+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Pseudomonas graminis</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    FX982_01587 Phosphate regulon sensor protein PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    FX982_01588 Phosphate regulon transcriptional regulatory protein PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    FX982_00241 Virulence sensor histidine kinase PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    FX982_00242 Virulence transcriptional regulatory protein PhoP	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    FX982_01727 Osmolarity sensor protein EnvZ	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    FX982_01726 Transcriptional regulatory protein OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    FX982_00246 Sensor protein RstB	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
C    FX982_00247 Transcriptional regulatory protein OmpR	K07661 rstA; two-component system, OmpR family, response regulator RstA 
B  CpxA-CpxR (envelope stress response)
C    FX982_02768 Transcriptional regulatory protein CpxR	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
B  BaeS-BaeR (envelope stress response)
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
C    FX982_02404 Sensor kinase CusS	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
C    FX982_04677 Sensor protein CzcS	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
C    FX982_02405 Transcriptional activator protein CzcR	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
C    FX982_04676 Transcriptional activator protein CzcR	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
B  CrdS-CrdR (copper resistance)
B  HprS-HprR (hydrogen peroxide response)
B  QseC-QseB (quorum sensing)
C    FX982_00121 Sensor protein QseC	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    FX982_00122 Transcriptional regulatory protein QseB	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    FX982_04361 Sensor protein KdpD	K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 
C    FX982_04360 KDP operon transcriptional regulatory protein KdpE	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
B  ArcB-ArcA (anoxic redox control)
B  TctE-TctD (tricarboxylic acid transport)
C    FX982_00437 Swarming motility regulation sensor protein RssA	K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] 
C    FX982_00438 Transcriptional regulatory protein tctD	K07774 tctD; two-component system, OmpR family, response regulator TctD 
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
C    FX982_00198 Sensor protein PfeS	K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3] 
C    FX982_00199 Transcriptional regulatory protein CpxR	K19610 pfeR; two-component system, OmpR family, response regulator PfeR 
B  NisK-NisR (lantibiotic biosynthesis)
B  QarB-QarCA (disk-forming signal response)
B  HssS-HssR (heme sensing)
B  Unclassified
C    FX982_02766 Sensor histidine kinase CpxA	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    FX982_00640 Transcriptional regulatory protein OmpR	K02483 K02483; two-component system, OmpR family, response regulator 
C    FX982_03002 Transcriptional regulatory protein QseB	K02483 K02483; two-component system, OmpR family, response regulator 
C    FX982_04366 Transcriptional regulatory protein OmpR	K02483 K02483; two-component system, OmpR family, response regulator 
C    FX982_04606 Transcriptional regulatory protein CusR	K02483 K02483; two-component system, OmpR family, response regulator 
C    FX982_04660 Transcriptional regulatory protein OmpR	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
B  NarQ-NarP (nitrate respiration)
B  UhpB-UhpA (hexose phosphates uptake)
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
B  BarA-UvrY (central carbon metabolism)
C    FX982_00200 Signal transduction histidine-protein kinase BarA	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    FX982_03755 Response regulator GacA	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    FX982_02501 Virulence sensor protein BvgS	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    FX982_03363 Virulence sensor protein BvgS	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    FX982_00362 Virulence factors putative positive transcription regulator BvgA	K07690 evgA; two-component system, NarL family, response regulator EvgA 
C    FX982_03364 Virulence factors putative positive transcription regulator BvgA	K07690 evgA; two-component system, NarL family, response regulator EvgA 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
C    FX982_01663 Sensor histidine kinase BtsS	K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3] 
C    FX982_01664 Sensory transduction protein LytR	K08083 algR; two-component system, LytTR family, response regulator AlgR 
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  BtsS-BtsR (pyruvate reutilization)
B  PyrS-PyrR (pyruvate reutilization)
B  Unclassified
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    FX982_01321 Sensory histidine kinase/phosphatase NtrB	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    FX982_01322 DNA-binding transcriptional regulator NtrC	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
C    FX982_00853 Transcriptional regulatory protein ZraR	K07713 zraR; two-component system, NtrC family, response regulator HydG 
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
C    FX982_02169 Sensor protein ZraS	K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] 
C    FX982_02168 Regulatory protein AtoC	K02667 pilR; two-component system, NtrC family, response regulator PilR 
B  GlrK-GlrR (amino sugar metabolism)
B  PgtB-PgtA (phosphoglycerate transport)
B  DctB-DctD (C4-dicarboxylate transport)
C    FX982_00469 C4-dicarboxylate transport sensor protein DctB	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
C    FX982_01750 C4-dicarboxylate transport sensor protein DctB	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
C    FX982_00470 C4-dicarboxylate transport transcriptional regulatory protein DctD	K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD 
C    FX982_01749 C4-dicarboxylate transport transcriptional regulatory protein DctD	K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD 
B  KinB-AlgB (alginate production)
C    FX982_01424 Alginate biosynthesis sensor protein KinB	K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] 
C    FX982_01423 Alginate biosynthesis transcriptional regulatory protein AlgB	K11384 algB; two-component system, NtrC family, response regulator AlgB 
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
C    FX982_03618 Sensor protein ZraS	K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] 
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    FX982_03960 Chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    FX982_04776 Chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    FX982_03962 Chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    FX982_04778 Chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    FX982_02819 Chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    FX982_03955 Chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    FX982_04374 Chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    FX982_04775 Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    FX982_02418 Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    FX982_04588 Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    FX982_04837 Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
C    FX982_01255 Chemotaxis protein CheA	K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) 
C    FX982_01259 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP	K02657 pilG; twitching motility two-component system response regulator PilG 
C    FX982_01258 Response regulator PleD	K02658 pilH; twitching motility two-component system response regulator PilH 
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
C    FX982_02517 Gliding motility regulatory protein	K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE 
C    FX982_02519 Phytochrome-like protein cph2	K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] 
C    FX982_02518 Chemotaxis response regulator protein-glutamate methylesterase	K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] 
B  Cph1-Rcp1 (light response)
C    FX982_04297 Phytochrome-like protein cph1	K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] 
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
C    FX982_03466 Response regulator receiver protein CpdR	K13589 cpdR; two-component system, cell cycle response regulator CpdR 
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
C    FX982_04805 Signal transduction histidine-protein kinase AtoS	K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] 
C    FX982_04804 Regulatory protein AtoC	K10943 flrC; two-component system, response regulator FlrC 
B  AauS-AauR (acidic amino acids utilization)
C    FX982_00385 C4-dicarboxylate transport sensor protein DctB	K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] 
C    FX982_00386 C4-dicarboxylate transport transcriptional regulatory protein DctD	K17061 aauR; two-component system, response regulator AauR 
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
C    FX982_02368 Sensor histidine kinase RegB	K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] 
C    FX982_02369 Photosynthetic apparatus regulatory protein RegA	K15012 regA; two-component system, response regulator RegA 
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
C    FX982_00071 Signal transduction histidine-protein kinase BarA	K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3] 
C    FX982_03521 Autoinducer 2 sensor kinase/phosphatase LuxQ	K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] 
C    FX982_04795 hypothetical protein	K20976 hptB; histidine phosphotransfer protein HptB 
B  PdtaS-PdtaR
B  NasS-NasT
C    FX982_04475 Nitrate transport protein NrtA	K22067 nasS; two-component system, oxyanion-binding sensor 
C    FX982_04476 putative transcriptional regulatory protein pdtaR	K07183 nasT; two-component system, response regulator / RNA-binding antiterminator 
B  Unclassified
C    FX982_00913 Autoinducer 2 sensor kinase/phosphatase LuxQ	K20971 ladS; two-component system, sensor histidine kinase LadS 
C    FX982_02103 Signal transduction histidine-protein kinase BarA	K20972 retS; two-component system, sensor histidine kinase RetS 
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#Last updated: August 13, 2026