+D Protein KO
#
Membrane Trafficking - Ogataea parapolymorpha
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
D HPODL_03379 Bud-specific protein with a potential role in membrane trafficking K28063 ESYT; extended synaptotagmin
D HPODL_04752 hypothetical protein K28063 ESYT; extended synaptotagmin
C Septins
D HPODL_03107 Cell division control protein 3 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D HPODL_03523 hypothetical protein K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D HPODL_03990 hypothetical protein K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D HPODL_00321 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D HPODL_02455 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D HPODL_02900 phosphatidylinositol 4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D HPODL_02636 p21-activated kinase 1 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D HPODL_02950 Serine/threonine protein kinase K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D HPODL_04575 putative protein serine/threonine kinase expressed at the end of meiosis K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D HPODL_00273 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D HPODL_02548 KIN2 Serine/threonine protein kinase involved in regulation of exocytosis K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D HPODL_00181 N-myristoylated calcium-binding protein that may have a role in intracellular signaling K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D HPODL_00120 Ras-related protein SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D HPODL_01653 calmodulin K02183 CALM; calmodulin
D HPODL_03961 hypothetical protein K02183 CALM; calmodulin
D HPODL_05110 hypothetical protein K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D HPODL_03120 hypothetical protein K15292 STXBP1; syntaxin-binding protein 1
D HPODL_00317 hypothetical protein K08518 STXBP5; syntaxin-binding protein 5
D HPODL_02025 hypothetical protein K19952 RABIF; guanine nucleotide exchange factor
D HPODL_04556 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D HPODL_04415 Ypt/Rab GTPase activating protein K19953 GRTP1; TBC1 domain family member 6
D HPODL_02870 GTPase-activating protein GYP2 K19951 TBC1D8_9; TBC1 domain family member 8/9
D HPODL_00015 Peroxisomal membrane protein PEX5 K13342 PEX5; peroxin-5
D HPODL_00303 Rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D HPODL_05326 Alpha subunit of Type II geranylgeranyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D HPODL_01200 Geranylgeranyl transferase type-2 subunit beta K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D HPODL_04653 Regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
C Rho GTPases
D HPODL_00427 Cell division control protein 42 K04393 CDC42; cell division control protein 42
D HPODL_02947 Ras-related C3 botulinum toxin substrate 1 K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D HPODL_00541 Exocyst complex component SEC3 K19983 EXOC1; exocyst complex component 1
D HPODL_01056 hypothetical protein K17637 EXOC2; exocyst complex component 2
D HPODL_04634 Exocyst complex component SEC6 K06110 EXOC3; exocyst complex component 3
D HPODL_03660 exocyst complex component 4 K06111 EXOC4; exocyst complex component 4
D HPODL_03385 Exocyst complex component SEC10 K19984 EXOC5; exocyst complex component 5
D HPODL_02931 Exocyst complex component SEC15 K19985 EXOC6; exocyst complex component 6
D HPODL_00656 Exocyst complex protein EXO70 K07195 EXOC7; exocyst complex component 7
D HPODL_05113 hypothetical protein K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D HPODL_01608 Tropomyosin K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D HPODL_01704 Chitin biosynthesis protein CHS5 K19877 CHS5; chitin biosynthesis protein CHS5
D HPODL_02170 Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms th K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
D HPODL_02241 hypothetical protein K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D HPODL_04615 hypothetical protein K19992 MSO1; protein MSO1
D HPODL_04620 SFH5 putative phosphatidylinositol transfer protein K19996 SFH5; phosphatidylinositol transfer protein SFH5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D HPODL_02092 Conserved hypothetical membrane protein K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
C Stx-TGN / EE
D HPODL_04671 T-SNARE affecting a late Golgi compartment protein 2 K08489 STX16; syntaxin 16
C Stx-cisGolgi
D HPODL_02971 Integral membrane protein SED5 K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
D HPODL_01859 hypothetical protein K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D HPODL_04486 Protein involved in cis-Golgi membrane traffic K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D HPODL_04235 hypothetical protein K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D HPODL_05341 hypothetical protein K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D HPODL_03087 hypothetical protein K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
D HPODL_02154 Conserved hypothetical membrane protein K08499 TLG1; member of the syntaxin family of t-SNAREs
C STX8
D HPODL_01208 hypothetical protein K08501 STX8; syntaxin 8
D HPODL_04306 hypothetical protein K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D HPODL_04473 Protein transport protein BET1 K08504 BET1; blocked early in transport 1
C Sft1
D HPODL_01853 hypothetical protein K08505 SFT1; protein transport protein SFT1
C Syp7
C Use1
D HPODL_02005 putative membrane protein K08507 USE1; unconventional SNARE in the endoplasmic reticulum protein 1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D HPODL_01293 Protein transport protein SEC9 K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D HPODL_00297 synaptobrevin vamp-like protein K08513 VAMP4; vesicle-associated membrane protein 4
D HPODL_03330 Vesicle-associated membrane protein 712 K08515 VAMP7; vesicle-associated membrane protein 7
C Ykt6
D HPODL_04891 SNARE protein YKT6, synaptobrevin/VAMP syperfamily K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D HPODL_04113 Protein transport protein SEC22 K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D HPODL_00317 hypothetical protein K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D HPODL_03120 hypothetical protein K15292 STXBP1; syntaxin-binding protein 1
D HPODL_05046 Protein SLY1 K19998 SCFD1; sec1 family domain-containing protein 1
C Palmitoyltransferases
D HPODL_01827 Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D HPODL_01514 hypothetical protein K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D HPODL_04246 Vesicular-fusion protein SEC18 K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D HPODL_05189 Vesicular-fusion protein SEC17 K15296 NAPA; alpha-soluble NSF attachment protein
D HPODL_01247 Sorting nexin-4 K17919 SNX4; sorting nexin-4
D HPODL_03229 Sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D HPODL_04328 Sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D HPODL_00959 Vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D HPODL_02504 Cell division control protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
D HPODL_00856 UBX (ubiquitin regulatory X) domain-containing protein K14012 NSFL1C; UBX domain-containing protein 1
D HPODL_00288 Protein vts1 K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D HPODL_00829 Clathrin heavy chain K04646 CLTC; clathrin heavy chain
C Dynamin
D HPODL_01543 Dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D HPODL_04273 AP-2 complex subunit alpha K11824 AP2A; AP-2 complex subunit alpha
D HPODL_04561 putative beta-adaptin (clathrin assembly protein complex 2 large beta chain) K11825 AP2B1; AP-2 complex subunit beta-1
D HPODL_00028 AP-1 complex subunit mu-1 K11826 AP2M1; AP-2 complex subunit mu-1
D HPODL_01074 Small subunit of the clathrin-associated adaptor complex AP-2 K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D HPODL_02300 hypothetical protein K20042 FCHO; F-BAR domain only protein
D HPODL_00638 hypothetical protein K12471 EPN; epsin
D HPODL_04747 putative epsin K12471 EPN; epsin
D HPODL_05219 hypothetical protein K12471 EPN; epsin
D HPODL_04107 putative calcium-binding protein K12472 EPS15; epidermal growth factor receptor substrate 15
D HPODL_05008 Clathrin coat assembly protein K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D HPODL_00269 hypothetical protein K12562 AMPH; amphiphysin
D HPODL_00423 Reduced viability upon starvation protein 167 K12562 AMPH; amphiphysin
D HPODL_01133 Actin-associated protein K12562 AMPH; amphiphysin
D HPODL_04266 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D HPODL_02489 hypothetical protein K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D HPODL_03394 Actin cytoskeleton-regulatory complex protein END3 K20048 END3; actin cytoskeleton-regulatory complex protein END3
D HPODL_02193 Heat shock protein 70 2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D HPODL_02202 Heat shock protein SSB1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D HPODL_02450 Heat shock protein 70 1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D HPODL_02900 phosphatidylinositol 4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D HPODL_03915 Protein LDB19 K20059 LDB19; arrestin-related trafficking adapter 1
D HPODL_00480 Protein ECM21 K20060 ECM21; arrestin-related trafficking adapter 2/8
D HPODL_00655 hypothetical protein K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D HPODL_04056 Protein ROG3 K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D HPODL_01150 pH-response regulator protein palF/RIM8 K20063 RIM8; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D HPODL_04556 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D HPODL_02226 phosphoinositide phosphatase K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D HPODL_02630 Polyphosphatidylinositol phosphatase INP53 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D HPODL_04854 Protein serine/threonine kinase K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D HPODL_00103 Protein kinase-like protein SCY1 K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D HPODL_01282 E3 ubiquitin-protein ligase pub1 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C Others
D HPODL_04014 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization K20040 HIP1R; huntingtin-interacting protein 1-related protein
D HPODL_01575 Calnexin K08054 CANX; calnexin
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D HPODL_01543 Dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D HPODL_03651 Elongation factor 2 (EF-2), also encoded by EFT1 K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D HPODL_00427 Cell division control protein 42 K04393 CDC42; cell division control protein 42
D HPODL_04777 ADP-ribosylation factor 1 K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D HPODL_02540 ADP-ribosylation factor 6 K07941 ARF6; ADP-ribosylation factor 6
D HPODL_02947 Ras-related C3 botulinum toxin substrate 1 K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C RhoA-dependent endocytosis
D HPODL_03673 GTP-binding protein RHO1 K04513 RHOA; Ras homolog gene family, member A
D HPODL_04158 GTP-binding protein RHO1 K04513 RHOA; Ras homolog gene family, member A
D HPODL_01543 Dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D HPODL_04585 Myosin-5 K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D HPODL_00707 GTP-binding protein K07827 KRAS; GTPase KRas
D HPODL_02947 Ras-related C3 botulinum toxin substrate 1 K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D HPODL_00427 Cell division control protein 42 K04393 CDC42; cell division control protein 42
C Kinases
D HPODL_03612 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D HPODL_04672 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D HPODL_02636 p21-activated kinase 1 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D HPODL_00321 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D HPODL_01860 sorting nexin 3 K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D HPODL_00269 hypothetical protein K12562 AMPH; amphiphysin
D HPODL_00423 Reduced viability upon starvation protein 167 K12562 AMPH; amphiphysin
D HPODL_01133 Actin-associated protein K12562 AMPH; amphiphysin
D HPODL_04066 Reduced viability upon starvation protein 161 K20120 BIN3; bridging integrator 3
D HPODL_04603 Reduced viability upon starvation protein 161 K20120 BIN3; bridging integrator 3
C F-BAR proteins
D HPODL_02551 SH3 domain protein implicated in the regulation of actin polymerization K20121 FNBP1; formin-binding protein 1
D HPODL_02300 hypothetical protein K20042 FCHO; F-BAR domain only protein
D HPODL_00395 RHO GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D HPODL_03654 GTP-binding protein ypt5 K07888 RAB5B; Ras-related protein Rab-5B
C Rab associated proteins
D HPODL_00499 Vacuolar protein sorting-associated protein 9a K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D HPODL_04556 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D HPODL_03612 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D HPODL_03479 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D HPODL_01865 Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
D HPODL_04777 ADP-ribosylation factor 1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D HPODL_02540 ADP-ribosylation factor 6 K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D HPODL_04380 ultradian oscillation regulator K12486 SMAP; stromal membrane-associated protein
D HPODL_04405 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D HPODL_02029 STT4 phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D HPODL_01904 Protein EFR3 K21842 EFR3; protein EFR3
D HPODL_04090 hypothetical protein K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D HPODL_03654 GTP-binding protein ypt5 K07888 RAB5B; Ras-related protein Rab-5B
D HPODL_03870 Ras-related protein Rab7 K07897 RAB7A; Ras-related protein Rab-7A
D HPODL_04813 GTPase K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D HPODL_01941 Endosomal subunit of membrane-associated retromer complex required for retrograde transport K18468 VPS35; vacuolar protein sorting-associated protein 35
D HPODL_00996 Vacuolar protein sorting-associated protein 29 K18467 VPS29; vacuolar protein sorting-associated protein 29
D HPODL_05258 Vacuolar protein sorting-associated protein 26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
C FERRY complex
C Rab associated proteins
D HPODL_03612 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D HPODL_03360 Proteasome subunit alpha type-4 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D HPODL_01330 hypothetical protein K18469 TBC1D5; TBC1 domain family member 5
D HPODL_03158 GTPase-activating protein GYP7 K20168 TBC1D15; TBC1 domain family member 15
D HPODL_00303 Rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D HPODL_05326 Alpha subunit of Type II geranylgeranyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D HPODL_01200 Geranylgeranyl transferase type-2 subunit beta K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D HPODL_00959 Vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
D HPODL_00081 hypothetical protein K07955 ARL8; ADP-ribosylation factor-like protein 8
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D HPODL_04910 peptide alpha-N-acetyltransferase K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D HPODL_04371 hypothetical protein K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D HPODL_00971 Vacuolar protein sorting-associated protein 27 K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D HPODL_01934 Class E vacuolar protein-sorting machinery protein HSE1 K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D HPODL_04070 ESCRT-I complex subunit TSG101 K12183 TSG101; ESCRT-I complex subunit TSG101
C ESCRT-II complex
D HPODL_04467 hypothetical protein K12188 SNF8; ESCRT-II complex subunit VPS22
D HPODL_01416 hypothetical protein K12189 VPS25; ESCRT-II complex subunit VPS25
D HPODL_04028 Vacuolar protein-sorting-associated protein 36 K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D HPODL_05137 Vacuolar protein-sorting-associated protein 46 K12197 CHMP1; charged multivesicular body protein 1
D HPODL_03292 class E vacuolar-protein sorting and endocytosis factor K12191 CHMP2A; charged multivesicular body protein 2A
D HPODL_04912 VPS24 involved in secretion K12193 VPS24; charged multivesicular body protein 3
D HPODL_00740 Vacuolar-sorting protein SNF7 K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D HPODL_03416 myristoylated subunit of escrtiii K12195 CHMP6; charged multivesicular body protein 6
D HPODL_03647 hypothetical protein K15053 CHMP7; charged multivesicular body protein 7
D HPODL_01182 Vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D HPODL_04398 hypothetical protein K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D HPODL_00432 pH-response regulator protein palA/RIM20 K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D HPODL_02807 hypothetical protein K20177 VPS3; vacuolar protein sorting-associated protein 3
D HPODL_04898 Vacuolar protein sorting-associated protein 8 K20178 VPS8; vacuolar protein sorting-associated protein 8
D HPODL_04202 Vacuolar membrane protein PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D HPODL_01881 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex K20180 VPS16; vacuolar protein sorting-associated protein 16
D HPODL_04457 Vacuolar membrane protein PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D HPODL_04495 Vacuolar protein sorting-associated protein 33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D HPODL_04202 Vacuolar membrane protein PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D HPODL_01881 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex K20180 VPS16; vacuolar protein sorting-associated protein 16
D HPODL_04457 Vacuolar membrane protein PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D HPODL_04495 Vacuolar protein sorting-associated protein 33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D HPODL_00591 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D HPODL_03831 Vacuolar protein sorting-associated protein 41 K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D HPODL_04653 Regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
C RAVE complex
D HPODL_04653 Regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
D HPODL_03383 hypothetical protein K25485 RAV2; regulator of V-ATPase in vacuolar membrane protein 2
D HPODL_00458 Suppressor of kinetochore protein 1 K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D HPODL_02277 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D HPODL_03736 AP-3 complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D HPODL_03192 hypothetical protein K12398 AP3M; AP-3 complex subunit mu
D HPODL_05111 Clathrin adaptor complex small chain K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
D HPODL_04628 hypothetical protein K22240 CNL1; biogenesis of lysosome-related organelles complex 1 subunit CNL1
D HPODL_01430 hypothetical protein K22241 SNN1; biogenesis of lysosome-related organelles complex 1 subunit SNN1
D HPODL_02276 hypothetical protein K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Lysosomal membrane proteins
C Others
D HPODL_03258 vacuolar fusion protein mon1 K20195 MON1; vacuolar fusion protein MON1
D HPODL_01083 hypothetical protein K21156 CCZ1; vacuolar fusion protein CCZ1, fungi type
D HPODL_03349 ubiquitin carboxyl-terminal hydrolase 8 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D HPODL_00275 STAM-binding protein K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
D HPODL_03825 Conserved hypothetical membrane protein K28212 LEPROT; OB-RGRP/VPS55 family protein
D HPODL_05276 putative membrane protein K28212 LEPROT; OB-RGRP/VPS55 family protein
D HPODL_02763 Vacuolar protein sorting-associated protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D HPODL_01170 Beige/BEACH domain protein K24781 BPH1; beige protein homolog 1
D HPODL_03868 Vacuolar segregation protein 7 K28440 VAC7; vacuolar segregation protein 7
D HPODL_01968 hypothetical protein K28441 TAG1; protein TAG1
D HPODL_01732 Specificity factor required for Rsp5p-dependent ubiquitination K28544 SSH4; SSH4 family protein
D HPODL_05324 Conserved hypothetical membrane protein K28544 SSH4; SSH4 family protein
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D HPODL_02772 Rab family protein K07880 RAB4B; Ras-related protein Rab-4B
D HPODL_03098 GTP-binding protein YPT31/YPT8 K07905 RAB11B; Ras-related protein Rab-11B
C Rab4 associated proteins
D HPODL_01247 Sorting nexin-4 K17919 SNX4; sorting nexin-4
C Rab11 associated proteins
D HPODL_02970 putative WD repeat-containing protein K20241 WDR44; WD repeat-containing protein 44
D HPODL_02171 Protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D HPODL_02931 Exocyst complex component SEC15 K19985 EXOC6; exocyst complex component 6
D HPODL_00039 hypothetical protein K20242 EVI5; ecotropic viral integration site 5 protein
D HPODL_00959 Vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D HPODL_04556 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D HPODL_00499 Vacuolar protein sorting-associated protein 9a K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D HPODL_03021 DNA repair protein rhp51 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D HPODL_01111 Golgi-associated retrograde protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D HPODL_02476 Vacuolar protein sorting-associated protein 53 K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D HPODL_01854 F-actin-capping protein subunit alpha K10364 CAPZA; F-actin-capping protein subunit alpha
D HPODL_05298 F-actin-capping protein subunit beta K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D HPODL_00996 Vacuolar protein sorting-associated protein 29 K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
D HPODL_03303 Protein CSF1 K24964 BLTP1; Bridge-like lipid transfer protein family member 1
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D HPODL_00959 Vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D HPODL_02870 GTPase-activating protein GYP2 K19951 TBC1D8_9; TBC1 domain family member 8/9
D HPODL_03143 hypothetical protein K20286 TMF1; TATA element modulatory factor
D HPODL_04556 hypothetical protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D HPODL_00260 Vacuolar protein sorting-associated protein K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D HPODL_04777 ADP-ribosylation factor 1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D HPODL_00441 ADP-ribosylation factor-like protein 1 K07942 ARL1; ADP-ribosylation factor-like protein 1
D HPODL_01155 ADP-ribosylation factor-like protein 3 K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D HPODL_02044 Zn finger-containing GTPase- Activating Protein for ARF K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D HPODL_02444 ADP-ribosylation factor GTPase-activating protein GLO3 K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D HPODL_04380 ultradian oscillation regulator K12486 SMAP; stromal membrane-associated protein
D HPODL_04405 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector K12486 SMAP; stromal membrane-associated protein
D HPODL_02949 Protein csx2 K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D HPODL_03984 Protein transport protein SEC7 K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D HPODL_04699 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D HPODL_03905 hypothetical protein K20289 COG2; conserved oligomeric Golgi complex subunit 2
D HPODL_03832 Conserved oligomeric Golgi complex subunit 3 K20290 COG3; conserved oligomeric Golgi complex subunit 3
D HPODL_03948 Conserved oligomeric Golgi complex subunit 4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
D HPODL_04171 Conserved oligomeric Golgi complex subunit 6 K20293 COG6; conserved oligomeric Golgi complex subunit 6
D HPODL_04751 Conserved oligomeric Golgi complex subunit 8 K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D HPODL_05112 hypothetical protein K20297 VPS51; vacuolar protein sorting-associated protein 51
D HPODL_01111 Golgi-associated retrograde protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D HPODL_02476 Vacuolar protein sorting-associated protein 53 K20299 VPS53; vacuolar protein sorting-associated protein 53
D HPODL_01998 Component of the GARP (Golgi-associated retrograde protein) complex K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D HPODL_04748 hypothetical protein K20300 TRAPPC1; trafficking protein particle complex subunit 1
D HPODL_05217 hypothetical protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D HPODL_02194 Trafficking protein particle complex subunit BET3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D HPODL_05076 hypothetical protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D HPODL_00994 Transport protein particle (TRAPP) complex subunit K20280 TRAPPC5; trafficking protein particle complex subunit 5
D HPODL_04208 Transport protein particle subunit K20304 TRAPPC6; trafficking protein particle complex subunit 6
D HPODL_05208 hypothetical protein K20305 TRAPPC8; trafficking protein particle complex subunit 8
D HPODL_05020 Transport protein particle subunit K20306 TRAPPC9; trafficking protein particle complex subunit 9
D HPODL_00063 hypothetical protein K20307 TRAPPC10; trafficking protein particle complex subunit 10
D HPODL_02053 hypothetical protein K20308 TRAPPC11; trafficking protein particle complex subunit 11
D HPODL_04557 hypothetical protein K20311 TRS65; trafficking protein particle complex II-specific subunit 65
D HPODL_05167 hypothetical protein K20312 TCA17; TRAPP-associated protein TCA17
B Others
C AP-1 complex
D HPODL_00510 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex K12391 AP1G1; AP-1 complex subunit gamma-1
D HPODL_02473 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex K12392 AP1B1; AP-1 complex subunit beta-1
D HPODL_01174 AP-1 complex subunit mu K12393 AP1M; AP-1 complex subunit mu
D HPODL_04736 hypothetical protein K12393 AP1M; AP-1 complex subunit mu
D HPODL_02800 Small subunit of the clathrin-associated adaptor complex AP-1 K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D HPODL_02277 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D HPODL_03736 AP-3 complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D HPODL_03192 hypothetical protein K12398 AP3M; AP-3 complex subunit mu
D HPODL_05111 Clathrin adaptor complex small chain K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D HPODL_04639 Golgi-localized, ADP-ribosylation factor binding protein K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D HPODL_04284 hypothetical protein K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D HPODL_02455 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D HPODL_02029 STT4 phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D HPODL_02900 phosphatidylinositol 4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D HPODL_04672 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D HPODL_04624 putative secreted protein K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D HPODL_03395 Vacuolar ATPase assembly integral membrane protein VPH2 K23542 TMEM199; TMEM199 family protein
D HPODL_04310 Membrane protein TMS1 K23544 SERINC1; serine incorporator 1
D HPODL_02530 Sorting nexin-3 K17918 SNX3_12; sorting nexin-3/12
D HPODL_04135 Sorting nexin MVP1 K17922 SNX8; sorting nexin-8
D HPODL_03183 Protein MON2 K26678 MON2; protein MON2
D HPODL_04110 Protein dopey K26680 DOP1; protein dopey
D HPODL_00606 hypothetical protein K27894 HID1; protein HID1
D HPODL_05348 putative membrane protein K26750 TVP15; golgi apparatus membrane protein TVP15
D HPODL_05166 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p K26751 TVP18; golgi apparatus membrane protein TVP18
D HPODL_05228 Golgi apparatus membrane protein TVP23 K26752 TVP23; golgi apparatus membrane protein TVP23
D HPODL_03548 Golgi apparatus membrane protein TVP38 K26753 TVP38; golgi apparatus membrane protein TVP38
D HPODL_02763 Vacuolar protein sorting-associated protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D HPODL_02702 Small COPII coat GTPase sar1 K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D HPODL_02171 Protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D HPODL_02589 component of the COPII coat of ER-Golgi vesicles K14005 SEC31; protein transport protein SEC31
D HPODL_01933 Protein transport protein SEC23 K14006 SEC23; protein transport protein SEC23
D HPODL_04367 Protein transport protein SEC23 K14006 SEC23; protein transport protein SEC23
D HPODL_02095 Protein transport protein SEC24 K14007 SEC24; protein transport protein SEC24
D HPODL_02488 Member of the Sec24p family K14007 SEC24; protein transport protein SEC24
D HPODL_04737 Guanine nucleotide-exchange factor SEC12 K14003 PREB; prolactin regulatory element-binding protein
D HPODL_00489 COPII coat assembly protein SEC16 K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D HPODL_04748 hypothetical protein K20300 TRAPPC1; trafficking protein particle complex subunit 1
D HPODL_05217 hypothetical protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D HPODL_02194 Trafficking protein particle complex subunit BET3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D HPODL_05076 hypothetical protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D HPODL_00994 Transport protein particle (TRAPP) complex subunit K20280 TRAPPC5; trafficking protein particle complex subunit 5
D HPODL_04208 Transport protein particle subunit K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D HPODL_00949 U3 snoRNP protein involved in maturation of pre-18S rRNA K20346 TMED4_9_11; p24 family protein alpha
D HPODL_04567 endosomal P24B protein precursor K20347 TMED2; p24 family protein beta-1
D HPODL_01700 hypothetical protein K20352 TMED10; p24 family protein delta-1
D HPODL_03235 Endoplasmic reticulum vesicle protein 25 K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D HPODL_03788 Protein disulfide-isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D HPODL_01064 hypothetical protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D HPODL_01411 hypothetical protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D HPODL_02615 protein disulfide isomerase family A, member 6 K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D HPODL_00816 Ras-related protein ORAB-1 K07874 RAB1A; Ras-related protein Rab-1A
C Rab associated proteins
D HPODL_01193 Prenylated Rab acceptor 1 K20359 RABAC1; PRA1 family protein 1
D HPODL_03504 putative membrane protein K20359 RABAC1; PRA1 family protein 1
D HPODL_03609 TBC1 domain family member 20 K20372 TBC1D20; TBC1 domain family member 20
D HPODL_02830 GTPase-activating protein K20360 TBC1D22; TBC1 domain family member 2
D HPODL_02498 Integral membrane protein K20362 YIF1; protein transport protein YIF1
D HPODL_05147 putative membrane protein K22939 IER3IP1; immediate early response 3-interacting protein 1
D HPODL_00316 Intracellular protein transport protein USO1 K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D HPODL_00761 putative membrane protein K10080 LMAN1; lectin, mannose-binding 1
D HPODL_05075 Conserved hypothetical membrane protein K10082 LMAN2; lectin, mannose-binding 2
D HPODL_01630 Mannosyl-oligosaccharide 1,2-alpha-mannosidase K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D HPODL_03514 hypothetical protein K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D HPODL_00373 ER-derived vesicles protein ERV46 K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D HPODL_03583 ER-derived vesicles protein ERV14 K20368 CNIH; protein cornichon
D HPODL_03068 er to golgi transport-related protein K20369 ERV29; ER-derived vesicles protein
D HPODL_02001 glucose-regulated protein precursor K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D HPODL_03310 Coatomer subunit alpha K05236 COPA; coatomer subunit alpha
D HPODL_02074 Coatomer subunit beta K17301 COPB1; coatomer subunit beta
D HPODL_02703 Coatomer subunit beta K17302 COPB2; coatomer subunit beta'
D HPODL_00281 coatomer subunit gamma K17267 COPG; coatomer subunit gamma
D HPODL_00723 Clathrin adaptor complex small chain K20471 COPD; coatomer subunit delta
D HPODL_01890 hypothetical protein K17268 COPE; coatomer subunit epsilon
D HPODL_04086 Zeta subunit of the coatomer complex (COPI) K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D HPODL_00708 hypothetical protein K20474 RINT1; RAD50-interacting protein 1
D HPODL_01913 hypothetical protein K11578 ZW10; protein transport protein DSL1/ZW10
D HPODL_01001 hypothetical protein K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D HPODL_02883 hypothetical protein K22384 GET1; tail-anchored protein insertion receptor
D HPODL_05033 hypothetical protein K22386 GET2; GET complex subunit GET2
D HPODL_04151 ATPase GET3 K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D HPODL_03589 hypothetical protein K23387 GET4; golgi to ER traffic protein 4
C Rab GTPases
C Rab associated proteins
D HPODL_02852 hypothetical protein K20476 RIC1; RAB6A-GEF complex partner protein 1
D HPODL_04219 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6 K20477 RGP1; RAB6A-GEF complex partner protein 2
D HPODL_01410 ER lumen protein retaining receptor K10949 KDELR; ER lumen protein retaining receptor
D HPODL_02830 GTPase-activating protein K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D HPODL_00842 Oxysterol-binding protein with ankyrin repeats K20456 OSBP; oxysterol-binding protein 1
D HPODL_01189 Oxysterol-binding protein K20463 OSBPL3_6_7; oxysterol-binding protein-related protein 3/6/7
D HPODL_04874 Oxysterol-binding protein K22285 OSBPL8; oxysterol-binding protein-related protein 8
D HPODL_01116 Protein KES1 K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D HPODL_03034 Protein YIP5 K22940 YIPF1_2; protein YIPF1/2
D HPODL_03056 Protein transport protein YIP1 K20363 YIPF5_7; protein YIPF5/7
D HPODL_02698 hypothetical protein K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D HPODL_02520 Conserved hypothetical membrane protein K23562 EMC1; ER membrane protein complex subunit 1
D HPODL_02657 hypothetical protein K23563 EMC2; ER membrane protein complex subunit 2
D HPODL_04973 hypothetical protein K23564 EMC3; ER membrane protein complex subunit 3
D HPODL_02932 hypothetical protein K23565 EMC4; ER membrane protein complex subunit 4
D HPODL_04850 hypothetical protein K23566 MMGT1; membrane magnesium transporter 1
C SEC61 complex
D HPODL_03320 Protein transport protein SEC61 subunit alpha K10956 SEC61A; protein transport protein SEC61 subunit alpha
D HPODL_04245 Subunit of the Ssh1 translocon complex K10956 SEC61A; protein transport protein SEC61 subunit alpha
D HPODL_01667 Protein transport protein Sec61 subunit beta K09481 SEC61B; protein transport protein SEC61 subunit beta
D HPODL_01583 Protein transport protein SSS1 K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D HPODL_02958 hypothetical protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D HPODL_03632 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D HPODL_02024 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity K23553 PGAP3; post-GPI attachment to proteins factor 3
D HPODL_03389 putative membrane protein of unknown function involved in Mn2+ homeostasis K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
D HPODL_03977 Protein TED1 K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
D HPODL_05375 Conserved hypothetical membrane protein K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D HPODL_05046 Protein SLY1 K19998 SCFD1; sec1 family domain-containing protein 1
D HPODL_02188 Conserved hypothetical membrane protein K20724 TMEM33; transmembrane protein 33
D HPODL_05170 putative membrane protein K20724 TMEM33; transmembrane protein 33
D HPODL_01457 Protein ARV1 K21848 ARV1; lipid intermediate transporter
D HPODL_05172 putative membrane protein K21849 KEG1; beta-1,6-glucan synthesis-associated protein KEG1
D HPODL_03214 Beta-glucan synthesis-associated protein KRE6 K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D HPODL_00959 Vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D HPODL_04059 hypothetical protein K26681 INSIG; insulin-induced protein
D HPODL_05360 Membrane protein involved in Golgi transport K26683 GOLT1; vesicle transport protein GOT1
D HPODL_03587 Protein SEY1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D HPODL_03959 Autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
D HPODL_00271 hypothetical protein K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D HPODL_04379 Serine/threonine-protein kinase ATG1 K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D HPODL_03959 Autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
D HPODL_00301 Autophagy-related protein 17 K08329 ATG17; autophagy-related protein 17
C PI3K complex
D HPODL_03612 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D HPODL_03479 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D HPODL_04150 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II K08334 BECN; beclin
C ATG9 transmembrane protein
D HPODL_03149 Autophagy-related protein 9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D HPODL_01040 Autophagy-related protein 21 K17908 WIPI1_2; autophagy-related protein 18
D HPODL_04964 Autophagy-related protein 18 K17908 WIPI1_2; autophagy-related protein 18
D HPODL_03060 Autophagy-related protein 2 K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D HPODL_01112 Ubiquitin-like protein ATG12 K08336 ATG12; ubiquitin-like protein ATG12
D HPODL_03851 Ubiquitin-like modifier-activating enzyme ATG7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D HPODL_05255 Ubiquitin-like-conjugating enzyme ATG10 K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
D HPODL_03429 Autophagy protein 5 K08339 ATG5; autophagy-related protein 5
D HPODL_05261 Autophagy-related protein 16 K08340 ATG16; autophagy-related protein 16
C Atg8 conjugation proteins
D HPODL_03718 Autophagy-related protein 8 K08341 GABARAP; GABA(A) receptor-associated protein
D HPODL_04394 cysteine protease ATG4 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D HPODL_03851 Ubiquitin-like modifier-activating enzyme ATG7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D HPODL_01803 Autophagy-related protein 3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D HPODL_00434 Alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D HPODL_01014 Aspartyl aminopeptidase 4 K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
D HPODL_05134 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D HPODL_03229 Sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D HPODL_04328 Sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D HPODL_01247 Sorting nexin-4 K17919 SNX4; sorting nexin-4
D HPODL_03503 putative lipase ATG15 K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D HPODL_01559 Autophagy-related protein 27 K21141 ATG27; autophagy-related protein 27
D HPODL_04593 Vacuolar protein 8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
C Scaffold proteins
D HPODL_05134 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D HPODL_03067 putative mitochondrial integral membrane protein K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C Other mitophagy associated proteins
D HPODL_04126 Glucokinase-1 K00844 HK; hexokinase [EC:2.7.1.1]
D HPODL_04428 hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D HPODL_04936 Hexokinase-2 K00844 HK; hexokinase [EC:2.7.1.1]
D HPODL_05125 hypothetical protein K22255 ATPIF1; ATPase inhibitor, mitochondrial
D HPODL_02790 putative secreted protein K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D HPODL_03618 Peroxisomal membrane protein PEX3 K13336 PEX3; peroxin-3
D HPODL_04224 Peroxisomal membrane protein PEX14 K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
D HPODL_03328 Peroxisomal membrane protein PEX1 K13338 PEX1; peroxin-1
D HPODL_01223 Peroxisomal membrane protein PEX6 K13339 PEX6; peroxin-6
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D HPODL_02504 Cell division control protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
D HPODL_04853 Histone deacetylase HDA1 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B Xenophagy
C Cargo receptors
D HPODL_01964 hypothetical protein K21348 CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2
C Other xenophagy associated proteins
B ER-phagy
C ER-phagy recepters
D HPODL_02451 subunit of ER protein- translocation complex K12275 SEC62; translocation protein SEC62
C Other ER-phagy associated proteins
D HPODL_01575 Calnexin K08054 CANX; calnexin
D HPODL_03420 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p K17278 PGRMC1_2; membrane-associated progesterone receptor component
C ER stress-related proteins
D HPODL_02001 glucose-regulated protein precursor K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D HPODL_04564 Eukaryotic translation initiation factor 2 subunit alpha K03237 EIF2S1; translation initiation factor 2 subunit 1
B Chaperone mediated autophagy (CMA)
C Selective cargos
D HPODL_02844 Aspartate aminotransferase, cytoplasmic K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D HPODL_04957 Glyceraldehyde-3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D HPODL_00350 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HPODL_01332 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HPODL_01513 Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D HPODL_05155 hypothetical protein K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D HPODL_02193 Heat shock protein 70 2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D HPODL_02202 Heat shock protein SSB1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D HPODL_02450 Heat shock protein 70 1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D HPODL_01825 ATP-dependent molecular chaperone HSC82 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D HPODL_00974 Elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D HPODL_02694 Elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D HPODL_02015 putative serine carboxypeptidase K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D HPODL_04650 Carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D HPODL_04593 Vacuolar protein 8 K08332 VAC8; vacuolar protein 8
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D HPODL_03067 putative mitochondrial integral membrane protein K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D HPODL_00013 Serine/threonine-protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D HPODL_04064 Target of rapamycin complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D HPODL_00261 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control K07204 RAPTOR; regulatory associated protein of mTOR
C mTORC2 complex
D HPODL_00013 Serine/threonine-protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D HPODL_04064 Target of rapamycin complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D HPODL_04018 Target of rapamycin complex 2 subunit AVO1 K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D HPODL_03302 Protein ste16 K08267 RICTOR; rapamycin-insensitive companion of mTOR
D HPODL_00713 Target of rapamycin complex 2 subunit AVO2 K25576 AVO2; target of rapamycin complex 2 subunit AVO2
D HPODL_03257 hypothetical protein K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
C SEACIT/GATOR1 complex
D HPODL_02573 Vacuolar membrane-associated protein IML1 K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D HPODL_04694 Nitrogen permease regulator NLRG/NPR2 K20405 NPRL2; nitrogen permease regulator 2
D HPODL_04075 Ser/Thr protein kinase involved in salt tolerance K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D HPODL_01662 hypothetical protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D HPODL_01046 hypothetical protein K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D HPODL_03650 WD40 repeat-containing protein K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D HPODL_03926 Nucleoporin SEH1 K14299 SEH1; nucleoporin SEH1
D HPODL_02171 Protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D HPODL_00816 Ras-related protein ORAB-1 K07874 RAB1A; Ras-related protein Rab-1A
D HPODL_00120 Ras-related protein SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D HPODL_04772 Serine/threonine-protein phosphatase PP2A-2 catalytic subunit K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D HPODL_03505 Essential protein involved in the TOR signaling pathway K17606 IGBP1; immunoglobulin-binding protein 1
D HPODL_02981 hypothetical protein K21249 UVRAG; UV radiation resistance-associated gene protein
D HPODL_03790 Autophagy-related protein 22 K06902 UMF1; MFS transporter, UMF1 family
D HPODL_02812 Vacuolar amino acid transporter 3 K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D HPODL_02886 Vacuolar transporter, exports large neutral amino acids from the vacuole K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D HPODL_00125 SVP1-like protein 2 K22991 WDR45; WD repeat-containing protein 45
D HPODL_02273 putative membrane protein K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
D HPODL_04262 hypothetical protein K27411 PHAF1; phagosome assembly factor 1
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
D HPODL_02947 Ras-related C3 botulinum toxin substrate 1 K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
B Actin-binding proteins
C Myosins
D HPODL_04585 Myosin-5 K10356 MYO1; myosin I
D HPODL_00296 Myosin-2 K10357 MYO5; myosin V
C Arp2/3 complex
D HPODL_03807 Actin-related protein 2/3 complex subunit 1 K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D HPODL_04461 Actin-related protein 2/3 complex subunit 2 K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D HPODL_00263 Actin-related protein 2/3 complex subunit 3 K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D HPODL_04470 Actin-related protein 2/3 complex subunit 4 K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D HPODL_05196 hypothetical protein K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D HPODL_03081 Actin-related protein 2 K17260 ACTR2; actin-related protein 2
D HPODL_02009 Actin-related protein 3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D HPODL_03580 Proline-rich protein LAS17 K23612 WASL; neural Wiskott-Aldrich syndrome protein
D HPODL_01068 putative actin-binding protein K20520 DBNL; drebrin-like protein
D HPODL_02489 hypothetical protein K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D HPODL_00269 hypothetical protein K12562 AMPH; amphiphysin
D HPODL_00423 Reduced viability upon starvation protein 167 K12562 AMPH; amphiphysin
D HPODL_01133 Actin-associated protein K12562 AMPH; amphiphysin
D HPODL_04266 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D HPODL_02144 hypothetical protein K20521 BBC1; myosin tail region-interacting protein MTI1
D HPODL_03892 Protein that induces appearance of [PIN+] prion when overproduced K20522 LSB1_2; LAS seventeen-binding protein 1/2
D HPODL_02016 Protein involved in the organization of the actin cytoskeleton K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D HPODL_04164 LAS seventeen-binding protein 5 K20524 LSB5; LAS seventeen-binding protein 5
D HPODL_03491 Type II phosphatidylinositol 4-kinase that binds Las17p K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D HPODL_05179 hypothetical protein K05759 PFN; profilin
D HPODL_02643 Cofilin K05765 CFL; cofilin
D HPODL_02066 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex K17261 CAP1_2; adenylyl cyclase-associated protein
D HPODL_00616 kinesin heavy chain K10396 KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
D HPODL_01385 ABC-type multidrug transport system K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B MARVEL domain-containing proteins
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D HPODL_00395 RHO GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
D HPODL_03844 Rho-type GTPase-activating protein 2 K08773 RALBP1; RalA-binding protein 1
C Rho guanine nucleotide exchange factors (GEFs)
D HPODL_00605 DOCK-like protein K05727 DOCK3; dedicator of cytokinesis protein 3
D HPODL_00352 hypothetical protein K28415 DENND11; DENN domain-containing protein 11
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: October 7, 2025