+F Repair protein KO
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DNA Repair and Recombination Proteins - Pseudoalteromonas translucida TAC125
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PSHAb0293 ogt; putative Methylated-DNA-[protein]-cysteine S-methyltransferase; O6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D PSHAa2200 putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D PSHAb0453 phr; putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PSHAa2561 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PSHAa0554 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PSHAa1099 nth; endonuclease III; DNA glycosylase/apyrimidinic (AP) lyase, acts on 5-formyluracil and 5-hydroxymethyluracil K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D PSHAb0342 putative S1/P1 Nuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D PSHAa2744 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PSHAb0293 ogt; putative Methylated-DNA-[protein]-cysteine S-methyltransferase; O6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D PSHAa2200 putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D PSHAb0453 phr; putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D PSHAa0994 conserved protein of unknown function K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
C BER (base exicision repair)
D DNA glycosylases
E PSHAa2561 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PSHAb0291 putative ADA regulatory protein (Regulatory protein of adaptative response) K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E PSHAa0554 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PSHAa0788 tag; putative 3-methyl-adenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E PSHAa0447 mutM; formamidopyrimidine DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E PSHAa1099 nth; endonuclease III; DNA glycosylase/apyrimidinic (AP) lyase, acts on 5-formyluracil and 5-hydroxymethyluracil K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E PSHAa1339 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E PSHAa0516 recJ; Single-stranded-DNA-specific exonuclease, 5'--> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E PSHAa1083 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E PSHAa2757 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E PSHAa2707 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
E PSHAa1110 uvrB; ATP-dependent DNA excision repair enzyme UvrAC K03702 uvrB; excinuclease ABC subunit B
E PSHAa1915 uvrC; DNA repair enzyme together with UvrAB; incision nuclease subunit C; repair of UV damage to DNA K03703 uvrC; excinuclease ABC subunit C
E PSHAa0122 uvrD; DNA-dependent ATPase I and helicase II; highly similar to PSHA_1_2804 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSHAa1096 uvrD; DNA helicase II. K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSHAa2757 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
E PSHAa1083 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F PSHAa0222 rpoB; DNA-directed RNA polymerase beta chain (RNAP beta subunit) (Transcriptase beta chain) (RNA polymerase beta subunit) K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F PSHAa0223 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F PSHAa2806 rpoA; DNA-directed RNA polymerase alpha chain (RNAP alpha subunit) (Transcriptase alpha chain) (RNA polymerase alpha subunit) K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F PSHAa2791 rpoZ; DNA-directed RNA polymerase omega chain (EC 2.7. 7.6) (RNAP omega subunit) (Transcriptase omega chain) (RNA polymerase omega subunit) K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F PSHAa1836 mfd; transcription-repair ATP-dependent coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E PSHAa0692 mutS; methyl-directed mismatch repair ATP-binding protein, dimer/tetramer, associates to MutL, triggers MutH activity on hemimethylated GATC K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E PSHAa0269 mutL; Enzyme in GATC methyl-directed mismatch repair, stimulates binding of Vsr and MutS to heteroduplex DNA K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E PSHAa0743 mutH; methyl-directed mismatch repair protein with restriction endonuclease-like domain K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E PSHAa1255 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E PSHAa0647 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E PSHAa2364 xseB; exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E PSHAa2015 dnaE; DNA polymerase III, alpha subunit; the entire polymerase contains 10 subunits K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E PSHAa0002 dnaN; DNA polymerase III, beta-subunit; processivity clamp of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E PSHAa2424 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E PSHAa1029 holA; Putative DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E PSHAa1802 holB; putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E PSHAa1435 putative DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSHAa1963 dnaQ; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSHAa0589 putative DNA polymerase, exonuclease activity K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSHAa1996 conserved protein of unknown function; putative enzyme K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PSHAa1201 putative DnaX, DNA polymerase III, gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E PSHAa1083 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E PSHAa0122 uvrD; DNA-dependent ATPase I and helicase II; highly similar to PSHA_1_2804 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSHAa1096 uvrD; DNA helicase II. K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PSHAa2705 ssb; Single-strand binding protein (SSB) (Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
E PSHAa2712 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E PSHAa1858 recB; exonuclease V, beta chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E PSHAa1859 recC; exonuclease V, gamma chain with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E PSHAa1857 recD; exonuclease V, alpha chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E PSHAa0694 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
E PSHAa1876 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
E PSHAa1875 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PSHAa1877 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E PSHAa2728 priA; Primosome factor Y, also called protein n'; ATP-dependent DNA helicase activity required for recA-dependent stable DNA replication mode; also involved in double-strand break repair K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E PSHAa2441 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E PSHAa1993 conserved protein of unknown function K04067 priC; primosomal replication protein N''
E PSHAa1255 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E PSHAb0054 sbcC; exonuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E PSHAa1895 putative orphan protein K03546 sbcC; DNA repair protein SbcC/Rad50
E PSHAb0055 sbcD; exonuclease sbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E PSHAa0694 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
E PSHAa0663 radA; putative DNA repair protein radA (DNA repair protein sms) K04485 radA; DNA repair protein RadA/Sms
E PSHAa0003 recF; gap repair protein with nucleoside triP hydrolase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction K03629 recF; DNA replication and repair protein RecF
E PSHAa2799 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E PSHAa0516 recJ; Single-stranded-DNA-specific exonuclease, 5'--> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E PSHAa0734 recO; DNA repair protein recO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
E PSHAa1203 recR; recombination protein recR K06187 recR; recombination protein RecR
E PSHAa1218 recN; DNA repair protein recN K03631 recN; DNA repair protein RecN (Recombination protein N)
E PSHAa2381 rdgC; nucleoid-associated protein K03554 rdgC; recombination associated protein RdgC
E PSHAa1876 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
E PSHAa1875 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PSHAa1877 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E PSHAa1985 yejH; putative ATP-dependent helicase with nucleoside triP hydrolase domain K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E PSHAb0054 sbcC; exonuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E PSHAa1895 putative orphan protein K03546 sbcC; DNA repair protein SbcC/Rad50
E PSHAb0055 sbcD; exonuclease sbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F PSHAa1421 gyrA; DNA gyrase, subunit A, type II topoisomerase K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F PSHAa0004 gyrB; DNA gyrase, subunit B (type II topoisomerase) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F PSHAa1348 topA; DNA topoisomerase type I, omega protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F PSHAa1287 hupA; DNA-binding protein HU-alpha (HU-2), likely to play a role in DNA replication and in rpo translation K05787 hupA; DNA-binding protein HU-alpha
F PSHAb0462 hupB; DNA-binding protein HU-beta (NS1) (HU-1) K03530 hupB; DNA-binding protein HU-beta
F PSHAa2059 hupB; DNA-binding protein HU-beta (NS1) (HU-1) K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F PSHAa0516 recJ; Single-stranded-DNA-specific exonuclease, 5'--> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F PSHAa0734 recO; DNA repair protein recO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
F PSHAa1203 recR; recombination protein recR K06187 recR; recombination protein RecR
F PSHAa1083 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F PSHAa0346 fis; DNA-binding protein for site-specific recombination and inversion, transcription of rRNA and tRNA operons, and DNA replication K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F PSHAa1902 ihfA; integration host factor (IHF), alpha subunit, DNA-bending protein, DNA replication K04764 ihfA; integration host factor subunit alpha
F PSHAa1426 ihfB; putative integration host factor (iHF), beta subunit, site-specific recombination K05788 ihfB; integration host factor subunit beta
E Supressor
F PSHAa1255 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F PSHAa2572 recQ; ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F PSHAb0119 putative helicase (recQ-like) K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F PSHAa2707 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
F PSHAa1110 uvrB; ATP-dependent DNA excision repair enzyme UvrAC K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D PSHAa2389 dinB; DNA polymerase IV, devoid of proofreading, damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D PSHAb0536 umuC; component of DNA polymerase V with UmuD K03502 umuC; DNA polymerase V
D PSHAb0537 umuD; component of DNA polymerase V K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D PSHAa0694 recA; RecA protein (Recombinase A) K03553 recA; recombination protein RecA
D PSHAa2873 lexA; transcriptional repressor for SOS response K01356 lexA; repressor LexA [EC:3.4.21.88]
D PSHAa1218 recN; DNA repair protein recN K03631 recN; DNA repair protein RecN (Recombination protein N)
D PSHAa1990 DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D PSHAa2705 ssb; Single-strand binding protein (SSB) (Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
D PSHAa0531 recX; putative regulatory protein, inhibitor of RecA recombinase and coprotease activities K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D PSHAa2762 rep; Rep helicase, a single-stranded DNA-dependent ATPase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D PSHAa1890 helD; putative helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D PSHAb0497 yoaA; putative ATP-dependent helicase YoaA with nucleotide triphosphate hydrolase domain, SOS repair, DinG family K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D PSHAa1991 dinG; putative ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D PSHAa2744 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PSHAa1418 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D PSHAa1417 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024