uncharacterized protein LOC111046227 isoform X2 K11865 MYSM1; histone H2A deubiquitinase [EC:3.4.19.-]
D 111047824 MPN domain-containing protein CG4751 K24173 MPND; MPN domain-containing protein
D 111043439 26S proteasome non-ATPase regulatory subunit 14 K03030 PSMD14; 26S proteasome regulatory subunit N11
D 111050100 AMSH-like protease K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
C PPPDE
D 111051731 deubiquitinase DESI2 K22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]
C ZUFSP
D 111056717 zinc finger-containing ubiquitin peptidase 1 isoform X1 K24134 ZUP1; zinc finger-containing ubiquitin peptidase 1 [EC:3.4.19.12]
C BRISC complex
D 111056727 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
D 111062169 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D 111049053 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
D 120351067 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
D 120355521 uncharacterized protein LOC120355521 K12173 BRE; BRCA1-A complex subunit BRE
B UBL-specific proteases (ULPs)
C 111046893 sentrin-specific protease 1-like K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C 111053926 sentrin-specific protease 1-like K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C 120350570 sentrin-specific protease 1-like K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C 111064119 sentrin-specific protease 8 isoform X1 K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C 120353148 uncharacterized protein LOC120353148 K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C 120354615 uncharacterized protein LOC120354615 K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C 120355226 uncharacterized protein LOC120355226 K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C 120356592 probable sentrin-specific protease 8 K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C 111046687 ubiquitin carboxyl-terminal hydrolase isozyme L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C 111051004 uncharacterized protein LOC111051004 isoform X5 K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C 120348780 desumoylating isopeptidase 1-like isoform X1 K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D 111043653 LOW QUALITY PROTEIN: COP9 signalosome complex subunit 1 K12175 GPS1; COP9 signalosome complex subunit 1
D 111057231 COP9 signalosome complex subunit 2 K12176 COPS2; COP9 signalosome complex subunit 2
D 111044795 LOW QUALITY PROTEIN: COP9 signalosome complex subunit 3 K12177 COPS3; COP9 signalosome complex subunit 3
D 111059226 COP9 signalosome complex subunit 4 isoform X1 K12178 COPS4; COP9 signalosome complex subunit 4
D 111064412 COP9 signalosome complex subunit 5 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D 111058253 COP9 signalosome complex subunit 6 K12179 COPS6; COP9 signalosome complex subunit 6
D 111052071 COP9 signalosome complex subunit 7 K12180 COPS7; COP9 signalosome complex subunit 7
D 111052025 COP9 signalosome complex subunit 8 K12181 COPS8; COP9 signalosome complex subunit 8
D 111052447 COP9 signalosome complex subunit 9 isoform X2 K28062 COPS9; COP9 signalosome complex subunit 9
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: October 2, 2025