+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Pseudomonas amygdali</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    BKM19_029125 phosphate regulon sensor histidine kinase PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    BKM19_029120 phoB; phosphate regulon transcriptional regulatory protein PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    BKM19_022115 histidine kinase	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    BKM19_022120 DNA-binding response regulator	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    BKM19_002810 two-component sensor histidine kinase	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    BKM19_002805 two-component system response regulator OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    BKM19_022150 sensor histidine kinase	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
B  CpxA-CpxR (envelope stress response)
C    BKM19_021205 DNA-binding response regulator	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
B  BaeS-BaeR (envelope stress response)
C    BKM19_017050 baeS; sensor histidine kinase efflux regulator BaeS	K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] 
C    BKM19_017055 DNA-binding response regulator	K07664 baeR; two-component system, OmpR family, response regulator BaeR 
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
C    BKM19_019705 HAMP domain-containing protein	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
C    BKM19_008500 sensor histidine kinase	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
C    BKM19_027800 sensor histidine kinase	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
C    BKM19_019700 DNA-binding response regulator	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
C    BKM19_008505 DNA-binding response regulator	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
C    BKM19_027805 DNA-binding response regulator	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
B  QseC-QseB (quorum sensing)
C    BKM19_020600 HAMP domain-containing protein	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    BKM19_020595 DNA-binding response regulator	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    BKM19_012880 sensor histidine kinase KdpD	K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 
C    BKM19_012885 DNA-binding response regulator	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
B  ArcB-ArcA (anoxic redox control)
B  TctE-TctD (tricarboxylic acid transport)
C    BKM19_023460 sensor histidine kinase	K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] 
C    BKM19_023465 DNA-binding response regulator	K07774 tctD; two-component system, OmpR family, response regulator TctD 
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    BKM19_022540 sensor histidine kinase	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    BKM19_018345 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    BKM19_012790 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    BKM19_008410 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    BKM19_022545 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    BKM19_018825 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
B  NarQ-NarP (nitrate respiration)
B  UhpB-UhpA (hexose phosphates uptake)
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
C    BKM19_009435 DNA-binding response regulator	K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB 
B  BarA-UvrY (central carbon metabolism)
C    BKM19_022050 hybrid sensor histidine kinase/response regulator	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    BKM19_017300 two-component system response regulator UvrY	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    BKM19_009425 PAS domain S-box protein	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    BKM19_013300 DNA-binding response regulator	K07690 evgA; two-component system, NarL family, response regulator EvgA 
C    BKM19_023055 DNA-binding response regulator	K07690 evgA; two-component system, NarL family, response regulator EvgA 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
C    BKM19_025640 PAS domain S-box protein	K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3] 
C    BKM19_025655 DNA-binding response regulator	K27077 pprB; two-component system, NarL family, response regulator PprB 
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
C    BKM19_000875 sensor histidine kinase	K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3] 
C    BKM19_000870 DNA-binding response regulator	K08083 algR; two-component system, LytTR family, response regulator AlgR 
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    BKM19_027965 nitrogen regulation protein NR(II)	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    BKM19_027970 ntrC; nitrogen regulation protein NR(I)	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
C    BKM19_005350 PAS domain-containing sensor histidine kinase	K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] 
C    BKM19_005345 sigma-54-dependent Fis family transcriptional regulator	K02667 pilR; two-component system, NtrC family, response regulator PilR 
B  GlrK-GlrR (amino sugar metabolism)
B  PgtB-PgtA (phosphoglycerate transport)
B  DctB-DctD (C4-dicarboxylate transport)
C    BKM19_023655 sensor histidine kinase	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
C    BKM19_028645 sensor histidine kinase	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
C    BKM19_023660 sigma-54-dependent Fis family transcriptional regulator	K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD 
C    BKM19_028650 sigma-54-dependent Fis family transcriptional regulator	K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD 
B  KinB-AlgB (alginate production)
C    BKM19_002840 PAS domain-containing sensor histidine kinase	K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] 
C    BKM19_002835 sigma-54-dependent Fis family transcriptional regulator	K11384 algB; two-component system, NtrC family, response regulator AlgB 
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    BKM19_006415 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    BKM19_020130 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    BKM19_006425 response regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    BKM19_020140 chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    BKM19_006390 chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    BKM19_020125 chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    BKM19_015235 chemotaxis protein CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    BKM19_020405 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    BKM19_008565 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    BKM19_019300 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
C    BKM19_004065 hybrid sensor histidine kinase/response regulator	K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) 
C    BKM19_004045 response regulator	K02657 pilG; twitching motility two-component system response regulator PilG 
C    BKM19_004050 response regulator	K02658 pilH; twitching motility two-component system response regulator PilH 
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
C    BKM19_009500 hybrid sensor histidine kinase/response regulator	K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE 
C    BKM19_009510 diguanylate cyclase response regulator	K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] 
C    BKM19_009505 chemotaxis response regulator protein-glutamate methylesterase	K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] 
B  Cph1-Rcp1 (light response)
C    BKM19_020560 histidine kinase	K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] 
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
C    BKM19_008345 response regulator	K11443 divK; two-component system, cell cycle response regulator DivK 
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
C    BKM19_020270 PAS domain-containing protein	K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] 
C    BKM19_020265 sigma-54-dependent Fis family transcriptional regulator	K10943 flrC; two-component system, response regulator FlrC 
B  AauS-AauR (acidic amino acids utilization)
C    BKM19_023170 sensor histidine kinase	K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] 
C    BKM19_023175 sigma-54-dependent Fis family transcriptional regulator	K17061 aauR; two-component system, response regulator AauR 
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
C    BKM19_024980 sensor histidine kinase	K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] 
C    BKM19_024975 DNA-binding response regulator	K15012 regA; two-component system, response regulator RegA 
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
C    BKM19_021580 hybrid sensor histidine kinase/response regulator	K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3] 
C    BKM19_012730 hybrid sensor histidine kinase/response regulator	K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] 
C    BKM19_020220 Hpt domain-containing protein	K20976 hptB; histidine phosphotransfer protein HptB 
C    BKM19_020225 fused response regulator/phosphatase	K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator 
B  PdtaS-PdtaR
B  NasS-NasT
C    BKM19_013180 nitrate ABC transporter substrate-binding protein	K22067 nasS; two-component system, oxyanion-binding sensor 
C    BKM19_013175 response regulator	K07183 nasT; two-component system, response regulator / RNA-binding antiterminator 
B  Unclassified
C    BKM19_025470 hybrid sensor histidine kinase/response regulator	K20971 ladS; two-component system, sensor histidine kinase LadS 
C    BKM19_025820 hybrid sensor histidine kinase/response regulator	K20972 retS; two-component system, sensor histidine kinase RetS 
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#Last updated: December 14, 2023