+F Repair protein KO
#
DNA Repair and Recombination Proteins - Penaeus chinensis (fleshy prawn)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 125041133 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 125030554 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 125035853 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 125042241 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 125040590 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 125042755 uncharacterized protein LOC125042755 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 125035980 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 125031166 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 125043195 LOW QUALITY PROTEIN: cilia- and flagella-associated protein 251-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 125028073 N-glycosylase/DNA lyase-like K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 125029634 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 125046740 endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 125044252 DNA-(apurinic or apyrimidinic site) endonuclease-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 125028293 DNA-(apurinic or apyrimidinic site) endonuclease 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 125039482 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 125030007 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
F 125039556 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 125028173 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 125038579 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 125041860 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 125029262 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 125041573 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 125032182 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 125029702 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 125026421 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 125038887 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 125031152 uncharacterized protein LOC125031152 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 125035785 DNA ligase 3-like isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 125046073 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 125036254 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 125029679 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 125038400 uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 125044977 high mobility group protein B2-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 125039374 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 125044992 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 125034231 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 125044645 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 125034772 poly [ADP-ribose] polymerase 2-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 125044931 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 125045079 protein mono-ADP-ribosyltransferase PARP3-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 125036094 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 125029048 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 125046917 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 125048031 cullin-4A-like K10609 CUL4; cullin 4
F 125043732 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 125046658 DNA damage-binding protein 2-like isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 125031900 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 125035261 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 125025782 serine-rich adhesin for platelets-like isoform X1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 125038151 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 125027543 DNA-directed RNA polymerase II subunit RPB3-like isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 125036258 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 125035116 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 125040523 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 125046123 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 125038577 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 125027980 DNA-directed RNA polymerase II subunit RPB9-like K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 125045609 DNA-directed RNA polymerase II subunit RPB11-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 125046917 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 125048031 cullin-4A-like K10609 CUL4; cullin 4
F 125043732 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 125034883 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 125037315 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 125039881 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 125033341 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 125045260 general transcription and DNA repair factor IIH helicase subunit XPB-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 125038520 general transcription and DNA repair factor IIH helicase subunit XPD-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 125041989 general transcription factor IIH subunit 1-like isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 125043368 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 125036070 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 125029488 general transcription factor IIH subunit 4-like isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 125045490 cyclin-dependent kinase 7-like isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 125030620 cyclin-H-like isoform X1 K06634 CCNH; cyclin H
E 125030737 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 125029081 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125039801 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 125041767 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 125035306 DNA repair protein complementing XP-A cells-like K10847 XPA; DNA-repair protein complementing XP-A cells
E 125047655 DNA excision repair protein ERCC-1-like isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 125042700 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 125039398 DNA excision repair protein ERCC-5 homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 125029702 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 125039768 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 125041087 cullin-3-like K03869 CUL3; cullin 3
E 125034315 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 125046786 elongin-C K03872 ELOC; elongin-C
E 125027935 elongin-B-like K03873 ELOB; elongin-B
E 125033287 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 125026668 protein lingerer-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 125025948 DNA mismatch repair protein Msh2-like K08735 MSH2; DNA mismatch repair protein MSH2
E 125033237 DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 125043762 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 125027172 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 125039526 LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh1-like K08734 MLH1; DNA mismatch repair protein MLH1
E 125039477 mismatch repair endonuclease PMS2-like isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 125046392 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 125039482 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 125030007 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E 125039556 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 125029081 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125039801 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 125041767 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 125045118 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
E 125043743 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 125038570 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 125045236 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
E 125041591 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 125041573 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 125041580 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 125044977 high mobility group protein B2-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 125039374 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 125029702 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 125036002 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 125032996 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 125025735 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 125039496 nibrin-like isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125029681 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125046667 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 125030351 BRISC and BRCA1-A complex member 2-like isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 125047091 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125037702 LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125032607 nucleolar protein dao-5-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 125032996 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 125025735 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 125039496 nibrin-like isoform X1 K10867 NBN; nibrin
D BRCA complex
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125035790 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 125037790 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 125037790 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 125047638 DNA repair protein RAD51 homolog 2-like isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 125028172 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 125035541 DNA repair protein RAD51 homolog 4-like isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 125027381 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 125042738 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 125033463 uncharacterized protein LOC125033463 K10873 RAD52; DNA repair and recombination protein RAD52
E 125027289 RAD52 motif-containing protein 1-like isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 125042617 LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 125031514 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 125025226 Werner syndrome ATP-dependent helicase homolog isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 125029433 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125038748 ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 125045040 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 125029433 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125032800 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125045656 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125043031 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 125032744 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 125029081 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125039801 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 125041767 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 125042253 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 125027353 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 125031516 serine/threonine-protein phosphatase 4 regulatory subunit 2-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 125042791 serine/threonine-protein phosphatase 4 regulatory subunit 3A-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 125032889 uncharacterized protein LOC125032889 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 125030443 uncharacterized protein LOC125030443 K19022 AP5B1; AP-5 complex subunit beta-1
D SMC5-SMC6 complex
E 125035162 structural maintenance of chromosomes protein 5-like K22803 SMC5; structural maintenance of chromosomes protein 5
E 125029570 structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 125025183 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 125041158 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 125042717 uncharacterized protein LOC125042717 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 125041845 crossover junction endonuclease EME1-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 125032854 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 125039564 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 125039577 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 125046187 crossover junction endonuclease MUS81-like isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 125046730 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 125028949 structure-specific endonuclease subunit slx1-like K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 125044265 uncharacterized protein LOC125044265 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 125035366 uncharacterized protein LOC125035366 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 125029459 spatacsin-like isoform X1 K19026 SPG11; spatacsin
E 125033308 LOW QUALITY PROTEIN: uncharacterized protein LOC125033308 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 125047967 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 125025778 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 125025823 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 125025907 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 125043781 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 125027253 uncharacterized protein LOC125027253 isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 125032976 uncharacterized protein LOC125032976 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 125031903 BRCA2-interacting transcriptional repressor EMSY-like isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 125030509 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 125043385 LOW QUALITY PROTEIN: tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 125044176 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 125043770 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 125047261 X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 125033169 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 125047435 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 125032996 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 125025735 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 125031867 DNA ligase 4-like K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 125025694 uncharacterized protein LOC125025694 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 125044992 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 125029617 DNA-directed DNA/RNA polymerase mu-like isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 125026421 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 125036254 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 125029679 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 125035807 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 125037094 jmjC domain-containing protein 8-like K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 125036506 uncharacterized protein LOC125036506 K10888 FANCA; fanconi anemia group A protein
E 125038472 uncharacterized protein LOC125038472 K10894 FANCG; fanconi anemia group G protein
E 125034261 E3 ubiquitin-protein ligase FANCL-like isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 125032872 uncharacterized protein LOC125032872 K10896 FANCM; fanconi anemia group M protein
E 125025186 Fanconi anemia core complex-associated protein 24-like K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 125043820 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 125027348 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 125039712 centromere protein S-like K11511 APITD1; centromere protein S
E 125043880 centromere protein X-like K15360 STRA13; centromere protein X
E 125027855 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 125029433 Bloom syndrome protein-like isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125032800 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125045656 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125043031 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 125032744 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 125034662 LOW QUALITY PROTEIN: Fanconi anemia group D2 protein-like K10891 FANCD2; fanconi anemia group D2 protein
E 125028262 Fanconi anemia group I protein-like K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 125035867 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125035790 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E 125047072 LOW QUALITY PROTEIN: fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 125037790 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 125028172 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 125036473 WD repeat-containing protein 48-like K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 125047826 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 125037599 serine/threonine-protein phosphatase 6 regulatory subunit 3-like isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 125028980 golgin subfamily A member 6-like protein 22 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 125031134 E3 ubiquitin-protein ligase rnf168-like isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 125029164 E3 ubiquitin-protein ligase HERC2-like isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 125047615 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
E 125045615 WD repeat-containing protein 70-like isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 125036002 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 125027062 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 125047022 DNA polymerase iota-like K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 125025657 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 125031545 DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 125032096 mucin-4-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 125032099 DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 125044654 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 125034405 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 125035770 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 125035329 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 125041573 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 125043770 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
D 125025141 DNA-dependent metalloprotease dvc-1-like isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 125041791 DNA-dependent metalloprotease SPRTN-like K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 125045663 uncharacterized protein LOC125045663 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 125044254 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 125029663 checkpoint protein HUS1-like K10903 HUS1; HUS1 checkpoint protein
C HRAD17(Rad24)-RFC complex
D 125043743 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 125038570 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 125045236 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 125041591 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
D 125027035 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 125037077 TIMELESS-interacting protein-like K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 125029653 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 125036170 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 125028957 TELO2-interacting protein 2-like isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 125042953 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 125032146 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 125033256 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 125047629 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 125035129 uncharacterized protein LOC125035129 K10905 ATRIP; ATR interacting protein
D 125044179 serine-protein kinase ATM-like K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 125047115 serine/threonine-protein kinase grp-like K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 125038545 serine/threonine-protein kinase Chk2-like isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 125039092 meiotic sister-chromatid recombination protein 3-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 125038312 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125034219 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 125031054 neuron navigator 3-like isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 125025849 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 125032149 period circadian protein-like isoform X1 K02633 PER2; period circadian protein 2
D 125036181 uncharacterized protein LOC125036181 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 125027054 microtubule-associated serine/threonine-protein kinase 4-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 125028591 uncharacterized protein LOC125028591 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 125037029 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 125033959 KN motif and ankyrin repeat domain-containing protein 1-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125040208 suppressor protein of bem1/bed5 double mutants-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 125030904 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 125036367 uncharacterized protein LOC125036367 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 125041248 replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 125039634 DNA polymerase theta-like isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 125031430 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 125039890 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 125046601 uncharacterized protein LOC125046601 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 125033698 DNA cross-link repair 1A protein-like isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 125044586 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
C Helicases
D 125031683 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 125033573 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 125036109 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 125045302 uncharacterized protein LOC125045302 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 125030772 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 125044055 oxidized purine nucleoside triphosphate hydrolase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 125046930 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 125034389 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125035205 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125024787 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125024838 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125035429 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125025994 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125044947 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 125043592 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 125041133 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 125042241 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 125040590 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 125035980 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 125031166 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 125045474 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 125045474 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 125034389 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125035205 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125024787 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125024838 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125035429 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125025994 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024