+C	Peptidases and inhibitors	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Peptidases and Inhibitors - Pseudomonas aeruginosa LESB58</h2>
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A<b>Aspartic peptidases</b>
B  Family A1: pepsin family
B  Family A2: retropepsin family
B  Family A5: thermopsin family
B  Family A8: signal peptidase II family
C    PLES_26981 putative lipoprotein signal peptidase LspA	K03101 lspA; signal peptidase II [EC:3.4.23.36] 
C    PLES_49421 lspA; prolipoprotein signal peptidase	K03101 lspA; signal peptidase II [EC:3.4.23.36] 
B  Family A22: presenilin family
B  Family A24: type IV prepilin peptidase family
C    PLES_49111 pilD; type 4 prepilin peptidase PilD	K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] 
C    PLES_46751 fppA; Flp prepilin peptidase A, FppA	K02278 cpaA; prepilin peptidase CpaA [EC:3.4.23.43] 
B  Family A25: gpr protease family
B  Family A26: omptin family
B  Family A28
B  Family A31: HybD endopeptidase family
B  Family A36
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A<b>Cysteine peptidases</b>
B  Family C1: papain family
B  Family C2: calpain family
B  Family C3: picornain family
B  Family C4: NIa protease family
B  Family C5
B  Family C9
B  Family C10: streptopain family
B  Family C11: clostripain family
B  Family C12: ubiquitin C-terminal hydrolase family
B  Family C13: legumain family
B  Family C14: caspase family
B  Family C15: pyroglutamyl peptidase I family
B  Family C16
B  Family C19: ubiquitin-specific protease family
B  Family C25: gingipain family
B  Family C26: gamma-glutamyl hydrolase family
C    PLES_12051 guaA; GMP synthase	K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] 
C    PLES_02931 spuA; probable glutamine amidotransferase	K07010 K07010; putative glutamine amidotransferase 
B  Family C27
B  Family C30
B  Family C37
B  Family C39
C    PLES_07841 probable toxin transporter	K13409 cvaB; ATP-binding cassette, subfamily B, bacterial CvaB/MchF/RaxB 
B  Family C40
C    PLES_15401 putative lipoprotein	K19303 mepH; murein DD-endopeptidase [EC:3.4.-.-] 
B  Family C44
C    PLES_19521 purF; amidophosphoribosyltransferase	K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] 
C    PLES_54261 gltB; glutamate synthase large chain precursor	K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] 
C    PLES_12211 probable aminotransferase	K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] 
C    PLES_59451 glmS; glucosamine--fructose-6-phosphateaminotransferase	K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] 
C    PLES_16011 probable glutamine amidotransferase	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
C    PLES_53841 asparagine synthetase (glutamine-hydrolyzing)	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
C    PLES_00521 phzH; potential phenazine-modifying enzyme	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
C    PLES_32371 probable asparagine synthetase	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
B  Family C45
B  Family C46: hedgehog family
B  Family C47: staphopain family
B  Family C48: Ulp1 endopeptidase family
B  Family C50: separase family
B  Family C54: Aut2 peptidase family
B  Family C55: YopJ protease family
B  Family C56: PfpI endopeptidase family
C    PLES_41841 conserved hypothetical protein	K05523 hchA; D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124] 
C    PLES_07561 probable protease	K05520 yhbO; deglycase [EC:3.5.1.124] 
C    PLES_03521 pfpI; protease PfpI	K05520 yhbO; deglycase [EC:3.5.1.124] 
C    PLES_47141 putative amidase/protease	K05520 yhbO; deglycase [EC:3.5.1.124] 
B  Family C57: vaccinia virus I7 peptidase family
B  Family C58
B  Family C59
B  Family C60
B  Family C63
B  Family C64
B  Family C65
B  Family C67
B  Family C69
B  Family C70
B  Family C75
B  Family C76
B  Family C78
B  Family C79
B  Family C82
C    PLES_22101 putative ErfK/YbiS/YcfS/YnhG family protein	K16291 erfK; L,D-transpeptidase ErfK/SrfK 
B  Family C83
B  Family C85
B  Family C86
B  Family C88
B  Family C89
B  Family C97
B  Family C98
B  Family C110
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A<b>Glutamic peptidases</b>
B  Family G1
B  Family G4
B  Family G5: prenyl protease 2 family
C    PLES_21801 putative protease	K07052 K07052; CAAX protease family protein 
C    PLES_55221 putative membrane protein	K07052 K07052; CAAX protease family protein 
#
A<b>Metallo peptidases</b>
B  Family M1
C    PLES_19771 pepN; aminopeptidase N	K01256 pepN; aminopeptidase N [EC:3.4.11.2] 
B  Family M2
B  Family M3
C    PLES_00681 prlC; oligopeptidase A	K01414 prlC; oligopeptidase A [EC:3.4.24.70] 
B  Family M4: thermolysin family
C    PLES_12581 lasB; elastase LasB	K01399 lasB; pseudolysin [EC:3.4.24.26] 
B  Family M5: mycolysin family
B  Family M6: immune inhibitor A family
B  Family M7: snapalysin family
B  Family M8: leishmanolysin family
B  Family M9
B  Family M10
C    PLES_40631 aprA; alkaline metalloproteinase precursor	K01406 prtC; serralysin [EC:3.4.24.40] 
B  Family M12: astacin/adamalysin family
B  Family M13: neprilysin family
B  Family M14: carboxypeptidase A family
B  Family M15: zinc D-Ala-D-Ala carboxypeptidase family
B  Family M16: pitrilysin family
C    PLES_03691 probable zinc protease	K07263 pqqL; zinc protease [EC:3.4.24.-] 
C    PLES_03681 putative peptidase	K07263 pqqL; zinc protease [EC:3.4.24.-] 
B  Family M17: leucyl aminopeptidase family
C    PLES_11431 pepA; leucine aminopeptidase	K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1] 
B  Family M18
B  Family M19: membrane dipeptidase family
C    PLES_57921 putative dipeptidase	K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] 
B  Family M20
C    PLES_22871 cpg2; carboxypeptidase G2 precursor	K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11] 
C    PLES_41591 dapE; succinyl-diaminopimelate desuccinylase	K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18] 
C    PLES_21421 probable hydrolase	K01451 hipO; hippurate hydrolase [EC:3.5.1.32] 
C    PLES_47221 probable hydrolase	K01451 hipO; hippurate hydrolase [EC:3.5.1.32] 
B  Family M23
C    PLES_34521 lasA; LasA protease precursor	K08642 lasA; LasA protease [EC:3.4.24.-] 
C    PLES_59471 hypothetical	K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-] 
B  Family M24
C    PLES_23331 probable methionine aminopeptidase	K01265 map; methionyl aminopeptidase [EC:3.4.11.18] 
C    PLES_13781 map; methionine aminopeptidase	K01265 map; methionyl aminopeptidase [EC:3.4.11.18] 
C    PLES_56181 pepP; aminopeptidase P	K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] 
B  Family M26
B  Family M27
B  Family M28: aminopeptidase Y family
B  Family M29: aminopeptidase T family
B  Family M32: carboxypeptidase Taq family
B  Family M34: anthrax lethal factor family
B  Family M35: deuterolysin family
B  Family M36: fungalysin family
B  Family M38: beta-aspartyl dipeptidase family
B  Family M41: FtsH endopeptidase family
C    PLES_51361 ftsH; cell division protein FtsH	K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] 
B  Family M42: glutamyl aminopeptidase family
B  Family M43: cytophagalysin family
B  Family M44
B  Family M48: Ste24 endopeptidase family
C    PLES_22351 htpX; heat shock protein HtpX	K03799 htpX; heat shock protein HtpX [EC:3.4.24.-] 
C    PLES_02731 putative putative Zn-dependent protease with chaperone function	K07387 K07387; metalloprotease [EC:3.4.24.-] 
C    PLES_43201 Putative Zn-dependent protease	K01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-] 
B  Family M49: dipeptidyl-peptidase III family
B  Family M50: S2P protease family
C    PLES_13861 putative membrane-associated zinc metalloprotease	K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] 
B  Family M54
B  Family M55: DppA aminopeptidase family
B  Family M56
B  Family M67
B  Family M72
B  Family M73
B  Family M74
B  Family M80
B  Family M82
B  Family M85
B  Family M88
C    PLES_05691 hypothetical protein	K21429 impA; immunomodulating metalloprotease 
B  Family M90
C    PLES_09461 conserved hypothetical protein	K09933 mtfA; MtfA peptidase 
#
A<b>Asparagine peptide lyases</b>
B  Family N1
B  Family N8
#
A<b>Mixed peptidases</b>
B  Family P1: DmpA aminopeptidase family
C    PLES_39261 putative D-aminopeptidase	K01266 dmpA; D-aminopeptidase [EC:3.4.11.19] 
B  Family P2
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A<b>Serine peptidases</b>
B  Family S1: chymotrypsin family
C    PLES_45771 mucD; serine protease MucD precursor	K04771 degP; serine protease Do [EC:3.4.21.107] 
C    PLES_48251 algW; AlgW protein	K04691 hhoB; serine protease DegS [EC:3.4.21.-] 
C    PLES_07521 piv; protease IV	K01337 E3.4.21.50; lysyl endopeptidase [EC:3.4.21.50] 
B  Family S3: togavirin family
B  Family S6
B  Family S7: flavivirin family
B  Family S8: subtilisin family
B  Family S9: prolyl oligopeptidase family
C    PLES_38781 probable oligopeptidase	K01354 ptrB; oligopeptidase B [EC:3.4.21.83] 
B  Family S10
B  Family S11: D-Ala-D-Ala carboxypeptidase A family
C    PLES_09771 dacC; D-ala-D-ala-carboxypeptidase	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
C    PLES_44471 pbpG; D-alanyl-D-alanine-endopeptidase	K07262 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-] 
B  Family S12: D-Ala-D-Ala carboxypeptidase B family
B  Family S13: D-Ala-D-Ala peptidase C family
C    PLES_20131 probable D-alanyl-D-alanine carboxypeptidase	K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] 
B  Family S14: ClpP endopeptidase family
C    PLES_17381 probable Clp-family ATP-dependent protease	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    PLES_35261 clpP; ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    PLES_25411 ClpP protease	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
B  Family S15
B  Family S16: lon protease family
C    PLES_35241 lon; Lon protease	K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53] 
C    PLES_45641 probable ATP-dependent protease	K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53] 
B  Family S21: assemblin family
B  Family S24: LexA family
C    PLES_20551 lexA; repressor protein LexA	K01356 lexA; repressor LexA [EC:3.4.21.88] 
B  Family S26: signal peptidase I family
C    PLES_38791 probable signal peptidase	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
C    PLES_45751 lepB; signal peptidase I	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
B  Family S28
B  Family S31
B  Family S32
B  Family S33
C    PLES_54701 prolyl aminopeptidase	K01259 pip; proline iminopeptidase [EC:3.4.11.5] 
B  Family S41: C-terminal processing peptidase family
C    PLES_18101 prc; periplasmic tail-specific protease	K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] 
C    PLES_55241 probable carboxyl-terminal protease	K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] 
B  Family S45
C    PLES_03011 putative penicillin amidase	K01434 pac; penicillin G amidase [EC:3.5.1.11] 
C    PLES_34311 putative penicillin acylase	K01434 pac; penicillin G amidase [EC:3.5.1.11] 
B  Family S49: protease IV family
C    PLES_20901 probable peptidase	K04773 sppA; protease IV [EC:3.4.21.-] 
C    PLES_34951 probable protease	K04774 sohB; serine protease SohB [EC:3.4.21.-] 
B  Family S50
B  Family S51
B  Family S53
B  Family S54: Rhomboid family
C    PLES_19741 hypothetical	K02441 glpG; rhomboid protease GlpG [EC:3.4.21.105] 
B  Family S55: SpoIVB peptidase family
B  Family S62
B  Family S66
C    PLES_55921 LD-carboxypeptidase	K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] 
B  Family S77: phage prohead processing peptidase family
B  Family S78
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A<b>Threonine peptidases</b>
B  Family T1: proteasome family
C    PLES_54431 hslV; heat shock protein HslV	K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2] 
B  Family T2
B  Family T3: gamma-glutamyltransferase family
C    PLES_03581 probable gamma-glutamyltranspeptidase precursor	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
C    PLES_01651 probable gamma-glutamyltranspeptidase	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
C    PLES_38431 ggt; gamma-glutamyltranspeptidase precursor	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
#
A<b>Peptidases of unknown catalytic type</b>
B  Family U32
C    PLES_58351 probable peptidase	K08303 prtC; U32 family peptidase [EC:3.4.-.-] 
C    PLES_10651 putative peptidase	K24845 ubiV; O2-independent ubiquinone biosynthesis protein UbiV 
C    PLES_10641 probable protease	K24844 ubiU; O2-independent ubiquinone biosynthesis protein UbiU 
B  Family U62
C    PLES_48511 pmbA; PmbA protein	K03592 pmbA; PmbA protein 
C    PLES_48531 putative tldD protein	K03568 tldD; TldD protein 
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A<b>Peptidase inhibitors</b>
B  Family I1: Kazal family
B  Family I2: Kunitz - BPTI family
B  Family I4: serpin family
B  Family I11: ecotin family
C    PLES_23231 eco; ecotin precursor	K08276 eco; ecotin 
B  Family I17: WAP-type family
B  Family I25: cystatin family
B  Family I27: calpastatin family
B  Family I32: IAP family
B  Family I34: IA3 family
B  Family I35: timp family
B  Family I39: alpha2M family
C    PLES_48691 putative membrane protein	K06894 yfhM; alpha-2-macroglobulin 
B  Family I47: latexin family
B  Family I49: proSAAS family
B  Family I51: IC family
B  Family I57: staphostatin B family
B  Family I63
B  Family I80
B  Family I87
C    PLES_53271 hflC; protease subunit HflC	K04087 hflC; modulator of FtsH protease HflC 
C    PLES_28561 hypothetical protein	K04087 hflC; modulator of FtsH protease HflC 
C    PLES_53281 hflK; protease subunit HflK	K04088 hflK; modulator of FtsH protease HflK 
B  Family I93
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#Last updated: May 29, 2024
#<br>Classification taken and modified from <a href="https://www.ebi.ac.uk/merops/">MEROPS</a>