+F Repair protein KO
#
DNA Repair and Recombination Proteins - Nematostella vectensis (starlet sea anemone)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 5500624 methylated-DNA--protein-cysteine methyltransferase isoform X2 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5500625 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5520940 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5513968 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 5510799 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 5518846 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 5498754 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D 5516123 deoxyribodipyrimidine photo-lyase isoform X2 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 5501949 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 5514443 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 5520554 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 5520665 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 5521622 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 5520959 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 5518147 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 5508480 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 5498168 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 5509335 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 5502149 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 5504723 probable endonuclease 4 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 5504729 exodeoxyribonuclease isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 5518245 DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 5521437 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 116612988 DNA polymerase zeta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 5509542 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 5499929 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 5503223 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 5513068 DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 5507798 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 5511854 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 5508812 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 5514420 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 116617619 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 5518046 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 5510104 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 5507731 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 116618295 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 5509532 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 5518965 tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 5514910 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 5504195 bifunctional polynucleotide phosphatase/kinase isoform X4 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 5507370 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 5518892 poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 5496732 poly [ADP-ribose] polymerase 2 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 5518592 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 5518843 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 5507588 DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 5504886 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 5509443 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 5507096 cullin-4A K10609 CUL4; cullin 4
F 5518106 cullin-4A K10609 CUL4; cullin 4
F 5514579 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 5511617 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 5508352 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 5508035 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 5512572 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 5517395 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 5502181 DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 5510770 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 5511656 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 5502514 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 5508737 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 5509443 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 5507096 cullin-4A K10609 CUL4; cullin 4
F 5518106 cullin-4A K10609 CUL4; cullin 4
F 5514579 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 5507825 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 116603932 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 5496670 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 5515888 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 5515749 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 5518880 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 5521566 LOW QUALITY PROTEIN: general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 116604769 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 5514226 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 5508886 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 5510514 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 5504341 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 5511895 cyclin-H K06634 CCNH; cyclin H
E 5516024 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 5507561 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116619139 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 5521318 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 116601490 DNA repair protein complementing XP-A cells-like K10847 XPA; DNA-repair protein complementing XP-A cells
E 116616556 LOW QUALITY PROTEIN: DNA excision repair protein ERCC-1-like K10849 ERCC1; DNA excision repair protein ERCC-1
E 5510648 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 5517309 DNA repair protein complementing XP-G cells homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 5510104 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 5508601 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 5506629 cullin-3 K03869 CUL3; cullin 3
E 5507929 cullin-3-B isoform X2 K03869 CUL3; cullin 3
E 5498125 cullin-3-B K03869 CUL3; cullin 3
E 5510354 cullin-5 K10612 CUL5; cullin 5
E 116614223 elongin-C K03872 ELOC; elongin-C
E 5508863 elongin-B K03873 ELOB; elongin-B
E 5519164 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 5502043 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 5509902 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 5510386 DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 5518402 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 5521257 PMS1 protein homolog 1 isoform X2 K10864 PMS1; DNA mismatch repair protein PMS1
E 5511465 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 5502326 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 5505269 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 5518913 DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 5521437 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 116612988 DNA polymerase zeta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 5509542 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 5499929 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 5503223 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 5513068 DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 5507561 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116619139 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 5521318 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 5503757 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 5511026 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 5512672 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 5512514 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 5512879 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 116617619 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 5502496 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 5510104 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 5521708 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 5507797 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 5516263 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 5513388 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5521126 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5507658 BRISC and BRCA1-A complex member 1 isoform X1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 5504437 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 5506613 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 116603519 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116604833 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 5510538 DNA topoisomerase 2-binding protein 1-A isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5504376 uncharacterized protein LOC5504376 isoform X3 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 5507797 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 5516263 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 5513388 nibrin K10867 NBN; nibrin
D BRCA complex
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5506070 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 116604034 DNA repair protein RAD51 homolog B-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 116604034 DNA repair protein RAD51 homolog B-like K04482 RAD51; DNA repair protein RAD51
E 5511987 DNA repair protein RAD51 homolog 2 isoform X2 K10869 RAD51L1; RAD51-like protein 1
E 116614798 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 5496071 DNA repair protein RAD51 homolog 2 K10870 RAD51L2; RAD51-like protein 2
E 116620708 DNA repair protein RAD51 homolog 4-like isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 5509936 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 116612147 DNA repair protein XRCC3-like isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 5522053 DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 5510193 RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 5507503 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 5499561 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 5503590 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 5510660 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 5510937 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 5503798 ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 5501897 Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 5504471 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 116605606 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5504286 LOW QUALITY PROTEIN: uncharacterized protein LOC5504286 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5503631 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 5505346 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 116605606 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5504286 LOW QUALITY PROTEIN: uncharacterized protein LOC5504286 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5516236 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 5511714 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 5502878 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 5510643 uncharacterized protein LOC5510643 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 5507561 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116619139 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 5521318 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 5522251 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 5508551 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 5520467 serine/threonine-protein phosphatase 4 regulatory subunit 2-A K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 5508241 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 5508503 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 5521363 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 5511857 AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 116611609 AP-5 complex subunit sigma-1-like K19024 AP5S1; AP-5 complex subunit sigma-1
E 5520223 AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 116610380 structural maintenance of chromosomes protein 5-like K22803 SMC5; structural maintenance of chromosomes protein 5
E 5509932 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 5519618 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 5518625 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 5520600 non-structural maintenance of chromosomes element 3 homolog isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 5520957 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 5513685 uncharacterized protein LOC5513685 isoform X2 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 5516851 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 5519092 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116618619 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 116604276 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 116614611 DNA repair protein SWI5 homolog isoform X1 K10991 SWI5; DNA repair protein Swi5/Sae3
E 5517453 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 5504005 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 5519269 uncharacterized protein LOC5519269 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 5517074 flap endonuclease GEN-like 2 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 5517657 spatacsin K19026 SPG11; spatacsin
E 5520704 LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 5514628 RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 5522061 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 5506872 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 5506873 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 116611529 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 5519476 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 5504686 uncharacterized protein LOC5504686 K23112 BRAT1; BRCA1-associated ATM activator 1
E 5517981 cilia- and flagella-associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 5513856 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 5504285 zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 5518359 uncharacterized protein LOC5518359 K25771 SWSAP1; ATPase SWSAP1
E 5517224 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 5510043 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 5510360 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 5508548 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 5502996 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
E 5509072 uncharacterized protein C17orf53 homolog K27803 HROB; homologous recombination OB-fold protein
E 116608847 LOW QUALITY PROTEIN: DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 5514320 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
E 5515572 Werner syndrome ATP-dependent helicase homolog isoform X1 K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 5521435 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 5508135 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 5505605 DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 5507797 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 5516263 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 5525240 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 5517242 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 5515507 non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 5507370 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 5507731 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 5514910 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 5520325 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 5510152 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 5504860 uncharacterized protein LOC5504860 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 5508140 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 5511712 LOW QUALITY PROTEIN: structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 5517775 uncharacterized protein LOC5517775 isoform X2 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 5510395 shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 5498431 shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 116603068 shieldin complex subunit 3-like isoform X1 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 5512233 Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 116614317 Fanconi anemia group B protein-like K10889 FANCB; fanconi anemia group B protein
E 116620108 uncharacterized protein LOC116620108 isoform X1 K10890 FANCC; fanconi anemia group C protein
E 5512430 uncharacterized protein LOC5512430 K10892 FANCE; fanconi anemia group E protein
E 5509739 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 5503392 LOW QUALITY PROTEIN: Fanconi anemia group M protein homolog K10896 FANCM; fanconi anemia group M protein
E 5511903 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 5507480 Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 5515184 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 5515189 transcription factor HES-2 K06054 HES1; hairy and enhancer of split 1
E 5515191 uncharacterized protein LOC5515191 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 5515194 transcription factor HES-1-A K06054 HES1; hairy and enhancer of split 1
E 5515199 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 5516994 transcription factor HES-4-A K06054 HES1; hairy and enhancer of split 1
E 5519483 centromere protein S K11511 APITD1; centromere protein S
E 116618546 centromere protein X-like K15360 STRA13; centromere protein X
E 5520025 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
E 5498829 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 116605606 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5504286 LOW QUALITY PROTEIN: uncharacterized protein LOC5504286 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 5516236 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 5511714 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 5502878 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 5510643 uncharacterized protein LOC5510643 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 5507668 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 5501981 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
E 5496743 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 5521771 uncharacterized protein LOC5521771 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5506070 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 116604833 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 116610121 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 116604034 DNA repair protein RAD51 homolog B-like K04482 RAD51; DNA repair protein RAD51
E 116614798 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 5496071 DNA repair protein RAD51 homolog 2 K10870 RAD51L2; RAD51-like protein 2
E 5511524 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 116613971 ubiquitin carboxyl-terminal hydrolase 1-like isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 5513594 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 5500872 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 5510007 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 5499666 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 5521659 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 5511996 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 5520841 E3 ubiquitin-protein ligase rnf8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 5512697 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 5508703 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 5511638 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 5512746 zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 5520058 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 5521708 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 5514019 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 5510511 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 5510686 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 5499735 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 5522291 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 5513863 uncharacterized protein LOC5513863 isoform X2 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 5515050 DNA polymerase nu isoform X2 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 116614310 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 5511158 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 116609537 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 5501210 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 5502219 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 5512277 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 116617619 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 5502996 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 5514928 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 5522005 uncharacterized protein LOC5522005 isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 5521729 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 5503944 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
D 5499076 cell cycle checkpoint protein RAD1 isoform X2 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 5505822 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 5511026 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 5512672 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 5512514 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 5512879 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 5503944 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
D 5499076 cell cycle checkpoint protein RAD1 isoform X2 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 5521315 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 5504595 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 116608844 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 5511524 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 5503357 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 5521968 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 5515305 LOW QUALITY PROTEIN: large proline-rich protein bag6 K23390 BAG6; large proline-rich protein BAG6
D 5519002 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 5520630 Golgi to ER traffic protein 4 homolog A K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 5518488 serine/threonine-protein kinase atr K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 5518921 ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 5507831 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 5501525 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 5502980 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 5516550 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 5511488 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 5514720 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 5514040 14-3-3 protein beta/alpha-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 5514753 14-3-3-like protein GF14 epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 116619473 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 5513135 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 5515635 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 5522233 mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 5521420 STE20-like serine/threonine-protein kinase isoform X2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 5521998 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 5522109 serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 5518329 serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 5499678 serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 5508516 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 5517858 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 5507497 KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 5502322 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 5507328 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116619609 abscission/NoCut checkpoint regulator-like K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 5514934 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 5504176 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 5510166 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 5517698 myb-binding protein 1A-like protein isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 5521592 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
D 5498193 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 5509988 three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 5515001 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 5502474 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 5510136 endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 116617952 DNA annealing helicase and endonuclease ZRANB3-like isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 5510402 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 5516815 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 5518229 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 5519569 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 5509907 cell division cycle 5-related protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 5511135 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 5511286 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 5504525 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 5502555 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 5509545 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 5506782 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 5499025 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 5518664 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 5522088 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 116619148 ribonucleoside-diphosphate reductase subunit M2-like isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 5513934 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 5513935 ribonucleoside-diphosphate reductase subunit M2 B isoform X2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 5500624 methylated-DNA--protein-cysteine methyltransferase isoform X2 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5500625 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5520940 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 5498754 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D 5516123 deoxyribodipyrimidine photo-lyase isoform X2 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 5501949 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 5521622 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 5520554 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 5520665 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 5520959 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 5502149 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E 5495615 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 5495615 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E 5509274 single-stranded DNA-binding protein 1-A, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F 116618728 DNA gyrase subunit A-like K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
F 5500439 putative ATP-dependent DNA helicase Q1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 116603394 mediator of RNA polymerase II transcription subunit 34-like K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 5509274 single-stranded DNA-binding protein 1-A, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 5502555 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 5518664 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024