+E Replication protein KO
#
DNA Replication Proteins - Paracoccidioides brasiliensis
%
!
AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D PADG_01937 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D PADG_05826 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D PADG_02433 uncharacterized protein K02605 ORC3; origin recognition complex subunit 3
D PADG_01317 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D PADG_08375 uncharacterized protein K02607 ORC5; origin recognition complex subunit 5
D PADG_05003 uncharacterized protein K02608 ORC6; origin recognition complex subunit 6
D PADG_01181 AAA family ATPase CDC6 K02213 CDC6; cell division control protein 6
D PADG_03481 MCM DNA helicase complex subunit MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D PADG_07901 MCM DNA helicase complex subunit MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D PADG_11664 uncharacterized protein K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D PADG_05775 MCM DNA helicase complex subunit MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D PADG_05450 MCM DNA helicase complex subunit MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D PADG_08558 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D PADG_05930 CDC7 protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D PADG_03596 protein serine/threonine kinase activating protein DBF4 K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D PADG_02964 DNA replication complex GINS protein psf1 K10732 GINS1; GINS complex subunit 1
D PADG_01247 uncharacterized protein K10733 GINS2; GINS complex subunit 2
D PADG_01758 DNA replication complex GINS protein psf3 K10734 GINS3; GINS complex subunit 3
D PADG_03667 uncharacterized protein K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D PADG_06912 uncharacterized protein K03507 DPB11; DNA replication regulator DPB11
D PADG_01927 uncharacterized protein K10731 SLD3; DNA replication regulator SLD3
D PADG_06687 DNA replication initiation factor CDC45 K06628 CDC45; cell division control protein 45
D PADG_00563 uncharacterized protein K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D PADG_11255 phosphomethylpyrimidine kinase K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D PADG_06880 DNA-directed DNA polymerase alpha subunit POL12 K02321 POLA2; DNA polymerase alpha subunit B
D PADG_06516 DNA primase subunit PRI1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D PADG_07805 DNA primase subunit PRI2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D PADG_05098 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D PADG_03843 DNA polymerase epsilon noncatalytic subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D PADG_01917 uncharacterized protein K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D PADG_01056 DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D PADG_04120 DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
D PADG_05001 uncharacterized protein K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D PADG_05673 DNA-directed DNA polymerase gamma MIP1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D PADG_07835 replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
D PADG_03459 uncharacterized protein K10739 RFA2; replication factor A2
C RFC (replication factor C)
D PADG_07061 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D PADG_04172 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D PADG_07059 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D PADG_02402 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D PADG_02085 RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D PADG_08085 ribonuclease HII K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D PADG_05396 uncharacterized protein K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D PADG_01822 bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D PADG_03265 uncharacterized protein K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D PADG_06009 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D PADG_12138 uncharacterized protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D PADG_05364 DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D PADG_05690 uncharacterized protein K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D PADG_04720 uncharacterized protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D PADG_04928 uncharacterized protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
E PADG_11211 uncharacterized protein K11109 POT1; protection of telomeres protein 1
E PADG_01112 uncharacterized protein K11109 POT1; protection of telomeres protein 1
E PADG_12463 uncharacterized protein K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
E PADG_01806 uncharacterized protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E PADG_01916 uncharacterized protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E PADG_03812 uncharacterized protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
C Telomerase complex (animals)
D PADG_12533 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E PADG_04948 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E PADG_04612 uncharacterized protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E PADG_07458 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E PADG_05875 centromere/microtubule-binding protein cbf5 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D PADG_12533 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E PADG_04107 mRNA splicing protein SMB1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E PADG_06856 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E PADG_01999 uncharacterized protein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E PADG_03214 mRNA splicing protein SME1 K11097 SNRPE; small nuclear ribonucleoprotein E
E PADG_02530 uncharacterized protein K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D PADG_04172 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D PADG_07059 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D PADG_02402 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D PADG_05078 DNA repair protein (mre11) K10865 MRE11; double-strand break repair protein MRE11
D PADG_01588 MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D PADG_05676 DNA-binding protein kinase TEL1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D PADG_03738 uncharacterized protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D PADG_07978 ssDNA endodeoxyribonuclease RAD1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D PADG_02607 uncharacterized protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D PADG_03996 uncharacterized protein K11135 PINX1; Pin2-interacting protein X1
D PADG_07657 uncharacterized protein K11137 TELO2; telomere length regulation protein
D PADG_06911 uncharacterized protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D PADG_04980 uncharacterized protein K23314 WRAP53; telomerase Cajal body protein 1
D PADG_04865 uncharacterized protein K25059 SDE2; replication stress response regulator SDE2
D PADG_00380 uncharacterized protein K25186 RTF2; replication termination factor 2
D PADG_05528 uncharacterized protein K22485 TBF1; protein TBF1
B DNA Topoisomerases
C PADG_07812 DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C PADG_06339 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C PADG_04954 DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E PADG_02085 RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E PADG_02085 RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E PADG_01822 bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E PADG_06009 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E PADG_05364 DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022