+F Repair protein KO
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DNA Repair and Recombination Proteins - Peromyscus leucopus (white-footed mouse)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 114692960 Mgmt; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 114686980 Alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 114699732 Alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
C BER (base exicision repair)
D DNA glycosylases
E 114686977 Ung; LOW QUALITY PROTEIN: uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 114706234 LOW QUALITY PROTEIN: uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 114704158 Ccno; LOW QUALITY PROTEIN: cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 114686948 LOW QUALITY PROTEIN: G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 114700613 Tdg; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 114709474 Mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 114696609 Smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 114707106 Mutyh; adenine DNA glycosylase isoform X2 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 114689643 Mbd4; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 114689601 Ogg1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 114690311 endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 114690376 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 114693803 LOW QUALITY PROTEIN: endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 114703335 Neil2; LOW QUALITY PROTEIN: endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 114699823 Neil3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 114680762 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 114696011 Apex1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 114702869 Apex2; DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 114684355 Pold1; DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 114693982 Pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 114698711 Pold3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
F 114686004 Pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 114682909 Pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 114684329 Pole2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 114683720 Pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 114694431 Pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 114699526 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 114703462 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 114689303 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 114703897 Lig1; DNA ligase 1 isoform X2 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 114705742 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 114709839 Xrcc1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 114691556 Lig3; DNA ligase 3 isoform X3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 114705014 Tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 114703261 Aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 114680635 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 114684339 bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 114691719 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114694848 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114702483 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114699146 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 114708142 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 114690631 Parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 114683791 Parp4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 114710984 Parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 114696016 Parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 114681334 Xpc; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 114687089 Rad23a; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 114695687 Rad23b; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 114687209 Cetn2; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 114707186 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 114694298 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 114688000 LOW QUALITY PROTEIN: cullin-4A-like K10609 CUL4; cullin 4
F 114701247 Cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 114709744 Cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 114703417 Ddb1; DNA damage-binding protein 1 isoform X2 K10610 DDB1; DNA damage-binding protein 1
F 114699687 Ddb2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 114693182 Polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 114681027 Polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 114694494 Polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 114691653 Polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 114684122 Polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 114694255 Polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 114683640 Polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 114683329 Polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 114681654 Polr2i; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 114693846 Polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 114710318 Polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 114705048 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 114698800 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 114706871 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 114708131 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 114703637 Polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 114707186 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 114694298 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 114688000 LOW QUALITY PROTEIN: cullin-4A-like K10609 CUL4; cullin 4
F 114701247 Cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 114709744 Cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 114703417 Ddb1; DNA damage-binding protein 1 isoform X2 K10610 DDB1; DNA damage-binding protein 1
F 114703434 Ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 114699354 Ercc6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 114694051 Uvssa; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 114695263 Elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 114709922 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 114691642 Ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 114709862 Ercc2; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 114685653 Gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 114703868 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 114704510 Gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 114687015 Gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 114706271 Gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 114703858 Cdk7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 114710512 Ccnh; cyclin-H K06634 CCNH; cyclin H
E 114683809 Mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 114691427 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 114705962 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 114693467 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 114696998 Rpa4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 114702363 Xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 114709837 Ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 114707331 Ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 114705318 Ercc5; DNA repair protein complementing XP-G cells isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 114689303 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 114703897 Lig1; DNA ligase 1 isoform X2 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 114706854 Mms19; LOW QUALITY PROTEIN: MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 114703314 Cul3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 114690280 Cul5; cullin-5 K10612 CUL5; cullin 5
E 114683462 elongin-C-like K03872 ELOC; elongin-C
E 114690123 Eloc; elongin-C K03872 ELOC; elongin-C
E 114692175 elongin-C-like K03872 ELOC; elongin-C
E 114684495 elongin-B-like K03873 ELOB; elongin-B
E 114680792 Elob; elongin-B K03873 ELOB; elongin-B
E 114688345 elongin-B-like K03873 ELOB; elongin-B
E 114689282 elongin-B-like K03873 ELOB; elongin-B
E 114692290 LOW QUALITY PROTEIN: elongin-B-like K03873 ELOB; elongin-B
E 114701918 elongin-B-like K03873 ELOB; elongin-B
E 114697227 Eloa; LOW QUALITY PROTEIN: elongin-A K15076 ELOA; elongin-A
E 114693379 LOW QUALITY PROTEIN: elongin-A-like K15076 ELOA; elongin-A
E 114707951 Ubap2l; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 114703245 Ubap2; ubiquitin-associated protein 2 isoform X3 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 114695418 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 114709214 Msh2; DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 114708052 Msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 114709246 Msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 114705161 Pms1; PMS1 protein homolog 1 isoform X3 K10864 PMS1; DNA mismatch repair protein PMS1
E 114685379 Mlh1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 114707575 Pms2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 114698077 Mlh3; LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 114684355 Pold1; DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 114693982 Pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 114698711 Pold3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E 114686004 Pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 114691427 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 114705962 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 114693467 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 114696998 Rpa4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 114702015 Rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 114697111 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 114693648 Rfc2; replication factor C subunit 2 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
E 114681474 Rfc3; LOW QUALITY PROTEIN: replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 114699654 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 114699526 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 114690720 Exo1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 114691719 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114694848 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114702483 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 114699146 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 114689303 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 114703897 Lig1; DNA ligase 1 isoform X2 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 114699597 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 114684999 Mre11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 114694600 Nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114693607 Bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114691769 Abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 114695734 LOW QUALITY PROTEIN: BRCA1-A complex subunit Abraxas 1-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 114689416 Uimc1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 114709584 Babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 114696301 Babam2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 114706183 Brcc3; lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 114695639 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 114709924 LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114699285 Brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 114697673 LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 114693525 Topbp1; LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114698163 Rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 114684999 Mre11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 114694600 Nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114699159 Brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 114692201 Palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 114704631 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 114704631 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 114697777 DNA repair protein RAD51 homolog 2 isoform X3 K10869 RAD51L1; RAD51-like protein 1
E 114699268 Rad51c; DNA repair protein RAD51 homolog 3 isoform X4 K10870 RAD51L2; RAD51-like protein 2
E 114710587 DNA repair protein RAD51 homolog 3-like isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 114691558 Rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 114700060 Xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 114703062 Xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 114700750 Rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 114689065 LOW QUALITY PROTEIN: RAD52 motif-containing protein 1-like K10874 RDM1; RAD52 motif-containing protein 1
E 114702205 RAD52 motif-containing protein 1-like isoform X2 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 114706887 Rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 114710957 Rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 114694580 Rad54b; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 114700291 Recql; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 114698502 Wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 114696195 Blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 114694194 Recql4; ATP-dependent DNA helicase Q4 isoform X5 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 114707040 Recql5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 114696195 Blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 114682573 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 114682715 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 114688580 Rmi1; recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 114695570 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 114691427 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 114705962 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 114693467 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 114696998 Rpa4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 114704335 Ppp4c; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 114696320 Ppp4r1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 114709817 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 114695384 Ppp4r2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 114705030 Ppp4r3a; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 114708312 Ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 114706072 Ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 114709181 Ap5b1; LOW QUALITY PROTEIN: AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 114696024 Ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 114699514 Ap5s1; AP-5 complex subunit sigma-1 isoform X1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 114705516 Ap5z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 114709950 Smc5; structural maintenance of chromosomes protein 5 isoform X2 K22803 SMC5; structural maintenance of chromosomes protein 5
E 114692005 Smc6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 114691997 protein LRATD1 K22805 FAM84A; protein FAM84A
E 114698824 Lratd1; LOW QUALITY PROTEIN: protein LRATD1 K22805 FAM84A; protein FAM84A
E 114692222 Nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 114701987 Nsmce2; E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 114695492 Nsmce3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 114709155 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 114692475 Nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 114700609 Eid3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 114708349 Slf1; LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 114708108 Slf2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 114692894 Eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 114681244 Eme2; probable crossover junction endonuclease EME2 isoform X1 K10883 EME2; crossover junction endonuclease EME2
E 114697784 Exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 114709144 Mus81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 114703836 Swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 114696725 Sfr1; LOW QUALITY PROTEIN: swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 114704328 Slx1a; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 114710642 Slx4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 114692007 Gen1; flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 114699603 Spg11; LOW QUALITY PROTEIN: spatacsin K19026 SPG11; spatacsin
E 114697776 Zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 114701443 Rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 114690944 Morf4l1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 114681847 Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 114702514 Fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 114709458 Spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 114701990 Lratd2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 114705504 Brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 114685803 Cfap410; cilia- and flagella-associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 114685078 Hdgfl2; hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 114682958 Zswim7; zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 114695246 Swsap1; ATPase SWSAP1 isoform X1 K25771 SWSAP1; ATPase SWSAP1
E 114698688 Emsy; BRCA2-interacting transcriptional repressor EMSY isoform X4 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 114686650 LOW QUALITY PROTEIN: heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 114699076 Mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 114694186 Tonsl; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 114709231 Bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 114700597 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
E 114702187 Hrob; homologous recombination OB-fold protein isoform X1 K27803 HROB; homologous recombination OB-fold protein
E 114699535 Mcm8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 114692558 Mcm9; LOW QUALITY PROTEIN: DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 114694312 Xrcc6; LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 114693626 Xrcc5; X-ray repair cross-complementing protein 5 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 114709460 Prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 114684999 Mre11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D DNA Ligase 4 complex
E 114695113 Lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 114680964 Xrcc4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 114709323 Nhej1; LOW QUALITY PROTEIN: non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 114708142 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 114693983 Polm; DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 114706872 Dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 114705742 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 114703261 Aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 114680635 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 114710823 Dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 114700890 Tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 114696418 Smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 114684099 Pwwp3a; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 114687285 Pwwp3b; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 114689011 PWWP domain-containing DNA repair factor 3A-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 114689183 LOW QUALITY PROTEIN: PWWP domain-containing DNA repair factor 3A-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 114692789 Paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 114691029 Cyren; cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 114681200 Jmjd8; jmjC domain-containing protein 8 isoform X2 K25792 JMJD8; jumonji domain-containing protein 8
E 114699532 Shld1; shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 114699336 Shld2; shieldin complex subunit 2 isoform X2 K26129 SHLD2; shieldin complex subunit 2
E 114703167 Shld3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
E 114702036 Bend4; LOW QUALITY PROTEIN: BEN domain-containing protein 4 K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E 114700998 Fanca; Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 114702925 Fancb; Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 114708417 Fancc; Fanconi anemia group C protein isoform X1 K10890 FANCC; fanconi anemia group C protein
E 114706149 Fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 114700523 Fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 114703223 Fancg; LOW QUALITY PROTEIN: Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 114710742 Fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 114684374 Fancm; Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 114698907 Faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 114680612 Faap100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 114707351 Hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 114709638 LOW QUALITY PROTEIN: centromere protein S-like K11511 APITD1; centromere protein S
E 114680646 Cenpx; centromere protein X K15360 STRA13; centromere protein X
E 114698115 Ube2t; ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 114696195 Blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 114682573 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 114682715 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 114688580 Rmi1; recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 114695570 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 114689613 Fancd2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 114696134 Fanconi anemia group I protein homolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 114682837 Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 114699159 Brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 114699285 Brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 114692201 Palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 114695497 Fan1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 114704631 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 114699268 Rad51c; DNA repair protein RAD51 homolog 3 isoform X4 K10870 RAD51L2; RAD51-like protein 2
E 114710587 DNA repair protein RAD51 homolog 3-like isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 114681257 Telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 114687263 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 114693745 Usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 114708308 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 114681287 Wdr48; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 114682771 Ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 114687702 Ppp6r1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 114693024 Ppp6r2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 114694547 Ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 114708178 Ankrd28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 114704864 Ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 114681808 Ankrd52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 114703983 Rnf8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 114695813 E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 114710044 Rnf168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 114698706 Rnf169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 114708977 Herc2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 114693170 Wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 114692775 Tprn; taperin K24164 TPRN; taperin
E 114688346 Zcwpw1; zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 114697352 Wdr70; WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 114704654 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 114699597 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 114705303 Polh; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 114690177 Poli; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 114694653 Polk; DNA polymerase kappa isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 114690795 Rev1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 114696886 Rev3l; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 114694062 Poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 114705419 Ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 114683061 Ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 114689588 Rad18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 114686246 Hltf; helicase-like transcription factor isoform X2 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 114680671 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 114692669 Ube2v1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 114700817 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 114707612 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 114709456 Ube2v2; ubiquitin-conjugating enzyme E2 variant 2 isoform X2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 114681934 Ube2n; ubiquitin-conjugating enzyme E2 N isoform X2 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 114699526 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 114700597 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 114707164 Sprtn; sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 114685984 Rad9a; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 114704566 Rad9b; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 114708031 Hus1; checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 114701141 Hus1b; checkpoint protein HUS1B K10996 HUS1B; checkpoint protein HUS1B
D 114710789 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 114703862 Rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 114697111 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 114693648 Rfc2; replication factor C subunit 2 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 114681474 Rfc3; LOW QUALITY PROTEIN: replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 114699654 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 114710789 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 114681789 Timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 114691480 Tipin; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 114704269 Clspn; LOW QUALITY PROTEIN: claspin K25773 CLSPN; claspin
C Triple T complex
D 114681257 Telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 114706754 Tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 114698505 Tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 114705863 Bag6; large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 114706203 Ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 114699945 Ubl4b; LOW QUALITY PROTEIN: ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 114682202 Get4; Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 114690969 Atr; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 114705189 LOW QUALITY PROTEIN: ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 114690277 Atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 114693171 Tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 114684003 Chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 114685972 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 114705236 Cdc25a; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 114699513 Cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 114705113 Cdc25c; M-phase inducer phosphatase 3 isoform X1 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 114698856 Ywhaq; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 114692606 Ywhab; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 114703643 Ywhaz; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 114694046 Ywhah; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 114710296 Ywhag; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 114691442 Ywhae; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 114700513 Nav2; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 114684461 Wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 114710459 Wee1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 114693157 Per1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 114700680 Per2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 114702636 Per3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 114687009 Mdc1; LOW QUALITY PROTEIN: mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 114684053 Pls3; plastin-3 isoform X1 K17336 PLS3; plastin-3
D 114699875 Aen; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 114709376 Plk3; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 114684130 Plk5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 114686274 Nek5; serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 114701101 Nek1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 114708182 Nek4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 114682455 Nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 114693510 Nek11; serine/threonine-protein kinase Nek11 isoform X3 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 114698426 Donson; protein downstream neighbor of Son isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 114685316 Kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 114693747 Kank4; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 114695239 Kank2; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 114710094 Kank1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 114705623 Chmp4c; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 114683424 Vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 114702807 Vps4b; vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 114704627 Zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 114690627 Sde2; LOW QUALITY PROTEIN: replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 114710724 Polq; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 114706313 Mybbp1a; LOW QUALITY PROTEIN: myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 114701184 Primpol; LOW QUALITY PROTEIN: DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 114705191 Trex1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 114706235 Trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 114697067 Dclre1a; DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 114684768 Dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 114704923 Exo5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 114680615 Endov; endonuclease V isoform X2 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 114696958 Zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 114709589 Ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 114691768 Helq; LOW QUALITY PROTEIN: helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 114708427 Ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 114703409 Prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 114707837 Cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 114698584 Bcas2; pre-mRNA-splicing factor SPF27 isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 114682938 Plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 114698798 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 114685114 Nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 114709696 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 114698779 Nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 114683901 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 114706610 Rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 114683031 Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 114698849 Rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 114692960 Mgmt; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 114686977 Ung; LOW QUALITY PROTEIN: uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 114706234 LOW QUALITY PROTEIN: uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 114696609 Smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 114709474 Mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 114707106 Mutyh; adenine DNA glycosylase isoform X2 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 114680762 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 114684452 Ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 114684452 Ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 114698798 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 114683901 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024