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Transfer RNA Biogenesis - Ovis aries (sheep)
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D 101106598 POP1; ribonucleases P/MRP protein subunit POP1 K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D 101106353 POP4; ribonuclease P protein subunit p29 isoform X2 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D 101119586 POP5; ribonuclease P/MRP protein subunit POP5 K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D 101103201 RPP30; ribonuclease P protein subunit p30 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D 101108347 RPP21; ribonuclease P protein subunit p21 isoform X1 K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
D 114108649 RPP14; ribonuclease P protein subunit p14 isoform X1 K14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
D 101118764 ribonuclease P protein subunit p14-like K14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
D 101102363 POP7; ribonuclease P protein subunit p20 isoform X2 K14527 RPP20; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
D 101121490 RPP25L; ribonuclease P protein subunit p25-like protein K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 101107390 RPP25; ribonuclease P protein subunit p25 K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 101109468 RPP38; ribonuclease P protein subunit p38 K14523 RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
D 101109398 RPP40; ribonuclease P protein subunit p40 isoform X1 K14530 RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D 101104921 ELAC2; zinc phosphodiesterase ELAC protein 2 isoform X2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 101118238 ELAC1; zinc phosphodiesterase ELAC protein 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 101114785 RNASET2; ribonuclease T2 isoform X2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
D 101109584 PTCD1; pentatricopeptide repeat-containing protein 1, mitochondrial K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
C CCA adding factors
D 101111583 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
D 101104017 TSEN2; tRNA-splicing endonuclease subunit Sen2 isoform X2 K15322 TSEN2; tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
D 101107041 TSEN34; tRNA-splicing endonuclease subunit Sen34 isoform X1 K15323 TSEN34; tRNA-splicing endonuclease subunit Sen34 [EC:4.6.1.16]
D 101107455 TSEN15; tRNA-splicing endonuclease subunit Sen15 isoform X2 K15324 TSEN15; tRNA-splicing endonuclease subunit Sen15
D 101120680 TSEN54; tRNA-splicing endonuclease subunit Sen54 isoform X2 K15326 TSEN54; tRNA-splicing endonuclease subunit Sen54
C tRNA splicing ligase complex
D 101118007 RTCB; RNA-splicing ligase RtcB homolog isoform X2 K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D 101123107 C3H2orf49; ashwin K15432 ASW; ashwin
D 101121523 RTRAF; RNA transcription, translation and transport factor protein K15433 CGI99; RLL motif containing protein 1
D 101105253 FAM98B; protein FAM98B K15434 FAM98B; protein FAM98B
D 105603612 LOW QUALITY PROTEIN: protein FAM98B K15434 FAM98B; protein FAM98B
D 101122091 DDX1; ATP-dependent RNA helicase DDX1 K13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]
D 101112630 ZBTB8OS; protein archease isoform X1 K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
D 101122992 TRPT1; tRNA 2'-phosphotransferase 1 isoform X1 K10669 TRPT1; 2'-phosphotransferase [EC:2.7.1.160]
B tRNA transport factors
C tRNA export factors
D 100302079 RAN; GTP-binding nuclear protein Ran K07936 RAN; GTP-binding nuclear protein Ran
D 105609617 GTP-binding nuclear protein Ran-like K07936 RAN; GTP-binding nuclear protein Ran
D 101115626 GTP-binding nuclear protein Ran-like K07936 RAN; GTP-binding nuclear protein Ran
D 105601843 LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran K07936 RAN; GTP-binding nuclear protein Ran
D 105605158 LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like K07936 RAN; GTP-binding nuclear protein Ran
D 101111086 XPOT; exportin-T isoform X2 K14288 XPOT; exportin-T
D 101118599 XPO1; exportin-1 isoform X1 K14290 XPO1; exportin-1
D 101115071 XPO5; exportin-5 isoform X2 K14289 XPO5; exportin-5
D 101110773 LOW QUALITY PROTEIN: elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 101109898 EEF1A2; elongation factor 1-alpha 2 K03231 EEF1A; elongation factor 1-alpha
D 101102857 LOW QUALITY PROTEIN: elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 100125610 LOW QUALITY PROTEIN: elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 101120236 elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 101114018 elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 100101228 EEF1A1; elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 101119944 elongation factor 1-alpha 2-like K03231 EEF1A; elongation factor 1-alpha
D 101103351 elongation factor 1-alpha 1-like K03231 EEF1A; elongation factor 1-alpha
D 101111229 elongation factor 1-alpha 1-like K03231 EEF1A; elongation factor 1-alpha
D 101117638 elongation factor 1-alpha 1-like K03231 EEF1A; elongation factor 1-alpha
D 101117816 elongation factor 1-alpha 1-like K03231 EEF1A; elongation factor 1-alpha
D 105601979 elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 101122739 SCYL1; N-terminal kinase-like protein isoform X1 K08876 SCYL1; SCY1-like protein 1
D 101122185 GTPBP1; GTP-binding protein 1 isoform X1 K24887 GTPBP1; GTP-binding protein 1
C tRNA import factors
D 101113231 TNPO3; transportin-3 isoform X1 K15436 TRPO3; transportin-3
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 101104590 EPRS1; bifunctional glutamate/proline--tRNA ligase isoform X2 K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]
D 101117387 EARS2; probable glutamate--tRNA ligase, mitochondrial isoform X2 K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 101122641 PARS2; probable proline--tRNA ligase, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D 101122877 IARS2; isoleucine--tRNA ligase, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 101109674 IARS1; isoleucine--tRNA ligase, cytoplasmic isoform X1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 101112134 LARS1; leucine--tRNA ligase, cytoplasmic isoform X2 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 101119512 LARS2; leucine--tRNA ligase, mitochondrial isoform X2 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 105605606 leucine--tRNA ligase, cytoplasmic K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 101121335 MARS1; methionine--tRNA ligase, cytoplasmic isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 114113204 MARS2; methionine--tRNA ligase, mitochondrial K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 101106974 QARS1; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 101117669 RARS1; arginine--tRNA ligase, cytoplasmic K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 101112906 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X2 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 101118293 KARS1; lysine--tRNA ligase isoform X3 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 100302097 DARS1; aspartate--tRNA ligase, cytoplasmic K22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 101114203 DARS2; aspartate--tRNA ligase, mitochondrial isoform X1 K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 101123184 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 101121350 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 105616104 aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 114112144 aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 100302342 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2 K15438 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2
D 100135689 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1 isoform X1 K15439 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1
C Other AARSs
D 101114460 AARS1; alanine--tRNA ligase, cytoplasmic isoform X2 K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 101114732 AARS2; alanine--tRNA ligase, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 678684 NARS1; asparagine--tRNA ligase, cytoplasmic isoform X1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 101108871 NARS2; probable asparagine--tRNA ligase, mitochondrial isoform X6 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 101101977 GARS1; glycine--tRNA ligase isoform X1 K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D 101105117 TARS2; threonine--tRNA ligase, mitochondrial isoform X6 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101111581 TARS3; threonine--tRNA ligase 2, cytoplasmic isoform X2 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101114306 TARS1; threonine--tRNA ligase 1, cytoplasmic isoform X2 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101113878 SARS2; serine--tRNA ligase, mitochondrial isoform X1 K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100135438 SARS1; serine--tRNA ligase, cytoplasmic K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 101116327 CARS2; probable cysteine--tRNA ligase, mitochondrial isoform X2 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 101119091 CARS1; cysteine--tRNA ligase, cytoplasmic isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 101102849 VARS1; valine--tRNA ligase isoform X3 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 101106890 VARS2; valine--tRNA ligase, mitochondrial isoform X1 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 101121599 histidine--tRNA ligase, mitochondrial isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 101120491 HARS1; histidine--tRNA ligase, cytoplasmic isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 101120705 FARS2; phenylalanine--tRNA ligase, mitochondrial isoform X1 K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 101105073 FARSA; phenylalanine--tRNA ligase alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 101119961 FARSB; phenylalanine--tRNA ligase beta subunit isoform X1 K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 101111862 YARS1; tyrosine--tRNA ligase, cytoplasmic K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101104981 YARS2; tyrosine--tRNA ligase, mitochondrial K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101102763 tyrosine--tRNA ligase, cytoplasmic-like K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101110551 WARS2; tryptophan--tRNA ligase, mitochondrial isoform X1 K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 101123073 WARS1; tryptophan--tRNA ligase, cytoplasmic K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D 101122541 DTD1; D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 105603710 D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 101116351 DTD2; D-aminoacyl-tRNA deacylase 2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 105612785 D-aminoacyl-tRNA deacylase 1-like K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 101107295 AARSD1; alanyl-tRNA editing protein Aarsd1 isoform X2 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
C AARS associated factors
D 101102703 TRNAU1AP; tRNA selenocysteine 1-associated protein 1 isoform X2 K25102 TRNAU1AP; tRNA selenocysteine 1-associated protein 1
D 101112491 adenosine 5'-monophosphoramidase HINT1 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 101104062 HINT1; adenosine 5'-monophosphoramidase HINT1 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 105603546 adenosine 5'-monophosphoramidase HINT1-like K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 114111378 adenosine 5'-monophosphoramidase HINT1-like K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 114115721 adenosine 5'-monophosphoramidase HINT1-like K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 114118461 adenosine 5'-monophosphoramidase HINT1-like K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 101112539 HINT2; adenosine 5'-monophosphoramidase HINT2 isoform X2 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 101122605 HINT3; adenosine 5'-monophosphoramidase HINT3 K12150 HINT3; adenosine 5'-monophosphoramidase HINT3 [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
D 101118042 ADAT1; tRNA-specific adenosine deaminase 1 isoform X8 K15440 TAD1; tRNA-specific adenosine deaminase 1 [EC:3.5.4.34]
D 101117852 ADAT2; tRNA-specific adenosine deaminase 2 isoform X2 K15441 TAD2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]
D 101117762 ADAT3; probable inactive tRNA-specific adenosine deaminase-like protein 3 K15442 TAD3; tRNA-specific adenosine deaminase 3
C Dihydorouridine synthases
D 101111894 DUS1L; tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1 K05542 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88]
D 101117185 DUS2; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like K05543 DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]
D 101110760 DUS3L; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1 K05544 DUS3; tRNA-dihydrouridine synthase 3 [EC:1.3.1.89]
D 101104143 DUS4L; tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X1 K05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]
C Methylthiotransferase
D 101121212 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2 K15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5]
C Methyltransferases
D 101121680 TRMT1; tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2 K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D 101122385 TRMT2A; tRNA (uracil-5-)-methyltransferase homolog A isoform X1 K15332 TRMT2A; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.-]
D 101119702 TRMT2B; LOW QUALITY PROTEIN: tRNA (uracil-5-)-methyltransferase homolog B K15331 TRMT2B; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D 101116202 TARBP1; probable methyltransferase TARBP1 isoform X1 K15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]
D 101106968 NSUN2; RNA cytosine C(5)-methyltransferase NSUN2 isoform X2 K15335 NSUN2; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]
D 101102108 NSUN3; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial K21969 NSUN3; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.-]
D 101113514 NSUN6; tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1 K21971 NSUN6; methyltransferase NSUN6 [EC:2.1.1.-]
D 101105080 TRMT5; tRNA (guanine(37)-N1)-methyltransferase K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D 101102182 TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 101102217 TRMT61B; tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 101116247 TRMT6; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1 K03256 TRM6; tRNA (adenine58-N1)-methyltransferase non-catalytic subunit
D 101113204 FTSJ1; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1 K14864 FTSJ1; tRNA (cytidine32/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]
D 101115780 METTL1; tRNA (guanine-N(7)-)-methyltransferase isoform X1 K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 101122450 METTL2A; tRNA N(3)-methylcytidine methyltransferase METTL2A isoform X1 K24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]
D 101118750 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1 K00599 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]
D 101104088 ALKBH8; alkylated DNA repair protein alkB homolog 8 K10770 ALKBH8; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]
D 101111193 TRMT10A; tRNA methyltransferase 10 homolog A K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 101106656 TRMT10B; tRNA methyltransferase 10 homolog B K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 101117511 TRMT11; tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1 K15430 TRM11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
D 101112862 TRMT13; tRNA:m(4)X modification enzyme TRM13 homolog isoform X1 K15446 TRM13; tRNA:m4X modification enzyme [EC:2.1.1.225]
D 101120164 TRMT44; probable tRNA (uracil-O(2)-)-methyltransferase isoform X1 K15447 TRM44; tRNASer (uridine44-2'-O)-methyltransferase [EC:2.1.1.211]
D 101121998 WDR4; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1 K15443 TRM82; tRNA (guanine-N(7)-)-methyltransferase subunit TRM82
D 101103769 TRMT112; multifunctional methyltransferase subunit TRM112-like protein K15448 TRM112; multifunctional methyltransferase subunit TRM112
D 101110692 TRDMT1; tRNA (cytosine(38)-C(5))-methyltransferase isoform X2 K15336 TRDMT1; tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204]
D 101103452 TRMO; tRNA (adenine(37)-N6)-methyltransferase isoform X1 K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D 101111335 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform X1 K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D 101106695 TRMT12; tRNA wybutosine-synthesizing protein 2 homolog K07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
D 101107062 TYW3; tRNA wybutosine-synthesizing protein 3 homolog isoform X1 K15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]
D 101110182 LCMT2; tRNA wybutosine-synthesizing protein 4 K15451 PPM2; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]
D 101103128 TYW5; tRNA wybutosine-synthesizing protein 5 isoform X1 K18066 TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]
D 101122013 BCDIN3D; RNA 5'-monophosphate methyltransferase K25191 BCDIN3D; RNA 5'-monophosphate methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 100302353 PUS1; pseudouridylate synthase 1 homolog K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 101112522 PUS3; tRNA pseudouridine(38/39) synthase K01855 PUS3; tRNA pseudouridine38/39 synthase [EC:5.4.99.45]
D 101119599 TRUB1; pseudouridylate synthase TRUB1 isoform X2 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 101115198 PUS7L; pseudouridylate synthase PUS7L isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 101122688 PUS7; pseudouridylate synthase 7 homolog isoform X2 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 101118346 PUS10; tRNA pseudouridine synthase Pus10 isoform X4 K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
D 101118235 RPUSD4; pseudouridylate synthase RPUSD4, mitochondrial K22538 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4 [EC:5.4.99.-]
C Thiolation factors
D 101110834 TRMU; mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1 K21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D 105601981 cytoplasmic tRNA 2-thiolation protein 1 K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D 105602080 cytoplasmic tRNA 2-thiolation protein 1 K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D 101106960 CTU2; cytoplasmic tRNA 2-thiolation protein 2 isoform X1 K14169 CTU2; cytoplasmic tRNA 2-thiolation protein 2
D 101118123 NFS1; cysteine desulfurase isoform X2 K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D 101120152 URM1; ubiquitin-related modifier 1 isoform X2 K12161 URM1; ubiquitin related modifier 1
D 101123226 MOCS3; adenylyltransferase and sulfurtransferase MOCS3 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KEOPS/EKC complex
D 101118291 TP53RK; EKC/KEOPS complex subunit TP53RK K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 101115213 OSGEP; tRNA N6-adenosine threonylcarbamoyltransferase K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 101113042 OSGEPL1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 101113315 TPRKB; EKC/KEOPS complex subunit TPRKB K15901 TPRKB; EKC/KEOPS complex subunit TPRKB/CGI121
D 101119118 LAGE3; EKC/KEOPS complex subunit LAGE3 K15902 LAGE3; EKC/KEOPS complex subunit LAGE3/PCC1
D 101115656 GON7; EKC/KEOPS complex subunit GON7 K15903 GON7; EKC/KEOPS complex subunit GON7
C Elongator complex
D 101115680 ELP1; elongator complex protein 1 K11373 ELP1; elongator complex protein 1
D 101107058 ELP2; elongator complex protein 2 isoform X1 K11374 ELP2; elongator complex protein 2
D 101115183 ELP3; elongator complex protein 3 isoform X2 K07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
D 101119754 ELP4; elongator complex protein 4 K11375 ELP4; elongator complex protein 4
D 101117858 ELP5; elongator complex protein 5 isoform X1 K11376 ELP5; elongator complex protein 5
D 101113703 ELP6; elongator complex protein 6 K11377 ELP6; elongator complex protein 6
C Elongator related proteins
D 101120039 DPH3; diphthamide biosynthesis protein 3 isoform X1 K15455 DPH3; diphthamide biosynthesis protein 3
D 105603371 diphthamide biosynthesis protein 3-like K15455 DPH3; diphthamide biosynthesis protein 3
D 114116977 diphthamide biosynthesis protein 3-like K15455 DPH3; diphthamide biosynthesis protein 3
D 101113710 KTI12; protein KTI12 homolog K15456 KTI12; protein KTI12
C Other tRNA modification factors
D 101119101 YRDC; threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D 101120119 TRIT1; tRNA dimethylallyltransferase isoform X1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 101112132 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 101109280 MTO1; protein MTO1 homolog, mitochondrial K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 101119045 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit 1 K00777 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit [EC:2.4.2.64]
D 101102525 QTRT2; queuine tRNA-ribosyltransferase accessory subunit 2 K15407 QTRT2; queuine tRNA-ribosyltransferase accessory subunit
D 101107459 SEPHS1; selenide, water dikinase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 101122245 SEPHS2; selenide, water dikinase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 101121057 THUMPD1; THUMP domain-containing protein 1 isoform X2 K06963 TAN1; tRNA acetyltransferase TAN1
D 101113674 THG1L; probable tRNA(His) guanylyltransferase isoform X1 K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
D 101110286 ATE1; arginyl-tRNA--protein transferase 1 isoform X2 K00685 ATE1; arginyl-tRNA---protein transferase [EC:2.3.2.8]
D 101108782 DALRD3; DALR anticodon-binding domain-containing protein 3 K24973 DALRD3; DALR anticodon-binding domain-containing protein 3
B tRNA degradation factors
C TRAMP complex
D 101116340 TENT4B; terminal nucleotidyltransferase 4B isoform X1 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 101106461 TENT4A; terminal nucleotidyltransferase 4A isoform X1 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 101108453 ZCCHC7; zinc finger CCHC domain-containing protein 7 isoform X1 K12597 AIR1_2; protein AIR1/2
D 101115066 MTREX; exosome RNA helicase MTR4 isoform X2 K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
C Rapid tRNA decay (RTD) pathway factors
D 101106821 XRN1; 5'-3' exoribonuclease 1 isoform X2 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D 101102410 XRN2; 5'-3' exoribonuclease 2 isoform X6 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D 114110582 LOW QUALITY PROTEIN: 5'-3' exoribonuclease 2-like K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D 101104841 BPNT1; 3'(2'),5'-bisphosphate nucleotidase 1 isoform X2 K01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
D 105615654 LOW QUALITY PROTEIN: angiogenin-1-like K16631 ANG; angiogenin [EC:3.1.27.-]
D 101113335 angiogenin-1-like K16631 ANG; angiogenin [EC:3.1.27.-]
D 101102441 IFIT5; interferon-induced protein with tetratricopeptide repeats 5 K24850 IFIT5; interferon-induced protein with tetratricopeptide repeats 5
#
AProkaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D 101104921 ELAC2; zinc phosphodiesterase ELAC protein 2 isoform X2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 101118238 ELAC1; zinc phosphodiesterase ELAC protein 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 101114785 RNASET2; ribonuclease T2 isoform X2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
C CCA adding factors
D 101111583 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D 101118007 RTCB; RNA-splicing ligase RtcB homolog isoform X2 K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 101112134 LARS1; leucine--tRNA ligase, cytoplasmic isoform X2 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 101119512 LARS2; leucine--tRNA ligase, mitochondrial isoform X2 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 105605606 leucine--tRNA ligase, cytoplasmic K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 101122641 PARS2; probable proline--tRNA ligase, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D 101111862 YARS1; tyrosine--tRNA ligase, cytoplasmic K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101104981 YARS2; tyrosine--tRNA ligase, mitochondrial K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101102763 tyrosine--tRNA ligase, cytoplasmic-like K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 101110551 WARS2; tryptophan--tRNA ligase, mitochondrial isoform X1 K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 101123073 WARS1; tryptophan--tRNA ligase, cytoplasmic K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 101105117 TARS2; threonine--tRNA ligase, mitochondrial isoform X6 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101111581 TARS3; threonine--tRNA ligase 2, cytoplasmic isoform X2 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101114306 TARS1; threonine--tRNA ligase 1, cytoplasmic isoform X2 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 101122877 IARS2; isoleucine--tRNA ligase, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 101109674 IARS1; isoleucine--tRNA ligase, cytoplasmic isoform X1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 101118293 KARS1; lysine--tRNA ligase isoform X3 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 101114460 AARS1; alanine--tRNA ligase, cytoplasmic isoform X2 K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 101114732 AARS2; alanine--tRNA ligase, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 101102849 VARS1; valine--tRNA ligase isoform X3 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 101106890 VARS2; valine--tRNA ligase, mitochondrial isoform X1 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 101121335 MARS1; methionine--tRNA ligase, cytoplasmic isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 114113204 MARS2; methionine--tRNA ligase, mitochondrial K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 101113878 SARS2; serine--tRNA ligase, mitochondrial isoform X1 K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100135438 SARS1; serine--tRNA ligase, cytoplasmic K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 101114203 DARS2; aspartate--tRNA ligase, mitochondrial isoform X1 K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 101116327 CARS2; probable cysteine--tRNA ligase, mitochondrial isoform X2 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 101119091 CARS1; cysteine--tRNA ligase, cytoplasmic isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 101117387 EARS2; probable glutamate--tRNA ligase, mitochondrial isoform X2 K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 101106974 QARS1; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 101117669 RARS1; arginine--tRNA ligase, cytoplasmic K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 101112906 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X2 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 101120705 FARS2; phenylalanine--tRNA ligase, mitochondrial isoform X1 K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 101105073 FARSA; phenylalanine--tRNA ligase alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 101119961 FARSB; phenylalanine--tRNA ligase beta subunit isoform X1 K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 101121599 histidine--tRNA ligase, mitochondrial isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 101120491 HARS1; histidine--tRNA ligase, cytoplasmic isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 678684 NARS1; asparagine--tRNA ligase, cytoplasmic isoform X1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 101108871 NARS2; probable asparagine--tRNA ligase, mitochondrial isoform X6 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
C Trans-editing factors
D 101122541 DTD1; D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 105603710 D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 101116351 DTD2; D-aminoacyl-tRNA deacylase 2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 105612785 D-aminoacyl-tRNA deacylase 1-like K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 101107295 AARSD1; alanyl-tRNA editing protein Aarsd1 isoform X2 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferases
C Methyltransferases
D 101115780 METTL1; tRNA (guanine-N(7)-)-methyltransferase isoform X1 K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 101112132 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 101103452 TRMO; tRNA (adenine(37)-N6)-methyltransferase isoform X1 K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 100302353 PUS1; pseudouridylate synthase 1 homolog K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 101119599 TRUB1; pseudouridylate synthase TRUB1 isoform X2 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 101115198 PUS7L; pseudouridylate synthase PUS7L isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 101122688 PUS7; pseudouridylate synthase 7 homolog isoform X2 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D 101118123 NFS1; cysteine desulfurase isoform X2 K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
D 101118291 TP53RK; EKC/KEOPS complex subunit TP53RK K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 101115213 OSGEP; tRNA N6-adenosine threonylcarbamoyltransferase K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 101113042 OSGEPL1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
C Other tRNA modification factors
D 101109280 MTO1; protein MTO1 homolog, mitochondrial K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 101120119 TRIT1; tRNA dimethylallyltransferase isoform X1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 101108950 PTS; 6-pyruvoyl tetrahydrobiopterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D 101107459 SEPHS1; selenide, water dikinase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 101122245 SEPHS2; selenide, water dikinase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 101119101 YRDC; threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
C 101120906 PNPT1; polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 101116513 ISG20; interferon-stimulated gene 20 kDa protein K12579 ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024