+E Replication protein KO
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DNA Replication Proteins - Pongo pygmaeus (Bornean orangutan)
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 129036525 ORC1; (RefSeq) origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 129031079 ORC2; (RefSeq) origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 129038459 ORC3; (RefSeq) origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 129031482 ORC4; (RefSeq) origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 129040448 ORC5; (RefSeq) origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 129015252 ORC6; (RefSeq) origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 129015197 CDT1; (RefSeq) DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 129017088 CDC6; (RefSeq) cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 129033162 MCM2; (RefSeq) DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 129038812 MCM3; (RefSeq) DNA replication licensing factor MCM3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 129042305 MCM4; (RefSeq) DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 129023629 MCM5; (RefSeq) DNA replication licensing factor MCM5 isoform X2 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 129031451 MCM6; (RefSeq) DNA replication licensing factor MCM6 isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 129041080 MCM7; (RefSeq) DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 129011458 CCNA1; (RefSeq) cyclin-A1 isoform X1 K06627 CCNA; cyclin-A
D 129034946 CCNA2; (RefSeq) cyclin-A2 isoform X2 K06627 CCNA; cyclin-A
D 129020992 CCNE1; (RefSeq) G1/S-specific cyclin-E1 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 129042533 CCNE2; (RefSeq) G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 129009303 CDK2; (RefSeq) cyclin-dependent kinase 2 isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 129034947 CDC7; (RefSeq) cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 129016920 DBF4B; (RefSeq) protein DBF4 homolog B isoform X1 K06629 DBF4; protein DBF4
D 129041423 DBF4; (RefSeq) protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 129021895 GINS1; (RefSeq) DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 129015038 GINS2; (RefSeq) DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 129016133 GINS3; (RefSeq) DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 129043112 GINS4; (RefSeq) DNA replication complex GINS protein SLD5 isoform X1 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 129033913 TOPBP1; (RefSeq) DNA topoisomerase 2-binding protein 1 isoform X3 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 129042961 RECQL4; (RefSeq) ATP-dependent DNA helicase Q4 isoform X7 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 129022911 CDC45; (RefSeq) cell division control protein 45 homolog isoform X1 K06628 CDC45; cell division control protein 45
D 129021399 MCM8; (RefSeq) DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 129039370 MCM9; (RefSeq) DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 129006552 MCM10; (RefSeq) protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 129006090 MCMBP; (RefSeq) mini-chromosome maintenance complex-binding protein isoform X1 K28390 MCMBP; minichromosome maintenance complex-binding protein
D 129010129 HELB; (RefSeq) DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 129008439 FAM111A; (RefSeq) serine protease FAM111A isoform X1 K24274 FAM111A; protein FAM111A
D 129013029 CINP; (RefSeq) cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 129042185 MTBP; (RefSeq) mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 129013732 TICRR; (RefSeq) treslin isoform X1 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 129025118 POLA1; (RefSeq) DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 129007936 POLA2; (RefSeq) DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 129010008 PRIM1; (RefSeq) DNA primase small subunit isoform X1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 129038917 PRIM2; (RefSeq) DNA primase large subunit isoform X2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 129010522 POLE; (RefSeq) DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 129012571 POLE2; (RefSeq) DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 129043840 POLE3; (RefSeq) DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 129030665 POLE4; (RefSeq) DNA polymerase epsilon subunit 4 isoform X1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 129020494 POLD1; (RefSeq) DNA polymerase delta catalytic subunit isoform X3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 129040341 POLD2; (RefSeq) DNA polymerase delta subunit 2 isoform X2 K02328 POLD2; DNA polymerase delta subunit 2
D 129008564 POLD3; (RefSeq) DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 129007098 POLD4; (RefSeq) DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 129013730 POLG; (RefSeq) DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 129017433 POLG2; (RefSeq) DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 129018266 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 129042402 RPA2; (RefSeq) replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 129041227 RPA3; (RefSeq) replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D 129023935 RPA4; (RefSeq) replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 129035828 RFC1; (RefSeq) replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 129032586 RFC4; (RefSeq) replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 129040224 RFC2; (RefSeq) replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 129009454 RFC5; (RefSeq) replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 129011241 RFC3; (RefSeq) replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 129017539 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 129030835 RNASEH1; (RefSeq) ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 129020187 RNASEH2A; (RefSeq) ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 129011617 RNASEH2B; (RefSeq) ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 129008415 RNASEH2C; (RefSeq) ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 129021903 PCNA; (RefSeq) proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 129006703 DNA2; (RefSeq) DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 129007404 FEN1; (RefSeq) flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 129031985 EXO1; (RefSeq) exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 129031446 ZRANB3; (RefSeq) DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 129019462 LIG1; (RefSeq) DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 129018335 ATAD5; (RefSeq) ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 129019332 DNMT1; (RefSeq) DNA (cytosine-5)-methyltransferase 1 isoform X2 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 129030052 DNMT3A; (RefSeq) DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 129021527 DNMT3B; (RefSeq) DNA (cytosine-5)-methyltransferase 3B isoform X2 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 129039166 GMNN; (RefSeq) geminin K10749 GMNN; geminin
D 129036593 MCIDAS; (RefSeq) multicilin K26119 MCIDAS; multicilin
D 129037565 CCNB1; (RefSeq) G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 129014163 CCNB2; (RefSeq) G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 129025277 CCNB3; (RefSeq) G2/mitotic-specific cyclin-B3 isoform X1 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 129006414 CDK1; (RefSeq) cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 129041296 POT1; (RefSeq) protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 129018740 telomeric repeat-binding factor 1-like K11110 TERF1; telomeric repeat-binding factor 1
E 129042394 TERF1; (RefSeq) telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 134738484 telomeric repeat-binding factor 1-like K11110 TERF1; telomeric repeat-binding factor 1
E 129015689 TERF2; (RefSeq) telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 129012855 TINF2; (RefSeq) TERF1-interacting nuclear factor 2 isoform X1 K11112 TINF2; TERF1-interacting nuclear factor 2
E 129015488 TERF2IP; (RefSeq) telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 129015635 ACD; (RefSeq) adrenocortical dysplasia protein homolog K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 129015588 TERB1; (RefSeq) telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 129014016 TERB2; (RefSeq) telomere repeats-binding bouquet formation protein 2 isoform X1 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 129007142 MAJIN; (RefSeq) membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 129016937 CTC1; (RefSeq) CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 129006359 STN1; (RefSeq) CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 129016971 TEN1; (RefSeq) CST complex subunit TEN1 isoform X2 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 129018272 SMG6; (RefSeq) telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 129032459 SMG5; (RefSeq) nonsense-mediated mRNA decay factor SMG5 isoform X1 K11125 SMG5; protein SMG5
D 129037404 TERT; (RefSeq) telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 129012178 TEP1; (RefSeq) telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 129035754 GAR1; (RefSeq) H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 129036455 NHP2; (RefSeq) H/ACA ribonucleoprotein complex subunit 2 isoform X1 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 129009790 LOW QUALITY PROTEIN: H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 129013805 NOP10; (RefSeq) H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 129024753 DKC1; (RefSeq) H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 129037404 TERT; (RefSeq) telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 129021375 SNRPB; (RefSeq) small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 129018667 SNRPD1; (RefSeq) small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 129019841 SNRPD2; (RefSeq) small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 129022937 SNRPD3; (RefSeq) small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 129013943 SNRPE; (RefSeq) small nuclear ribonucleoprotein E isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 129015749 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 129033555 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 129044499 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 129009284 SNRPF; (RefSeq) small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 129006551 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129006754 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129013296 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129019368 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129030289 SNRPG; (RefSeq) small nuclear ribonucleoprotein G isoform X3 K11099 SNRPG; small nuclear ribonucleoprotein G
E 129030478 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129031617 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 129040788 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 129032586 RFC4; (RefSeq) replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 129040224 RFC2; (RefSeq) replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 129009454 RFC5; (RefSeq) replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 129011241 RFC3; (RefSeq) replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 129007517 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X5 K10865 MRE11; double-strand break repair protein MRE11
D 129036367 RAD50; (RefSeq) DNA repair protein RAD50 isoform X2 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 129042203 NBN; (RefSeq) nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 129008963 ATM; (RefSeq) serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 129042234 WRN; (RefSeq) bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 129014212 BLM; (RefSeq) RecQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 129042304 PRKDC; (RefSeq) DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 129015578 ERCC4; (RefSeq) DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 129034988 PARP1; (RefSeq) poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 129012177 PARP2; (RefSeq) poly [ADP-ribose] polymerase 2 isoform X1 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D 129042013 TNKS; (RefSeq) poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 129045176 TNKS2; (RefSeq) poly [ADP-ribose] polymerase tankyrase-2 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 129042697 PINX1; (RefSeq) PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 129021345 RTEL1; (RefSeq) regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 129015933 TELO2; (RefSeq) telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 129020194 TRIR; (RefSeq) telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 129032023 RIF1; (RefSeq) telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 129013655 PIF1; (RefSeq) ATP-dependent DNA helicase PIF1 isoform X1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 129036334 PURA; (RefSeq) transcriptional activator protein Pur-alpha isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 129042233 PURG; (RefSeq) purine-rich element-binding protein gamma isoform X1 K21800 PURG; purine-rich element-binding protein gamma
D 129017146 WRAP53; (RefSeq) telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 129044224 SDE2; (RefSeq) splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 129021435 RTF2; (RefSeq) replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 129021637 TOP1; (RefSeq) DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 129042212 TOP1MT; (RefSeq) DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 129017190 TOP2A; (RefSeq) DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 129033905 TOP2B; (RefSeq) DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 129018032 TOP3A; (RefSeq) DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 129022830 TOP3B; (RefSeq) DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 129040013 SSBP1; (RefSeq) single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 129017539 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 129030835 RNASEH1; (RefSeq) ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 129017539 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 129030835 RNASEH1; (RefSeq) ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 129006703 DNA2; (RefSeq) DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 129007404 FEN1; (RefSeq) flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 129019462 LIG1; (RefSeq) DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025