+F Repair protein KO
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DNA Repair and Recombination Proteins - Octopus sinensis (East Asian common octopus)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 115229765 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 115224663 DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 115232595 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 115215175 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 115222223 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 115223095 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115230844 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115208763 cyclin-B2-1-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 115227526 uncharacterized protein LOC115227526 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 115215690 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 115230427 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 115223688 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 115221337 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 115223301 N-glycosylase/DNA lyase-like isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 115215723 exodeoxyribonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 115229756 LOW QUALITY PROTEIN: probable endonuclease 4 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 115213835 DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 115217496 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 115223493 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 115211748 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 115222552 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 115211854 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 115224273 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 115214768 DNA polymerase epsilon subunit 3 isoform X1 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 115231478 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 115223569 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 115231475 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115212066 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 115227360 uncharacterized protein LOC115227360 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 115211797 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 115211876 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 115221560 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 115218063 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 115213365 tyrosyl-DNA phosphodiesterase 1 isoform X3 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 115222296 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 115210968 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 115213950 uncharacterized protein F21D5.5 isoform X2 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 115214265 glutamic acid-rich protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 115223197 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 115217306 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 115223838 poly [ADP-ribose] polymerase 2 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 115226113 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 115216665 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 115218629 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115219630 cullin-4A K10609 CUL4; cullin 4
F 115214111 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 115215864 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 115223158 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 115220865 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 115228972 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 115209631 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 115223909 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 115223935 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 115218472 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 115221702 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 115211926 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 115220428 DNA-directed RNA polymerase II subunit RPB11-a-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 115226171 DNA-directed RNA polymerase II subunit RPB11-a-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 115218629 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115219630 cullin-4A K10609 CUL4; cullin 4
F 115214111 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 115222376 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 115218860 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 115223511 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 115225821 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 115225722 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 115218521 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 115209354 general transcription factor IIH subunit 2 isoform X2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 115224353 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 115213563 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 115232524 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 115219779 cyclin-H isoform X1 K06634 CCNH; cyclin H
E 115213098 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 115224297 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 115218625 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 115227970 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 115215096 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 115218056 DNA repair protein complementing XP-A cells homolog isoform X1 K10847 XPA; DNA-repair protein complementing XP-A cells
E 115218575 DNA excision repair protein ERCC-1-like isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 115210617 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 115225701 DNA repair protein complementing XP-G cells homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 115211797 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 115219824 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 115210873 probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog K24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1
E 115215881 cytosolic iron-sulfur assembly component 2A-like K26403 CIAO2; cytosolic iron-sulfur assembly component 2
E 115218060 cytosolic iron-sulfur assembly component 2B-like K26403 CIAO2; cytosolic iron-sulfur assembly component 2
E 115223190 cullin-5 K10612 CUL5; cullin 5
E 115219550 elongin-C K03872 ELOC; elongin-C
E 115215696 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 115215942 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 115209288 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 115209337 DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 115210797 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 115225827 PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 115211578 DNA mismatch repair protein Mlh1 isoform X2 K08734 MLH1; DNA mismatch repair protein MLH1
E 115213062 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 118762464 DNA mismatch repair protein Mlh3-like isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 115217496 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 115223493 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 115211748 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 115222552 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 115224297 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 115218625 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 115227970 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 115215096 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 115209697 replication factor C subunit 1 isoform X3 K10754 RFC1; replication factor C subunit 1
E 115209352 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 115214287 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 115230219 LOW QUALITY PROTEIN: replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 115210822 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 115224713 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 115227722 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 115231475 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115217460 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 115214265 glutamic acid-rich protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 115211797 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 115224452 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 115223932 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115217443 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 115210726 nibrin isoform X2 K10867 NBN; nibrin
D BRCA1-core complex
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D BRCA1-A complex
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 115214049 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 115217324 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 115223759 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 118763026 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 115213081 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 115220846 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 115210247 uncharacterized protein LOC115210247 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 115223932 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115217443 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 115210726 nibrin isoform X2 K10867 NBN; nibrin
D BRCA complex
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 115214409 breast cancer type 2 susceptibility protein-like isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 115213211 uncharacterized protein LOC115213211 K10897 PALB2; partner and localizer of BRCA2
E 115211888 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 115211888 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 115210636 DNA repair protein RAD51 homolog 2-like K10869 RAD51L1; RAD51-like protein 1
E 115224865 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 115217183 DNA repair protein RAD51 homolog 4-like isoform X2 K10871 RAD51L3; RAD51-like protein 3
E 115222764 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 115217405 DNA repair protein XRCC3-like isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 115224048 DNA repair and recombination protein rti1-like K10873 RAD52; DNA repair and recombination protein RAD52
E 115211036 RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 115218480 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 115209081 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 115216521 DNA repair and recombination protein RAD54B isoform X4 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 115213964 ATP-dependent DNA helicase Q1-like isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 115225761 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 115225861 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115224046 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 115221370 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 115225861 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115224247 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115232347 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115210355 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 115214907 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 115224297 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 115218625 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 115227970 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 115215096 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 115226588 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 115208818 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 115212772 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 115217184 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 115222688 serine/threonine-protein phosphatase 4 regulatory subunit 4-like K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 115218012 AP-5 complex subunit beta-1-like isoform X1 K19022 AP5B1; AP-5 complex subunit beta-1
E 115213435 AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 115223108 uncharacterized protein LOC115223108 K19024 AP5S1; AP-5 complex subunit sigma-1
E 115211704 AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 115220996 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 115216675 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 115223461 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 115209799 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 115228770 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 115222934 EP300-interacting inhibitor of differentiation 3-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 115224441 SMC5-SMC6 complex localization factor protein 1-like K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 115218804 SMC5-SMC6 complex localization factor protein 2-like K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 115211950 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 115223224 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 115209745 crossover junction endonuclease MUS81-like isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 115230834 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 115224575 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 115219260 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 115226227 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 115217132 uncharacterized protein LOC115217132 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 115216269 flap endonuclease GEN homolog 1-like isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 115220307 uncharacterized protein LOC115220307 isoform X2 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 115220926 spatacsin isoform X1 K19026 SPG11; spatacsin
E 115217108 zinc finger FYVE domain-containing protein 26-like K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 115214153 RAD51-associated protein 1 isoform X2 K20778 RAD51AP1; RAD51-associated protein 1
E 115217856 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 115217873 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 115217206 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X2 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115217218 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115221705 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115231345 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115231394 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115232247 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 118765413 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 118766486 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115214336 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 115214308 uncharacterized protein LOC115214308 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 115209265 cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 115219629 formin-J K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 115229958 zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 115222068 putative GPI-anchored protein pfl2 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 118763576 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 115232670 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 115223933 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 115209074 PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
E 115223961 uncharacterized protein LOC115223961 isoform X3 K27803 HROB; homologous recombination OB-fold protein
E 115217372 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 115223712 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
E 115212241 hornerin isoform X2 K15047 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1
E 115213441 uncharacterized protein LOC115213441 K15047 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1
E 115217557 heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 K15047 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1
E 115223998 uncharacterized protein LOC115223998 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 115214087 X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 115209677 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 115211686 DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 115223932 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115217443 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 115209209 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 115224279 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 115209249 zinc finger protein 112-like isoform X3 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 115223197 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 115211876 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 115222296 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 115210968 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 115217013 putative uncharacterized protein DDB_G0277255 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 115224018 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 115209208 structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 115213454 jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 115218231 uncharacterized protein LOC115218231 isoform X1 K10889 FANCB; fanconi anemia group B protein
E 115213826 uncharacterized protein LOC115213826 K10892 FANCE; fanconi anemia group E protein
E 115214310 uncharacterized protein LOC115214310 isoform X1 K10893 FANCF; fanconi anemia group F protein
E 115221305 uncharacterized protein LOC115221305 K10894 FANCG; fanconi anemia group G protein
E 115229943 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 115224527 uncharacterized protein LOC115224527 K10896 FANCM; fanconi anemia group M protein
E 115219869 Fanconi anemia core complex-associated protein 24-like K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 115232188 transcription factor HES-4-A K06054 HES1; hairy and enhancer of split 1
E 115226110 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 115225861 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115224247 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115232347 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115210355 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 115214907 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 115223925 Fanconi anemia group D2 protein-like K10891 FANCD2; fanconi anemia group D2 protein
E 115231813 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 115216805 breast cancer type 1 susceptibility protein homolog isoform X5 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 115214409 breast cancer type 2 susceptibility protein-like isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 115213081 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 115213211 uncharacterized protein LOC115213211 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 115222901 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 115211888 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 115224865 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 115209396 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 115220889 serine-rich adhesin for platelets-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 115215739 WD repeat-containing protein 48-like isoform X2 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 115215322 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 115227379 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 115223817 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 115216830 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 115211029 E3 ubiquitin-protein ligase RNF8 isoform X2 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 115222150 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 115222504 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2-like K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 115222260 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 115224492 homeobox protein 2-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 115226580 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 115224452 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
E 115222835 abasic site processing protein HMCES K28434 HMCES; abasic site processing protein HMCES
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 115217926 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 115220566 DNA polymerase kappa-like isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 115231612 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 115224752 DNA repair protein REV1-like isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 115223813 uncharacterized protein LOC115223813 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 115210691 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 115222522 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 118761300 ubiquitin-conjugating enzyme E2 A-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 115209655 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 115229490 ubiquitin-conjugating enzyme variant MMS2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 115231868 ubiquitin-conjugating enzyme variant MMS2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 115213152 ubiquitin-conjugating enzyme E2 N isoform X2 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 115231475 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 115209074 PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
D 115218092 sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 115232666 sprT-like domain-containing protein Spartan isoform X3 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 115226059 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 115216502 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 115216735 checkpoint protein HUS1-like K10903 HUS1; HUS1 checkpoint protein
D 115213126 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 115214227 cell cycle checkpoint protein RAD17-like isoform X2 K06662 HRAD17; cell cycle checkpoint protein
D 115209352 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 115214287 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 115230219 LOW QUALITY PROTEIN: replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 115210822 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115224713 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 115227722 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 115213126 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 115227513 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 115218083 uncharacterized protein DDB_G0286591-like isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 115217680 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 115209396 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 115213155 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 115218106 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 115222831 large proline-rich protein bag6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 115219361 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 115229498 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 115225794 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 115217079 serine-rich adhesin for platelets K10905 ATRIP; ATR interacting protein
D 115232583 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 115221768 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 115226143 LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk2-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 115214992 M-phase inducer phosphatase-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 115210376 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 115228363 14-3-3-like protein 2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 115229933 14-3-3-like protein K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 115213049 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 115218233 14-3-3 family protein artA K06630 YWHAE; 14-3-3 protein epsilon
D 115228128 14-3-3 protein 3-like K06630 YWHAE; 14-3-3 protein epsilon
D 115229196 14-3-3-like protein GF14-E K06630 YWHAE; 14-3-3 protein epsilon
D 115222805 neuron navigator 2-like isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 115232369 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 115209080 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 115215013 mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 115216994 plastin-1 isoform X1 K17336 PLS3; plastin-3
D 115227365 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 115210218 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 115211008 serine/threonine-protein kinase Nek1 isoform X2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 115219809 serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 115210651 serine/threonine-protein kinase Nek11-like K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 115220312 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 115213887 probable GPI-anchored adhesin-like protein PGA55 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 115209197 protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115210344 vacuolar protein sorting-associated protein 4B isoform X2 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115228807 LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115223579 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 115224089 DNA polymerase theta-like isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 115226064 myb-binding protein 1A-like protein isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 115224036 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 115229578 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 115232505 three-prime repair exonuclease 1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 115232648 DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 115217574 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 115222570 endonuclease V-like isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 118762149 serine/threonine-protein kinase TNNI3K-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 115219761 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 115219667 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 115213078 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 115223287 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 115210861 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 115220961 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 115212427 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 115222998 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 115219714 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115213935 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 115210348 ribonucleoside-diphosphate reductase small chain K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 115229765 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 115222223 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 115223095 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115230844 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115230427 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 115215690 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 115223688 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 115212391 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 115212391 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 115219714 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: October 9, 2025