+F Repair protein KO
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DNA Repair and Recombination Proteins - Papio anubis (olive baboon)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101007829 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 101011226 ALKBH2; DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 101021086 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 101002683 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 101012053 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 101023969 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101017410 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 101026837 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 101025544 MUTYH; adenine DNA glycosylase isoform X2 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 101019682 MBD4; methyl-CpG-binding domain protein 4 isoform X3 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 101003455 OGG1; N-glycosylase/DNA lyase isoform X3 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 101014182 NEIL1; LOW QUALITY PROTEIN: endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 101008640 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 101010354 NEIL3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 101024677 NTHL1; endonuclease III-like protein 1 isoform X5 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 101000737 APEX1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 101020803 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100997559 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 101012085 POLD2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 101023456 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 101019925 POLD4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 101016601 POLE; LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 101026689 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 103878140 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 101025211 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 101016590 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 101024032 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101003042 LIG1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 101018348 POLB; DNA polymerase beta isoform X2 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100998954 XRCC1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 101011623 LIG3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 101002721 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X2 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 101024645 APTX; aprataxin isoform X2 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101008678 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101019279 PNKP; bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 100137373 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100846950 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101009923 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 101019467 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 101019495 PARP4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100999337 PARP2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 101007590 XPC; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 101019378 RAD23B; UV excision repair protein RAD23 homolog B isoform X3 K10839 RAD23; UV excision repair protein RAD23
F 101007079 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 101009450 CETN2; centrin-2 isoform X2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 101025661 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101012140 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 101025606 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 101001825 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100998564 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100998821 POLR2A; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 101005833 POLR2B; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 101006304 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 101011026 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 110741273 POLR2E; LOW QUALITY PROTEIN: DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 101026595 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 101006252 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X2 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 101002187 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 101021248 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 110743057 DNA-directed RNA polymerases I, II, and III subunit RPABC5-like K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 110741160 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 100997880 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a isoform X1 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 108585500 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 101025661 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101012140 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 101025606 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 101001825 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 101013203 ERCC8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 101014911 ERCC6; DNA excision repair protein ERCC-6 isoform X2 K10841 ERCC6; DNA excision repair protein ERCC-6
F 101015747 UVSSA; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 101013571 ELOF1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 101004610 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 101024209 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X2 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 101005211 GTF2H1; general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 101013583 GTF2H2; general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 101013130 GTF2H3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 103883597 GTF2H4; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 101023137 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 101016788 CDK7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 101016184 CCNH; cyclin-H isoform X2 K06634 CCNH; cyclin H
E 101002720 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 101017924 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 101004377 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 101019820 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 101021390 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 101023341 XPA; DNA repair protein complementing XP-A cells isoform X2 K10847 XPA; DNA-repair protein complementing XP-A cells
E 101025144 ERCC1; DNA excision repair protein ERCC-1 isoform X2 K10849 ERCC1; DNA excision repair protein ERCC-1
E 101020920 ERCC4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 101002794 ERCC5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 101003042 LIG1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 101010502 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 101025784 CUL3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 101019706 CUL5; LOW QUALITY PROTEIN: cullin-5 K10612 CUL5; cullin 5
E 101026337 ELOC; elongin-C isoform X1 K03872 ELOC; elongin-C
E 101008741 ELOB; elongin-B isoform X1 K03873 ELOB; elongin-B
E 101016599 ELOA; elongin-A isoform X1 K15076 ELOA; elongin-A
E 101001863 ELOA2; elongin-A2 K15076 ELOA; elongin-A
E 101014596 UBAP2; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 100999017 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 116269731 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 116269741 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 101005434 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 101002001 MSH3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 101006470 MSH6; DNA mismatch repair protein Msh6 isoform X2 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100999364 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 101013658 MLH1; DNA mismatch repair protein Mlh1 isoform X3 K08734 MLH1; DNA mismatch repair protein MLH1
E 101015014 PMS2; LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 101019178 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100997559 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 101012085 POLD2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 101023456 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 101019925 POLD4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 101017924 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 101004377 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 101019820 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 101021390 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 101002449 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 101016627 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 101017332 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 101026603 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 101026886 RFC3; replication factor C subunit 3 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 101016590 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100999751 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100137373 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 101003042 LIG1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100137438 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 101007622 MRE11; double-strand break repair protein MRE11 isoform X3 K10865 MRE11; double-strand break repair protein MRE11
E 100137539 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100526779 NBN; nibrin isoform X2 K10867 NBN; nibrin
D BRCA1-core complex
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101002976 BARD1; BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101006623 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 101023167 UIMC1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 101026896 BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 101010417 BABAM2; BRISC and BRCA1-A complex member 2 isoform X7 K12173 BRE; BRCA1-A complex subunit BRE
E 101005739 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X4 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100998699 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101000224 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100526778 RBBP8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 101007622 MRE11; double-strand break repair protein MRE11 isoform X3 K10865 MRE11; double-strand break repair protein MRE11
E 100137539 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100526779 NBN; nibrin isoform X2 K10867 NBN; nibrin
D BRCA complex
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101020669 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 101007550 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 101017256 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 101017256 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 101001187 RAD51B; DNA repair protein RAD51 homolog 2 isoform X5 K10869 RAD51L1; RAD51-like protein 1
E 101017335 RAD51C; DNA repair protein RAD51 homolog 3 isoform X3 K10870 RAD51L2; RAD51-like protein 2
E 101011978 RAD51D; DNA repair protein RAD51 homolog 4 isoform X2 K10871 RAD51L3; RAD51-like protein 3
E 101010935 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 101022574 XRCC3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 101016954 RAD52; DNA repair protein RAD52 homolog isoform X3 K10873 RAD52; DNA repair and recombination protein RAD52
E 101023950 RDM1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 101005191 RAD54L; DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100997639 RAD54L2; helicase ARIP4 isoform X2 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 101021996 RAD54B; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 101005644 RECQL; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 101014667 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 101008865 BLM; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101026824 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 101005580 RECQL5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 101008865 BLM; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101013118 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101025704 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101008704 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101008511 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 101017924 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 101004377 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 101019820 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 101021390 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 101005722 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 101025264 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X5 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101019194 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101002998 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X4 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 101022378 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101014529 PPP4R3C; LOW QUALITY PROTEIN: protein PPP4R3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101014901 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101000742 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 101015420 AP5B1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 101010853 AP5M1; AP-5 complex subunit mu-1 isoform X2 K19023 AP5M1; AP-5 complex subunit mu-1
E 101008655 AP5S1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 101018766 AP5Z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 101002079 SMC5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 101012651 SMC6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 101008319 LRATD1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 101021491 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X2 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 101025761 NSMCE2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100998282 NSMCE3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 101005405 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 101019544 EID3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 101004083 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 101004476 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 101007759 EME1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 101017608 EME2; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 101007812 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 101009026 MUS81; crossover junction endonuclease MUS81 isoform X2 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 101027004 SEM1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 101006268 SWI5; LOW QUALITY PROTEIN: DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 101011455 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 101010963 SLX1A; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 101003271 SLX4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 101013014 GEN1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 101025983 SPG11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 101000152 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X2 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 101007124 RAD51AP1; RAD51-associated protein 1 isoform X3 K20778 RAD51AP1; RAD51-associated protein 1
E 101004799 MORF4L1; mortality factor 4-like protein 1 isoform X2 K11339 MORF4L1; mortality factor 4-like protein 1
E 100998762 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 101014599 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100998415 SPIDR; DNA repair-scaffolding protein isoform X9 K22806 SPIDR; DNA repair-scaffolding protein
E 100998986 LRATD2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 101014595 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 101025935 CFAP410; cilia- and flagella-associated protein 410 isoform X3 K23456 CFAP410; cilla- and flagella-associated protein
E 101011636 HDGFL2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 101001610 ZSWIM7; zinc finger SWIM domain-containing protein 7 isoform X2 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 101009852 SWSAP1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 101008221 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X4 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 101002546 HSF2BP; heat shock factor 2-binding protein isoform X2 K25791 HSF2BP; heat shock factor 2-binding protein
E 101023849 MMS22L; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 101005286 TONSL; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 101012105 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X7 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 101009234 PARPBP; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
E 101003953 HROB; uncharacterized protein C17orf53 homolog isoform X3 K27803 HROB; homologous recombination OB-fold protein
E 101021776 MCM8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 101009408 MCM9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 101003888 XRCC6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 101008555 XRCC5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100999716 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X2 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 101007622 MRE11; double-strand break repair protein MRE11 isoform X3 K10865 MRE11; double-strand break repair protein MRE11
E 100137539 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 101007647 LIG4; DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100846951 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 100846948 NHEJ1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100846950 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101012679 POLM; DNA-directed DNA/RNA polymerase mu isoform X4 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 101004822 DNTT; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 101018348 POLB; DNA polymerase beta isoform X2 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 101024645 APTX; aprataxin isoform X2 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101008678 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100846949 DCLRE1C; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 101003358 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 101020549 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 101012261 PWWP3B; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 101014014 PAXX; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 101023351 CYREN; cell cycle regulator of non-homologous end joining isoform X2 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 103888093 SHLD1; shieldin complex subunit 1 isoform X1 K26128 SHLD1; shieldin complex subunit 1
E 101019203 SHLD2; LOW QUALITY PROTEIN: shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 116275026 SHLD3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
E 101017952 BEND4; BEN domain-containing protein 4 isoform X1 K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E 101019294 FANCA; Fanconi anemia group A protein isoform X2 K10888 FANCA; fanconi anemia group A protein
E 100998732 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 101017453 FANCC; Fanconi anemia group C protein isoform X2 K10890 FANCC; fanconi anemia group C protein
E 101016535 FANCE; Fanconi anemia group E protein isoform X2 K10892 FANCE; fanconi anemia group E protein
E 101016505 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 100999401 FANCG; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 100999974 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 101020933 FANCM; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 101009412 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 101026654 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 101006374 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 101013291 centromere protein S K11511 APITD1; centromere protein S
E 101008189 CENPS; centromere protein S K11511 APITD1; centromere protein S
E 101011271 CENPX; centromere protein X isoform X3 K15360 STRA13; centromere protein X
E 101009586 UBE2T; ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 101008865 BLM; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101013118 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101025704 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101008704 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101008511 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100999229 FANCD2; LOW QUALITY PROTEIN: Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 101020004 FANCI; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 101022062 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101020669 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100998699 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101007550 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 101002009 FAN1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 101017256 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 101017335 RAD51C; DNA repair protein RAD51 homolog 3 isoform X3 K10870 RAD51L2; RAD51-like protein 2
E 101013699 TELO2; telomere length regulation protein TEL2 homolog isoform X3 K11137 TELO2; telomere length regulation protein
E 101020260 USP1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 101000327 WDR48; WD repeat-containing protein 48 isoform X4 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 101021459 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 101015701 PPP6R1; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 101004127 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 101026382 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 101020516 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 101018505 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 101011003 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 101007524 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X2 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 101025578 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 101025571 RNF169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 101024443 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 101005466 WRAP53; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 101016262 TPRN; LOW QUALITY PROTEIN: taperin K24164 TPRN; taperin
E 101010074 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X4 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 101004199 WDR70; WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 100137438 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 101023003 POLH; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 101024902 POLI; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 101006298 POLK; DNA polymerase kappa isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 101018984 REV1; DNA repair protein REV1 isoform X7 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 101011068 REV3L; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 101009799 POLN; DNA polymerase nu isoform X1 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 101003064 UBE2A; ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 101024798 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 101009263 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 101002190 HLTF; helicase-like transcription factor isoform X3 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 101000405 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 103876449 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101010755 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101025419 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101000633 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101013449 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 103884777 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101022098 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 103880518 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 101016590 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101009234 PARPBP; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 101007029 SPRTN; sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 101014892 GCNA; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 101013999 RAD9A; cell cycle checkpoint control protein RAD9A isoform X2 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 101022360 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 101003124 HUS1B; checkpoint protein HUS1B K10996 HUS1B; checkpoint protein HUS1B
D 101024315 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 101010466 RAD17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 101016627 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101017332 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101026603 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 101026886 RFC3; replication factor C subunit 3 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 101024315 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 101012878 TIMELESS; protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 101009432 TIPIN; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 101004019 CLSPN; claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 101013699 TELO2; telomere length regulation protein TEL2 homolog isoform X3 K11137 TELO2; telomere length regulation protein
D 101021162 TTI1; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 101018818 TTI2; TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 101018509 UBL4B; ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 100997113 UBL4A; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 100999993 GET4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 101017442 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 101011610 ATRIP; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 101021695 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 101006608 TP53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 101019580 CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 101015280 CHEK2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 101017438 CDC25A; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 101007465 CDC25B; M-phase inducer phosphatase 2 isoform X7 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 101017717 CDC25C; M-phase inducer phosphatase 3 isoform X5 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 101022263 YWHAQ; 14-3-3 protein theta isoform X4 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101021050 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101022352 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101012101 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101005569 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100126764 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 101010193 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 101022165 NAV2; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 101001148 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101011958 WEE1; wee1-like protein kinase isoform X3 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101017574 PER1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 101001232 PER2; period circadian protein homolog 2 isoform X2 K02633 PER2; period circadian protein 2
D 101017174 PER3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 100997783 MDC1; mediator of DNA damage checkpoint protein 1 isoform X3 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 101018464 PLS3; plastin-3 isoform X2 K17336 PLS3; plastin-3
D 101015828 AEN; apoptosis-enhancing nuclease isoform X2 K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 101020739 PLK3; serine/threonine-protein kinase PLK3 isoform X1 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 101008575 NEK4; serine/threonine-protein kinase Nek4 isoform X3 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101022312 NEK1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101009740 NEK5; serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101015314 NEK10; serine/threonine-protein kinase Nek10 isoform X2 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 101011255 NEK11; serine/threonine-protein kinase Nek11 isoform X2 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100137248 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 101018166 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101023719 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101005593 KANK2; KN motif and ankyrin repeat domain-containing protein 2 isoform X2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101026607 KANK4; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101016217 KLLN; killin K23389 KLLN; killin
D 101014609 SLFN11; schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 101017392 CHMP4C; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 116271491 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100997079 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101007665 VPS4A; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101018931 ZFYVE19; LOW QUALITY PROTEIN: abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 101011020 SDE2; replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 101005448 POLQ; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 101012579 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 101024672 PRIMPOL; DNA-directed primase/polymerase protein isoform X5 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 101012435 TREX1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 101007324 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 101000527 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 101018254 DCLRE1B; 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 101009242 EXO5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 101019391 endonuclease V isoform X2 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 101024383 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100997209 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 101006285 HELQ; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 101017805 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 101007031 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 101005001 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 101023673 BCAS2; pre-mRNA-splicing factor SPF27 isoform X2 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 101016660 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 101015097 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 116275879 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101010799 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 101021881 NUDT18; LOW QUALITY PROTEIN: 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 101013459 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116275855 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101021447 RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 101026728 RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 101026110 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101007829 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 101012053 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 101026837 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 101025544 MUTYH; adenine DNA glycosylase isoform X2 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 101024677 NTHL1; endonuclease III-like protein 1 isoform X5 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 101026290 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X3 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 101026290 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X3 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 101015097 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 116275879 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101013459 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116275855 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024