+F Repair protein KO
#
DNA Repair and Recombination Proteins - Pseudomonas aeruginosa PA7
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PSPA7_4403 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D PSPA7_5309 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PSPA7_4770 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PSPA7_1099 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PSPA7_5884 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PSPA7_1634 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E PSPA7_3423 hypothetical protein K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D PSPA7_4971 putative pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_2466 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_1950 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_5642 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_1657 hydrolase, nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_6097 dut; deoxyuridine 5-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PSPA7_4403 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D PSPA7_1546 putative methylated-DNA--protein-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D PSPA7_3190 regulatory protein ada (Regulatory protein of adaptative response) K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D PSPA7_5309 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PSPA7_4770 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PSPA7_3585 alkA; DNA-3-methyladenine glycosylase 2 K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E PSPA7_1099 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PSPA7_5884 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PSPA7_0010 tag; DNA-3-methyladenine glycosidase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E PSPA7_0450 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E PSPA7_1634 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E PSPA7_0921 xth2; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E PSPA7_6108 crc; catabolite repression control protein K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E PSPA7_2692 xth1; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E PSPA7_1395 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E PSPA7_3804 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E PSPA7_6293 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E PSPA7_0866 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E PSPA7_1990 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E PSPA7_2614 uvrC; excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E PSPA7_6233 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSPA7_6293 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E PSPA7_3804 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F PSPA7_0830 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F PSPA7_0831 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F PSPA7_0862 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F PSPA7_6113 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F PSPA7_2157 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E PSPA7_1519 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E PSPA7_5675 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E PSPA7_4884 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E PSPA7_1339 xseA; exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E PSPA7_1059 xseB; exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E PSPA7_1499 dnaE; DNA polymerase III, alpha chain K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E PSPA7_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E PSPA7_1281 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E PSPA7_1119 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E PSPA7_2200 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E PSPA7_3480 dnaQ; DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSPA7_1893 putative nuclease K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSPA7_3801 DNA polymerase III subunit tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E PSPA7_3804 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E PSPA7_6233 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSPA7_0868 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E PSPA7_4462 Ssb K03111 ssb; single-strand DNA-binding protein
E PSPA7_2376 DNA adenine methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E PSPA7_4452 DNA adenine methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E PSPA7_2517 very short patch repair endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E PSPA7_4851 recB; exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E PSPA7_4852 recC; exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E PSPA7_4850 recD; exodeoxyribonuclease V, alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E PSPA7_1523 recA; protein RecA K03553 recA; recombination protein RecA
E PSPA7_4542 ruvA; holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E PSPA7_4541 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PSPA7_4543 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E PSPA7_5787 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E PSPA7_2528 hypothetical protein K04067 priC; primosomal replication protein N''
E PSPA7_4884 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E PSPA7_4849 nuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E PSPA7_4848 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E PSPA7_1523 recA; protein RecA K03553 recA; recombination protein RecA
E PSPA7_5249 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E PSPA7_0003 recF; RecF protein K03629 recF; DNA replication and repair protein RecF
E PSPA7_6122 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E PSPA7_1395 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E PSPA7_4747 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E PSPA7_3799 recR; recombination protein RecR K06187 recR; recombination protein RecR
E PSPA7_5483 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E PSPA7_1858 hypothetical protein K03554 rdgC; recombination associated protein RdgC
E PSPA7_4542 ruvA; holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E PSPA7_4541 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PSPA7_4543 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E PSPA7_4849 nuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E PSPA7_4848 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E PSPA7_4875 hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E PSPA7_3156 Ku protein K10979 ku; DNA end-binding protein Ku
E PSPA7_3173 ligD; DNA ligase D K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F PSPA7_1961 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F PSPA7_0004 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F PSPA7_2148 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F PSPA7_4465 DNA topoisomerase I, plasmid K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F PSPA7_2998 hypothetical protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F PSPA7_6125 putative DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
F PSPA7_3493 hupB; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
F PSPA7_1168 putative DNA binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F PSPA7_1395 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F PSPA7_4747 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F PSPA7_3799 recR; recombination protein RecR K06187 recR; recombination protein RecR
F PSPA7_3804 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F PSPA7_5573 fis; DNA-binding protein Fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F PSPA7_2510 ihfA; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F PSPA7_1968 ihfB; integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F PSPA7_4884 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F PSPA7_1786 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F PSPA7_0866 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F PSPA7_1990 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D PSPA7_4587 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D PSPA7_0100 protein MucA K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D PSPA7_1523 recA; protein RecA K03553 recA; recombination protein RecA
D PSPA7_2152 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D PSPA7_5483 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D PSPA7_3400 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D PSPA7_4839 hypothetical protein K14160 imuA; protein ImuA
D PSPA7_4840 hypothetical protein K14161 imuB; protein ImuB
D PSPA7_4841 putative DNA polymerase alpha chain K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D PSPA7_0868 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D PSPA7_4462 Ssb K03111 ssb; single-strand DNA-binding protein
D PSPA7_1524 hypothetical protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D PSPA7_6070 rep; ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D PSPA7_4334 hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D PSPA7_1849 putative ATP-dependent DNA helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D PSPA7_4429 DEAD/DEAH box helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D PSPA7_4971 putative pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_2466 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_1950 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_5642 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_1657 hydrolase, nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSPA7_6097 dut; deoxyuridine 5-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D PSPA7_6298 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D PSPA7_4224 ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide reductase) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D PSPA7_4225 nrdB; ribonucleoside reductase, small chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024