+E Replication protein KO
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DNA Replication Proteins - Nipponia nippon (crested ibis)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 104009290 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 104010190 ORC2; LOW QUALITY PROTEIN: origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 104021954 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 104009791 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 104010732 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 104011295 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 104023641 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 104016871 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 104014680 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 104019797 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 104021568 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 104009786 MCM6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 104020619 MCM7; DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 104019145 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 104010931 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 104016423 CCNE2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 104013280 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 104017516 CDK2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 104015485 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 104014037 DBF4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 104022119 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 104023580 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 104017404 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 104016025 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 104012125 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104015856 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 104021130 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 104014923 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 104008918 MCM9; LOW QUALITY PROTEIN: DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 104014618 MCM10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 104011049 HELB; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 104014547 CINP; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 104018015 MTBP; mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 104017242 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 104022501 POLA1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 104015919 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 104020916 PRIM2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 104010608 POLE; LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 104019457 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 104022693 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 104022610 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 104022757 POLD3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 104017240 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 104014369 POLG2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 104012764 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 104015783 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 104012806 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 104009821 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 104016116 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104019599 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104020287 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 104010554 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 104009158 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 104010888 RNASEH2B; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
C Other elongation factors
D 104013482 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 104008931 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 104011543 EXO1; LOW QUALITY PROTEIN: exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 104009757 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 104014375 ATAD5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 104018403 DNMT1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104015768 DNMT3A; LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 104018311 DNMT3B; DNA (cytosine-5)-methyltransferase 3B K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 104018177 GMNN; geminin K10749 GMNN; geminin
D 104009114 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 104016845 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 104012632 CCNB3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 104013461 CDK1; cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 104010697 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 104016180 TERF1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 104023611 TERF2; telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 104023600 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
E 104013287 CCDC79; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 104016785 uncharacterized protein C15orf43 homolog K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 104016329 uncharacterized protein C11orf85 homolog K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 104008659 CTC1; CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 104022315 OBFC1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 104022847 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 104012761 SMG6; LOW QUALITY PROTEIN: telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 104012283 SMG5; protein SMG5 K11125 SMG5; protein SMG5
D 104013406 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 104021312 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 104011893 DKC1; H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 104013406 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 104018327 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 104012116 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 104011439 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 104011707 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
C ELG1-RFC complex
D 104016116 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104019599 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104020287 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 104010554 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 104017340 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
D 104012013 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 104016497 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 104023113 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 104016604 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 104017027 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 104019798 PRKDC; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 104009304 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 104019272 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 104008690 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 104023104 PARP4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 104021345 TNKS; tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 104013918 TNKS2; tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 104014696 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 104020058 RTEL1; regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 104011478 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 104009796 RIF1; telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 104015563 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 104009008 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 104016605 PURG; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 104019292 SDE2; LOW QUALITY PROTEIN: protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 104013090 RTFDC1; protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 104009555 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 104020597 TOP1MT; DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 104009903 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 104013961 TOP2B; DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 104021179 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 104015123 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 104009158 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 104009158 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 104013482 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 104008931 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022