+C Two-component system KO
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Two-Component System - Pseudomonas aeruginosa PA1R
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C PA1R_gp3291 Phosphate regulon sensor protein PhoR (SphS) K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C PA1R_gp3290 Phosphate regulon transcriptional regulatory protein PhoB (SphR) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C PA1R_gp4790 Sensor protein PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C PA1R_gp4789 Transcriptional regulatory protein PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C PA1R_gp3132 Osmolarity sensory histidine kinase EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C PA1R_gp3133 Two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C PA1R_gp4769 Sensor histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C PA1R_gp4768 Transcriptional regulatory protein RstA K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C PA1R_gp1035 Copper-sensing two-component system response regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C PA1R_gp3974 Two-component response regulator CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C PA1R_gp3973 Two-component response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C PA1R_gp0631 Osmosensitive K+ channel histidine kinase KdpD K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1R_gp0318 Heavy metal sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1R_gp2808 Heavy metal sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1R_gp0317 DNA-binding heavy metal response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA1R_gp2807 DNA-binding heavy metal response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA1R_gp0630 putative two-component response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C PA1R_gp0276 sensor histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA1R_gp2693 Sensory histidine kinase QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA1R_gp0275 Two-component system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
C PA1R_gp2692 Two-component system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C PA1R_gp5216 Osmosensitive K+ channel histidine kinase KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C PA1R_gp5217 DNA-binding response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C PA1R_gp4249 Tricarboxylate transport sensor protein TctE K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C PA1R_gp4248 Tricarboxylate transport transcriptional regulator TctD K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
C PA1R_gp5421 Sensory histidine kinase in two-component regulatory system with RstA K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C PA1R_gp5422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein K18073 parR; two-component system, OmpR family, response regulator ParR
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C PA1R_gp0495 Two-component sensor histidine kinase PfeS, enterobactin K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA1R_gp4456 Two-component sensor histidine kinase PfeS, enterobactin K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA1R_gp4455 Two-component response regulator PfeR, enterobactin K19610 pfeR; two-component system, OmpR family, response regulator PfeR
C PA1R_gp0494 Two-component response regulator PfeR, enterobactin K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C PA1R_gp1037 Putative two-component system sensor kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PA1R_gp0458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein K02483 K02483; two-component system, OmpR family, response regulator
C PA1R_gp1023 DNA-binding response regulator GltR, controls specific porins for the entry of glucose K02483 K02483; two-component system, OmpR family, response regulator
C PA1R_gp1992 DNA-binding heavy metal response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C PA1R_gp1768 Nitrate/nitrite sensor protein K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C PA1R_gp0177 DNA-binding response regulator, LuxR family K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C PA1R_gp1769 Nitrate/nitrite response regulator protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C PA1R_gp0731 Two Component Transcriptional Regulator, LuxR family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA1R_gp1969 putative response regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA1R_gp1571 DNA-binding response regulator, LuxR family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C PA1R_gp4454 BarA sensory histidine kinase (VarS, GacS) K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C PA1R_gp0385 BarA-associated response regulator UvrY (GacA, SirA) K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C PA1R_gp0381 Virulence sensor protein bvgS precursor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA1R_gp1836 Hybrid sensory histidine kinase in two-component regulatory system with EvgA K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA1R_gp0880 DNA-binding response regulator, LuxR family K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA1R_gp1838 DNA-binding response regulator, LuxR family K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA1R_gp3545 DNA-binding response regulator, LuxR family K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C PA1R_gp2190 Sensory box histidine kinase K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]
C PA1R_gp2193 DNA-binding response regulator, LuxR family K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C PA1R_gp3196 Autolysin sensor kinase K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C PA1R_gp3195 Autolysis response regulater LytR K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C PA1R_gp3051 Nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C PA1R_gp3052 Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C PA1R_gp2642 Two-component sensor CbrB: intrcellular carbon:nitrogen balance K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C PA1R_gp2450 Two-component sensor PilS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C PA1R_gp2451 Type IV fimbriae expression regulatory protein PilR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C PA1R_gp3096 Signal transduction histidine kinase regulating C4-dicarboxylate transport system K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA1R_gp3446 C4-dicarboxylate transport sensor protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA1R_gp3097 C4-dicarboxylate transport transcriptional regulatory protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C PA1R_gp3445 Nitrogen regulation protein NR(I) K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C PA1R_gp3418 Sensory box histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C PA1R_gp3417 Response regulator of zinc sigma-54-dependent two-component system K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C PA1R_gp0368 Signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C PA1R_gp3692 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA1R_gp5040 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA1R_gp3693 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA1R_gp5038 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA1R_gp3687 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA1R_gp5041 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA1R_gp1187 Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C PA1R_gp3924 Component of chemotactic signal transduction system K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C PA1R_gp3919 twitching motility protein PilG K02657 pilG; twitching motility two-component system response regulator PilG
C PA1R_gp3920 twitching motility protein PilH K02658 pilH; twitching motility two-component system response regulator PilH
C PA1R_gp3925 Chemotaxis response regulator protein-glutamate methylesterase CheB K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C PA1R_gp1561 Sensor histidine kinase/response regulator K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C PA1R_gp1559 diguanylate cyclase (GGDEF domain) with PAS/PAC sensor K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C PA1R_gp1560 Chemotaxis response regulator protein-glutamate methylesterase group 3 operon K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C PA1R_gp2087 DNA-binding response regulator, LuxR family K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C PA1R_gp4710 Flagellar sensor histidine kinase FleS K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C PA1R_gp4711 Flagellar regulatory protein FleQ K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C PA1R_gp4944 Signal transduction histidine kinase regulating C4-dicarboxylate transport system K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C PA1R_gp4943 Two component, Sigma-54 Specific, central transcriptional regulator of acidic amino acid uptake K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C PA1R_gp2394 Sensor histidine kinase PrrB (RegB) K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C PA1R_gp2393 Dna binding response regulator PrrA (RegA) K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C PA1R_gp0655 sensor histidine kinase/response regulator K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C PA1R_gp5192 Sensor histidine kinase/response regulator K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PA1R_gp1183 Hpt domain protein K20976 hptB; histidine phosphotransfer protein HptB
C PA1R_gp1184 Serine phosphatase RsbU, regulator of sigma subunit K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C PA1R_gp5403 Nitrate ABC transporter, nitrate-binding protein K22067 nasS; two-component system, oxyanion-binding sensor
C PA1R_gp1201 Two component response regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
C PA1R_gp5402 Response regulator NasT K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C PA1R_gp1865 Sensor histidine kinase K20971 ladS; two-component system, sensor histidine kinase LadS
C PA1R_gp2777 integral membrane sensor hybrid histidine kinase K20972 retS; two-component system, sensor histidine kinase RetS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023