+C Two-component system KO
#
Two-Component System - Pseudomonas citronellolis
%
!
AOmpR family
B PhoR-PhoB (phosphate starvation response)
C PcP3B5_60900 phoR; Phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C PcP3B5_60890 phoB; Phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C PcP3B5_41820 phoQ_2; Virulence sensor histidine kinase PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C PcP3B5_41830 phoP; Virulence transcriptional regulatory protein PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C PcP3B5_02910 envZ_1; Osmolarity sensor protein EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C PcP3B5_02900 ompR_1; Transcriptional regulatory protein OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C PcP3B5_41980 rstB; Sensor protein RstB K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C PcP3B5_41990 ompR_7; Transcriptional regulatory protein OmpR K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C PcP3B5_16450 ompR_2; Transcriptional regulatory protein OmpR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C PcP3B5_06130 creC; Sensor protein CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C PcP3B5_06120 creB; Transcriptional regulatory protein CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C PcP3B5_36270 baeS; Signal transduction histidine-protein kinase BaeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C PcP3B5_36260 baeR_2; Transcriptional regulatory protein BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C PcP3B5_22250 cusS_2; Sensor kinase CusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PcP3B5_00900 czcS; Sensor protein CzcS precursor K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PcP3B5_22260 copR; Transcriptional activator protein CopR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PcP3B5_00910 czcR_1; Transcriptional activator protein CzcR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C PcP3B5_54500 qseC; Sensor protein QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PcP3B5_54490 qseB_2; Transcriptional regulatory protein QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C PcP3B5_40050 kdpD; Sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C PcP3B5_40040 kdpE; KDP operon transcriptional regulatory protein KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C PcP3B5_49190 rssA_3; Swarming motility regulation sensor protein RssA K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C PcP3B5_49200 tctD; Transcriptional regulatory protein tctD K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
C PcP3B5_13580 pleD_3; Response regulator PleD K14981 chvI; two-component system, OmpR family, response regulator ChvI
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C PcP3B5_13820 pfeS_1; Sensor protein PfeS K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PcP3B5_48350 pfeS_3; Sensor protein PfeS K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PcP3B5_13830 baeR_1; Transcriptional regulatory protein BaeR K19610 pfeR; two-component system, OmpR family, response regulator PfeR
C PcP3B5_48360 baeR_3; Transcriptional regulatory protein BaeR K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C PcP3B5_16430 pfeS_2; Sensor protein PfeS K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PcP3B5_36310 cpxA; Sensor protein CpxA K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PcP3B5_33380 ompR_4; Transcriptional regulatory protein OmpR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_28030 cusR; Transcriptional regulatory protein CusR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_28040 czcR_3; Transcriptional activator protein CzcR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_40100 ompR_6; Transcriptional regulatory protein OmpR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_16590 ompR_3; Transcriptional regulatory protein OmpR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_36320 ompR_5; Transcriptional regulatory protein OmpR K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_02150 arcA_1; Aerobic respiration control protein ArcA K02483 K02483; two-component system, OmpR family, response regulator
C PcP3B5_39470 qseB_1; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C PcP3B5_34280 narX_1; Nitrate/nitrite sensor protein NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C PcP3B5_50550 narX_2; Nitrate/nitrite sensor protein NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C PcP3B5_34270 narL_1; Nitrate/nitrite response regulator protein NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C PcP3B5_50560 narL_3; Nitrate/nitrite response regulator protein NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C PcP3B5_36780 liaS; Sensor histidine kinase LiaS K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C PcP3B5_12770 rcsC_1; Sensor histidine kinase RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C PcP3B5_12790 rcsC_2; Sensor histidine kinase RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C PcP3B5_12800 rcsB_1; Transcriptional regulatory protein RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PcP3B5_24080 rcsB_3; Transcriptional regulatory protein RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PcP3B5_19890 rcsB_2; Transcriptional regulatory protein RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C PcP3B5_48370 barA_3; Signal transduction histidine-protein kinase BarA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C PcP3B5_25430 uvrY_2; Response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C PcP3B5_18580 bvgS_1; Virulence sensor protein BvgS precursor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PcP3B5_18820 bvgS_2; Virulence sensor protein BvgS precursor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PcP3B5_24390 bvgS_3; Virulence sensor protein BvgS precursor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PcP3B5_18570 bvgA_1; Virulence factors putative positive transcription regulator BvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C PcP3B5_18810 bvgA_2; Virulence factors putative positive transcription regulator BvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C PcP3B5_54060 bvgA_5; Virulence factors putative positive transcription regulator BvgA K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C PcP3B5_13700 dctB_2; C4-dicarboxylate transport sensor protein DctB K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]
C PcP3B5_13560 fixJ; Transcriptional regulatory protein FixJ K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
#
ASpo family
B KinABCDE-Spo0FA (sporulation control)
#
ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
#
ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C PcP3B5_04180 ypdA; Sensor histidine kinase YpdA K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C PcP3B5_27770 LytTr DNA-binding domain protein K08083 algR; two-component system, LytTR family, response regulator AlgR
C PcP3B5_04190 lytR; Sensory transduction protein LytR K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C PcP3B5_58710 glnL; Nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C PcP3B5_58720 glnG; Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C PcP3B5_10480 zraS_1; Sensor protein ZraS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C PcP3B5_10470 zraR_1; Transcriptional regulatory protein ZraR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C PcP3B5_02300 dctB_1; C4-dicarboxylate transport sensor protein DctB K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PcP3B5_59170 dctB_4; C4-dicarboxylate transport sensor protein DctB K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PcP3B5_59180 dctD_3; C4-dicarboxylate transport transcriptional regulatory protein DctD K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C PcP3B5_02290 dctD_1; C4-dicarboxylate transport transcriptional regulatory protein DctD K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C PcP3B5_62120 kinB; Alginate biosynthesis sensor protein KinB K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C PcP3B5_62110 algB_2; Alginate biosynthesis transcriptional regulatory protein AlgB K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C PcP3B5_29340 cheA_3; Chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PcP3B5_18120 cheA_2; Chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PcP3B5_29360 hypothetical protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PcP3B5_18100 cheY_2; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PcP3B5_29300 cheB_2; Chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PcP3B5_18130 cheB1; Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PcP3B5_19050 cheV_2; Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C PcP3B5_16030 cheV_1; Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C PcP3B5_05540 cheA_1; Chemotaxis protein CheA K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C PcP3B5_05490 walR; Transcriptional regulatory protein WalR K02657 pilG; twitching motility two-component system response regulator PilG
C PcP3B5_05500 pleD_2; Response regulator PleD K02658 pilH; twitching motility two-component system response regulator PilH
C PcP3B5_05550 cheB_1; Chemotaxis response regulator protein-glutamate methylesterase K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C PcP3B5_48550 frzE; Gliding motility regulatory protein K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C PcP3B5_48530 cph2_11; Phytochrome-like protein cph2 K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C PcP3B5_48540 cheB_3; Chemotaxis response regulator protein-glutamate methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
#
ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
#
ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C PcP3B5_28210 todT_1; Response regulator protein TodT K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
#
AOther families
B FlrB-FlrC (polar flagellar synthesis)
C PcP3B5_16290 zraS_2; Sensor protein ZraS K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C PcP3B5_16300 zraR_3; Transcriptional regulatory protein ZraR K10943 flrC; two-component system, response regulator FlrC
C PcP3B5_35600 zraR_6; Transcriptional regulatory protein ZraR K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C PcP3B5_51650 dctB_3; C4-dicarboxylate transport sensor protein DctB K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C PcP3B5_51660 dctD_2; C4-dicarboxylate transport transcriptional regulatory protein DctD K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C PcP3B5_11300 regB; Sensor histidine kinase RegB K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C PcP3B5_11310 regA; Photosynthetic apparatus regulatory protein RegA K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C PcP3B5_20710 barA_1; Signal transduction histidine-protein kinase BarA K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C PcP3B5_40270 luxQ_2; Autoinducer 2 sensor kinase/phosphatase LuxQ K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PcP3B5_36870 rcsC_3; Sensor histidine kinase RcsC K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PcP3B5_43760 Hpt domain protein K20976 hptB; histidine phosphotransfer protein HptB
C PcP3B5_43770 afsQ1; Transcriptional regulatory protein AfsQ1 K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C PcP3B5_39130 nrtA_2; Nitrate transport protein NrtA precursor K22067 nasS; two-component system, oxyanion-binding sensor
C PcP3B5_39140 pdtaR; putative transcriptional regulatory protein pdtaR K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C PcP3B5_13550 luxQ_1; Autoinducer 2 sensor kinase/phosphatase LuxQ K20971 ladS; two-component system, sensor histidine kinase LadS
C PcP3B5_09180 rpfC_2; Sensory/regulatory protein RpfC K20971 ladS; two-component system, sensor histidine kinase LadS
C PcP3B5_56010 barA_4; Signal transduction histidine-protein kinase BarA K20972 retS; two-component system, sensor histidine kinase RetS
C PcP3B5_51580 bvgS_4; Virulence sensor protein BvgS precursor K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023