+F Repair protein KO
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DNA Repair and Recombination Proteins - Plasmodium falciparum HB3
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PFHG_00197 conserved hypothetical protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PFHG_05125 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PFHG_00019 conserved hypothetical protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PFHG_01914 conserved hypothetical protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PFHG_00566 hypothetical protein similar to endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E PFHG_02836 apurinic/apyrimidinic endonuclease Apn1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F PFHG_02617 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F PFHG_01080 conserved hypothetical protein K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F PFHG_04267 hypothetical protein similar to DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F PFHG_02075 hypothetical protein similar to DNA polymerase epsilon subunit b K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E PFHG_02913 hypothetical protein similar to proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
E PFHG_03284 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E PFHG_03580 hypothetical protein similar to proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E PFHG_03399 hypothetical protein similar to flap endonuclease-1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E PFHG_01978 hypothetical protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E PFHG_02443 conserved hypothetical protein K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F PFHG_03771 conserved hypothetical protein K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F PFHG_00876 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F PFHG_03645 conserved hypothetical protein K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F PFHG_00867 DNA-directed RNA polymerase II largest subunit K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F PFHG_02012 DNA-directed RNA polymerase II 135 kDa polypeptide K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F PFHG_01359 conserved hypothetical protein K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F PFHG_00775 conserved hypothetical protein K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F PFHG_02385 DNA-directed RNA polymerases I K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F PFHG_02802 conserved hypothetical protein K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F PFHG_00383 hypothetical protein similar to DNA-directed RNA polymerase ii 15.1 kDa polypeptide K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F PFHG_04830 DNA-directed RNA polymerase II 8.2 kDa polypeptide K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F PFHG_01985 predicted protein K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F PFHG_02124 hypothetical protein K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F PFHG_00876 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E Other TCR factor
F PFHG_01423 hypothetical protein K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E PFHG_02514 hypothetical protein similar to RAD25 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E PFHG_04562 hypothetical protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E PFHG_03061 conserved hypothetical protein K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E PFHG_02159 conserved hypothetical protein K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E PFHG_05245 conserved hypothetical protein K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E PFHG_04457 conserved hypothetical protein K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E PFHG_00184 conserved hypothetical protein K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E PFHG_03411 conserved hypothetical protein K07466 RFA1; replication factor A1
D Other NER factors
E PFHG_03615 conserved hypothetical protein K10849 ERCC1; DNA excision repair protein ERCC-1
E PFHG_03788 hypothetical protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E PFHG_00780 conserved hypothetical protein K10846 ERCC5; DNA excision repair protein ERCC-5
E PFHG_01978 hypothetical protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E PFHG_05165 hypothetical protein similar to DNA mismatch repair enzyme K08735 MSH2; DNA mismatch repair protein MSH2
E PFHG_05295 hypothetical protein K08735 MSH2; DNA mismatch repair protein MSH2
E PFHG_00892 conserved hypothetical protein K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E PFHG_01926 hypothetical protein similar to DNA mismatch repair enzyme K08734 MLH1; DNA mismatch repair protein MLH1
E PFHG_02190 hypothetical protein K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E PFHG_02617 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E PFHG_01080 conserved hypothetical protein K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E PFHG_03411 conserved hypothetical protein K07466 RFA1; replication factor A1
D RFC (replication factor C)
E PFHG_02694 hypothetical protein similar to replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E PFHG_02681 replication factor C K10755 RFC2_4; replication factor C subunit 2/4
E PFHG_02135 replication factor c subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E PFHG_01785 conserved hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
E PFHG_04842 replication factor C3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E PFHG_02913 hypothetical protein similar to proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
E PFHG_03284 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E PFHG_03580 hypothetical protein similar to proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E PFHG_01281 conserved hypothetical protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E PFHG_01978 hypothetical protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E PFHG_00360 conserved hypothetical protein K10865 MRE11; double-strand break repair protein MRE11
E PFHG_01225 hypothetical protein similar to DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E PFHG_00360 conserved hypothetical protein K10865 MRE11; double-strand break repair protein MRE11
E PFHG_01225 hypothetical protein similar to DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E PFHG_04408 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E PFHG_04408 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
E PFHG_02414 hypothetical protein similar to DNA topoisomerase iii K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E PFHG_03411 conserved hypothetical protein K07466 RFA1; replication factor A1
D Protein phosphatase 4
E PFHG_04198 serine/threonine-protein phosphatase PP-X isozyme 2 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
D AP-5 complex
D SMC5-SMC6 complex
E PFHG_04720 conserved hypothetical protein K22803 SMC5; structural maintenance of chromosomes protein 5
E PFHG_02844 conserved hypothetical protein K22804 SMC6; structural maintenance of chromosomes protein 6
D Other HR factors
E PFHG_01249 hypothetical protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E PFHG_03969 conserved hypothetical protein K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E PFHG_02663 conserved hypothetical protein K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
E PFHG_00360 conserved hypothetical protein K10865 MRE11; double-strand break repair protein MRE11
E PFHG_01225 hypothetical protein similar to DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E PFHG_02414 hypothetical protein similar to DNA topoisomerase iii K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E PFHG_04408 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
C Other DSBR factors
D Protein phosphatase 6
E PFHG_02064 serine/threonine-protein phosphatase 6 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
D Others
E PFHG_00020 conserved hypothetical protein K23314 WRAP53; telomerase Cajal body protein 1
E PFHG_01324 conserved hypothetical protein K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D PFHG_02547 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D PFHG_00878 hypothetical protein similar to ubiquitin-conjugating enzyme K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D PFHG_04369 hypothetical protein K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D PFHG_01060 hypothetical protein K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D PFHG_02863 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D PFHG_02913 hypothetical protein similar to proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
D PFHG_03284 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D PFHG_03580 hypothetical protein similar to proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
D PFHG_02681 replication factor C K10755 RFC2_4; replication factor C subunit 2/4
D PFHG_02135 replication factor c subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D PFHG_01785 conserved hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
D PFHG_04842 replication factor C3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
D PFHG_00295 conserved hypothetical protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D PFHG_05289 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D PFHG_05195 14-3-3 protein K06630 YWHAE; 14-3-3 protein epsilon
D PFHG_00693 hypothetical protein similar to suppressor protein of bem1/bed5 double mutants K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D PFHG_00705 conserved hypothetical protein K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D PFHG_01085 conserved hypothetical protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D PFHG_01325 Myb2 protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D PFHG_00562 conserved hypothetical protein K12861 BCAS2; pre-mRNA-splicing factor SPF27
D PFHG_02373 pre-mRNA-splicing factor PRP46 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D PFHG_01890 hypothetical protein similar to deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D PFHG_00282 ribonucleoside-diphosphate reductase K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D PFHG_00441 ribonucleotide reductase small subunit K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D PFHG_02606 hypothetical protein similar to ribonucleotide reductase small subunit K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PFHG_00197 conserved hypothetical protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PFHG_05125 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PFHG_00019 conserved hypothetical protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PFHG_01914 conserved hypothetical protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PFHG_00566 hypothetical protein similar to endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E PFHG_00204 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F PFHG_00076 hypothetical protein similar to DNA-directed RNA polymerase K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F PFHG_03594 hypothetical protein similar to DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E PFHG_00204 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PFHG_00925 hypothetical protein similar to single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F PFHG_01622 conserved hypothetical protein K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F PFHG_03974 hypothetical protein similar to DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D PFHG_00925 hypothetical protein similar to single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D PFHG_01890 hypothetical protein similar to deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024