+C Two-component system KO
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Two-Component System - Pseudomonas aeruginosa PAO581
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C M801_5406 phoR; phosphate regulon sensor kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C M801_5405 phoB; phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C M801_1218 his Kinase A domain protein K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C M801_1217 hypothetical protein K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C M801_5242 HAMP domain protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C M801_5243 hypothetical protein K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C M801_1196 HAMP domain protein K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C M801_1195 hypothetical protein K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C M801_3181 hypothetical protein K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C M801_475 creC; sensor protein CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C M801_474 hypothetical protein K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C M801_1478 heavy metal sensor kinase family protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C M801_2460 heavy metal sensor kinase family protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C M801_2775 heavy metal sensor kinase family protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C M801_4922 heavy metal sensor kinase family protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C M801_1477 response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C M801_2459 response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C M801_4920 response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C M801_2774 copR; transcriptional activator protein CopR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C M801_4807 his Kinase A domain protein K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C M801_4806 response regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C M801_1680 kdpD; sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C M801_1681 hypothetical protein K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C M801_781 HAMP domain protein K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C M801_780 response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
C M801_1851 HAMP domain protein K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C M801_1852 hypothetical protein K18073 parR; two-component system, OmpR family, response regulator ParR
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C M801_2635 pfeS; sensor protein pfeS K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C M801_962 pfeS; sensor protein pfeS K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C M801_961 hypothetical protein K19610 pfeR; two-component system, OmpR family, response regulator PfeR
C M801_2634 hypothetical protein K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C M801_3183 HAMP domain protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C M801_4098 response regulator K02483 K02483; two-component system, OmpR family, response regulator
C M801_3168 hypothetical protein K02483 K02483; two-component system, OmpR family, response regulator
C M801_2603 hypothetical protein K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C M801_3870 HAMP domain protein K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C M801_3871 bacterial regulatory s, luxR family protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C M801_3703 bacterial regulatory s, luxR family protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C M801_4076 bacterial regulatory s, luxR family protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C M801_2867 bacterial regulatory s, luxR family protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C M801_960 HAMP domain protein K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C M801_2531 bacterial regulatory s, luxR family protein K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C M801_3941 bvgS; virulence sensor protein BvgS K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C M801_2526 his Kinase A domain protein K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C M801_3017 bvgA; virulence factors putative positive transcription regulator BvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C M801_3943 bvgA; virulence factors putative positive transcription regulator BvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C M801_35 bvgA; virulence factors putative positive transcription regulator BvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C M801_4300 sensory box protein K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]
C M801_4303 bacterial regulatory s, luxR family protein K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C M801_5307 histidine kinase family protein K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C M801_5306 response regulator K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C M801_5162 PAS fold family protein K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C M801_5163 ntrC; nitrogen regulation protein NR K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C M801_4755 AAA domain family protein K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C M801_4561 his Kinase A domain protein K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C M801_4562 bacterial regulatory, Fis family protein K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C M801_5564 his Kinase A domain protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C M801_5207 his Kinase A domain protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C M801_5563 AAA domain family protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C M801_5208 AAA domain family protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C M801_5536 kinB; alginate biosynthesis sensor protein kinB K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C M801_5535 algB; alginate biosynthesis transcriptional regulatory protein AlgB K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C M801_2513 his Kinase A domain protein K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C M801_183 cheW-like domain protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C M801_1498 cheW-like domain protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C M801_184 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C M801_1496 cheY; chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C M801_178 cheB2; response regulator K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C M801_1499 cheB1; response regulator K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C M801_3333 cheW-like domain protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C M801_424 cheW-like domain protein K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C M801_419 response regulator K02657 pilG; twitching motility two-component system response regulator PilG
C M801_420 response regulator K02658 pilH; twitching motility two-component system response regulator PilH
C M801_425 cheB methylesterase family protein K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C M801_3693 cheW-like domain protein K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C M801_3691 diguanylate cyclase domain protein K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C M801_3692 cheB methylesterase family protein K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C M801_4194 bacterial regulatory s, luxR family protein K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C M801_1135 sensory box protein K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C M801_1136 bacterial regulatory, Fis family protein K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C M801_1375 his Kinase A domain protein K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C M801_1374 AAA domain family protein K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C M801_4505 his Kinase A domain protein K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C M801_4504 bacterial regulatory, Fis family protein K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C M801_2791 his Kinase A domain protein K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C M801_1655 HAMP domain protein K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C M801_2037 sensory box protein K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C M801_3329 hpt domain protein K20976 hptB; histidine phosphotransfer protein HptB
C M801_3330 stage II sporulation E family protein K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C M801_1833 NMT1-like family protein K22067 nasS; two-component system, oxyanion-binding sensor
C M801_1832 response regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
C M801_3347 amiR; aliphatic amidase regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C M801_3970 response regulator K20971 ladS; two-component system, sensor histidine kinase LadS
C M801_4891 response regulator K20972 retS; two-component system, sensor histidine kinase RetS
C M801_3450 his Kinase A domain protein K20972 retS; two-component system, sensor histidine kinase RetS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023