+C Two-component system KO
#
Two-Component System - Paenibacillus sp. FSL R7-0331
%
!
AOmpR family
B PhoR-PhoB (phosphate starvation response)
C R70331_29550 membrane protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C R70331_10330 histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C R70331_10335 chemotaxis protein CheY K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
C R70331_01380 XRE family transcriptional regulator K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
C R70331_23020 response regulator K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C R70331_15305 histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C R70331_28055 histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C R70331_13965 hypothetical protein K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C R70331_15310 XRE family transcriptional regulator K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C R70331_20605 histidine kinase K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
C R70331_16105 hypothetical protein K07775 resD; two-component system, OmpR family, response regulator ResD
C R70331_20610 transcriptional regulator K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C R70331_31155 histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
C R70331_31160 PhoP family transcriptional regulator K07668 vicR; two-component system, OmpR family, response regulator VicR
C R70331_09660 PhoP family transcriptional regulator K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
C R70331_09400 transcriptional regulator K07669 mprA; two-component system, OmpR family, response regulator MprA
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
C R70331_19530 histidine kinase K11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3]
C R70331_19535 PhoB family transcriptional regulator K11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
C R70331_21760 membrane protein K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
C R70331_24355 membrane protein K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
C R70331_21765 PhoB family transcriptional regulator K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ
C R70331_24360 transcriptional regulator K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
C R70331_30595 histidine kinase K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
C R70331_16125 hypothetical protein K18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
B VanS-VanR (VanE type vancomycin resistance)
C R70331_12470 DeoR faimly transcriptional regulator K18349 vanRC; two-component system, OmpR family, response regulator VanR
C R70331_20720 DeoR faimly transcriptional regulator K18349 vanRC; two-component system, OmpR family, response regulator VanR
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C R70331_03805 histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C R70331_11845 PhoB family transcriptional regulator K18941 arlR; two-component system, OmpR family, response regulator ArlR
C R70331_03800 PhoB family transcriptional regulator K18941 arlR; two-component system, OmpR family, response regulator ArlR
C R70331_04230 PhoB family transcriptional regulator K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C R70331_02545 membrane protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C R70331_09405 histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C R70331_29555 heme response regulator HssR K02483 K02483; two-component system, OmpR family, response regulator
C R70331_15645 heme response regulator HssR K02483 K02483; two-component system, OmpR family, response regulator
C R70331_02550 transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C R70331_22195 heme response regulator HssR K02483 K02483; two-component system, OmpR family, response regulator
C R70331_14760 heme transporter CcmC K02483 K02483; two-component system, OmpR family, response regulator
#
ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
C R70331_12475 hypothetical protein K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
C R70331_29210 histidine kinase K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]
C R70331_29205 chemotaxis protein CheY K07692 degU; two-component system, NarL family, response regulator DegU
B DesK-DesR (membrane lipid fluidity regulation)
C R70331_13425 histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C R70331_13430 transcriptional regulatory protein DesR K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
C R70331_26995 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C R70331_09385 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C R70331_04590 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C R70331_09390 LuxR family transcriptional regulator K11618 liaR; two-component system, NarL family, response regulator LiaR
C R70331_26990 LuxR family transcriptional regulator K11618 liaR; two-component system, NarL family, response regulator LiaR
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
C R70331_15480 histidine kinase K07683 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3]
C R70331_15485 LuxR family transcriptional regulator K07696 nreC; two-component system, NarL family, response regulator NreC
B YdfH-YdfI
C R70331_11635 hypothetical protein K11623 ydfH; two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3]
C R70331_11640 chemotaxis protein CheY K11624 ydfI; two-component system, NarL family, response regulator YdfI
B SalK-SalR
C R70331_03190 hypothetical protein K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
C R70331_03195 hypothetical protein K14989 salR; two-component system, NarL family, secretion system response regulator SalR
B PprA–PprB (biofilm formation)
B Unclassified
#
ASpo family
B KinABCDE-Spo0FA (sporulation control)
C R70331_04550 hypothetical protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C R70331_04555 histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C R70331_02610 hypothetical protein K07698 kinC; two-component system, sporulation sensor kinase C [EC:2.7.13.3]
C R70331_00465 histidine kinase K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]
C R70331_00595 CheY-like receiver K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
C R70331_21305 chemotaxis protein CheY K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
#
ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
C R70331_07775 histidine kinase K11614 yufL; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]
C R70331_07780 transcriptional regulator K11615 malR; two-component system, CitB family, response regulator MalR
C R70331_09135 transcriptional regulator K11615 malR; two-component system, CitB family, response regulator MalR
B Unclassified
#
ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
C R70331_19070 hypothetical protein K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C R70331_07745 hypothetical protein K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C R70331_19065 hypothetical protein K07707 agrA; two-component system, LytTR family, response regulator AgrA
C R70331_07750 hypothetical protein K07707 agrA; two-component system, LytTR family, response regulator AgrA
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C R70331_01645 membrane protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C R70331_10855 hypothetical protein K02477 K02477; two-component system, LytTR family, response regulator
C R70331_01650 LytTR family transcriptional regulator K02477 K02477; two-component system, LytTR family, response regulator
C R70331_09965 hypothetical protein K02477 K02477; two-component system, LytTR family, response regulator
C R70331_30345 hypothetical protein K02477 K02477; two-component system, LytTR family, response regulator
#
ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
#
ACheA family
B CheA-CheYBV (chemotaxis)
C R70331_14455 hypothetical protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C R70331_19195 hypothetical protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C R70331_12630 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C R70331_18410 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C R70331_18460 chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C R70331_12650 chemotaxis protein K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C R70331_18415 chemotaxis protein CheY K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
#
ACell cycle family
B PleC-PleD (cell fate control)
C R70331_27790 hypothetical protein K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
#
ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
#
ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
#
AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C R70331_03090 histidine kinase K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C R70331_03095 histidine kinase K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
C R70331_30705 sensor with HAMP domain protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_21540 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_05295 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_10030 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_07915 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_03860 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_04055 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_20050 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_30930 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_06945 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_06995 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_12050 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_17760 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_22470 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_27145 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_01990 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_07485 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_07570 membrane protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_07600 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_19840 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_21970 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_08585 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_11765 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_30200 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_08200 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_08275 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_22690 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_27680 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_21600 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_22035 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_13405 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_22870 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_28005 membrane protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_10490 hypothetical protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_11730 sensor with HAMP domain protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C R70331_21535 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_05300 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_10495 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_10035 chemotaxis protein CheY K07720 yesN; two-component system, response regulator YesN
C R70331_07910 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_03855 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_04050 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_20055 transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_30935 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_06990 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_12045 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_17765 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_22360 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_27140 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_27150 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_07455 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_07490 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_07575 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_07605 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_19835 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_21975 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_22040 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_11735 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_11760 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_22865 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_28010 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_30700 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_08205 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_08280 chemotaxis protein CheY K07720 yesN; two-component system, response regulator YesN
C R70331_13415 response regulator K07720 yesN; two-component system, response regulator YesN
C R70331_22695 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_27685 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_01995 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_21595 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_18810 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
C R70331_08240 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_08590 chemotaxis protein CheY K07720 yesN; two-component system, response regulator YesN
C R70331_08680 hypothetical protein K07720 yesN; two-component system, response regulator YesN
C R70331_16210 AraC family transcriptional regulator K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C R70331_27575 histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C R70331_22210 histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C R70331_05000 hypothetical protein K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
B PdtaS-PdtaR
B NasS-NasT
C R70331_15020 histidine kinase K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C R70331_29865 hypothetical protein K19694 chiS; two-component system, sensor histidine kinase ChiS
C R70331_30350 histidine kinase K19694 chiS; two-component system, sensor histidine kinase ChiS
C R70331_10730 hypothetical protein K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023